BRPI0510319A - inibidores da enzima integrase de hiv - Google Patents

inibidores da enzima integrase de hiv

Info

Publication number
BRPI0510319A
BRPI0510319A BRPI0510319-3A BRPI0510319A BRPI0510319A BR PI0510319 A BRPI0510319 A BR PI0510319A BR PI0510319 A BRPI0510319 A BR PI0510319A BR PI0510319 A BRPI0510319 A BR PI0510319A
Authority
BR
Brazil
Prior art keywords
integrase enzyme
enzyme inhibitors
hiv integrase
hiv
inhibitors
Prior art date
Application number
BRPI0510319-3A
Other languages
English (en)
Inventor
Klaus Ruprecht Dress
Qiyue Hu
Ted William Johnson
Michael Bruno Plewe
Steven Paul Tanis
Hai Wang
Anle Yang
Chunfeng Yin
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0510319A publication Critical patent/BRPI0510319A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

INIBIDORES DA ENZIMA INTEGRASE DE HIV. A presente invenção refere-se a compostos de fórmula (I), e sais e solvatos farmaceuticamente aceitáveis dos mesmos, sua síntese e seu uso como moduladores ou inibidores da enzima integrase do vírus da imunodeficiência humana ("HIV").
BRPI0510319-3A 2004-04-26 2005-04-14 inibidores da enzima integrase de hiv BRPI0510319A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56570504P 2004-04-26 2004-04-26
US66050205P 2005-03-09 2005-03-09
PCT/IB2005/001029 WO2005103003A2 (en) 2004-04-26 2005-04-14 Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0510319A true BRPI0510319A (pt) 2007-10-16

Family

ID=35033770

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510319-3A BRPI0510319A (pt) 2004-04-26 2005-04-14 inibidores da enzima integrase de hiv

Country Status (7)

Country Link
US (1) US7468375B2 (pt)
EP (1) EP1756103A2 (pt)
JP (1) JP2007534739A (pt)
BR (1) BRPI0510319A (pt)
CA (1) CA2564356A1 (pt)
MX (1) MXPA06012449A (pt)
WO (1) WO2005103003A2 (pt)

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CN102060855B (zh) * 2009-11-12 2014-04-16 上海药明康德新药开发有限公司 一种八氢-吡喏-并[3,4-c]吡啶-衍生物的制备方法
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EP2712315B1 (en) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
EP2768805B1 (en) 2011-10-20 2020-03-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
JP6046154B2 (ja) 2011-10-20 2016-12-14 オリソン ヘノミクス エセ． アー． Ｌｓｄ１阻害剤としての（ヘテロ）アリールシクロプロピルアミン化合物
WO2013073875A1 (ko) * 2011-11-15 2013-05-23 한국화학연구원 신규한 항바이러스성 피롤로피리딘 유도체 및 이의 제조방법
TWI627173B (zh) 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
TWI704146B (zh) 2013-09-26 2020-09-11 比利時商健生藥品公司 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
EP3105218B1 (en) * 2014-02-13 2019-09-25 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
JP6602779B2 (ja) * 2014-02-13 2019-11-06 インサイト・コーポレイション Ｌｓｄ１阻害剤としてのシクロプロピルアミン類
CA2960336C (en) * 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Compounds as nik inhibitors
KR102523405B1 (ko) 2014-10-23 2023-04-18 얀센 파마슈티카 엔.브이. Ｎｉｋ 억제제로서의 신규 피라졸로피리미딘 유도체
EP3209654B1 (en) 2014-10-23 2018-10-03 Janssen Pharmaceutica N.V. New pyrazole derivatives as nik inhibitors
EA033238B1 (ru) 2014-10-23 2019-09-30 Янссен Фармацевтика Нв Новые производные тиенопиримидина в качестве ингибиторов nik
EP3241830A1 (de) 2016-05-04 2017-11-08 Bayer CropScience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
PT3455204T (pt) * 2016-05-09 2026-01-27 Jubilant Epicore LLC Compostos de ciclopropil-amida como inibidores duplos de lsd1/hdac
RU2019104378A (ru) 2016-07-19 2020-08-19 Байер Кропсайенс Акциенгезельшафт Конденсированные бициклические гетероциклические производные в качестве средств для борьбы с вредителями
MX2019001918A (es) 2016-08-15 2019-09-06 Bayer Cropscience Ag Derivados del heterociclo biciclico condensado como agentes de control de plagas.
PL3604303T3 (pl) * 2017-03-24 2023-04-11 St Pharm Co., Ltd. Nowa pochodna pirolopirydyny, sposób jej wytwarzania oraz jej zastosowanie
AU2018300980A1 (en) 2017-07-12 2020-01-02 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
IL273924B2 (en) 2017-10-20 2024-07-01 Univ Vanderbilt Antagonists of the muscarinic acetylcholine receptor m4
EP4196473B1 (en) 2020-08-13 2024-10-02 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
KR102909106B1 (ko) * 2020-08-20 2026-01-07 에스티팜 주식회사 피롤로피리딘 유도체 및 이들의 용도
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CA2578841A1 (en) 2004-09-07 2006-03-16 Pfizer Inc. Inhibitors of the hiv integrase enzyme

Also Published As

Publication number Publication date
WO2005103003A2 (en) 2005-11-03
CA2564356A1 (en) 2005-11-03
MXPA06012449A (es) 2007-01-17
JP2007534739A (ja) 2007-11-29
EP1756103A2 (en) 2007-02-28
US20050277662A1 (en) 2005-12-15
US7468375B2 (en) 2008-12-23
WO2005103003A3 (en) 2006-03-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.