ATE453627T1 - Herstellung von verbindungen zur bestimmung der hypoxie - Google Patents

Herstellung von verbindungen zur bestimmung der hypoxie

Info

Publication number
ATE453627T1
ATE453627T1 AT00960168T AT00960168T ATE453627T1 AT E453627 T1 ATE453627 T1 AT E453627T1 AT 00960168 T AT00960168 T AT 00960168T AT 00960168 T AT00960168 T AT 00960168T AT E453627 T1 ATE453627 T1 AT E453627T1
Authority
AT
Austria
Prior art keywords
compounds
methods
preparation
preparing
disclosed
Prior art date
Application number
AT00960168T
Other languages
English (en)
Inventor
William Dolbier
An-Rong Li
Cameron Koch
Alexander Kachur
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Application granted granted Critical
Publication of ATE453627T1 publication Critical patent/ATE453627T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00960168T 1999-07-21 2000-07-20 Herstellung von verbindungen zur bestimmung der hypoxie ATE453627T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14474799P 1999-07-21 1999-07-21
PCT/US2000/040437 WO2001007414A1 (en) 1999-07-21 2000-07-20 Preparation of compounds useful for the detection of hypoxia

Publications (1)

Publication Number Publication Date
ATE453627T1 true ATE453627T1 (de) 2010-01-15

Family

ID=22509947

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00960168T ATE453627T1 (de) 1999-07-21 2000-07-20 Herstellung von verbindungen zur bestimmung der hypoxie

Country Status (9)

Country Link
US (1) US7432295B2 (de)
EP (2) EP2098514A1 (de)
JP (1) JP5085824B2 (de)
AT (1) ATE453627T1 (de)
AU (1) AU780133B2 (de)
CA (1) CA2379974C (de)
DE (1) DE60043616D1 (de)
ES (1) ES2340912T3 (de)
WO (1) WO2001007414A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1453723B1 (de) 2001-12-12 2009-07-15 Single Buoy Moorings Inc. Schwenkbares lng-entladesystem
JP2009525114A (ja) 2006-02-01 2009-07-09 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 改良型の放射線治療計画手順
DE102006015467A1 (de) 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
US9056136B2 (en) 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
MX2009007395A (es) * 2007-01-09 2009-07-17 Bayer Schering Pharma Ag Marcacion radioactiva por fluoracion de aziridinas.
EP2039678A1 (de) 2007-09-18 2009-03-25 Bayer CropScience AG Verfahren zum Herstellen von 4-Aminobut-2-enoliden
EP2107058A1 (de) 2008-03-31 2009-10-07 Bayer CropScience AG Substituierte Enaminothiocarbonylverbindungen
US20110251189A1 (en) * 2008-12-10 2011-10-13 Bhaskar Chandra Das Hypoxia targeted compounds for cancer diagnosis and therapy
WO2010135180A1 (en) * 2009-05-19 2010-11-25 The Trustees Of The University Of Pennsylvania Catalysis of fluorine addition to double bonds
EP2264008A1 (de) 2009-06-18 2010-12-22 Bayer CropScience AG Substituierte Enaminocarbonylverbindungen
AU2015322871A1 (en) * 2014-09-25 2017-03-23 Nihon Medi-Physics Co., Ltd. Renal imaging agent

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505349A (en) * 1966-04-18 1970-04-07 Hoffmann La Roche 2-nitro-imidazolyl-1-acetamides
EP0669913B1 (de) * 1992-11-19 2003-03-05 The Trustees Of The University Of Pennsylvania Nachweis von hypoxia
US6252087B1 (en) * 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
US6855828B1 (en) * 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
US5721265A (en) * 1994-08-05 1998-02-24 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
US7230115B1 (en) * 1999-07-21 2007-06-12 The Trustees Of The University Of Pennsylvania Preparation of compounds useful for the detection of hypoxia
GB9917725D0 (en) 1999-07-28 1999-09-29 Medical Res Council Peptides
US12330098B2 (en) 2018-11-29 2025-06-17 Fluitec N.V. Filter housings, purification skids and methods of use thereof

Also Published As

Publication number Publication date
DE60043616D1 (de) 2010-02-11
EP1202973A1 (de) 2002-05-08
ES2340912T3 (es) 2010-06-11
JP5085824B2 (ja) 2012-11-28
JP2004501055A (ja) 2004-01-15
EP1202973A4 (de) 2004-08-18
AU780133B2 (en) 2005-03-03
US20060159618A1 (en) 2006-07-20
EP2098514A1 (de) 2009-09-09
WO2001007414A1 (en) 2001-02-01
EP1202973B1 (de) 2009-12-30
US7432295B2 (en) 2008-10-07
CA2379974C (en) 2011-10-25
AU7136800A (en) 2001-02-13
CA2379974A1 (en) 2001-02-01
AU780133C (en) 2001-02-13

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