ATE454444T1 - Verfahren zur herstellung rekombinanter proteine - Google Patents

Verfahren zur herstellung rekombinanter proteine

Info

Publication number
ATE454444T1
ATE454444T1 AT04768294T AT04768294T ATE454444T1 AT E454444 T1 ATE454444 T1 AT E454444T1 AT 04768294 T AT04768294 T AT 04768294T AT 04768294 T AT04768294 T AT 04768294T AT E454444 T1 ATE454444 T1 AT E454444T1
Authority
AT
Austria
Prior art keywords
recombinant protein
coli host
periplasm
growth rate
host cell
Prior art date
Application number
AT04768294T
Other languages
English (en)
Inventor
David John Glover
Mukesh Sehdev
Dominic Gambier Reeks
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29226759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE454444(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Application granted granted Critical
Publication of ATE454444T1 publication Critical patent/ATE454444T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Jellies, Jams, And Syrups (AREA)
AT04768294T 2003-09-09 2004-09-02 Verfahren zur herstellung rekombinanter proteine ATE454444T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0321100.0A GB0321100D0 (en) 2003-09-09 2003-09-09 Biological products
PCT/GB2004/003747 WO2005024000A1 (en) 2003-09-09 2004-09-02 Methods for producing recombinant proteins

Publications (1)

Publication Number Publication Date
ATE454444T1 true ATE454444T1 (de) 2010-01-15

Family

ID=29226759

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04768294T ATE454444T1 (de) 2003-09-09 2004-09-02 Verfahren zur herstellung rekombinanter proteine

Country Status (20)

Country Link
US (2) US7754447B2 (de)
EP (1) EP1664278B1 (de)
JP (1) JP4568722B2 (de)
KR (1) KR20060125704A (de)
CN (1) CN1849389B (de)
AT (1) ATE454444T1 (de)
AU (1) AU2004270929B2 (de)
BR (1) BRPI0413813A (de)
CA (1) CA2536099C (de)
DE (1) DE602004025011D1 (de)
EA (1) EA200600554A1 (de)
ES (1) ES2339352T3 (de)
GB (1) GB0321100D0 (de)
IL (1) IL173474A0 (de)
MX (1) MXPA06002589A (de)
NO (1) NO20061576L (de)
PL (1) PL1664278T3 (de)
SG (1) SG145696A1 (de)
WO (1) WO2005024000A1 (de)
ZA (1) ZA200601177B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE515566T1 (de) * 2005-05-26 2011-07-15 Cytos Biotechnology Ag Skalierbares fermentationsverfahren
US20110117087A1 (en) 2009-10-26 2011-05-19 Reinhard Franze Method for the production of a glycosylated immunoglobulin
SG11201404991YA (en) 2012-02-23 2014-09-26 Stage Cell Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
KR102036671B1 (ko) * 2012-03-12 2019-11-26 한미사이언스 주식회사 대장균의 고농도 배양방법
CN107683135A (zh) 2015-03-09 2018-02-09 因特克林医疗有限公司 用于治疗非酒精性脂肪肝疾病和/或脂肪营养不良的方法
RU2761555C2 (ru) 2015-10-22 2021-12-09 Джуно Терапьютикс Гмбх Способы, наборы, средства и устройства для трансдукции
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
JP2019510517A (ja) 2016-03-29 2019-04-18 ジェルター， インコーポレイテッド 細胞質内体積に対するペリプラズム体積の比率が０．５：１および１０：１の間にあるグラム陰性細菌におけるタンパク質の発現
AU2018249822A1 (en) 2017-04-03 2019-10-31 Coherus Biosciences Inc. PPArgamma agonist for treatment of progressive supranuclear palsy
AU2018260380B2 (en) 2017-04-27 2025-02-13 Juno Therapeutics Gmbh Oligomeric particle reagents and methods of use thereof
US11180541B2 (en) 2017-09-28 2021-11-23 Geltor, Inc. Recombinant collagen and elastin molecules and uses thereof
WO2020089343A1 (en) 2018-10-31 2020-05-07 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
WO2020118043A1 (en) 2018-12-07 2020-06-11 Coherus Biosciences, Inc. Methods for producing recombinant proteins
GB2597416A (en) 2019-04-12 2022-01-26 Geltor Inc Recombinant elastin and production thereof
WO2021072210A1 (en) 2019-10-11 2021-04-15 Coherus Biosciences, Inc. Methods of purifying ranibizumab or a ranibizumab variant
WO2021072182A1 (en) 2019-10-11 2021-04-15 Coherus Biosciences, Inc. Methods for producing ranibizumab
CN113355264B (zh) * 2021-06-28 2022-03-08 山东智汇达海洋生物科技有限公司 一株产甘油的嗜高温菌及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0335567A3 (de) * 1988-03-30 1990-11-14 Biogen, Inc. Kontrollierte Freisetzung periplasmatischer Proteine in das Medium
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
GB9215540D0 (en) 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
DK1332222T3 (da) * 2000-11-03 2009-07-06 Genentech Inc Stofskifteændringer i fermenteringer der udtrykker rekombinante proteiner
JP5544063B2 (ja) 2003-08-13 2014-07-09 サンド・アクチエンゲゼルシヤフト 組換えポリペプチドの生産のための発現ベクター、形質転換宿主細胞及び発酵方法

Also Published As

Publication number Publication date
EP1664278B1 (de) 2010-01-06
CN1849389B (zh) 2012-05-23
MXPA06002589A (es) 2006-06-05
AU2004270929A1 (en) 2005-03-17
SG145696A1 (en) 2008-09-29
KR20060125704A (ko) 2006-12-06
CA2536099C (en) 2015-11-17
US20080044817A1 (en) 2008-02-21
JP4568722B2 (ja) 2010-10-27
USRE44512E1 (en) 2013-10-01
US7754447B2 (en) 2010-07-13
CN1849389A (zh) 2006-10-18
ZA200601177B (en) 2007-04-25
EP1664278A1 (de) 2006-06-07
WO2005024000A1 (en) 2005-03-17
BRPI0413813A (pt) 2006-10-17
IL173474A0 (en) 2006-06-11
DE602004025011D1 (de) 2010-02-25
AU2004270929B2 (en) 2010-01-21
PL1664278T3 (pl) 2010-06-30
EA200600554A1 (ru) 2006-08-25
ES2339352T3 (es) 2010-05-19
CA2536099A1 (en) 2005-03-17
GB0321100D0 (en) 2003-10-08
JP2007504815A (ja) 2007-03-08
NO20061576L (no) 2006-04-07

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