ATE399758T1 - Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheiten - Google Patents
Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheitenInfo
- Publication number
- ATE399758T1 ATE399758T1 AT05767873T AT05767873T ATE399758T1 AT E399758 T1 ATE399758 T1 AT E399758T1 AT 05767873 T AT05767873 T AT 05767873T AT 05767873 T AT05767873 T AT 05767873T AT E399758 T1 ATE399758 T1 AT E399758T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- acids
- neurodegenerative diseases
- derivatives
- phenylalkanecarbonic
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04425604 | 2004-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE399758T1 true ATE399758T1 (de) | 2008-07-15 |
Family
ID=35462580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05767873T ATE399758T1 (de) | 2004-08-03 | 2005-07-26 | Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheiten |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7531692B2 (de) |
| EP (1) | EP1778623B1 (de) |
| JP (1) | JP4866851B2 (de) |
| KR (1) | KR101156393B1 (de) |
| CN (1) | CN1984878B (de) |
| AT (1) | ATE399758T1 (de) |
| AU (1) | AU2005270949B2 (de) |
| BR (1) | BRPI0513647A (de) |
| CA (1) | CA2576009C (de) |
| CY (1) | CY1110401T1 (de) |
| DE (1) | DE602005007912D1 (de) |
| DK (1) | DK1778623T3 (de) |
| ES (1) | ES2309778T3 (de) |
| HR (1) | HRP20080494T3 (de) |
| NO (1) | NO339921B1 (de) |
| PL (1) | PL1778623T3 (de) |
| PT (1) | PT1778623E (de) |
| RS (1) | RS50601B (de) |
| SI (1) | SI1778623T1 (de) |
| WO (1) | WO2006016219A2 (de) |
| ZA (1) | ZA200700945B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4472691B2 (ja) * | 2003-02-21 | 2010-06-02 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 神経変性疾患の処置のための１−フェニルアルカンカルボン酸誘導体 |
| CN102844290B (zh) | 2010-04-21 | 2015-06-17 | 奇斯药制品公司 | 用于治疗转甲状腺素蛋白淀粉样变性的1-(2-氟联苯-4-基)-烷基羧酸衍生物 |
| CN102905701A (zh) | 2010-06-04 | 2013-01-30 | 奇斯药制品公司 | 用于治疗朊病毒病的1-(2-氟联苯-4-基)-环丙烷羧酸衍生物 |
| US9592210B2 (en) | 2011-12-22 | 2017-03-14 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment |
| AR090581A1 (es) | 2012-04-04 | 2014-11-19 | Chiesi Farma Spa | Derivados de acidos 1-(2-halo-bifenil-4-il)-alcancarboxilicos para el tratamiento de enfermedades neurodegenerativas |
| US20150335596A1 (en) | 2014-05-26 | 2015-11-26 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome |
| US11498904B2 (en) | 2017-11-14 | 2022-11-15 | Merck Sharp & Dohme Llc | Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors |
| BR112020008258B8 (pt) | 2017-11-14 | 2023-01-31 | Merck Sharp & Dohme | Compostos de biarila substituída ou seus sais farmaceuticamente aceitáveis, sua composição e seu uso como inibidores de indoleamina 2,3-dioxigenase (ido) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1283489B1 (it) * | 1996-07-23 | 1998-04-21 | Chiesi Farma Spa | Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico |
| US6211235B1 (en) * | 1996-11-22 | 2001-04-03 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting β-amyloid peptide release and/or its synthesis |
| US6191166B1 (en) * | 1997-11-21 | 2001-02-20 | Elan Pharmaceuticals, Inc. | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis |
| US6117901A (en) | 1996-11-22 | 2000-09-12 | Athena Neurosciences, Inc. | N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for use |
| EP0977989A1 (de) | 1997-02-04 | 2000-02-09 | Trega Biosciences, Inc. | 4-substituierte chinolinderivate und kombinatorische 4-substituierte-chinolin-bibliotheken |
| US5994379A (en) | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
| FR2842523A1 (fr) * | 2002-07-17 | 2004-01-23 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| JP4472691B2 (ja) | 2003-02-21 | 2010-06-02 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 神経変性疾患の処置のための１−フェニルアルカンカルボン酸誘導体 |
-
2005
- 2005-07-26 SI SI200530328T patent/SI1778623T1/sl unknown
- 2005-07-26 EP EP05767873A patent/EP1778623B1/de not_active Expired - Lifetime
- 2005-07-26 US US11/572,974 patent/US7531692B2/en not_active Expired - Fee Related
- 2005-07-26 AT AT05767873T patent/ATE399758T1/de active
- 2005-07-26 KR KR1020067027604A patent/KR101156393B1/ko not_active Expired - Fee Related
- 2005-07-26 JP JP2007524411A patent/JP4866851B2/ja not_active Expired - Fee Related
- 2005-07-26 HR HR20080494T patent/HRP20080494T3/xx unknown
- 2005-07-26 PT PT05767873T patent/PT1778623E/pt unknown
- 2005-07-26 WO PCT/IB2005/002189 patent/WO2006016219A2/en not_active Ceased
- 2005-07-26 ES ES05767873T patent/ES2309778T3/es not_active Expired - Lifetime
- 2005-07-26 CN CN200580023905XA patent/CN1984878B/zh not_active Expired - Fee Related
- 2005-07-26 DE DE602005007912T patent/DE602005007912D1/de not_active Expired - Lifetime
- 2005-07-26 AU AU2005270949A patent/AU2005270949B2/en not_active Ceased
- 2005-07-26 CA CA2576009A patent/CA2576009C/en not_active Expired - Fee Related
- 2005-07-26 ZA ZA200700945A patent/ZA200700945B/xx unknown
- 2005-07-26 PL PL05767873T patent/PL1778623T3/pl unknown
- 2005-07-26 DK DK05767873T patent/DK1778623T3/da active
- 2005-07-26 RS RSP-2008/0392A patent/RS50601B/sr unknown
- 2005-07-26 BR BRPI0513647-4A patent/BRPI0513647A/pt not_active IP Right Cessation
-
2007
- 2007-01-31 NO NO20070665A patent/NO339921B1/no not_active IP Right Cessation
-
2008
- 2008-09-04 CY CY20081100961T patent/CY1110401T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005007912D1 (de) | 2008-08-14 |
| KR20070038982A (ko) | 2007-04-11 |
| CN1984878A (zh) | 2007-06-20 |
| CY1110401T1 (el) | 2015-04-29 |
| WO2006016219A3 (en) | 2006-04-27 |
| CA2576009A1 (en) | 2006-02-16 |
| AU2005270949B2 (en) | 2011-02-03 |
| JP2008509124A (ja) | 2008-03-27 |
| KR101156393B1 (ko) | 2012-06-13 |
| EP1778623B1 (de) | 2008-07-02 |
| HRP20080494T3 (hr) | 2008-11-30 |
| BRPI0513647A (pt) | 2008-05-13 |
| JP4866851B2 (ja) | 2012-02-01 |
| EP1778623A2 (de) | 2007-05-02 |
| PL1778623T3 (pl) | 2008-12-31 |
| AU2005270949A1 (en) | 2006-02-16 |
| US20080096968A1 (en) | 2008-04-24 |
| NO20070665L (no) | 2007-05-02 |
| PT1778623E (pt) | 2008-09-29 |
| RS50601B (sr) | 2010-05-07 |
| US7531692B2 (en) | 2009-05-12 |
| CN1984878B (zh) | 2011-06-08 |
| ES2309778T3 (es) | 2008-12-16 |
| HK1104280A1 (en) | 2008-01-11 |
| SI1778623T1 (sl) | 2008-10-31 |
| NO339921B1 (no) | 2017-02-13 |
| WO2006016219A2 (en) | 2006-02-16 |
| ZA200700945B (en) | 2008-09-25 |
| CA2576009C (en) | 2013-02-26 |
| DK1778623T3 (da) | 2008-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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