ATE455535T1 - Topische zusammensetzungen zur verabreichung von prostaglandin e1 - Google Patents

Topische zusammensetzungen zur verabreichung von prostaglandin e1

Info

Publication number: ATE455535T1
Authority: AT; Austria
Prior art keywords: prostaglandin; composition; administration; aliphatic; mixture
Prior art date: 1997-11-05

Application number

AT98957603T

Other languages

English (en)

Inventor

Servet Buyuktimkin

Nadir Buyuktimkin

James Yeager

Original Assignee

Nexmed Holdings Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-05

Filing date

1998-11-05

Publication date

2010-02-15

1998-11-05 Application filed by Nexmed Holdings Inc filed Critical Nexmed Holdings Inc

2010-02-15 Application granted granted Critical

2010-02-15 Publication of ATE455535T1 publication Critical patent/ATE455535T1/de

Links

239000000203 mixture Substances 0.000 title abstract 7
GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 title abstract 3
229960000711 alprostadil Drugs 0.000 title abstract 3
GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 title abstract 3
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 title abstract 3
230000000699 topical effect Effects 0.000 title abstract 2
125000001931 aliphatic group Chemical group 0.000 abstract 2
239000007853 buffer solution Substances 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
150000002634 lipophilic molecules Chemical class 0.000 abstract 2
239000003961 penetration enhancing agent Substances 0.000 abstract 2
KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 abstract 1
-1 N,N-disubstituted amino Chemical group 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
150000004676 glycans Chemical class 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Reproductive Health (AREA)
Oil, Petroleum & Natural Gas (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Inorganic Chemistry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT98957603T 1997-11-05 1998-11-05 Topische zusammensetzungen zur verabreichung von prostaglandin e1 ATE455535T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/964,509 US6046244A (en)	1997-11-05	1997-11-05	Topical compositions for prostaglandin E1 delivery
PCT/US1998/023576 WO1999022714A1 (en)	1997-11-05	1998-11-05	Topical compositions for prostaglandin e1 delivery

Publications (1)

Publication Number	Publication Date
ATE455535T1 true ATE455535T1 (de)	2010-02-15

Family

ID=25508632

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT98957603T ATE455535T1 (de)	1997-11-05	1998-11-05	Topische zusammensetzungen zur verabreichung von prostaglandin e1
AT99923024T ATE273714T1 (de)	1997-11-05	1999-05-13	Topische zusammensetzungen zur prostaglandin e1 abgabe

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT99923024T ATE273714T1 (de)	1997-11-05	1999-05-13	Topische zusammensetzungen zur prostaglandin e1 abgabe

Country Status (20)

Country	Link
US (1)	US6046244A (de)
EP (2)	EP1028708B1 (de)
JP (2)	JP4491560B2 (de)
KR (2)	KR100576986B1 (de)
CN (2)	CN1191060C (de)
AT (2)	ATE455535T1 (de)
AU (1)	AU757086B2 (de)
BR (2)	BR9813945A (de)
CA (2)	CA2309165A1 (de)
DE (2)	DE69841463D1 (de)
DK (2)	DK1028708T3 (de)
ES (2)	ES2338389T3 (de)
HK (1)	HK1044289B (de)
HU (1)	HU230300B1 (de)
IL (3)	IL135914A0 (de)
MX (1)	MXPA01011560A (de)
PT (1)	PT1178833E (de)
TR (2)	TR200002158T2 (de)
TW (1)	TW443933B (de)
WO (2)	WO1999022714A1 (de)

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US7629384B2 (en)	1997-09-17	2009-12-08	Strategic Science & Technologies, Llc	Topical delivery of L-arginine to cause beneficial effects
US7914814B2 (en)	1997-09-17	2011-03-29	Strategic Science & Technologies, Llc	Topical delivery of arginine of cause beneficial effects
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GR1003199B (el) *	1998-08-14	1999-09-01		Χρηση της μισοπροστολης ή και της μισοπροστολης οξυ για την παρασκευη φαρμακευτικου προιοντος για τη θεραπευτικη αντιμετωπιση της σεξουαλικης δυσλειτουργιας στις γυναικες
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US7105571B2 (en) *	2000-01-10	2006-09-12	Nexmed Holdings, Inc.	Prostaglandin compositions and methods of treatment for male erectile dysfunction
US6323241B1 (en) *	2000-01-10	2001-11-27	Nexmed (Holdings) Inc.	Prostaglandin compositions and methods of treatment for male erectile dysfunction
KR100402334B1 (ko) *	2000-06-23	2003-10-22	환인제약 주식회사	알프로스타딜 외용제
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US20040092494A9 (en) *	2000-08-30	2004-05-13	Dudley Robert E.	Method of increasing testosterone and related steroid concentrations in women
US6503894B1 (en) *	2000-08-30	2003-01-07	Unimed Pharmaceuticals, Inc.	Pharmaceutical composition and method for treating hypogonadism
KR100373540B1 (ko) *	2000-09-20	2003-02-25	최한곤	프로스타글란딘 ｅ1용 요도좌제 조성물
KR100810404B1 (ko) *	2001-12-18	2008-03-04	환인제약 주식회사	알프로스타딜 알킬 에스테르를 함유하는 외용제 조성물
US20050159485A1 (en) *	2002-01-04	2005-07-21	Jost-Price Edward R.	Combinations for the treatment of immunoinflammatory disorders and proliferative skin diseases
MXPA04007828A (es) *	2002-02-15	2004-10-15	Nexmed Holdings Inc	Composicion de prostaglandina para eltratamiento de la disfuncion erectil.
AU2003228819A1 (en) *	2002-05-03	2003-11-17	Combinatorx, Incorporated	Combinations for the treatment of inflammatory skin disorders
USRE45353E1 (en) *	2002-07-17	2015-01-27	Crucible Intellectual Property, Llc	Method of making dense composites of bulk-solidifying amorphous alloys and articles thereof
GB0222522D0 (en)	2002-09-27	2002-11-06	Controlled Therapeutics Sct	Water-swellable polymers
US20050181030A1 (en) *	2003-01-03	2005-08-18	Mo Y. J.	Topical stabilized prostaglandin E compound dosage forms
US6841574B2 (en) *	2003-01-03	2005-01-11	Nexmed Holdings, Inc.	Topical stabilized prostaglandin E compound dosage forms
EP1605913A2 (de) *	2003-03-21	2005-12-21	Nexmed (Holdings), Inc.	Förderung der angiogenese durch prostaglandin-zusammensetzungen und verfahren
EP1605948A1 (de) *	2003-03-21	2005-12-21	Nexmed Holdings, Inc.	Prostaglandin- zusammensetzungen zur behandlung von erektionsstörungen
EP1635770B1 (de) *	2003-03-21	2009-05-27	Nexmed Holdings, Inc.	Antimykotischer nagellack und anwendungsverfahren
EP1608378A1 (de) *	2003-04-02	2005-12-28	Nexmed (Holdings), Inc.	Prostaglandin-zusammensetzungen und ihre verwendung zur behandlung von vasospasmus
US9226909B2 (en)	2004-04-19	2016-01-05	Strategic Science & Technologies, Llc	Beneficial effects of increasing local blood flow
US9050365B2 (en) *	2004-04-19	2015-06-09	Strategic Science & Technologies, Llc	Transdermal delivery of beneficial substances effected by a hostile biophysical environment
EP2380579A1 (de) *	2004-04-19	2011-10-26	Strategic Science & Technologies, LLC	Vorteilhafte Wirkungen der Verstärkung des lokalen Blutflusses
AU2012201048B2 (en) *	2004-04-19	2013-06-06	Strategic Science & Technologies, Llc	Transdermal delivery of beneficial substances effected by a hostile biophysical environment
US20050276865A1 (en) *	2004-05-20	2005-12-15	Servet Buyuktimkin	Peroxide compounds for the prevention and treatment of sexual dysfunction in humans
GB0417401D0 (en) *	2004-08-05	2004-09-08	Controlled Therapeutics Sct	Stabilised prostaglandin composition
US20070088012A1 (en) *	2005-04-08	2007-04-19	Woun Seo	Method of treating or preventing type-2 diabetes
GEP20125432B (en)	2005-10-12	2012-03-26	Unimed Pharmaceuticals Llc	Improved testosterone gel and use thereof
US8358785B2 (en) *	2006-05-30	2013-01-22	Siemens Audiologische Technik Gmbh	Hearing system with wideband pulse transmitter
GB0613333D0 (en)	2006-07-05	2006-08-16	Controlled Therapeutics Sct	Hydrophilic polyurethane compositions
GB0613638D0 (en)	2006-07-08	2006-08-16	Controlled Therapeutics Sct	Polyurethane elastomers
US7560489B2 (en) *	2006-10-11	2009-07-14	Nexmed Holdings, Inc.	Stabilized prostaglandin E composition
GB0620685D0 (en)	2006-10-18	2006-11-29	Controlled Therapeutics Sct	Bioresorbable polymers
EP2343978A4 (de)	2008-10-03	2013-11-27	Nexmed Holdings Inc	Stabilisierte zusammensetzung zur behandlung von schuppenflechte
US11684624B2 (en)	2009-06-24	2023-06-27	Strategic Science & Technologies, Llc	Treatment of erectile dysfunction and other indications
US12138268B2 (en)	2009-06-24	2024-11-12	Strategic Science & Technologies, Llc	Treatment of erectile dysfunction and other indications
EP3045171A1 (de)	2009-06-24	2016-07-20	Strategic Science & Technologies, LLC	Topische zusammensetzung
WO2010151241A1 (en)	2009-06-24	2010-12-29	Strategic Science & Technologies, Llc	Topical composition containing naproxen
JP5864543B2 (ja) *	2010-05-04	2016-02-17	ネクスメッドホールディングス，インコーポレイテッド	小分子治療剤の組成物
AU2011306050A1 (en) *	2010-09-24	2013-04-11	Nexmed Holdings, Inc.	Enhanced transbuccal drug delivery system and compositions
CN103442723A (zh)	2010-12-29	2013-12-11	战略科学与技术有限责任公司	治疗变态反应和其它适应症的系统和方法
CN105920603B (zh)	2010-12-29	2022-02-11	战略科学与技术有限责任公司	勃起功能障碍和其它适应症的治疗
RU2633236C2 (ru)	2011-04-07	2017-10-11	Нексмед Холдингс, Инк.	Способы и композиции для лечения болезни рейно
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1997
- 1997-11-05 US US08/964,509 patent/US6046244A/en not_active Expired - Lifetime
1998
- 1998-11-05 IL IL13591498A patent/IL135914A0/xx not_active IP Right Cessation
- 1998-11-05 AT AT98957603T patent/ATE455535T1/de active
- 1998-11-05 EP EP98957603A patent/EP1028708B1/de not_active Expired - Lifetime
- 1998-11-05 ES ES98957603T patent/ES2338389T3/es not_active Expired - Lifetime
- 1998-11-05 CN CNB988129159A patent/CN1191060C/zh not_active Expired - Lifetime
- 1998-11-05 DK DK98957603.8T patent/DK1028708T3/da active
- 1998-11-05 JP JP2000518648A patent/JP4491560B2/ja not_active Expired - Lifetime
- 1998-11-05 BR BR9813945-2A patent/BR9813945A/pt not_active Application Discontinuation
- 1998-11-05 KR KR1020007004907A patent/KR100576986B1/ko not_active Expired - Lifetime
- 1998-11-05 WO PCT/US1998/023576 patent/WO1999022714A1/en not_active Ceased
- 1998-11-05 DE DE69841463T patent/DE69841463D1/de not_active Expired - Lifetime
- 1998-11-05 CA CA002309165A patent/CA2309165A1/en not_active Abandoned
- 1998-11-05 TR TR2000/02158T patent/TR200002158T2/xx unknown
- 1998-12-07 TW TW087118421A patent/TW443933B/zh not_active IP Right Cessation
1999
- 1999-05-13 ES ES99923024T patent/ES2224661T3/es not_active Expired - Lifetime
- 1999-05-13 KR KR10-2001-7014474A patent/KR100462442B1/ko not_active Expired - Lifetime
- 1999-05-13 PT PT99923024T patent/PT1178833E/pt unknown
- 1999-05-13 BR BR9917299-2A patent/BR9917299A/pt not_active Application Discontinuation
- 1999-05-13 AT AT99923024T patent/ATE273714T1/de active
- 1999-05-13 HU HU0201145A patent/HU230300B1/hu unknown
- 1999-05-13 EP EP99923024A patent/EP1178833B1/de not_active Expired - Lifetime
- 1999-05-13 HK HK02105901.5A patent/HK1044289B/en not_active IP Right Cessation
- 1999-05-13 JP JP2000617929A patent/JP2002544240A/ja active Pending
- 1999-05-13 DE DE69919594T patent/DE69919594T2/de not_active Expired - Lifetime
- 1999-05-13 AU AU39891/99A patent/AU757086B2/en not_active Expired
- 1999-05-13 DK DK99923024T patent/DK1178833T3/da active
- 1999-05-13 MX MXPA01011560A patent/MXPA01011560A/es active IP Right Grant
- 1999-05-13 TR TR2002/00146T patent/TR200200146T2/xx unknown
- 1999-05-13 CA CA002373821A patent/CA2373821C/en not_active Expired - Lifetime
- 1999-05-13 CN CNB998167886A patent/CN1195523C/zh not_active Expired - Lifetime
- 1999-05-13 WO PCT/US1999/010596 patent/WO2000069469A1/en not_active Ceased
- 1999-05-13 IL IL14647099A patent/IL146470A0/xx unknown
2001
- 2001-11-13 IL IL146470A patent/IL146470A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1178833E (pt)	2004-11-30
IL146470A (en)	2010-12-30
BR9813945A (pt)	2002-01-22
TW443933B (en)	2001-07-01
AU3989199A (en)	2000-12-05
HK1044289A1 (en)	2002-10-18
EP1178833B1 (de)	2004-08-18
AU757086B2 (en)	2003-01-30
CN1191060C (zh)	2005-03-02
EP1028708A1 (de)	2000-08-23
CA2309165A1 (en)	1999-05-14
MXPA01011560A (es)	2002-06-04
TR200002158T2 (tr)	2000-11-21
JP2002544240A (ja)	2002-12-24
CA2373821C (en)	2003-10-07
KR20020012218A (ko)	2002-02-15
JP2001521886A (ja)	2001-11-13
HUP0201145A3 (en)	2004-05-28
EP1178833A1 (de)	2002-02-13
EP1028708B1 (de)	2010-01-20
DK1028708T3 (da)	2010-05-03
ES2338389T3 (es)	2010-05-06
HUP0201145A2 (hu)	2002-12-28
HK1034678A1 (en)	2001-11-02
CN1195523C (zh)	2005-04-06
IL135914A0 (en)	2001-05-20
EP1028708A4 (de)	2006-01-18
DE69919594T2 (de)	2005-09-15
KR100576986B1 (ko)	2006-05-10
HK1044289B (en)	2005-01-07
CA2373821A1 (en)	2000-11-23
WO2000069469A1 (en)	2000-11-23
US6046244A (en)	2000-04-04
HU230300B1 (hu)	2015-12-28
DE69919594D1 (de)	2004-09-23
TR200200146T2 (tr)	2002-06-21
CN1354677A (zh)	2002-06-19
KR100462442B1 (ko)	2004-12-17
CN1284862A (zh)	2001-02-21
ATE273714T1 (de)	2004-09-15
WO1999022714A1 (en)	1999-05-14
IL146470A0 (en)	2002-07-25
BR9917299A (pt)	2002-07-09
KR20010031836A (ko)	2001-04-16
DE69841463D1 (de)	2010-03-11
ES2224661T3 (es)	2005-03-01
DK1178833T3 (da)	2004-11-22
JP4491560B2 (ja)	2010-06-30

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