ATE452882T1 - Herstellung von quetiapin - Google Patents
Herstellung von quetiapinInfo
- Publication number
- ATE452882T1 ATE452882T1 AT04767074T AT04767074T ATE452882T1 AT E452882 T1 ATE452882 T1 AT E452882T1 AT 04767074 T AT04767074 T AT 04767074T AT 04767074 T AT04767074 T AT 04767074T AT E452882 T1 ATE452882 T1 AT E452882T1
- Authority
- AT
- Austria
- Prior art keywords
- quetiapine
- preparation
- compound
- discloses
- well
- Prior art date
Links
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004431 quetiapine Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50498103P | 2003-09-23 | 2003-09-23 | |
| PCT/FI2004/000560 WO2005028458A1 (en) | 2003-09-23 | 2004-09-23 | Preparation of quetiapine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE452882T1 true ATE452882T1 (de) | 2010-01-15 |
Family
ID=34375548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04767074T ATE452882T1 (de) | 2003-09-23 | 2004-09-23 | Herstellung von quetiapin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7863441B2 (de) |
| EP (1) | EP1664007B1 (de) |
| JP (1) | JP2007505864A (de) |
| AT (1) | ATE452882T1 (de) |
| CA (1) | CA2538745A1 (de) |
| DE (1) | DE602004024798D1 (de) |
| ES (1) | ES2335589T3 (de) |
| PT (1) | PT1664007E (de) |
| WO (1) | WO2005028458A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1664009B1 (de) * | 2003-09-23 | 2011-01-19 | Fermion Oy | Verfahren zur herstellung von quetiapin |
| EP1869007A1 (de) | 2005-04-14 | 2007-12-26 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von quetiapinfumaraten |
| US8101597B2 (en) | 2007-05-07 | 2012-01-24 | Actavis Group Ptc Ehf | Quetiapine salts and their polymorphs |
| US20080287418A1 (en) * | 2007-05-16 | 2008-11-20 | Astrazeneca Ab | Extended Release Compositions and Methods for Their Manufacture |
| EP2245021B1 (de) | 2008-01-31 | 2012-09-12 | Fermion Oy | Verfahren zur herstellung von quetiapin |
| JP2012519683A (ja) | 2009-03-04 | 2012-08-30 | ランバクシー ラボラトリーズ リミテッド | フマル酸クエチアピンの調製方法 |
| CN101891707B (zh) * | 2010-07-29 | 2012-10-17 | 浙江海正药业股份有限公司 | 喹硫平或其可药用盐的制备方法 |
| US20140057303A1 (en) | 2012-08-21 | 2014-02-27 | Janssen Pharmaceutica Nv | Antibodies to Olanzapine Haptens and Use Thereof |
| WO2014031645A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to risperidone haptens and use thereof |
| EP2888263B1 (de) | 2012-08-21 | 2018-05-09 | Janssen Pharmaceutica NV | Haptene aus risperidon und paliperidon |
| EP3305784B1 (de) | 2012-08-21 | 2020-08-12 | Janssen Pharmaceutica NV | Haptene von quetiapin zur verwendung bei immunoassays |
| CN110054694B (zh) | 2012-08-21 | 2024-02-20 | 詹森药业有限公司 | 阿立哌唑半抗原的抗体及其用途 |
| HK1211958A1 (en) | 2012-08-21 | 2016-06-03 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone and use thereof |
| CA2882489A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone haptens and use thereof |
| AU2013305879B2 (en) | 2012-08-21 | 2017-10-12 | Saladax Biomedical Inc. | Antibodies to aripiprazole and use thereof |
| PL3321254T3 (pl) | 2012-08-21 | 2021-01-11 | Janssen Pharmaceutica Nv | Hapteny arypiprazolu i ich zastosowanie w testach immunologicznych |
| PT3462173T (pt) | 2012-08-21 | 2021-04-28 | Janssen Pharmaceutica Nv | Anticorpos contra risperidona e utilização dos mesmos |
| AU2013305930B2 (en) | 2012-08-21 | 2017-08-24 | Saladax Biomedical Inc. | Haptens of paliperidone |
| CA2882454C (en) | 2012-08-21 | 2020-08-11 | Matthew Garrett DONAHUE | Haptens of olanzapine |
| JP6216926B2 (ja) | 2012-08-21 | 2017-10-25 | ヤンセン ファーマシューティカ エヌ．ベー． | オランザピンに対する抗体及びその使用 |
| PL3333195T3 (pl) | 2012-08-21 | 2021-02-22 | Janssen Pharmaceutica Nv | Przeciwciała względem kwetiapiny i ich zastosowania |
| PL3663317T3 (pl) | 2012-08-21 | 2023-06-05 | Janssen Pharmaceutica Nv | Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie |
| CN103396382B (zh) * | 2013-07-29 | 2015-05-20 | 太仓市茜泾化工有限公司 | 一种喹硫平中间体的制备方法 |
| CN104803947A (zh) * | 2015-03-12 | 2015-07-29 | 常州康丽制药有限公司 | 11-(1-哌嗪基)二苯并[b,f][1,4]硫氮杂*富马酸盐的制备方法 |
| AU2016372069A1 (en) | 2015-12-17 | 2018-06-07 | Saladax Biomedical Inc. | Antibodies to risperidone and use thereof |
| WO2017106508A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| CN114181172B (zh) * | 2021-12-27 | 2023-12-22 | 浙江苏泊尔制药有限公司 | 一种富马酸喹硫平的高效制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA979441A (en) * | 1967-02-27 | 1975-12-09 | American Cyanamid Company | 11-(piperazinyl) dibenz (b,f) (1,4) oxazepines and analogous thiazepines |
| US3539573A (en) * | 1967-03-22 | 1970-11-10 | Jean Schmutz | 11-basic substituted dibenzodiazepines and dibenzothiazepines |
| HU227039B1 (en) * | 2000-01-25 | 2010-05-28 | Egis Gyogyszergyar Nyilvanosan | New process for the production of quetiapine and intermediates therefor |
| RU2344123C9 (ru) | 2001-04-16 | 2009-05-20 | Шеринг Корпорейшн | 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора |
| ES2223294B2 (es) * | 2003-08-08 | 2005-10-01 | Vita Cientifica, S.L. | Procedimiento de preparacion de un compuesto farmaceuticamente activo. |
| EP1664009B1 (de) * | 2003-09-23 | 2011-01-19 | Fermion Oy | Verfahren zur herstellung von quetiapin |
-
2004
- 2004-09-23 WO PCT/FI2004/000560 patent/WO2005028458A1/en not_active Ceased
- 2004-09-23 JP JP2006526653A patent/JP2007505864A/ja not_active Ceased
- 2004-09-23 US US10/572,409 patent/US7863441B2/en not_active Expired - Fee Related
- 2004-09-23 AT AT04767074T patent/ATE452882T1/de active
- 2004-09-23 ES ES04767074T patent/ES2335589T3/es not_active Expired - Lifetime
- 2004-09-23 PT PT04767074T patent/PT1664007E/pt unknown
- 2004-09-23 CA CA002538745A patent/CA2538745A1/en not_active Abandoned
- 2004-09-23 DE DE602004024798T patent/DE602004024798D1/de not_active Expired - Lifetime
- 2004-09-23 EP EP04767074A patent/EP1664007B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004024798D1 (de) | 2010-02-04 |
| PT1664007E (pt) | 2010-02-15 |
| EP1664007B1 (de) | 2009-12-23 |
| WO2005028458A1 (en) | 2005-03-31 |
| US7863441B2 (en) | 2011-01-04 |
| JP2007505864A (ja) | 2007-03-15 |
| EP1664007A1 (de) | 2006-06-07 |
| CA2538745A1 (en) | 2005-03-31 |
| US20070111987A1 (en) | 2007-05-17 |
| ES2335589T3 (es) | 2010-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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