ATE454455T1 - Leitsequenzen zur anleitung von polypeptidsekretion und verfahren zur herstellung - Google Patents
Leitsequenzen zur anleitung von polypeptidsekretion und verfahren zur herstellungInfo
- Publication number
- ATE454455T1 ATE454455T1 AT06719694T AT06719694T ATE454455T1 AT E454455 T1 ATE454455 T1 AT E454455T1 AT 06719694 T AT06719694 T AT 06719694T AT 06719694 T AT06719694 T AT 06719694T AT E454455 T1 ATE454455 T1 AT E454455T1
- Authority
- AT
- Austria
- Prior art keywords
- guiding
- production
- heterologous
- polypeptides
- sequences
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000028327 secretion Effects 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64701305P | 2005-01-27 | 2005-01-27 | |
| PCT/US2006/002951 WO2006081430A2 (en) | 2005-01-27 | 2006-01-27 | Leader sequences for directing secretion of polypeptides and methods for production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE454455T1 true ATE454455T1 (de) | 2010-01-15 |
Family
ID=36741080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06719694T ATE454455T1 (de) | 2005-01-27 | 2006-01-27 | Leitsequenzen zur anleitung von polypeptidsekretion und verfahren zur herstellung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080286834A1 (de) |
| EP (1) | EP1841874B1 (de) |
| JP (2) | JP2008528033A (de) |
| AT (1) | ATE454455T1 (de) |
| AU (1) | AU2006207999A1 (de) |
| CA (1) | CA2589895A1 (de) |
| DE (1) | DE602006011574D1 (de) |
| DK (1) | DK1841874T3 (de) |
| WO (1) | WO2006081430A2 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2336832T3 (es) | 2005-07-22 | 2010-04-16 | Five Prime Therapeutics, Inc. | Composiciones y procedimientos para tratar enfermedades con proteinas de fusion de fgfr. |
| EP1937815B1 (de) | 2005-09-13 | 2015-05-13 | National Research Council of Canada | Verfahren und zusammensetzungen zur modulation der tumorzellaktivität |
| US9060961B2 (en) * | 2006-11-09 | 2015-06-23 | University Of Washington | Molecules and methods for treatment and detection of cancer |
| WO2009056330A1 (en) * | 2007-10-31 | 2009-05-07 | Eth Zurich | Soluble truncated apom proteins and medical uses thereof |
| US20110212055A1 (en) * | 2008-03-25 | 2011-09-01 | Commissiong John W | Neurodegenerative disorders |
| FR2933773B1 (fr) * | 2008-07-10 | 2013-02-15 | Biomerieux Sa | Procede de dosage de la proteine disulfide isomerase pour le diagnostic in vitro du cancer colorectal |
| CN102171343B (zh) | 2008-08-04 | 2017-07-14 | 戊瑞治疗有限公司 | Fgfr细胞外结构域酸性区突变蛋白 |
| WO2010075194A1 (en) * | 2008-12-22 | 2010-07-01 | St. Jude Children's Research Hospital | Prokaryotic expression of soluble, active dkk |
| JP2010183885A (ja) * | 2009-02-13 | 2010-08-26 | Kobe Univ | タンパク質の製造方法およびそれに用いる発現ベクター |
| EP2478003A4 (de) | 2009-09-15 | 2013-05-29 | Five Prime Therapeutics Inc | Haarwuchsverfahren unter verwendung extrazellulärer fgfr4-domänen |
| CA2780457A1 (en) | 2009-11-13 | 2011-05-19 | Five Prime Therapeutics, Inc. | Use of fgfr1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in fgfr2 |
| WO2011063523A1 (en) | 2009-11-24 | 2011-06-03 | Alethia Biotherapeutics Inc. | Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume |
| EP2512501A4 (de) | 2009-12-17 | 2014-01-01 | Five Prime Therapeutics Inc | Haarwuchsverfahren unter verwendung extrazellulärer fgfr3-domänen |
| SMT201900074T1 (it) | 2010-05-04 | 2019-02-28 | Five Prime Therapeutics Inc | Anticorpi che legano csf1r |
| WO2012006027A1 (en) | 2010-06-28 | 2012-01-12 | Five Prime Therapeutics, Inc. | Fzd8 extracellular domains and fzd8 extracellular domain fusion molecules and treatments using same |
| EP2444495A1 (de) * | 2010-10-20 | 2012-04-25 | Algenics | Sekretion rekombinanter Polypeptide im extrazellularen Medium eines Diatoms |
| BR112013012041A2 (pt) | 2010-11-15 | 2016-11-08 | Five Prime Therapeutics Inc | ''terapias de combinações de domínio extracelular fgfr1" |
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| US8951972B2 (en) | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
| CA2824805A1 (en) | 2011-01-14 | 2012-07-19 | Five Prime Therapeutics, Inc. | Il-27 antagonists for treating inflammatory diseases |
| CA2855818A1 (en) | 2011-11-14 | 2013-05-23 | Five Prime Therapeutics, Inc. | A method of treating lung cancer having an fgfr1 gene amplification or fgfr1 overexpression |
| WO2013123588A1 (en) | 2012-02-22 | 2013-08-29 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
| KR20150018533A (ko) | 2012-05-11 | 2015-02-23 | 파이브 프라임 테라퓨틱스, 인크. | 콜로니 자극 인자 1 수용체(csf1r)에 결속하는 항체들에 의한 질병 상태의 치료 방법 |
| WO2013185069A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Pulmonary delivery of mrna to non-lung target cells |
| CN104684582A (zh) | 2012-08-31 | 2015-06-03 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| EP2929035A1 (de) | 2012-12-07 | 2015-10-14 | Shire Human Genetic Therapies, Inc. | Lipidnanopartikel zur freisetzung von mrna |
| EP2970940B1 (de) | 2013-03-14 | 2018-07-25 | Translate Bio, Inc. | Therapeutische mrna-zusammensetzungen und verwendung zur behandlung von krankheiten und störungen |
| CN105452296B (zh) | 2013-08-01 | 2020-09-25 | 戊瑞治疗有限公司 | 无岩藻糖基化抗fgfr2iiib抗体 |
| CN113350501A (zh) | 2014-06-23 | 2021-09-07 | 戊瑞治疗有限公司 | 用结合集落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| AU2015339306B2 (en) | 2014-10-29 | 2021-07-22 | Bristol-Myers Squibb Company | Combination therapy for cancer |
| EA201791421A1 (ru) | 2014-12-22 | 2017-10-31 | Файв Прайм Терапьютикс, Инк. | Антитела против csf1r для лечения pvns |
| RS60614B1 (sr) | 2015-03-23 | 2020-08-31 | Jounce Therapeutics Inc | Antitela za icos |
| BR112017020952A2 (pt) | 2015-04-13 | 2018-07-10 | Five Prime Therapeutics Inc | método de tratamento de câncer, composição e uso da composição |
| CA2998208A1 (en) | 2015-10-22 | 2017-04-27 | Jounce Therapeutics, Inc. | Gene signatures for determining icos expression |
| US10799559B2 (en) | 2016-04-25 | 2020-10-13 | Five Prime Therapeutics, Inc. | NOPE for treatment of pathological muscle loss and weakness |
| RS62589B1 (sr) | 2016-11-02 | 2021-12-31 | Jounce Therapeutics Inc | Antitela na pd-1 i njihova upotreba |
| WO2018144097A1 (en) | 2016-11-04 | 2018-08-09 | Akeagen Llc | Genetically modified non-human animals and methods for producing heavy chain-only antibodies |
| US20190330376A1 (en) * | 2016-12-29 | 2019-10-31 | Development Center For Biotechnology | Peptides derived from kininogen-1 for protein drugs in vivo half-life extensions |
| JP2020512357A (ja) | 2017-03-31 | 2020-04-23 | ファイブ プライム セラピューティクス， インコーポレイテッド | 抗ｇｉｔｒ抗体を使用した癌の併用療法 |
| US20200024351A1 (en) | 2017-04-03 | 2020-01-23 | Jounce Therapeutics, Inc. | Compositions and Methods for the Treatment of Cancer |
| AU2018281334A1 (en) | 2017-06-06 | 2019-12-19 | Kindred Biosciences, Inc. | Erythropoietin and analogs for veterinary use |
| CA3087166A1 (en) | 2017-12-22 | 2019-06-27 | Jounce Therapeutics, Inc. | Antibodies to lilrb2 |
| TWI819024B (zh) | 2018-07-09 | 2023-10-21 | 美商戊瑞治療有限公司 | 結合至ｉｌｔ４的抗體 |
| CN113613727A (zh) * | 2019-01-11 | 2021-11-05 | 嘉立医疗科技(广州)有限公司 | 多特异性前趋化因子治疗蛋白（park）及其制备和使用方法 |
| JP7810554B2 (ja) | 2019-03-01 | 2026-02-03 | アケロイス バイオファーマ， インコーポレイテッド | 抗原特異的免疫細胞におけるｃｄ１６０機能をモジュレートする方法およびその使用 |
| WO2021178001A1 (en) * | 2020-03-05 | 2021-09-10 | Curie Co. Inc. | Methods for cell free protein expression of mature polypeptides derived from zymogens and proproteins |
| CN117964757A (zh) | 2020-02-14 | 2024-05-03 | 吉利德科学公司 | 与ccr8结合的抗体和融合蛋白及其用途 |
| US20230303695A1 (en) | 2020-08-10 | 2023-09-28 | Tengfei XIAO | Compositions and methods for treating autoimmune diseases and cancers by targeting igsf8 |
| WO2023235699A1 (en) | 2022-05-31 | 2023-12-07 | Jounce Therapeutics, Inc. | Antibodies to lilrb4 and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712114A (en) * | 1995-06-06 | 1998-01-27 | Basf Aktiengesellschaft | Compositions for expression of proteins in host cells using a preprocollagen signal sequence |
| ES2183601T3 (es) * | 1998-08-17 | 2003-03-16 | Europ Lab Molekularbiolog | Metodo para purificar complejos de biomoleculas o proteinas. |
| US20080242603A1 (en) * | 2004-02-20 | 2008-10-02 | Yan Wang | Novel Apo2L and IL-24 Polypeptides, Polynucleotides, and Methods of Their Use |
| CA2574654C (en) * | 2004-07-22 | 2014-02-18 | Five Prime Therapeutics, Inc. | Compositions and methods of use for mgd-csf in disease treatment |
-
2006
- 2006-01-27 EP EP06719694A patent/EP1841874B1/de not_active Expired - Lifetime
- 2006-01-27 WO PCT/US2006/002951 patent/WO2006081430A2/en not_active Ceased
- 2006-01-27 DK DK06719694.9T patent/DK1841874T3/da active
- 2006-01-27 JP JP2007553266A patent/JP2008528033A/ja active Pending
- 2006-01-27 AT AT06719694T patent/ATE454455T1/de not_active IP Right Cessation
- 2006-01-27 AU AU2006207999A patent/AU2006207999A1/en not_active Abandoned
- 2006-01-27 CA CA002589895A patent/CA2589895A1/en not_active Abandoned
- 2006-01-27 DE DE602006011574T patent/DE602006011574D1/de not_active Expired - Lifetime
- 2006-01-27 US US11/883,065 patent/US20080286834A1/en not_active Abandoned
-
2009
- 2009-01-19 JP JP2009009381A patent/JP2009131268A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006207999A1 (en) | 2006-08-03 |
| US20080286834A1 (en) | 2008-11-20 |
| DE602006011574D1 (de) | 2010-02-25 |
| EP1841874B1 (de) | 2010-01-06 |
| DK1841874T3 (da) | 2010-05-17 |
| WO2006081430A3 (en) | 2007-04-05 |
| EP1841874A2 (de) | 2007-10-10 |
| JP2008528033A (ja) | 2008-07-31 |
| JP2009131268A (ja) | 2009-06-18 |
| CA2589895A1 (en) | 2006-08-03 |
| WO2006081430A2 (en) | 2006-08-03 |
| WO2006081430A9 (en) | 2006-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |