ATE452881T1 - Katalysiertes verfahren zur herstellung von c-5- substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1 - Google Patents
Katalysiertes verfahren zur herstellung von c-5- substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1Info
- Publication number
- ATE452881T1 ATE452881T1 AT06827425T AT06827425T ATE452881T1 AT E452881 T1 ATE452881 T1 AT E452881T1 AT 06827425 T AT06827425 T AT 06827425T AT 06827425 T AT06827425 T AT 06827425T AT E452881 T1 ATE452881 T1 AT E452881T1
- Authority
- AT
- Austria
- Prior art keywords
- 11beta
- producing
- type
- substituted heterocyclic
- hydroxysteroid dehydrogenase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000004277 11-beta-hydroxysteroid dehydrogenases Human genes 0.000 title 1
- 108090000874 11-beta-hydroxysteroid dehydrogenases Proteins 0.000 title 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000008645 11-beta-Hydroxysteroid Dehydrogenase Type 1 Human genes 0.000 abstract 1
- 108010088011 11-beta-Hydroxysteroid Dehydrogenase Type 1 Proteins 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73857405P | 2005-11-22 | 2005-11-22 | |
| PCT/US2006/042913 WO2007061600A1 (en) | 2005-11-22 | 2006-11-01 | CATALYZED PROCESS OF MAKING C-5-SUBSTITUTED HETEROCYCLIC INHIBITORS OF 11ß-HYDROXY STEROID DEHYDROGENASE TYPE 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE452881T1 true ATE452881T1 (de) | 2010-01-15 |
Family
ID=37882184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06827425T ATE452881T1 (de) | 2005-11-22 | 2006-11-01 | Katalysiertes verfahren zur herstellung von c-5- substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7541474B2 (de) |
| EP (1) | EP1951695B1 (de) |
| AT (1) | ATE452881T1 (de) |
| AU (1) | AU2006317070B2 (de) |
| CA (1) | CA2630558A1 (de) |
| DE (1) | DE602006011360D1 (de) |
| ES (1) | ES2335141T3 (de) |
| WO (1) | WO2007061600A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006011360D1 (de) | 2005-11-22 | 2010-02-04 | Amgen Inc | Katalysiertes verfahren zur herstellung von c-5-substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1 |
| WO2009002445A1 (en) * | 2007-06-21 | 2008-12-31 | Amgen Inc. | Process for making substituted 2-amino-thiazolones |
| EP2321290B1 (de) * | 2008-07-29 | 2012-06-20 | Amgen, Inc | Asymmetrisches verfahren zur herstellung substituierter 2-aminothiazolone |
| WO2012051139A1 (en) | 2010-10-15 | 2012-04-19 | Amgen Inc. | New uses for substituted 2-amino-thiazolones in treating alzheimer's disease |
| CN109153644B (zh) | 2016-03-16 | 2022-10-21 | H·李·莫菲特癌症中心研究有限公司 | 用以增强效应t细胞功能的针对cereblon的小分子 |
| EP3820532A4 (de) | 2018-07-11 | 2022-04-06 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Dimere immunmodulatorische verbindungen gegen cereblonbasierte mechanismen |
| CN108976170B (zh) * | 2018-08-14 | 2022-04-22 | 华南理工大学 | 一种5-三氟甲基-4h-咪唑啉-4-酮衍生物及合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005247929B2 (en) | 2004-05-24 | 2010-03-11 | Amgen Inc. | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| DE602006011360D1 (de) | 2005-11-22 | 2010-02-04 | Amgen Inc | Katalysiertes verfahren zur herstellung von c-5-substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1 |
-
2006
- 2006-11-01 DE DE602006011360T patent/DE602006011360D1/de active Active
- 2006-11-01 WO PCT/US2006/042913 patent/WO2007061600A1/en not_active Ceased
- 2006-11-01 AT AT06827425T patent/ATE452881T1/de not_active IP Right Cessation
- 2006-11-01 AU AU2006317070A patent/AU2006317070B2/en not_active Ceased
- 2006-11-01 CA CA002630558A patent/CA2630558A1/en not_active Abandoned
- 2006-11-01 EP EP06827425A patent/EP1951695B1/de active Active
- 2006-11-01 ES ES06827425T patent/ES2335141T3/es active Active
- 2006-11-01 US US11/590,922 patent/US7541474B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007061600A1 (en) | 2007-05-31 |
| DE602006011360D1 (de) | 2010-02-04 |
| US7541474B2 (en) | 2009-06-02 |
| ES2335141T3 (es) | 2010-03-22 |
| US20070117985A1 (en) | 2007-05-24 |
| CA2630558A1 (en) | 2007-05-31 |
| AU2006317070A1 (en) | 2007-05-31 |
| EP1951695B1 (de) | 2009-12-23 |
| AU2006317070B2 (en) | 2011-06-23 |
| EP1951695A1 (de) | 2008-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602006017192D1 (de) | Verfahren zur herstellung von oligonukleotiden | |
| ATE510930T1 (de) | Zusammensetzungen und verfahren zur bearbeitung und amplifikation von dna mit verwendung mehrerer enzyme in einer einzigen reaktion | |
| WO2007134086A3 (en) | Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis | |
| ATE462012T1 (de) | Ezymatisches verfahren zur herstellung von 2-o- glyceryl-alpha-d-glucopyranosid | |
| DE60335965D1 (de) | Verfahren zur herstellung von endprodukten aus kohlenstoffsubstraten | |
| DE602004024964D1 (de) | Verfahren zur herstellung von alkohol | |
| ATE501264T1 (de) | Enzymatische verfahren zur herstellung 4- substituierter 3-hydroxybuttersäure-derivate | |
| MX2009013869A (es) | Proceso para hacer 2-amino-tiazolonas sustituidas. | |
| ATE524427T1 (de) | Verfahren zur herstellung von 3-methyl-1,5- pentandiol | |
| DE602006011360D1 (de) | Katalysiertes verfahren zur herstellung von c-5-substituierten heterocyclischen inhibitoren von 11beta-hydroxysteroiddehydrogenase vom typ 1 | |
| ATE452117T1 (de) | Verfahren zur herstellung von cyclischen ketonen | |
| ATE430140T1 (de) | Verfahren zur herstellung von ä1,4,5ü- oxadiazepinderivaten | |
| DE502005000428D1 (de) | Verfahren zur Herstellung von 1,2-Diaminocyclohexan-Platin(II)-Komplexen | |
| DE502005000378D1 (de) | Verfahren zur Herstellung von Mercaptoorganyl (alkoxysilan) | |
| ATE410409T1 (de) | Verfahren zur herstellung von gesättigten nitrilen | |
| ATE384046T1 (de) | Verfahren zur asymmetrischen hydrierung, das sich für die herstellung von cycloalkanindolderivaten eignet | |
| ATE459723T1 (de) | Verfahren zur herstellung von (4s)-3,4-dihydroxy- 2,6,6-trimethyl-cyclohex-2-enon und derivaten davon unter verwendung der azoarcus phenylethanol dehydrogenase | |
| ATE503767T1 (de) | Herstellung eines von willenbrand faktor- präparates mit hoher spezifischer aktivität | |
| DE102005054282A1 (de) | Verfahren zur Herstellung von überwiegend ein Enantiomer enthaltendem 1,1,1-Trifluorisopropanol | |
| ATE380066T1 (de) | Verfahren zur herstellung von membranen | |
| ATE529413T1 (de) | Verfahren zur synthese von aryloxydiaminopyrimidinen | |
| ATE515502T1 (de) | Verfahren zur herstellung von tetranorlabdanderivaten | |
| ATE513840T1 (de) | Verfahren zur herstellung optisch aktiver diphosphane | |
| ATE549315T1 (de) | Verfahren zur herstellung von kristallinem perindopril | |
| ATE423775T1 (de) | Verfahren zur herstellung von lactonen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |