ATE454395T1 - Oestrogenderivate als steroid sulphatase inhibitoren - Google Patents

Oestrogenderivate als steroid sulphatase inhibitoren

Info

Publication number: ATE454395T1
Authority: AT; Austria
Prior art keywords: group; steroid sulphatase; ring system; estrogen derivatives; sulphatase inhibitors
Prior art date: 2003-03-24

Application number

AT04713124T

Other languages

English (en)

Inventor

Mathew Leese

Alan Purohit

Michael John Reed

Simon Paul Newman

Surinder K Chander

Fabrice Jourdan

Barry V L Potter

Original Assignee

Sterix Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-24

Filing date

2004-02-20

Publication date

2010-01-15

2003-03-24 Priority claimed from GB0306717A external-priority patent/GB0306717D0/en

2003-07-07 Priority claimed from GB0315885A external-priority patent/GB0315885D0/en

2004-02-20 Application filed by Sterix Ltd filed Critical Sterix Ltd

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE454395T1 publication Critical patent/ATE454395T1/de

Links

102000009134 Steryl-Sulfatase Human genes 0.000 title 1
108010087999 Steryl-Sulfatase Proteins 0.000 title 1
229940011871 estrogen Drugs 0.000 title 1
239000000262 estrogen Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000003637 steroidlike Effects 0.000 abstract 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
150000001336 alkenes Chemical class 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
IOVCWXUNBOPUCH-UHFFFAOYSA-M nitrite group Chemical group N(=O)[O-] IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 abstract 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical group NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
125000000565 sulfonamide group Chemical group 0.000 abstract 1
125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Enzymes And Modification Thereof (AREA)

AT04713124T 2003-03-24 2004-02-20 Oestrogenderivate als steroid sulphatase inhibitoren ATE454395T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0306717A GB0306717D0 (en)	2003-03-24	2003-03-24	Compound
GB0315885A GB0315885D0 (en)	2003-07-07	2003-07-07	Compound
PCT/GB2004/000705 WO2004085459A1 (en)	2003-03-24	2004-02-20	Oestrogen derivatives as inhibitors of steroid sulphatase

Publications (1)

Publication Number	Publication Date
ATE454395T1 true ATE454395T1 (de)	2010-01-15

Family

ID=33099976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04713124T ATE454395T1 (de)	2003-03-24	2004-02-20	Oestrogenderivate als steroid sulphatase inhibitoren

Country Status (14)

Country	Link
US (1)	US7893284B2 (de)
EP (1)	EP1608671B1 (de)
JP (1)	JP4719144B2 (de)
AT (1)	ATE454395T1 (de)
AU (1)	AU2004224053B2 (de)
BR (1)	BRPI0408703A (de)
CA (1)	CA2520142C (de)
DE (1)	DE602004024966D1 (de)
DK (1)	DK1608671T3 (de)
EA (1)	EA011123B1 (de)
ES (1)	ES2339450T3 (de)
MX (1)	MXPA05010339A (de)
PL (1)	PL378577A1 (de)
WO (1)	WO2004085459A1 (de)

Families Citing this family (32)

