ATE454385T1 - Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung - Google Patents

Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung

Info

Publication number
ATE454385T1
ATE454385T1 AT03751203T AT03751203T ATE454385T1 AT E454385 T1 ATE454385 T1 AT E454385T1 AT 03751203 T AT03751203 T AT 03751203T AT 03751203 T AT03751203 T AT 03751203T AT E454385 T1 ATE454385 T1 AT E454385T1
Authority
AT
Austria
Prior art keywords
application
pharmaceutical composition
hiv integrase
integrase inhibitor
inhibitor
Prior art date
Application number
AT03751203T
Other languages
English (en)
Inventor
Qiyue Hu
Atsuo Kuki
Dawn Marie Nowlin
Michael Bruno Plewe
Hai Wang
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE454385T1 publication Critical patent/ATE454385T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT03751203T 2002-10-31 2003-10-27 Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung ATE454385T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42251302P 2002-10-31 2002-10-31
PCT/IB2003/004735 WO2004039803A2 (en) 2002-10-31 2003-10-27 Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use

Publications (1)

Publication Number Publication Date
ATE454385T1 true ATE454385T1 (de) 2010-01-15

Family

ID=32230367

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03751203T ATE454385T1 (de) 2002-10-31 2003-10-27 Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung

Country Status (16)

Country Link
US (3) US7135482B2 (de)
EP (1) EP1558611B1 (de)
JP (1) JP2006506398A (de)
AR (1) AR041864A1 (de)
AT (1) ATE454385T1 (de)
AU (1) AU2003269421A1 (de)
BR (1) BR0315820A (de)
CA (1) CA2500487A1 (de)
DE (1) DE60330890D1 (de)
GT (1) GT200300231A (de)
MX (1) MXPA05004343A (de)
NL (1) NL1024676C2 (de)
PA (1) PA8586801A1 (de)
TW (1) TW200424199A (de)
UY (1) UY28048A1 (de)
WO (1) WO2004039803A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
DE602005002746T2 (de) 2004-04-26 2008-02-07 Pfizer Inc. Inhibitoren des hiv-integrase-enzyms
EP1873155A1 (de) * 2004-04-26 2008-01-02 Pfizer Inc. Hemmer des HIV-Integrase-Enzyms
MXPA06012449A (es) 2004-04-26 2007-01-17 Pfizer Inhibidores de la enzima integrasa de vih.
WO2006027694A1 (en) * 2004-09-07 2006-03-16 Pfizer Inc. Inhibitors of the hiv integrase enzyme
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
WO2006121831A2 (en) * 2005-05-10 2006-11-16 Merck & Co., Inc. Hiv integrase inhibitors
JP2009510157A (ja) * 2005-10-03 2009-03-12 ファイザー・プロダクツ・インク Ｈｉｖインテグラーゼ酵素の阻害剤
BRPI0616657A2 (pt) * 2005-10-07 2011-06-28 Pfizer Prod Inc inibidores da enzima hiv integrase
US20080079207A1 (en) * 2006-09-28 2008-04-03 Williams Controils Industries, Inc. Methods and apparatus for a lever control
WO2009146555A1 (en) * 2008-06-04 2009-12-10 Ambrilia Biopharma Inc. Hiv integrase inhibitors from pyridoxine
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
SG181423A1 (en) * 2009-12-23 2012-07-30 Univ Leuven Kath Novel antiviral compounds
NZ610315A (en) 2010-11-15 2015-08-28 Univ Leuven Kath Antiviral condensed heterocyclic compounds
CN104185420B (zh) 2011-11-30 2017-06-09 埃默里大学 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂
GB201321735D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
EP0627436A1 (de) 1991-08-08 1994-12-07 TSUMURA & CO. Carcinostatische verbindungen und ihre herstellung
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
US5262537A (en) * 1993-03-19 1993-11-16 Anaquest, Inc. Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
EP0713877A1 (de) 1993-07-19 1996-05-29 LUO, Xuande Qinghaosuderivate zur bekämpfung von aids
GB2306476A (en) * 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US6057297A (en) 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
WO1998018473A1 (en) * 1996-10-31 1998-05-07 Merck & Co., Inc. Benzodiazepine hydrazide derivatives as inhibitors of hiv integrase
GB2327674A (en) * 1997-07-29 1999-02-03 Merck & Co Inc HIV integrase inhibitors
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
HUP0302962A2 (hu) 1998-06-12 2003-12-29 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása
EP1187837B1 (de) * 1999-05-12 2007-07-18 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Thiazepin-hemmer von hiv-1 integrase
US6245806B1 (en) * 1999-08-03 2001-06-12 Merck & Co., Inc. HIV integrase inhibitors
AU8009900A (en) * 1999-10-13 2001-04-23 Merck & Co., Inc. Hiv integrase inhibitors
EP1209158A1 (de) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substitutierte beta-Carboline
JP2004517802A (ja) * 2000-06-16 2004-06-17 ブリストルーマイヤーズ スクイブ カンパニー Ｈｉｖインテグラーゼ阻害剤
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
CZ20032332A3 (cs) 2001-03-01 2003-11-12 Shionogi & Co., Ltd. Heteroarylové sloučeniny obsahující dusík, které mají inhibiční aktivitu proti HIV integrase
JP4176477B2 (ja) * 2001-03-01 2008-11-05 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環誘導体
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
ES2278064T3 (es) 2001-10-19 2007-08-01 Transtech Pharma Inc. Derivados de beta-carbolina como inhibidores de ptp.
ATE355064T1 (de) 2001-10-26 2006-03-15 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
AU2002349675A1 (en) 2001-12-05 2003-06-17 Shionogi And Co., Ltd. Derivative having hiv integrase inhibitory activity
BR0214842A (pt) 2001-12-12 2005-01-11 Bristol Myers Squibb Co Inibidores de integrase hiv
CA2472372C (en) 2002-01-17 2010-08-17 Melissa Egbertson Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
WO2003077857A2 (en) 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2003082881A2 (en) * 2002-03-28 2003-10-09 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
US20050165000A1 (en) * 2002-04-10 2005-07-28 Robertson Sandra K. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
WO2004035076A1 (en) 2002-10-15 2004-04-29 Chiron Corporation Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
DE602005002746T2 (de) 2004-04-26 2008-02-07 Pfizer Inc. Inhibitoren des hiv-integrase-enzyms
MXPA06012449A (es) 2004-04-26 2007-01-17 Pfizer Inhibidores de la enzima integrasa de vih.
WO2006027694A1 (en) 2004-09-07 2006-03-16 Pfizer Inc. Inhibitors of the hiv integrase enzyme

Also Published As

Publication number Publication date
US7368571B2 (en) 2008-05-06
US20080221154A1 (en) 2008-09-11
NL1024676C2 (nl) 2005-12-14
WO2004039803A2 (en) 2004-05-13
US20070004768A1 (en) 2007-01-04
PA8586801A1 (es) 2005-02-04
EP1558611A2 (de) 2005-08-03
NL1024676A1 (nl) 2004-05-06
GT200300231A (es) 2004-06-23
MXPA05004343A (es) 2005-08-03
US7135482B2 (en) 2006-11-14
AU2003269421A8 (en) 2004-05-25
AU2003269421A1 (en) 2004-05-25
AR041864A1 (es) 2005-06-01
WO2004039803A3 (en) 2004-09-16
DE60330890D1 (de) 2010-02-25
US20040147547A1 (en) 2004-07-29
TW200424199A (en) 2004-11-16
EP1558611B1 (de) 2010-01-06
CA2500487A1 (en) 2004-05-13
BR0315820A (pt) 2005-09-13
UY28048A1 (es) 2004-05-31
JP2006506398A (ja) 2006-02-23

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