ATE420204T1 - Verfahren zur detektion von erkrankungen - Google Patents

Verfahren zur detektion von erkrankungen

Info

Publication number
ATE420204T1
ATE420204T1 AT00960085T AT00960085T ATE420204T1 AT E420204 T1 ATE420204 T1 AT E420204T1 AT 00960085 T AT00960085 T AT 00960085T AT 00960085 T AT00960085 T AT 00960085T AT E420204 T1 ATE420204 T1 AT E420204T1
Authority
AT
Austria
Prior art keywords
detecting diseases
sample
detecting
diseases
integrity
Prior art date
Application number
AT00960085T
Other languages
English (en)
Inventor
Anthony Shuber
Original Assignee
Exact Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Sciences Corp filed Critical Exact Sciences Corp
Application granted granted Critical
Publication of ATE420204T1 publication Critical patent/ATE420204T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AT00960085T 1999-12-07 2000-09-08 Verfahren zur detektion von erkrankungen ATE420204T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16945799P 1999-12-07 1999-12-07
US09/514,865 US6919174B1 (en) 1999-12-07 2000-02-28 Methods for disease detection

Publications (1)

Publication Number Publication Date
ATE420204T1 true ATE420204T1 (de) 2009-01-15

Family

ID=26865071

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00960085T ATE420204T1 (de) 1999-12-07 2000-09-08 Verfahren zur detektion von erkrankungen

Country Status (8)

Country Link
US (3) US6919174B1 (de)
EP (1) EP1238103B1 (de)
JP (1) JP2003516161A (de)
AT (1) ATE420204T1 (de)
AU (1) AU7130100A (de)
CA (1) CA2393709C (de)
DE (1) DE60041355D1 (de)
WO (1) WO2001042502A2 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1169479B1 (de) 1999-04-09 2006-06-28 EXACT Sciences Corporation Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
WO2001042503A2 (en) * 1999-12-07 2001-06-14 Exact Sciences Corporation Apparatus and methods for drug screening based on nucleic acid analysis
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
CA2394921A1 (en) 1999-12-07 2001-06-14 Anthony P. Shuber Supracolonic aerodigestive neoplasm detection
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US7776524B2 (en) 2002-02-15 2010-08-17 Genzyme Corporation Methods for analysis of molecular events
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
ITMI20030434A1 (it) 2003-03-07 2004-09-08 Istituto Oncologico Romagnolo Coope Rativa Sociale Metodo per l'individuazione di tumori del colon-retto.
US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
US20050014165A1 (en) * 2003-07-18 2005-01-20 California Pacific Medical Center Biomarker panel for colorectal cancer
WO2005111244A2 (en) * 2004-05-10 2005-11-24 Exact Sciences Corporation Methods for detecting a mutant nucleic acid
WO2005113769A1 (en) * 2004-05-14 2005-12-01 Exact Sciences Corporation Method for stabilizing biological samples for nucleic acid analysis
WO2006026654A2 (en) 2004-08-27 2006-03-09 Exact Sciences Corporation Method for detecting a recombinant event
CA2584723A1 (en) 2004-10-22 2006-05-04 Redpath Integrated Pathology, Inc. Enhanced amplifiability of minute fixative-treated tissue samples, minute stained cytology samples, and other minute sources of dna
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US9777314B2 (en) * 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
EP2041299A4 (de) * 2006-07-14 2010-01-13 Aviva Biosciences Corp Verfahren und zusammensetzungen für den nachweis seltener zellen aus einer biologischen probe
EP2167683A4 (de) 2007-05-31 2010-10-20 California Pacific Med Center Verfahren zur vorhersage oder diagnose einer magen-darm-störung oder -krankheit
US8883440B2 (en) * 2007-07-26 2014-11-11 Nancy M. Lee Method to predict or diagnose a gastrointestinal disorder or disease
CA2793877A1 (en) * 2010-03-22 2011-09-29 Esoterix Genetic Laboratories, Llc Mutations associated with cystic fibrosis
GB201107466D0 (en) 2011-05-05 2011-06-15 Loktionov Alexandre Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
WO2012177656A2 (en) 2011-06-19 2012-12-27 Abogen, Inc. Devices, solutions and methods for sample collection
US9341628B2 (en) 2012-11-30 2016-05-17 Interpace Diagnostics Corporation Methods for measuring carcinoembryonic antigen
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
US10138524B2 (en) 2013-12-19 2018-11-27 Exact Sciences Development Company, Llc Synthetic nucleic acid control molecules
KR102392407B1 (ko) 2014-03-07 2022-04-29 디엔에이 제노텍 인코퍼레이티드 생물학적 샘플에서 핵산을 안정화하기 위한 조성물 및 방법
EP3978624B1 (de) 2016-07-19 2025-03-26 Exact Sciences Corporation Methylierte kontroll-dna
WO2018017710A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Nucleic acid control molecules from non-human organisms
WO2018209180A1 (en) 2017-05-12 2018-11-15 Laboratory Corporation Of America Holdings Compositions and methods to detect non-coeliac gluten sensitivity
CA3057420C (en) 2017-05-12 2023-08-01 Laboratory Corporation Of America Holdings Systems and methods for biomarker identificaton
EP4455310A3 (de) 2017-12-20 2025-01-08 Laboratory Corporation of America Holdings Identifizierung von biomarkern für kopf-hals-krebs
CN112424605A (zh) 2018-05-11 2021-02-26 美国控股实验室公司 用于检测肾纤维化的组合物和方法
WO2023200404A2 (en) * 2022-04-13 2023-10-19 Lucence Life Sciences Pte. Ltd. Method for determining cfdna fragment size ratio and fragment size distribution
WO2025006972A1 (en) 2023-06-30 2025-01-02 Laboratory Corporation Of America Holdings Methods, compositions, and systems to detect head and neck cancer in saliva samples

Family Cites Families (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3413464A (en) 1965-04-29 1968-11-26 Ibm Method for measuring the nucleic acid in biological cells after enhancement in an acidic solution
US4101279A (en) 1977-04-06 1978-07-18 Muhammed Javed Aslam Device for the collection and processing of stool specimens
US4333734A (en) 1980-01-18 1982-06-08 Sloan-Kettering Institute For Cancer Research Diagnostic device for fecal occult blood and method of use
US4535058A (en) 1982-10-01 1985-08-13 Massachusetts Institute Of Technology Characterization of oncogenes and assays based thereon
US4309782A (en) 1980-09-11 1982-01-12 Esteban Paulin Device for collecting fecal specimens
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US5482834A (en) 1982-05-17 1996-01-09 Hahnemann University Evaluation of nucleic acids in a biological sample hybridization in a solution of chaotrophic salt solubilized cells
US4445235A (en) 1982-09-13 1984-05-01 Pearl Slover Stool specimen collector
US4578358A (en) 1983-05-03 1986-03-25 Warner-Lambert Company Collection of specimens and detection of occult blood therein
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4871838A (en) 1985-07-23 1989-10-03 The Board Of Rijks Universiteit Leiden Probes and methods for detecting activated ras oncogenes
US4705050A (en) 1985-10-02 1987-11-10 Markham Charles W Moisture-activated floatation device
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
CA1341576C (en) 1986-08-11 2008-07-08 Thaddeus P. Dryja Diagnosis of retinoblastoma
US4735905A (en) 1986-08-15 1988-04-05 V-Tech, Inc. Specimen-gathering apparatus and method
US4935342A (en) 1986-12-01 1990-06-19 Syngene, Inc. Method of isolating and purifying nucleic acids from biological samples
AU625169B2 (en) 1987-03-23 1992-07-02 Imperial Chemical Industries Plc Molecular markers
US4857300A (en) 1987-07-27 1989-08-15 Cytocorp, Inc. Cytological and histological fixative formulation and methods for using same
US5688657A (en) 1988-03-31 1997-11-18 International Bio-Immune Systems, Inc. Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor
IL89964A0 (en) 1988-04-15 1989-12-15 Montefiore Med Center Method for determining malignant progression,cdna,polypeptides encoded thereby and pharmaceutical compositions containing the same
FR2630000A1 (fr) 1988-04-18 1989-10-20 Sultan Bernard Flacon destine a recueillir un echantillon biologique urinaire pour examen cytobacteriologique
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
IE66572B1 (en) 1989-02-13 1996-01-24 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
US5087617A (en) 1989-02-15 1992-02-11 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
US5248671A (en) 1989-02-15 1993-09-28 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
US5380645A (en) 1989-03-16 1995-01-10 The Johns Hopkins University Generalized method for assessment of colorectal carcinoma
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
EP0390323B2 (de) 1989-03-29 2012-08-08 Johns Hopkins University Nachweis des Ausfalls des Wildtyps des p53-Gens
US5192501A (en) 1989-04-04 1993-03-09 Helena Laboratories Corporation Method of formulating a test ink for a fecal occult blood test product
US5196167A (en) 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5589335A (en) 1989-04-05 1996-12-31 Amoco Corporation Hybridization promotion reagents
DK0407789T3 (da) 1989-06-23 1993-11-01 Canon Kk Fremgangsmåde til detektering af nukleinsyrer
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
US5213961A (en) * 1989-08-31 1993-05-25 Brigham And Women's Hospital Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction
CA2029219A1 (en) 1989-11-08 1991-05-09 Mary K. Estes Methods and reagents to detect and characterize norwalk and related viruses
US5641628A (en) 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
US5137806A (en) 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
ES2115611T3 (es) 1990-01-04 1998-07-01 Univ Johns Hopkins Gen suprimido en el cancer colorrectal humano.
US5126239A (en) 1990-03-14 1992-06-30 E. I. Du Pont De Nemours And Company Process for detecting polymorphisms on the basis of nucleotide differences
US5200314A (en) 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
DK0489149T3 (da) 1990-06-27 2001-12-27 Univ Princeton Prober til påvisning af mutant P53
JPH06510363A (ja) 1990-10-29 1994-11-17 ディカルブ　プラント　ジェネティクス 磁気性粒子を使用する生物学的材料の単離
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
AU1366992A (en) 1991-01-16 1992-08-27 Cancer Institute, The Inherited and somatic mutations of apc gene in colorectal cancer of humans
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
EP0571539A4 (en) 1991-02-05 1994-06-29 Kamal Bahar Simple test for detecting carcinoembryonic antigen
WO1992013971A1 (en) 1991-02-05 1992-08-20 Lifecodes Corporation Molecular genetic identification using probes that recognize polymorphic loci
WO1992016657A1 (en) 1991-03-13 1992-10-01 E.I. Du Pont De Nemours And Company Method of identifying a nucleotide present at a defined position in a nucleic acid
US5330892A (en) 1991-03-13 1994-07-19 The Johns Hopkins University MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans
US5378602A (en) 1991-05-29 1995-01-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six
US5468610A (en) 1991-05-29 1995-11-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Three highly informative microsatellite repeat polymorphic DNA markers
US5149506A (en) 1991-08-09 1992-09-22 Sage Products, Inc. Stool collection and transport device
US5506105A (en) 1991-12-10 1996-04-09 Dade International Inc. In situ assay of amplified intracellular mRNA targets
EP1134293A3 (de) 1992-03-04 2004-01-07 The Regents of The University of California Vergleichende Genomhybridisierung
AU3919293A (en) 1992-03-27 1993-11-08 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
JP3633932B2 (ja) 1992-04-01 2005-03-30 ザ ジョーンズ ホプキンズ ユニバーシティー スクール オブ メディシン 糞便試料から単離した哺乳類の核酸を検出する方法、およびその検出用試薬
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
JP3399948B2 (ja) 1992-06-26 2003-04-28 ザ トラスティーズ オブ プリンストン ユニバーシティ Ｐ９０抗体またはプローブを用いた前癌細胞または癌細胞の検出方法
ATE231881T1 (de) 1992-07-02 2003-02-15 Savyon Diagnostics Ltd Verfahren zur einfachen nukleotid-primer- verlängerung zum nachweis spezifischer allele und dafür geeigneter kit
US5710028A (en) 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
US5409586A (en) 1992-08-26 1995-04-25 Hitachi, Ltd. Method for analyzing nucleic acid or protein and apparatus therefor
US5547838A (en) * 1992-10-01 1996-08-20 Life Technologies, Inc. Method for the rapid and ultra-sensitive detection of leukemic cells
US6214542B1 (en) 1992-10-20 2001-04-10 The United States Of America As Represented By The Department Of Health And Human Services Quantification of indicators of fibrosis
IL103600A0 (en) 1992-10-30 1993-03-15 Yeda Res & Dev Method and kit for cancer diagnosis
US5436142A (en) 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
US5331973A (en) 1993-03-15 1994-07-26 Fiedler Paul N Method for obtaining stool samples for gastrointestinal cancer testing
CA2092115C (en) 1993-03-22 1998-12-15 Janet L. Taylor Testing for infestation of rapeseed and other cruciferae by the fungus leptosphaeria maculans (blackleg infestation)
US5518901A (en) * 1993-04-19 1996-05-21 Murtagh; James J. Methods for adapting nucleic acid for detection, sequencing, and cloning using exonuclease
US5492808A (en) 1993-05-05 1996-02-20 The Johns Hopkins University Means for detecting familial colon cancer (FCC)
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US5466576A (en) 1993-07-02 1995-11-14 Fred Hutchinson Cancer Research Center Modulation of PIF-1-type helicases
DE69431510T2 (de) 1993-07-08 2003-02-27 Johnson & Johnson Clinical Diagnostics, Inc. Verfahren zur Koamplifikation zweier unterschiedlicher Nukleinsäure-Sequenzen unter Verwendung der Polymerase-Kettenreaktion
WO1995002068A1 (en) 1993-07-09 1995-01-19 Wakunaga Seiyaku Kabushiki Kaisha Method of discriminating nucleic acid and testing set for discriminating nucleic acid
US5439819A (en) * 1993-08-27 1995-08-08 The Regents Of The University Of California Chimeric protein tyrosine kinases
FR2709761B1 (fr) 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
US5472842A (en) 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
WO1995009928A1 (en) 1993-10-06 1995-04-13 The Regents Of The University Of California Methods for detecting cancer-associated chromosome deletions using in situ hybridization
GB9322795D0 (en) 1993-11-05 1993-12-22 Wellcome Found Novel compounds
US5561041A (en) 1993-11-12 1996-10-01 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
US5416025A (en) 1993-11-29 1995-05-16 Krepinsky; Jiri J. Screening test for early detection of colorectal cancer
WO1995015400A1 (en) 1993-12-03 1995-06-08 The Johns Hopkins University Genotyping by simultaneous analysis of multiple microsatellite loci
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5709998A (en) 1993-12-15 1998-01-20 The Johns Hopkins University Molecular diagnosis of familial adenomatous polyposis
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US5538851A (en) 1993-12-22 1996-07-23 Institut Pasteur And Cneva Primers for the amplification of genes coding for the enterotoxin and the lecithinase of Clostridium perfringens and their application to the determination of the presence and numeration of these bacteriae
WO1995018818A1 (en) 1994-01-03 1995-07-13 Children's Hospital Of Philadelphia Polymorphism at codon 36 of the p53 gene
US6025127A (en) 1994-01-14 2000-02-15 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection in histologic tissue
CA2162150C (en) 1994-03-18 2010-03-30 Mark H. Skolnick Germline mutations in the mts gene and method for detecting predisposition to cancer at the mts gene
SE9500023L (sv) 1994-05-17 1995-11-18 Beki Ab Sätt att detektera cancer
US5496470A (en) 1994-05-27 1996-03-05 Barnes International, Inc. Magnetic separator
US6037465A (en) 1994-06-14 2000-03-14 Invitek Gmbh Universal process for isolating and purifying nucleic acids from extremely small amounts of highly contaminated various starting materials
US5667987A (en) 1994-07-12 1997-09-16 Bristol-Myers Squibb Company P53 response genes
MXPA00009654A (es) 1994-08-31 2005-09-08 Univ Johns Hopkins Med Deteccion de secuencias de acidos nucleicos hipermutables en tejidos.
US5702886A (en) 1994-10-05 1997-12-30 The Johns Hopkins University Chromosome I8Q loss and prognosis in colorectal cancer
JPH10507366A (ja) 1994-10-21 1998-07-21 ゼネカ・リミテッド Ｐｃｒによるテロメアｄｎａの可変性の特性決定法
US5629178A (en) 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
US5512441A (en) 1994-11-15 1996-04-30 American Health Foundation Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US5463782A (en) 1994-11-21 1995-11-07 Eric V. Carlson Foldable stool sample collection device
CA2220951A1 (en) * 1995-02-01 1996-08-08 Research Development Foundation Detecting dna damage, measuring dna repair rates, and monitoring dna repair enzyme activity
US5599662A (en) 1995-02-17 1997-02-04 Hoffmann-La Roche Inc. Oliconucleotide primers and probes for the detection of HIV-1
AU5296496A (en) 1995-03-24 1996-10-16 Mitokor Mutation detection by differential primer extension of mutant and wildtype target sequences
DE19530132C2 (de) 1995-08-16 1998-07-16 Max Planck Gesellschaft Verfahren zur Reinigung, Stabilisierung oder Isolierung von Nukleinsäuren aus biologischen Materialien
GB9517914D0 (en) 1995-09-02 1995-11-01 Tepnel Medical Ltd Identification of bases in nucleic acid sequences
GB9518156D0 (en) 1995-09-06 1995-11-08 Medical Res Council Method of isolating cells
ES2220997T3 (es) 1995-12-22 2004-12-16 Exact Sciences Corporation Metodos para la deteccion de poblaciones clonales de celulas transformadas en una muestra celular genomicamente heterogenea.
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
EP0784096A1 (de) 1996-01-10 1997-07-16 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Polymorphismus und Heterozygotieverlust in einem Lungentumor-Suppressor-Gen
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
AU720489B2 (en) 1996-01-30 2000-06-01 Exact Sciences Corporation Methods for detecting colon cancer from stool samples
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5897999A (en) 1996-03-22 1999-04-27 The Johns Hopkins University Cancer drug screen based on cell cycle uncoupling
US5645995A (en) 1996-04-12 1997-07-08 Baylor College Of Medicine Methods for diagnosing an increased risk for breast or ovarian cancer
US5736333A (en) * 1996-06-04 1998-04-07 The Perkin-Elmer Corporation Passive internal references for the detection of nucleic acid amplification products
US5976800A (en) 1996-06-28 1999-11-02 The Regents Of The University Of California Enhancement of cancer cell death
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US6146828A (en) 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6143529A (en) * 1996-08-14 2000-11-07 Exact Laboratories, Inc. Methods for improving sensitivity and specificity of screening assays
EP0920535B1 (de) 1996-08-26 2007-11-14 Invitek Gesellschaft für Biotechnik & Biodesign mbH. Verfahren zum nachweis klinisch relevanter veränderungen der dns-sequenz des ki-ras-onkogens, seine verwendung und testkit zur früherkennung von tumoren
US5856104A (en) 1996-10-28 1999-01-05 Affymetrix, Inc. Polymorphisms in the glucose-6 phosphate dehydrogenase locus
US6235474B1 (en) * 1996-12-30 2001-05-22 The Johns Hopkins University Methods and kits for diagnosing and determination of the predisposition for diseases
EP0975797A1 (de) 1997-02-28 2000-02-02 Exact Laboratories, Inc. Verfahren zur analyse von nukleinsäuren
US5830665A (en) 1997-03-03 1998-11-03 Exact Laboratories, Inc. Contiguous genomic sequence scanning
GB9704444D0 (en) * 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
DE19712332A1 (de) 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Mikrosatelliten-Instabilität zur Tumordiagnostik
US6566101B1 (en) 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
AU7816898A (en) 1997-06-16 1999-01-04 Exact Laboratories, Inc. Methods for stool sample preparation
US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US5888778A (en) 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US20020004201A1 (en) * 1997-06-16 2002-01-10 Lapidus Stanley N. Methods for the detection of loss of heterozygosity
GB9715034D0 (en) 1997-07-18 1997-09-24 Zeneca Ltd Assay
US6013442A (en) 1997-08-05 2000-01-11 Wisconsin Alumni Res Found Direct quantitation of low copy number RNA
AU8694598A (en) 1997-08-06 1999-03-01 Ludwig Institute For Cancer Research Methods for quantifying nucleic acid molecules
US5942396A (en) 1997-08-19 1999-08-24 The Rockefeller University Method for identifying individuals at risk for colorectal neoplasia by quantifying normal colonic mucosal epithelial cell apoptosis
DE19736691A1 (de) 1997-08-22 1999-02-25 Michael Prof Dr Med Giesing Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
JP2001520054A (ja) 1997-10-23 2001-10-30 エグザクト サイエンシーズ コーポレイション Ｐｃｒを用いる分子診断におけるコンタミネーションを検出するための方法
US6251660B1 (en) 1997-11-25 2001-06-26 Mosaic Technologies, Inc. Devices and methods for detecting target molecules in biological samples
EP1068518A2 (de) 1998-03-03 2001-01-17 Exact Sciences Corporation Reinigungs- und nachweisverfahren mittels reversibler affinitätselektrophorese
EP1066408A4 (de) * 1998-03-05 2002-09-25 Diadexus Inc Ein neuartiges verfahren zur detektion und darstellung endometrischer und uteruskrebse
WO1999066077A2 (en) 1998-06-16 1999-12-23 Exact Laboratories, Inc. Methods for the detection of nucleic acids
WO1999066078A1 (en) 1998-06-18 1999-12-23 Mosaic Technologies Denaturing gradient affinity electrophoresis and methods of use thereof
CA2330732A1 (en) 1998-06-19 1999-12-23 Mosaic Technologies Detection of non-viral organisms with srp rna
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
WO2000011215A2 (en) 1998-08-14 2000-03-02 Exact Laboratories, Inc. Method for diagnostic screening
US20020001800A1 (en) 1998-08-14 2002-01-03 Stanley N. Lapidus Diagnostic methods using serial testing of polymorphic loci
WO2000020643A1 (en) 1998-10-05 2000-04-13 Mosaic Technologies Reverse displacement assay for detection of nucleic acid sequences
CA2352456A1 (en) 1998-11-23 2000-06-02 Exact Sciences Corporation Primer extension methods utilizing donor and acceptor molecules for detecting nucleic acids
WO2000032820A1 (en) 1998-11-23 2000-06-08 Exact Laboratories, Inc. Method for detecting target sequences in small proportions in heterogeneous samples
WO2000031298A1 (en) 1998-11-23 2000-06-02 Exact Laboratories, Inc. Methods for detecting lower-frequency molecules
CA2372667A1 (en) 1999-01-10 2000-11-23 Steven Laken Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
AU752817B2 (en) 1999-02-25 2002-10-03 Exact Sciences Corporation Methods for preserving DNA integrity
ATE265040T1 (de) 1999-02-26 2004-05-15 Exact Sciences Corp Biochemische reinigungsgeräte mit immobilisierten fangsonden und ihre anwendungen
EP1235930A2 (de) 1999-04-02 2002-09-04 Mosaic Technologies Electrophoretische anlyse von zielmolekülen unter benutzung von adapter molekülen
US20020004206A1 (en) 1999-04-09 2002-01-10 Berger Barry M. Methods of screening for disease
EP1169479B1 (de) 1999-04-09 2006-06-28 EXACT Sciences Corporation Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
AU4669600A (en) 1999-05-03 2000-11-17 Exact Laboratories, Inc. Stool specimen collector
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6849403B1 (en) * 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
CA2394921A1 (en) 1999-12-07 2001-06-14 Anthony P. Shuber Supracolonic aerodigestive neoplasm detection
US6919174B1 (en) * 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
WO2001042503A2 (en) 1999-12-07 2001-06-14 Exact Sciences Corporation Apparatus and methods for drug screening based on nucleic acid analysis
WO2001064950A2 (en) 2000-02-28 2001-09-07 Exact Sciences Corporation Device and method for preparing a sample for analysis
US6415555B1 (en) * 2000-04-27 2002-07-09 Restaurant Technology, Inc. System and method for accepting customer orders
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
JP2004521630A (ja) 2001-03-15 2004-07-22 エグザクト サイエンシーズ コーポレイション 変更検出のための方法
US20030049659A1 (en) 2001-05-29 2003-03-13 Lapidus Stanley N. Devices and methods for isolating samples into subsamples for analysis

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JP2003516161A (ja) 2003-05-13
DE60041355D1 (de) 2009-02-26
WO2001042502A2 (en) 2001-06-14
US20060121495A1 (en) 2006-06-08
US20080248471A1 (en) 2008-10-09
AU7130100A (en) 2001-06-18
WO2001042502A3 (en) 2002-01-17
CA2393709A1 (en) 2001-06-14
EP1238103B1 (de) 2009-01-07
CA2393709C (en) 2014-07-08
EP1238103A2 (de) 2002-09-11

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