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GB0113920D0 (en)	2001-06-07	2001-08-01	Sterix Ltd	Composition
US8030298B2 (en)	2005-05-26	2011-10-04	Abbott Products Gmbh	17β-HSD1 and STS inhibitors
US8288367B2 (en)	2006-11-30	2012-10-16	Solvay Pharmaceuticals Gmbh	Substituted estratriene derivatives as 17BETA HSD inhibitors
WO2008090517A2 (en) *	2007-01-26	2008-07-31	Piramal Life Sciences Limited	Enriched plant extract, compound, and methods for the treatment of proliferative disorders
EP2149371A1 (de)	2008-07-28	2010-02-03	PregLem S.A.	Verwendung von Steroid-Sulfatase-Hemmern zur Behandlung von Frühgeburtsleiden
US20110190323A1 (en) *	2008-08-28	2011-08-04	President And Fellows Of Harvard College	Cortistatin analogues and syntheses thereof
EP2421882A4 (de) *	2009-04-22	2013-05-08	Harvard College	Angiogenesehemmer
US9388210B2 (en)	2011-02-25	2016-07-12	Washington University	Neuroactive 17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
EP3572417B1 (de)	2011-10-14	2025-12-17	Sage Therapeutics, LLC	3,3-disubstituierte 19-nor-pregnan verbindungen, zusammensetzungen damit und verwendungen davon
HUE039057T2 (hu)	2012-12-18	2018-12-28	Univ Washington	Kezelési eljárásokban alkalmazható neuroaktív 19-alkoxi-17-szubsztituált szteroidok
US9512170B2 (en)	2013-03-01	2016-12-06	Washington University	Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
US9365502B2 (en)	2013-03-11	2016-06-14	Washington University	Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
US9562026B2 (en)	2013-03-14	2017-02-07	Washington University	Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
KR102396328B1 (ko)	2013-04-17	2022-05-10	세이지 테라퓨틱스, 인크.	19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
US9725481B2 (en)	2013-04-17	2017-08-08	Sage Therapeutics, Inc.	19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
US20160068563A1 (en)	2013-04-17	2016-03-10	Boyd L. Harrison	19-nor neuroactive steroids and methods of use thereof
EP2986624B1 (de)	2013-04-17	2020-03-25	Sage Therapeutics, Inc.	Neuroaktive 19-nor-steroide zur verwendung zur behandlung von krankheiten
SI3021852T1 (sl)	2013-07-19	2021-07-30	Sage Therapeutics, Inc.	Nevroaktivni steroidi, sestavki in uporabe le-teh
AU2014308621C1 (en)	2013-08-23	2022-01-06	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
AU2014369834B2 (en)	2013-12-24	2018-12-20	President And Fellows Of Harvard College	Cortistatin analogues and syntheses and uses thereof
US10246482B2 (en)	2014-06-18	2019-04-02	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
ME03809B (de)	2014-10-16	2021-04-20	Sage Therapeutics Inc	Zusammensetzungen und verfahren zur behandlung von störungen des zentralen nervensystems
CN117024501A (zh)	2014-10-16	2023-11-10	萨奇治疗股份有限公司	靶向cns障碍的组合物和方法
WO2016082789A1 (en)	2014-11-27	2016-06-02	Sage Therapeutics, Inc.	Compositions and methods for treating cns disorders
RS61530B1 (sr)	2015-01-26	2021-04-29	Sage Therapeutics Inc	Kompozicije i postupci za lečenje poremećaja cns
EP4155314A1 (de)	2015-02-20	2023-03-29	Sage Therapeutics, Inc.	Neuroaktive steroide, zusammensetzungen und verwendungen davon
WO2016182932A1 (en)	2015-05-08	2016-11-17	President And Fellows Of Harvard College	Cortistatin analogues, syntheses, and uses thereof
EP3316889A4 (de)	2015-07-01	2018-11-14	President and Fellows of Harvard College	Cortistatin-analoga sowie synthese und verwendungen davon
JP6992748B2 (ja) *	2016-06-15	2022-02-03	ソニーグループ株式会社	情報処理装置、観察システム、観察方法及びプログラム
MA45599A (fr)	2016-07-11	2019-05-15	Sage Therapeutics Inc	Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
WO2018013615A1 (en)	2016-07-11	2018-01-18	Sage Therapeutics, Inc.	C7, c12, and c16 substituted neuroactive steroids and their methods of use
SG11202112391UA (en)	2019-05-31	2021-12-30	Sage Therapeutics Inc	Neuroactive steroids and compositions thereof

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US4994439A (en) *	1989-01-19	1991-02-19	California Biotechnology Inc.	Transmembrane formulations for drug administration
DE19723794A1 (de) *	1997-06-06	1998-12-10	Jenapharm Gmbh	Nichtestrogene Derivate des Estradiols mit antioxidativer Aktivität
US6288050B1 (en) *	1997-07-18	2001-09-11	Duquesne University Of The Holy Ghost	Steroid sulfatase inhibitors and methods for making and using the same
GB2331987B (en) *	1997-12-04	2002-11-27	Imperial College	Polycyclic sulphamate inhibitors of oestrone sulphatase
US6046186A (en) *	1997-12-24	2000-04-04	Sri International	Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
AU765386B2 (en) *	1998-06-10	2003-09-18	Sterix Limited	Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-(o)-sulphamate for inhibition of estrone sulphatase
JP5042411B2 (ja) *	1999-04-30	2012-10-03	ステリックスリミテッド	抗腫瘍剤としてのエストロン誘導体の使用
JPWO2001081364A1 (ja) *	2000-04-24	2004-01-08	協和醗酵工業株式会社	エストラ−１，３，５（１０）−トリエン誘導体
DE60112438T2 (de) *	2000-05-11	2006-06-08	Research Institute For Medicine And Chemistry Inc., Cambridge	2-substituirte pregna-1,3,5(10)-trien- und chola-1,3,5(10)-trien- derivate und ihre biologische aktivität
GB0020498D0 (en) *	2000-08-18	2000-10-11	Sterix Ltd	Compound
AU8494601A (en) *	2000-08-18	2002-03-04	Univ Illinois	Prodrugs of betulinic acid derivatives for the treatment of cancer and HIV
WO2002062347A1 (en)	2001-02-05	2002-08-15	Oncology Sciences Corporation	Method and composition of novel compounds for the therapy and targeting of the primary modalities of cancer cell proliferation and homeostasis
GB0421106D0 (en) *	2004-09-22	2004-10-27	Sterix Ltd	Compound

2004
- 2004-02-20 PL PL378577A patent/PL378577A1/pl not_active Application Discontinuation
- 2004-02-20 AT AT04713124T patent/ATE454395T1/de not_active IP Right Cessation
- 2004-02-20 DE DE602004024966T patent/DE602004024966D1/de not_active Expired - Lifetime
- 2004-02-20 AU AU2004224053A patent/AU2004224053B2/en not_active Ceased
- 2004-02-20 WO PCT/GB2004/000705 patent/WO2004085459A1/en not_active Ceased
- 2004-02-20 MX MXPA05010339A patent/MXPA05010339A/es active IP Right Grant
- 2004-02-20 DK DK04713124.8T patent/DK1608671T3/da active
- 2004-02-20 BR BRPI0408703-8A patent/BRPI0408703A/pt not_active IP Right Cessation
- 2004-02-20 EP EP04713124A patent/EP1608671B1/de not_active Expired - Lifetime
- 2004-02-20 JP JP2006505892A patent/JP4719144B2/ja not_active Expired - Fee Related
- 2004-02-20 EA EA200501426A patent/EA011123B1/ru not_active IP Right Cessation
- 2004-02-20 CA CA2520142A patent/CA2520142C/en not_active Expired - Fee Related
- 2004-02-20 ES ES04713124T patent/ES2339450T3/es not_active Expired - Lifetime
2005
- 2005-09-23 US US11/233,945 patent/US7893284B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2004224053B2 (en)	2011-06-09
AU2004224053A1 (en)	2004-10-07
CA2520142A1 (en)	2004-10-07
EA011123B1 (ru)	2008-12-30
US20060094696A1 (en)	2006-05-04
DK1608671T3 (da)	2010-05-10
WO2004085459A1 (en)	2004-10-07
MXPA05010339A (es)	2005-12-14
JP2006521335A (ja)	2006-09-21
PL378577A1 (pl)	2006-05-02
US7893284B2 (en)	2011-02-22
HK1082258A1 (en)	2006-06-02
CA2520142C (en)	2011-01-04
EP1608671B1 (de)	2010-01-06
BRPI0408703A (pt)	2006-03-07
EA200501426A1 (ru)	2006-06-30
EP1608671A1 (de)	2005-12-28
ES2339450T3 (es)	2010-05-20
JP4719144B2 (ja)	2011-07-06
DE602004024966D1 (de)	2010-02-25

Legal Events

Date	Code	Title	Description
2010-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE454395T1 (de)	2010-01-15	Oestrogenderivate als steroid sulphatase inhibitoren
ES2194446T3 (es)	2003-11-16	Derivados de bibiclooctano utilizados como plastificantes.
DOP2011000301A (es)	2011-10-31	Derivados de azaadamantano y metodos de uso de los mismos
GT200100007A (es)	2001-10-19	Antagonistas del factor liberador de corticotropina.
ES2185338T3 (es)	2003-04-16	Derivados de fumagilol y procedimientos para su fabricacion.
CY1110237T1 (el)	2015-01-14	Συνθεση οιστετρολης δια στεροειδων προερχομενων απο οιστρονη
ATE303399T1 (de)	2005-09-15	Steroide als agonisten für fxr
TR200101906T2 (tr)	2001-12-21	Antiviral ajanlar olarak kuinolinkarboksamitler
HRP20090195T1 (hr)	2009-05-31	Inhibitori mitotičkih kinezina
AR067613A1 (es)	2009-10-14	Inhibidores de adn-pk, uso y sintesis de los mismos
ATE283253T1 (de)	2004-12-15	Substituierte aminopropoxyarylderivate als lxr agonisten
CR9375A (es)	2008-01-29	Derivados de ciclopropanocarboxamida
AR006390A1 (es)	1999-08-25	Derivados de lactama
DE60032440D1 (de)	2007-02-01	Halterung für die Brennkammer einer Gasturbine
DK1311619T3 (da)	2007-01-29	Anvendelse af en bitumen/vokssammensætning
HRP20090474T1 (hr)	2009-10-31	Postupak i intermedijeri za sintezu kaspofungina
PT1087986E (pt)	2002-08-30	Undecanoato de 7alfa-metil-19-nortestosterona com actividade androgenica
ATE411287T1 (de)	2008-10-15	Neue metallproteinaseinhibitoren
AR064306A1 (es)	2009-03-25	Antagonistas del receptor de angiotensina ii
DK1051177T3 (da)	2006-07-24	Steroide 3-O-Sulfamatderivater som inhibitorer af östronsulfatase
GB2423992A (en)	2006-09-13	Alkoxylated alkylphenol-formaldehyde-diamine polymer
DE69913705D1 (de)	2004-01-29	Neue cofaktoren für methyltransferasen
MX2008011292A (es)	2008-09-10	Compuestos esteroidales como inhibidores de esteroide sulfatasa.
DK1255745T3 (da)	2004-05-17	Syntese af vandoplöseligt 9-dihydro-paclitaxel afledninger fra 9-dihydro-13-acetylbaccatin III
AR032712A1 (es)	2003-11-19	Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen