ATE549315T1 - Verfahren zur herstellung von kristallinem perindopril - Google Patents
Verfahren zur herstellung von kristallinem perindoprilInfo
- Publication number
- ATE549315T1 ATE549315T1 AT06776370T AT06776370T ATE549315T1 AT E549315 T1 ATE549315 T1 AT E549315T1 AT 06776370 T AT06776370 T AT 06776370T AT 06776370 T AT06776370 T AT 06776370T AT E549315 T1 ATE549315 T1 AT E549315T1
- Authority
- AT
- Austria
- Prior art keywords
- producing crystalline
- perindopril
- crystalline perindopril
- preparation
- relates
- Prior art date
Links
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 3
- 229960002582 perindopril Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 125000005210 alkyl ammonium group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200500214 | 2005-07-25 | ||
| PCT/EP2006/007258 WO2007017087A1 (en) | 2005-07-25 | 2006-07-24 | Process for the preparation of crystalline perindopril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE549315T1 true ATE549315T1 (de) | 2012-03-15 |
Family
ID=37451139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06776370T ATE549315T1 (de) | 2005-07-25 | 2006-07-24 | Verfahren zur herstellung von kristallinem perindopril |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7923570B2 (de) |
| EP (1) | EP1910287B1 (de) |
| JP (1) | JP4972643B2 (de) |
| CN (1) | CN101228126B (de) |
| AT (1) | ATE549315T1 (de) |
| AU (1) | AU2006278866B2 (de) |
| BR (1) | BRPI0613976A2 (de) |
| CA (1) | CA2615691C (de) |
| EA (1) | EA013018B1 (de) |
| MX (1) | MX2008001151A (de) |
| SI (1) | SI1910287T1 (de) |
| UA (1) | UA92752C2 (de) |
| WO (1) | WO2007017087A1 (de) |
| ZA (1) | ZA200800138B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008002066A (es) * | 2005-08-12 | 2008-04-16 | Sandoz Ag | Neuva forma cristalina de perindopril-erbumina. |
| ATE502045T1 (de) * | 2005-08-12 | 2011-04-15 | Lek Pharmaceuticals | Verfahren zur herstellung von perindoprilerbumin |
| SI22543A (sl) * | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
| GB0910692D0 (en) * | 2009-06-20 | 2009-08-05 | Teva Pharma | Compound |
| CN111116709B (zh) * | 2019-12-31 | 2022-06-24 | 北京鑫开元医药科技有限公司 | 一种培哚普利制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| US20020107230A1 (en) * | 2000-12-22 | 2002-08-08 | Waldon R. Forrest | Methods and formulations for the treatment of female sexual dysfunction |
| GB2395195A (en) * | 2002-11-18 | 2004-05-19 | Cipla Ltd | Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors |
| AU2003263584A1 (en) * | 2003-08-21 | 2005-03-10 | Hetero Drugs Limited | Process for pure perindopril tert-butylamine salt |
| SI21704A (en) * | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia |
-
2006
- 2006-07-24 UA UAA200801935A patent/UA92752C2/ru unknown
- 2006-07-24 BR BRPI0613976-0A patent/BRPI0613976A2/pt not_active IP Right Cessation
- 2006-07-24 AU AU2006278866A patent/AU2006278866B2/en not_active Ceased
- 2006-07-24 MX MX2008001151A patent/MX2008001151A/es active IP Right Grant
- 2006-07-24 JP JP2008523205A patent/JP4972643B2/ja not_active Expired - Fee Related
- 2006-07-24 CN CN2006800268517A patent/CN101228126B/zh not_active Expired - Fee Related
- 2006-07-24 SI SI200631349T patent/SI1910287T1/sl unknown
- 2006-07-24 AT AT06776370T patent/ATE549315T1/de active
- 2006-07-24 EA EA200800200A patent/EA013018B1/ru not_active IP Right Cessation
- 2006-07-24 US US11/996,438 patent/US7923570B2/en not_active Expired - Fee Related
- 2006-07-24 WO PCT/EP2006/007258 patent/WO2007017087A1/en not_active Ceased
- 2006-07-24 CA CA2615691A patent/CA2615691C/en not_active Expired - Fee Related
- 2006-07-24 EP EP06776370A patent/EP1910287B1/de not_active Not-in-force
-
2008
- 2008-01-07 ZA ZA200800138A patent/ZA200800138B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1910287A1 (de) | 2008-04-16 |
| MX2008001151A (es) | 2008-03-13 |
| AU2006278866A1 (en) | 2007-02-15 |
| CA2615691A1 (en) | 2007-02-15 |
| EP1910287B1 (de) | 2012-03-14 |
| CA2615691C (en) | 2015-11-10 |
| CN101228126B (zh) | 2011-10-19 |
| JP2009502833A (ja) | 2009-01-29 |
| US20080306135A1 (en) | 2008-12-11 |
| SI1910287T1 (sl) | 2012-09-28 |
| CN101228126A (zh) | 2008-07-23 |
| BRPI0613976A2 (pt) | 2011-02-22 |
| WO2007017087A1 (en) | 2007-02-15 |
| EA013018B1 (ru) | 2010-02-26 |
| US7923570B2 (en) | 2011-04-12 |
| JP4972643B2 (ja) | 2012-07-11 |
| AU2006278866B2 (en) | 2012-03-15 |
| ZA200800138B (en) | 2009-08-26 |
| UA92752C2 (ru) | 2010-12-10 |
| EA200800200A1 (ru) | 2008-06-30 |
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