ATE452881T1 - Katalysiertes verfahren zur herstellung von c-5- substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1 - Google Patents
Katalysiertes verfahren zur herstellung von c-5- substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1Info
- Publication number
- ATE452881T1 ATE452881T1 AT06827425T AT06827425T ATE452881T1 AT E452881 T1 ATE452881 T1 AT E452881T1 AT 06827425 T AT06827425 T AT 06827425T AT 06827425 T AT06827425 T AT 06827425T AT E452881 T1 ATE452881 T1 AT E452881T1
- Authority
- AT
- Austria
- Prior art keywords
- 11beta
- producing
- type
- substituted heterocyclic
- hydroxysteroid dehydrogenase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000004277 11-beta-hydroxysteroid dehydrogenases Human genes 0.000 title 1
- 108090000874 11-beta-hydroxysteroid dehydrogenases Proteins 0.000 title 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000008645 11-beta-Hydroxysteroid Dehydrogenase Type 1 Human genes 0.000 abstract 1
- 108010088011 11-beta-Hydroxysteroid Dehydrogenase Type 1 Proteins 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73857405P | 2005-11-22 | 2005-11-22 | |
| PCT/US2006/042913 WO2007061600A1 (en) | 2005-11-22 | 2006-11-01 | CATALYZED PROCESS OF MAKING C-5-SUBSTITUTED HETEROCYCLIC INHIBITORS OF 11ß-HYDROXY STEROID DEHYDROGENASE TYPE 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE452881T1 true ATE452881T1 (de) | 2010-01-15 |
Family
ID=37882184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06827425T ATE452881T1 (de) | 2005-11-22 | 2006-11-01 | Katalysiertes verfahren zur herstellung von c-5- substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7541474B2 (de) |
| EP (1) | EP1951695B1 (de) |
| AT (1) | ATE452881T1 (de) |
| AU (1) | AU2006317070B2 (de) |
| CA (1) | CA2630558A1 (de) |
| DE (1) | DE602006011360D1 (de) |
| ES (1) | ES2335141T3 (de) |
| WO (1) | WO2007061600A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE452881T1 (de) | 2005-11-22 | 2010-01-15 | Amgen Inc | Katalysiertes verfahren zur herstellung von c-5- substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1 |
| EP2173729A1 (de) | 2007-06-21 | 2010-04-14 | Amgen Inc. | Verfahren zur herstellung substituierter 2-aminothiazolone |
| EP2321290B1 (de) * | 2008-07-29 | 2012-06-20 | Amgen, Inc | Asymmetrisches verfahren zur herstellung substituierter 2-aminothiazolone |
| US20130310431A1 (en) | 2010-10-15 | 2013-11-21 | Amgen Inc | Uses for substituted 2-amino-thiazolones in treating alzheimer's disease |
| CA3017740A1 (en) | 2016-03-16 | 2017-09-21 | Pearlie BURNETTE | Small molecules against cereblon to enhance effector t cell function |
| EA202190248A1 (ru) | 2018-07-11 | 2021-06-16 | Х. Ли Моффитт Кэнсер Сентер Энд Рисерч Инститьют, Инк. | Димерные иммуномодулирующие соединения против механизмов на основе цереблона |
| CN108976170B (zh) * | 2018-08-14 | 2022-04-22 | 华南理工大学 | 一种5-三氟甲基-4h-咪唑啉-4-酮衍生物及合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1964956B (zh) * | 2004-05-24 | 2013-03-27 | 安美基公司 | 11-β-羟基类固醇脱氢酶1型的抑制剂 |
| ATE452881T1 (de) | 2005-11-22 | 2010-01-15 | Amgen Inc | Katalysiertes verfahren zur herstellung von c-5- substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1 |
-
2006
- 2006-11-01 AT AT06827425T patent/ATE452881T1/de not_active IP Right Cessation
- 2006-11-01 WO PCT/US2006/042913 patent/WO2007061600A1/en not_active Ceased
- 2006-11-01 US US11/590,922 patent/US7541474B2/en not_active Expired - Fee Related
- 2006-11-01 CA CA002630558A patent/CA2630558A1/en not_active Abandoned
- 2006-11-01 DE DE602006011360T patent/DE602006011360D1/de active Active
- 2006-11-01 AU AU2006317070A patent/AU2006317070B2/en not_active Ceased
- 2006-11-01 ES ES06827425T patent/ES2335141T3/es active Active
- 2006-11-01 EP EP06827425A patent/EP1951695B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006317070A1 (en) | 2007-05-31 |
| AU2006317070B2 (en) | 2011-06-23 |
| ES2335141T3 (es) | 2010-03-22 |
| CA2630558A1 (en) | 2007-05-31 |
| WO2007061600A1 (en) | 2007-05-31 |
| US7541474B2 (en) | 2009-06-02 |
| DE602006011360D1 (de) | 2010-02-04 |
| US20070117985A1 (en) | 2007-05-24 |
| EP1951695B1 (de) | 2009-12-23 |
| EP1951695A1 (de) | 2008-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |