ATE454375T1 - 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors - Google Patents
1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptorsInfo
- Publication number
- ATE454375T1 ATE454375T1 AT97944749T AT97944749T ATE454375T1 AT E454375 T1 ATE454375 T1 AT E454375T1 AT 97944749 T AT97944749 T AT 97944749T AT 97944749 T AT97944749 T AT 97944749T AT E454375 T1 ATE454375 T1 AT E454375T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- alkyl
- disorders
- general formula
- formula
- Prior art date
Links
- XNCMQRWVMWLODV-UHFFFAOYSA-N 1-phenylbenzimidazole Chemical class C1=NC2=CC=CC=C2N1C1=CC=CC=C1 XNCMQRWVMWLODV-UHFFFAOYSA-N 0.000 title 1
- 102000004300 GABA-A Receptors Human genes 0.000 title 1
- 108090000839 GABA-A Receptors Proteins 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 208000015114 central nervous system disease Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 1
- 108091008681 GABAA receptors Proteins 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, amino Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK115796 | 1996-10-21 | ||
| PCT/DK1997/000462 WO1998017651A1 (en) | 1996-10-21 | 1997-10-21 | 1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE454375T1 true ATE454375T1 (de) | 2010-01-15 |
Family
ID=8101649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97944749T ATE454375T1 (de) | 1996-10-21 | 1997-10-21 | 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6218547B1 (de) |
| EP (1) | EP0934281B1 (de) |
| JP (1) | JP2001502675A (de) |
| CN (1) | CN1115336C (de) |
| AT (1) | ATE454375T1 (de) |
| AU (1) | AU726447B2 (de) |
| CA (1) | CA2267114A1 (de) |
| CZ (1) | CZ127299A3 (de) |
| DE (1) | DE69739733D1 (de) |
| NZ (1) | NZ334868A (de) |
| RU (1) | RU2194699C2 (de) |
| SK (1) | SK42499A3 (de) |
| WO (1) | WO1998017651A1 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998017651A1 (en) * | 1996-10-21 | 1998-04-30 | Neurosearch A/S | 1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators |
| US6465484B1 (en) | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| AU744939B2 (en) * | 1997-09-26 | 2002-03-07 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| AU1224499A (en) * | 1997-12-09 | 1999-06-28 | Neurosearch A/S | Chemical compounds for use as anxiolytic agents and a method for the identification of anxiolytic compounds |
| WO2000003971A1 (en) * | 1998-07-15 | 2000-01-27 | Meiji Seika Kaisha, Ltd. | Process for producing 4-substituted-2-nitro-fluorobenzenes |
| WO2000025780A1 (en) * | 1998-10-29 | 2000-05-11 | Bristol-Myers Squibb Company | Compounds derived from an amine nucleus that are inhibitors of impdh enzyme |
| WO2000059905A1 (en) * | 1999-04-02 | 2000-10-12 | Neurogen Corporation | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS |
| US6281237B1 (en) | 1999-04-02 | 2001-08-28 | Neurogen Corporation | N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives |
| US6271241B1 (en) | 1999-04-02 | 2001-08-07 | Neurogen Corporation | Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors |
| US6358949B1 (en) | 1999-04-02 | 2002-03-19 | Neurogen Corporation | Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors |
| US6627624B1 (en) | 1999-04-02 | 2003-09-30 | Neurogen Corporation | Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
| US6380210B1 (en) | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
| IL146403A0 (en) | 1999-06-22 | 2002-07-25 | Neurosearch As | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
| WO2002050057A1 (en) * | 2000-12-20 | 2002-06-27 | Neurosearch A/S | Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders |
| ATE359276T1 (de) * | 2001-12-20 | 2007-05-15 | Lundbeck & Co As H | Aryloxyphenyl und arylsulfanylphenylderivate |
| EA007475B1 (ru) * | 2001-12-20 | 2006-10-27 | Х. Лундбекк А/С | Производные арилоксифенила и арилсульфанилфенила |
| EP1613618A2 (de) | 2003-04-03 | 2006-01-11 | Neurosearch A/S | Benzimidazol derivate und ihre verwendung als modulatoren des gaba-a rezeptoren komplexes |
| DE602004011914T2 (de) * | 2003-04-03 | 2008-06-12 | Neurosearch A/S | Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren |
| WO2004089912A1 (en) * | 2003-04-10 | 2004-10-21 | Neurosearch A/S | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
| JP4769720B2 (ja) * | 2003-08-21 | 2011-09-07 | オーエスアイ・ファーマシューテイカルズ・エル・エル・シー | Ｎ−置換ベンズイミダゾリルｃ−Ｋｉｔ阻害剤 |
| JP2007509108A (ja) * | 2003-10-23 | 2007-04-12 | アクゾ ノベル ナムローゼ フェンノートシャップ | １，５，７−三置換ベンズイミダゾール誘導体及びｇａｂａａ受容体複合体を調節するためのその使用 |
| AU2004290499C1 (en) * | 2003-11-03 | 2011-02-24 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| WO2005121132A1 (ja) * | 2004-06-11 | 2005-12-22 | Shionogi & Co., Ltd. | 抗ｈｃｖ作用を有する縮合ヘテロ環化合物 |
| AU2006233894A1 (en) * | 2005-04-13 | 2006-10-19 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
| US20090062304A1 (en) * | 2005-04-19 | 2009-03-05 | Lene Teuber | Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex |
| EP1874758A1 (de) * | 2005-04-19 | 2008-01-09 | Neurosearch A/S | Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexes |
| WO2006111517A1 (en) * | 2005-04-19 | 2006-10-26 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| KR20080034475A (ko) * | 2005-08-19 | 2008-04-21 | 아벤티스 파마슈티칼스 인크. | 수면제 및ｒ(＋)-알파-(2,3-디메톡시-페닐)-1-[2-(4-플루오로페닐)에틸]-4-피페리딘메탄올의 복합물 및 이의 치료학적 용도 |
| ES2336142T3 (es) * | 2005-08-19 | 2010-04-08 | Aventis Pharmaceuticals Inc. | Combinacion de un agente hipnotico y un compuesto sustituido, con bis arilo y heteroarilo y aplicacion terapeutica del mismo. |
| EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| EP2275095A3 (de) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenese durch modulation des Muscarinrezeptors |
| EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| CA2632395A1 (en) * | 2005-12-05 | 2007-06-14 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| US20070244143A1 (en) * | 2006-03-08 | 2007-10-18 | Braincells, Inc | Modulation of neurogenesis by nootropic agents |
| US20100216734A1 (en) * | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| TWI391381B (zh) * | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
| US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| JP2009536667A (ja) * | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| EP2382975A3 (de) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| AU2007299920A1 (en) * | 2006-09-19 | 2008-03-27 | Braincells, Inc. | PPAR Mediated Modulation of Neurogenesis |
| RU2451017C2 (ru) * | 2007-03-01 | 2012-05-20 | Мицубиси Танабе Фарма Корпорейшн | Бензимидазольное соединение и его фармацевтическое применение |
| JP5251876B2 (ja) | 2007-07-24 | 2013-07-31 | アステラス製薬株式会社 | ベンズイミダゾール誘導体 |
| JPWO2010087319A1 (ja) | 2009-01-27 | 2012-08-02 | アステラス製薬株式会社 | 前立腺癌治療剤として有効な物質のスクリーニング方法 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US8222246B2 (en) * | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| EP4417596B1 (de) | 2017-11-06 | 2026-04-29 | Acelot, Inc. | Kleinmolekülige arzneimittel und zugehörige verfahren zur behandlung von krankheiten im zusammenhang mit a-beta-42-oligomerbildung |
| WO2020065642A1 (en) | 2018-09-25 | 2020-04-02 | Pepticom Ltd. | Positive allosteric modulators of gabaa receptor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5158969A (en) * | 1991-08-21 | 1992-10-27 | Neurosearch A/S | Indole derivatives as potassium channel blockers |
| DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| AU675484B2 (en) | 1993-03-24 | 1997-02-06 | Neurosearch A/S | Benzimidazole compounds, their use and preparation |
| US5554630A (en) * | 1993-03-24 | 1996-09-10 | Neurosearch A/S | Benzimidazole compounds |
| BR9608056A (pt) | 1995-04-21 | 1999-11-30 | Neurosearch As | Compostos de benzimidazol, composições farmacêuticas contendo os compostos e sua utilização. |
| PL183853B1 (pl) | 1995-04-21 | 2002-07-31 | Neurosearch As | Nowa pochodna benzimidazolu i środek farmaceutyczny |
| WO1998017651A1 (en) * | 1996-10-21 | 1998-04-30 | Neurosearch A/S | 1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators |
-
1997
- 1997-10-21 WO PCT/DK1997/000462 patent/WO1998017651A1/en not_active Ceased
- 1997-10-21 SK SK424-99A patent/SK42499A3/sk unknown
- 1997-10-21 CN CN97198988A patent/CN1115336C/zh not_active Expired - Fee Related
- 1997-10-21 NZ NZ334868A patent/NZ334868A/en unknown
- 1997-10-21 CA CA002267114A patent/CA2267114A1/en not_active Abandoned
- 1997-10-21 RU RU99110508/04A patent/RU2194699C2/ru not_active IP Right Cessation
- 1997-10-21 DE DE69739733T patent/DE69739733D1/de not_active Expired - Lifetime
- 1997-10-21 AU AU46161/97A patent/AU726447B2/en not_active Ceased
- 1997-10-21 CZ CZ991272A patent/CZ127299A3/cs unknown
- 1997-10-21 US US09/269,643 patent/US6218547B1/en not_active Expired - Fee Related
- 1997-10-21 AT AT97944749T patent/ATE454375T1/de not_active IP Right Cessation
- 1997-10-21 JP JP10518852A patent/JP2001502675A/ja active Pending
- 1997-10-21 EP EP97944749A patent/EP0934281B1/de not_active Expired - Lifetime
-
2001
- 2001-01-25 US US09/768,506 patent/US6503925B1/en not_active Expired - Fee Related
-
2002
- 2002-11-20 US US10/299,854 patent/US6710044B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0934281A1 (de) | 1999-08-11 |
| CN1115336C (zh) | 2003-07-23 |
| EP0934281B1 (de) | 2010-01-06 |
| US20030166638A1 (en) | 2003-09-04 |
| SK42499A3 (en) | 2000-05-16 |
| AU4616197A (en) | 1998-05-15 |
| DE69739733D1 (de) | 2010-02-25 |
| CN1234025A (zh) | 1999-11-03 |
| US6710044B2 (en) | 2004-03-23 |
| US6503925B1 (en) | 2003-01-07 |
| WO1998017651A1 (en) | 1998-04-30 |
| RU2194699C2 (ru) | 2002-12-20 |
| NZ334868A (en) | 2001-02-23 |
| CA2267114A1 (en) | 1998-04-30 |
| CZ127299A3 (cs) | 1999-09-15 |
| US6218547B1 (en) | 2001-04-17 |
| JP2001502675A (ja) | 2001-02-27 |
| AU726447B2 (en) | 2000-11-09 |
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