ATE453617T1 - Substituierte n-arylbenzamide und verwandte verbindungen zur behandlung von amyloidkrankheiten und synukleinopathien - Google Patents
Substituierte n-arylbenzamide und verwandte verbindungen zur behandlung von amyloidkrankheiten und synukleinopathienInfo
- Publication number
- ATE453617T1 ATE453617T1 AT05749770T AT05749770T ATE453617T1 AT E453617 T1 ATE453617 T1 AT E453617T1 AT 05749770 T AT05749770 T AT 05749770T AT 05749770 T AT05749770 T AT 05749770T AT E453617 T1 ATE453617 T1 AT E453617T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- synucleinopathies
- substituted
- related compounds
- arylbenzamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57066904P | 2004-05-12 | 2004-05-12 | |
| US62952504P | 2004-11-18 | 2004-11-18 | |
| PCT/US2005/016677 WO2005113489A1 (en) | 2004-05-12 | 2005-05-12 | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453617T1 true ATE453617T1 (de) | 2010-01-15 |
Family
ID=34969702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05749770T ATE453617T1 (de) | 2004-05-12 | 2005-05-12 | Substituierte n-arylbenzamide und verwandte verbindungen zur behandlung von amyloidkrankheiten und synukleinopathien |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7745490B2 (de) |
| EP (1) | EP1751097B1 (de) |
| JP (1) | JP5203701B2 (de) |
| KR (1) | KR101168451B1 (de) |
| AT (1) | ATE453617T1 (de) |
| AU (1) | AU2005245412B2 (de) |
| BR (1) | BRPI0510803A (de) |
| CA (1) | CA2566090C (de) |
| DE (1) | DE602005018634D1 (de) |
| DK (1) | DK1751097T3 (de) |
| ES (1) | ES2337162T3 (de) |
| IL (1) | IL179160A (de) |
| MX (1) | MXPA06012603A (de) |
| NO (1) | NO20065717L (de) |
| NZ (1) | NZ551589A (de) |
| RU (1) | RU2381213C2 (de) |
| SG (1) | SG137850A1 (de) |
| WO (1) | WO2005113489A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090124690A1 (en) * | 2000-04-03 | 2009-05-14 | Alberte Randall S | Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins |
| US20070208087A1 (en) * | 2001-11-02 | 2007-09-06 | Sanders Virginia J | Compounds, compositions and methods for the treatment of inflammatory diseases |
| US20090227647A1 (en) * | 2008-03-05 | 2009-09-10 | Thomas Lake | Compounds, Compositions and Methods for the Treatment of Islet Amyloid Polypeptide (IAPP) Accumulation in Diabetes |
| JP2009531443A (ja) * | 2006-03-29 | 2009-09-03 | フォールドアールエックス ファーマシューティカルズ インコーポレーティッド | α−シヌクレイン毒性の抑制 |
| EP2098226A1 (de) * | 2008-03-06 | 2009-09-09 | Forschungsverbund Berlin e.V. | AKAP-PKA-Interaktionshemmer zur Anwendung in der Behandlung von Herzkrankheiten |
| EP2554163A4 (de) * | 2010-03-26 | 2013-07-17 | Univ Hokkaido Nat Univ Corp | Therapeutischer wirkstoff für neurodegenerative erkrankungen |
| US20120251448A1 (en) * | 2011-03-03 | 2012-10-04 | Hefti Franz F | Compounds for Use in the Detection of Neurodegenerative Diseases |
| CN111315735B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 二氢苯并咪唑酮 |
| US10799551B2 (en) | 2017-09-25 | 2020-10-13 | Amorepacific Corporation | Composition for enhancing cognitive function comprising green tea extract which has modified amounts of ingredients |
| KR102011033B1 (ko) * | 2017-09-25 | 2019-08-14 | (주)아모레퍼시픽 | 성분 함량이 변화된 녹차 추출물을 포함하는 인지기능 개선용 조성물 |
| US20220041591A1 (en) * | 2018-10-19 | 2022-02-10 | Auckland Uniservices Limited | Compounds for treating diabetes and/or related conditions |
| WO2020181232A1 (en) | 2019-03-06 | 2020-09-10 | C4 Therapeutics, Inc. | Heterocyclic compounds for medical treatment |
| US20250326713A1 (en) * | 2022-05-20 | 2025-10-23 | Merck Sharp & Dohme Llc | INHIBITORS OF MsbA AS ANTIBIOTICS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF |
| CN117682973B (zh) * | 2022-09-26 | 2026-03-20 | 中国药科大学 | 磺酰胺类化合物及其医药用途 |
| EP4686725A1 (de) | 2024-08-02 | 2026-02-04 | Technische Universität München, in Vertretung des Freistaats Bayern | Amyloidhemmende peptide |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5916871A (ja) * | 1982-07-20 | 1984-01-28 | Shionogi & Co Ltd | スルホンアミド系ベンズアミド類 |
| JPS63132237A (ja) * | 1986-11-21 | 1988-06-04 | Konica Corp | 迅速処理を行なつても優れた発色性を有するハロゲン化銀写真感光材料 |
| MX9203460A (es) * | 1988-09-12 | 1992-09-01 | Upjohn Co | Nuevos analogos cc-1065 que tienen dos subunidades cpi. |
| GB8914660D0 (en) * | 1989-06-26 | 1989-08-16 | Fujisawa Pharmaceutical Co | Aniline derivatives,processes for production thereof and pharmaceutical compositions comprising the same |
| JPH04285955A (ja) * | 1991-03-14 | 1992-10-12 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| JP2002516276A (ja) * | 1998-05-22 | 2002-06-04 | アバニール・ファーマシューティカルズ | ＩｇＥのモジュレータとしてのベンゾイミダゾール誘導体 |
| CN1263733C (zh) * | 1998-10-22 | 2006-07-12 | 神经研究公司 | 取代苯基衍生物,它们的制备和用途 |
| JP4623453B2 (ja) * | 1999-10-14 | 2011-02-02 | 旭化成イーマテリアルズ株式会社 | アミドフェノール化合物 |
| HUP0400280A3 (en) * | 2001-06-07 | 2006-01-30 | Ligand Pharmaceuticals Inc San | Modulators of peroxisome proliferator activated receptors, process for their preparation and pharmaceutical compositions containing them |
| SI1511710T1 (sl) * | 2002-05-31 | 2014-04-30 | Proteotech, Inc. | Spojine, sestavki in postopki za zdravljenje amiloidnih bolezni in sinukleinopatij, kot je Alzheimerjeva bolezen, diabetes tipa 2 in Parkinsova bolezen |
| AU2003275225A1 (en) * | 2002-09-20 | 2004-04-08 | Genelabs Technologies, Inc. | Novel aromatic compounds possessing antifungal or antibacterial activity |
-
2005
- 2005-05-12 AU AU2005245412A patent/AU2005245412B2/en not_active Ceased
- 2005-05-12 NZ NZ551589A patent/NZ551589A/en not_active IP Right Cessation
- 2005-05-12 WO PCT/US2005/016677 patent/WO2005113489A1/en not_active Ceased
- 2005-05-12 BR BRPI0510803-9A patent/BRPI0510803A/pt not_active IP Right Cessation
- 2005-05-12 MX MXPA06012603A patent/MXPA06012603A/es active IP Right Grant
- 2005-05-12 SG SG200717673-8A patent/SG137850A1/en unknown
- 2005-05-12 DE DE602005018634T patent/DE602005018634D1/de not_active Expired - Lifetime
- 2005-05-12 DK DK05749770.3T patent/DK1751097T3/da active
- 2005-05-12 EP EP05749770A patent/EP1751097B1/de not_active Expired - Lifetime
- 2005-05-12 ES ES05749770T patent/ES2337162T3/es not_active Expired - Lifetime
- 2005-05-12 KR KR1020067026028A patent/KR101168451B1/ko not_active Expired - Fee Related
- 2005-05-12 JP JP2007513368A patent/JP5203701B2/ja not_active Expired - Fee Related
- 2005-05-12 AT AT05749770T patent/ATE453617T1/de active
- 2005-05-12 RU RU2006143761/04A patent/RU2381213C2/ru not_active IP Right Cessation
- 2005-05-12 CA CA2566090A patent/CA2566090C/en not_active Expired - Fee Related
-
2006
- 2006-01-09 US US11/328,748 patent/US7745490B2/en not_active Expired - Fee Related
- 2006-11-09 IL IL179160A patent/IL179160A/en not_active IP Right Cessation
- 2006-12-12 NO NO20065717A patent/NO20065717L/no not_active Application Discontinuation
-
2008
- 2008-08-29 US US12/201,183 patent/US20090060838A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1751097A1 (de) | 2007-02-14 |
| EP1751097B1 (de) | 2009-12-30 |
| RU2006143761A (ru) | 2008-06-20 |
| US20090060838A1 (en) | 2009-03-05 |
| JP5203701B2 (ja) | 2013-06-05 |
| US20060199838A1 (en) | 2006-09-07 |
| JP2007537287A (ja) | 2007-12-20 |
| KR20070015612A (ko) | 2007-02-05 |
| WO2005113489A1 (en) | 2005-12-01 |
| IL179160A (en) | 2011-04-28 |
| DE602005018634D1 (de) | 2010-02-11 |
| ES2337162T3 (es) | 2010-04-21 |
| DK1751097T3 (da) | 2010-05-10 |
| KR101168451B1 (ko) | 2012-07-25 |
| BRPI0510803A (pt) | 2007-11-06 |
| US7745490B2 (en) | 2010-06-29 |
| RU2381213C2 (ru) | 2010-02-10 |
| SG137850A1 (en) | 2007-12-28 |
| AU2005245412B2 (en) | 2011-08-04 |
| NZ551589A (en) | 2009-10-30 |
| AU2005245412A1 (en) | 2005-12-01 |
| NO20065717L (no) | 2007-02-08 |
| CA2566090C (en) | 2013-07-23 |
| IL179160A0 (en) | 2007-03-08 |
| MXPA06012603A (es) | 2007-04-12 |
| CA2566090A1 (en) | 2005-12-01 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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