ATE454385T1 - Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung - Google Patents

Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung

Info

Publication number
ATE454385T1
ATE454385T1 AT03751203T AT03751203T ATE454385T1 AT E454385 T1 ATE454385 T1 AT E454385T1 AT 03751203 T AT03751203 T AT 03751203T AT 03751203 T AT03751203 T AT 03751203T AT E454385 T1 ATE454385 T1 AT E454385T1
Authority
AT
Austria
Prior art keywords
application
pharmaceutical composition
hiv integrase
integrase inhibitor
inhibitor
Prior art date
Application number
AT03751203T
Other languages
English (en)
Inventor
Qiyue Hu
Atsuo Kuki
Dawn Marie Nowlin
Michael Bruno Plewe
Hai Wang
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE454385T1 publication Critical patent/ATE454385T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03751203T 2002-10-31 2003-10-27 Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung ATE454385T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42251302P 2002-10-31 2002-10-31
PCT/IB2003/004735 WO2004039803A2 (en) 2002-10-31 2003-10-27 Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use

Publications (1)

Publication Number Publication Date
ATE454385T1 true ATE454385T1 (de) 2010-01-15

Family

ID=32230367

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03751203T ATE454385T1 (de) 2002-10-31 2003-10-27 Hiv-integrase-hemmers, pharmazeutischen zusammensetzung und ihre anwendung

Country Status (16)

Country Link
US (3) US7135482B2 (de)
EP (1) EP1558611B1 (de)
JP (1) JP2006506398A (de)
AR (1) AR041864A1 (de)
AT (1) ATE454385T1 (de)
AU (1) AU2003269421A1 (de)
BR (1) BR0315820A (de)
CA (1) CA2500487A1 (de)
DE (1) DE60330890D1 (de)
GT (1) GT200300231A (de)
MX (1) MXPA05004343A (de)
NL (1) NL1024676C2 (de)
PA (1) PA8586801A1 (de)
TW (1) TW200424199A (de)
UY (1) UY28048A1 (de)
WO (1) WO2004039803A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
EP1873155A1 (de) * 2004-04-26 2008-01-02 Pfizer Inc. Hemmer des HIV-Integrase-Enzyms
BRPI0510319A (pt) 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
DE602005002746T2 (de) * 2004-04-26 2008-02-07 Pfizer Inc. Inhibitoren des hiv-integrase-enzyms
JP2008512442A (ja) * 2004-09-07 2008-04-24 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
WO2006121831A2 (en) * 2005-05-10 2006-11-16 Merck & Co., Inc. Hiv integrase inhibitors
JP2009510157A (ja) * 2005-10-03 2009-03-12 ファイザー・プロダクツ・インク Ｈｉｖインテグラーゼ酵素の阻害剤
BRPI0616657A2 (pt) * 2005-10-07 2011-06-28 Pfizer Prod Inc inibidores da enzima hiv integrase
US20080079207A1 (en) * 2006-09-28 2008-04-03 Williams Controils Industries, Inc. Methods and apparatus for a lever control
US8742123B2 (en) 2008-06-04 2014-06-03 Taimed Biologics, Inc. HIV integrase inhibitors from pyridoxine
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
WO2011076765A1 (en) * 2009-12-23 2011-06-30 Katholieke Universiteit Leuven Novel antiviral compounds
KR20140003438A (ko) 2010-11-15 2014-01-09 카톨리에케 유니버시테이트 루벤 항바이러스성 축합 헤테로사이클릭 화합물
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

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* Cited by examiner, † Cited by third party
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NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
US5616609A (en) * 1991-08-08 1997-04-01 Ikekawa; Tetsuro Carcinostatic compound and production thereof
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
US5262537A (en) * 1993-03-19 1993-11-16 Anaquest, Inc. Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
EP0713877A1 (de) * 1993-07-19 1996-05-29 LUO, Xuande Qinghaosuderivate zur bekämpfung von aids
GB2306476A (en) * 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US6057297A (en) * 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
AU4917397A (en) * 1996-10-31 1998-05-22 Merck & Co., Inc. Benzodiazepine hydrazide derivatives as inhibitors of hiv integrase
GB2327674A (en) * 1997-07-29 1999-02-03 Merck & Co Inc HIV integrase inhibitors
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
EP1086101B1 (de) 1998-06-12 2002-12-18 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Betacarbolinverbindungen
AU777036B2 (en) * 1999-05-12 2004-09-30 Antonio Garofalo Thiazepine inhibitors of HIV-1 integrase
US6245806B1 (en) * 1999-08-03 2001-06-12 Merck & Co., Inc. HIV integrase inhibitors
AU8009900A (en) * 1999-10-13 2001-04-23 Merck & Co., Inc. Hiv integrase inhibitors
EP1209158A1 (de) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substitutierte beta-Carboline
JP2004517802A (ja) * 2000-06-16 2004-06-17 ブリストルーマイヤーズ スクイブ カンパニー Ｈｉｖインテグラーゼ阻害剤
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
CN1659143A (zh) 2001-03-01 2005-08-24 盐野义制药株式会社 具有hiv整合酶抑制活性的含氮杂芳基化合物
JP4176477B2 (ja) * 2001-03-01 2008-11-05 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環誘導体
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
EP1438310B1 (de) 2001-10-19 2006-12-20 TransTech Pharma Inc. Beta-carbolin-derivate als ptp-inhibitoren
CA2463975A1 (en) 2001-10-26 2003-05-01 Maria Emilia Di Francesco Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
AU2002349675A1 (en) 2001-12-05 2003-06-17 Shionogi And Co., Ltd. Derivative having hiv integrase inhibitory activity
CA2469592C (en) 2001-12-12 2005-08-23 Bristol-Myers Squibb Company Hiv integrase inhibitors
EP1467970B1 (de) 2002-01-17 2007-08-22 Merck & Co., Inc. Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen
WO2003077857A2 (en) 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2003082881A2 (en) * 2002-03-28 2003-10-09 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
EP1499391A2 (de) * 2002-04-10 2005-01-26 Merck & Co., Inc. Pharmazeutische zusammensetzungen mit einem hiv-integrase-hemmer und einem nichtionischen tensid
AU2002335027A1 (en) 2002-10-15 2004-05-04 Chiron Corporation Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) * 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
DE602005002746T2 (de) 2004-04-26 2008-02-07 Pfizer Inc. Inhibitoren des hiv-integrase-enzyms
BRPI0510319A (pt) 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
JP2008512442A (ja) 2004-09-07 2008-04-24 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤

Also Published As

Publication number Publication date
WO2004039803A2 (en) 2004-05-13
US7135482B2 (en) 2006-11-14
AU2003269421A8 (en) 2004-05-25
UY28048A1 (es) 2004-05-31
TW200424199A (en) 2004-11-16
EP1558611A2 (de) 2005-08-03
EP1558611B1 (de) 2010-01-06
AR041864A1 (es) 2005-06-01
MXPA05004343A (es) 2005-08-03
BR0315820A (pt) 2005-09-13
PA8586801A1 (es) 2005-02-04
DE60330890D1 (de) 2010-02-25
NL1024676C2 (nl) 2005-12-14
US20070004768A1 (en) 2007-01-04
US20080221154A1 (en) 2008-09-11
US20040147547A1 (en) 2004-07-29
GT200300231A (es) 2004-06-23
AU2003269421A1 (en) 2004-05-25
WO2004039803A3 (en) 2004-09-16
NL1024676A1 (nl) 2004-05-06
CA2500487A1 (en) 2004-05-13
US7368571B2 (en) 2008-05-06
JP2006506398A (ja) 2006-02-23

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