ATE453722T1 - Mittel zur detektion von enzymaktivitäten in biologischen proben und verfahren zu dessen gebrauch - Google Patents

Mittel zur detektion von enzymaktivitäten in biologischen proben und verfahren zu dessen gebrauch

Info

Publication number
ATE453722T1
ATE453722T1 AT98908564T AT98908564T ATE453722T1 AT E453722 T1 ATE453722 T1 AT E453722T1 AT 98908564 T AT98908564 T AT 98908564T AT 98908564 T AT98908564 T AT 98908564T AT E453722 T1 ATE453722 T1 AT E453722T1
Authority
AT
Austria
Prior art keywords
fluorophores
protease
biological samples
detecting
enzym
Prior art date
Application number
AT98908564T
Other languages
English (en)
Inventor
Akira Komoriya
Beverly Packard
Original Assignee
Oncoimmunin Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoimmunin Inc filed Critical Oncoimmunin Inc
Application granted granted Critical
Publication of ATE453722T1 publication Critical patent/ATE453722T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)
    • G01N2333/96469—Interleukin 1-beta convertase-like enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT98908564T 1997-02-20 1998-02-20 Mittel zur detektion von enzymaktivitäten in biologischen proben und verfahren zu dessen gebrauch ATE453722T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/802,981 US6037137A (en) 1997-02-20 1997-02-20 Fluorogenic peptides for the detection of protease activity
PCT/US1998/003000 WO1998037226A1 (en) 1997-02-20 1998-02-20 Compositions for the detection of enzyme activity in biological samples and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE453722T1 true ATE453722T1 (de) 2010-01-15

Family

ID=25185248

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98908564T ATE453722T1 (de) 1997-02-20 1998-02-20 Mittel zur detektion von enzymaktivitäten in biologischen proben und verfahren zu dessen gebrauch

Country Status (8)

Country Link
US (3) US6037137A (de)
EP (1) EP0988394B1 (de)
JP (2) JP4298796B2 (de)
AT (1) ATE453722T1 (de)
AU (1) AU745148B2 (de)
CA (1) CA2280811C (de)
DE (1) DE69841419D1 (de)
WO (1) WO1998037226A1 (de)

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CA2280811A1 (en) 1998-08-27
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EP0988394A4 (de) 2003-04-23
US20080199898A1 (en) 2008-08-21
EP0988394A1 (de) 2000-03-29
AU745148B2 (en) 2002-03-14
WO1998037226A1 (en) 1998-08-27
JP4298796B2 (ja) 2009-07-22
US6037137A (en) 2000-03-14
CA2280811C (en) 2015-11-03
US6936687B1 (en) 2005-08-30
DE69841419D1 (de) 2010-02-11
EP0988394B1 (de) 2009-12-30

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