BRPI0510319A - inibidores da enzima integrase de hiv - Google Patents

inibidores da enzima integrase de hiv

Info

Publication number
BRPI0510319A
BRPI0510319A BRPI0510319-3A BRPI0510319A BRPI0510319A BR PI0510319 A BRPI0510319 A BR PI0510319A BR PI0510319 A BRPI0510319 A BR PI0510319A BR PI0510319 A BRPI0510319 A BR PI0510319A
Authority
BR
Brazil
Prior art keywords
integrase enzyme
enzyme inhibitors
hiv integrase
hiv
inhibitors
Prior art date
Application number
BRPI0510319-3A
Other languages
English (en)
Inventor
Klaus Ruprecht Dress
Qiyue Hu
Ted William Johnson
Michael Bruno Plewe
Steven Paul Tanis
Hai Wang
Anle Yang
Chunfeng Yin
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0510319A publication Critical patent/BRPI0510319A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

INIBIDORES DA ENZIMA INTEGRASE DE HIV. A presente invenção refere-se a compostos de fórmula (I), e sais e solvatos farmaceuticamente aceitáveis dos mesmos, sua síntese e seu uso como moduladores ou inibidores da enzima integrase do vírus da imunodeficiência humana ("HIV").
BRPI0510319-3A 2004-04-26 2005-04-14 inibidores da enzima integrase de hiv BRPI0510319A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56570504P 2004-04-26 2004-04-26
US66050205P 2005-03-09 2005-03-09
PCT/IB2005/001029 WO2005103003A2 (en) 2004-04-26 2005-04-14 Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0510319A true BRPI0510319A (pt) 2007-10-16

Family

ID=35033770

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510319-3A BRPI0510319A (pt) 2004-04-26 2005-04-14 inibidores da enzima integrase de hiv

Country Status (7)

Country Link
US (1) US7468375B2 (pt)
EP (1) EP1756103A2 (pt)
JP (1) JP2007534739A (pt)
BR (1) BRPI0510319A (pt)
CA (1) CA2564356A1 (pt)
MX (1) MXPA06012449A (pt)
WO (1) WO2005103003A2 (pt)

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DE602005002746T2 (de) 2004-04-26 2008-02-07 Pfizer Inc. Inhibitoren des hiv-integrase-enzyms
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EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
DK2493871T3 (da) 2009-10-30 2014-11-10 Prestwick Chemical Sas Nye oximderivater samt deres anvendelse som allosteriske modulatorer af metabotropiske glutamatreceptorer
CN102060855B (zh) * 2009-11-12 2014-04-16 上海药明康德新药开发有限公司 一种八氢-吡喏-并[3,4-c]吡啶-衍生物的制备方法
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
WO2011106574A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
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US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
WO2012013728A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
EP2712315B1 (en) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
AU2012324803B9 (en) 2011-10-20 2017-08-24 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
SG11201401066PA (en) 2011-10-20 2014-10-30 Oryzon Genomics Sa (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
HUE046795T2 (hu) * 2011-11-15 2020-03-30 St Pharm Co Ltd Új vírusellenes pirrolopiridin származékok és eljárás azok elõállítására
TWI704146B (zh) 2013-09-26 2020-09-11 比利時商健生藥品公司 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物
TWI627173B (zh) 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
GB201321735D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
US9493450B2 (en) * 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
PE20161573A1 (es) * 2014-02-13 2017-01-19 Incyte Corp Ciclopropilamina como inhibidor de la lsd1
JP6603713B2 (ja) 2014-10-23 2019-11-06 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｉｋ阻害剤としての新規のチエノピリミジン誘導体
CA2960574C (en) 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Pyrazolopyrimidine derivatives as nik inhibitors
AU2015334917B2 (en) * 2014-10-23 2019-08-29 Janssen Pharmaceutica Nv New compounds as NIK inhibitors
CN107074818B (zh) 2014-10-23 2020-04-17 詹森药业有限公司 作为nik抑制剂的吡唑衍生物
EP3241830A1 (de) 2016-05-04 2017-11-08 Bayer CropScience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
WO2017195216A1 (en) 2016-05-09 2017-11-16 Jubilant Biosys Limited Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors
CA3031139A1 (en) 2016-07-19 2018-01-25 Bayer Cropscience Aktiengesellschaft Condensed bicyclic heterocycle derivatives as pest control agents
ES2938615T3 (es) 2016-08-15 2023-04-13 Bayer Cropscience Ag Derivados del heterociclo bicíclico condensado como agentes de control de plagas
AU2017405244C9 (en) * 2017-03-24 2021-03-04 St Pharm Co., Ltd. Novel pyrrolopyridine derivative, method for producing same, and use thereof
US11299481B2 (en) 2017-10-20 2022-04-12 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
WO2022036177A1 (en) 2020-08-13 2022-02-17 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
KR102909106B1 (ko) * 2020-08-20 2026-01-07 에스티팜 주식회사 피롤로피리딘 유도체 및 이들의 용도
WO2024028654A2 (en) * 2022-08-05 2024-02-08 The Governing Council Of The University Of Toronto Histone deacetylase inhibitors and use of the same

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DE602005002746T2 (de) 2004-04-26 2008-02-07 Pfizer Inc. Inhibitoren des hiv-integrase-enzyms
WO2006027694A1 (en) 2004-09-07 2006-03-16 Pfizer Inc. Inhibitors of the hiv integrase enzyme

Also Published As

Publication number Publication date
MXPA06012449A (es) 2007-01-17
CA2564356A1 (en) 2005-11-03
WO2005103003A3 (en) 2006-03-16
US20050277662A1 (en) 2005-12-15
EP1756103A2 (en) 2007-02-28
US7468375B2 (en) 2008-12-23
WO2005103003A2 (en) 2005-11-03
JP2007534739A (ja) 2007-11-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.