ATE455558T1 - Modifiziertes adenovirus-hexon-protein und anwendungen davon - Google Patents

Modifiziertes adenovirus-hexon-protein und anwendungen davon

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Publication number
ATE455558T1
ATE455558T1 AT07835738T AT07835738T ATE455558T1 AT E455558 T1 ATE455558 T1 AT E455558T1 AT 07835738 T AT07835738 T AT 07835738T AT 07835738 T AT07835738 T AT 07835738T AT E455558 T1 ATE455558 T1 AT E455558T1
Authority
AT
Austria
Prior art keywords
hexon protein
applications
modified adenovirus
adenovirus hexon
adenovirus
Prior art date
Application number
AT07835738T
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English (en)
Inventor
Soumitra Roy
James Wilson
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Application granted granted Critical
Publication of ATE455558T1 publication Critical patent/ATE455558T1/de

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AT07835738T 2006-04-28 2007-04-27 Modifiziertes adenovirus-hexon-protein und anwendungen davon ATE455558T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79607806P 2006-04-28 2006-04-28
PCT/US2007/010347 WO2008010864A2 (en) 2006-04-28 2007-04-27 Modified adenovirus hexon protein and uses thereof

Publications (1)

Publication Number Publication Date
ATE455558T1 true ATE455558T1 (de) 2010-02-15

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AT07835738T ATE455558T1 (de) 2006-04-28 2007-04-27 Modifiziertes adenovirus-hexon-protein und anwendungen davon

Country Status (15)

Country Link
US (3) US20090074810A1 (de)
EP (1) EP2012822B1 (de)
JP (1) JP5889514B2 (de)
CN (1) CN101437538A (de)
AT (1) ATE455558T1 (de)
CY (1) CY1110002T1 (de)
DE (1) DE602007004470D1 (de)
DK (1) DK2012822T3 (de)
ES (1) ES2341501T3 (de)
HR (1) HRP20100228T1 (de)
PL (1) PL2012822T3 (de)
PT (1) PT2012822E (de)
RS (1) RS51250B (de)
SI (1) SI2012822T1 (de)
WO (1) WO2008010864A2 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE530672T1 (de) * 2001-06-22 2011-11-15 Univ Pennsylvania Rekombinante adenoviren mit affen-adenovirus proteinen und verwendung davon.
HU230364B1 (hu) * 2001-11-21 2016-03-29 The Trustees Of The University Of Pennsylvania Simian adenovírus nukleinsav és aminosav-szekvencia, azt tartalmazó vektorok, és eljárások annak alkalmazására
CA2567741A1 (en) 2004-05-25 2006-03-30 Chimeracore, Inc. Self-assembling nanoparticle drug delivery system
EP2018156B1 (de) 2006-04-07 2010-03-17 Chimeros, Inc. Zusammensetzungen und verfahren zur behandlung von b-zellen-malignomen
EP3128010A1 (de) 2007-11-28 2017-02-08 The Trustees Of The University Of Pennsylvania Simian-adenoviren sadv-30 der unterfamilie e und verwendungen davon
CN102131920B (zh) 2007-11-28 2013-11-06 宾夕法尼亚大学托管会 猿猴亚家族C腺病毒SAdV-40、-31和-34及其应用
HRP20170395T1 (hr) 2007-11-28 2017-05-05 The Trustees Of The University Of Pennsylvania Podporodice adenovirusa b majmuna sadv-28, 27,-29,-32,-33, i -35 i njihove primjene
EP2325298B1 (de) 2008-03-04 2016-10-05 The Trustees Of The University Of Pennsylvania AFFENADENOVIREN SAdV-36, -42.1, -42.2, AND -44 UND DEREN NUTZUNG
ES2552688T3 (es) 2008-10-31 2015-12-01 The Trustees Of The University Of Pennsylvania Adenovirus de simio con proteínas de la cápside hexónica de SAdV-46 y usos del mismo
WO2010120874A2 (en) 2009-04-14 2010-10-21 Chimeros, Inc. Chimeric therapeutics, compositions, and methods for using same
CA2762203A1 (en) 2009-05-29 2010-12-02 Soumitra Roy Simian adenovirus 41 and uses thereof
RU2012107702A (ru) 2009-07-31 2013-09-10 Пэксвэкс, Инк. Векторы на основе аденовирусов
CN102844329B (zh) 2010-04-14 2016-01-20 财团法人牧岩生命工学研究所 分离自猿腺病毒血清型19的六邻体、其高变区和使用其的嵌合型腺病毒
AU2011332025B2 (en) 2010-11-23 2015-06-25 The Trustees Of The University Of Pennsylvania Subfamily E simian adenoviruses A1321, A1325, A1295, A1309 and A1322 and uses thereof
JP2014527072A (ja) 2011-09-09 2014-10-09 バイオメド リアルティー, エル.ピー. ウイルスタンパク質の集合を制御するための方法および組成物
CN103242433B (zh) * 2012-02-14 2016-12-14 中国医学科学院病原生物学研究所 一种腺病毒非结构蛋白免疫原、其抗体及应用
MX358019B (es) 2012-05-18 2018-08-02 Univ Pennsylvania Adenovirus de simio de la subfamilia e a1302, a1320, a1331 y a1337 y sus usos.
WO2014078688A2 (en) 2012-11-16 2014-05-22 Beth Israel Deaconess Medical Center, Inc. Recombinant adenoviruses and use thereof
US9222142B2 (en) * 2013-01-15 2015-12-29 The Regents Of The University Of California Adenoviruses and their use
KR102089121B1 (ko) 2013-03-14 2020-03-13 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양살상형 아데노바이러스 조성물
CA2928908C (en) 2013-11-01 2021-01-12 Pfizer Inc. Vectors for expression of prostate-associated antigens
CN103865923B (zh) * 2014-01-28 2017-04-26 中国人民解放军第三0二医院 流感病毒为载体的HAdV嵌合疫苗的制备及其应用
EP2940128A1 (de) 2014-04-30 2015-11-04 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Adenovirus mit einem albuminbindenden Teil
WO2015191508A1 (en) 2014-06-09 2015-12-17 Voyager Therapeutics, Inc. Chimeric capsids
EP3198009B1 (de) 2014-09-24 2021-09-08 Salk Institute for Biological Studies Onkolytische tumorviren und verfahren zur verwendung
CN112553229A (zh) 2014-11-05 2021-03-26 沃雅戈治疗公司 用于治疗帕金森病的aadc多核苷酸
MX2017006217A (es) 2014-11-14 2018-05-02 Voyager Therapeutics Inc Polinucleotidos moduladores.
RU2020108189A (ru) 2014-11-14 2020-03-11 Вояджер Терапьютикс, Инк. Композиции и способы лечения бокового амиотрофического склероза (als)
EP3230441A4 (de) 2014-12-12 2018-10-03 Voyager Therapeutics, Inc. Zusammensetzungen und verfahren zur herstellung von scaav
WO2016146894A1 (en) 2015-03-17 2016-09-22 Tilt Biotherapeutics Oy Oncolytic adenoviruses coding for bi-specific antibodies and methods and uses related thereto
BR112018016986A2 (pt) * 2016-02-23 2019-02-05 Immune Design Corp preparações de vetor retroviral multigenômico e métodos e sistemas para preparação e uso das mesmas
EP3390428B1 (de) 2016-02-23 2019-09-25 Salk Institute for Biological Studies Test mit hohem durchsatz zur messung der adenovirusreplikationskinetik
JP7015551B2 (ja) 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
EP3448874A4 (de) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. Zusammensetzungen zur behandlung einer erkrankung
US11299751B2 (en) 2016-04-29 2022-04-12 Voyager Therapeutics, Inc. Compositions for the treatment of disease
AU2017267665C1 (en) 2016-05-18 2023-10-05 Voyager Therapeutics, Inc. Modulatory polynucleotides
BR112018073472A2 (pt) 2016-05-18 2019-08-27 Voyager Therapeutics, Inc. composições e métodos de tratamento da doença de huntington
AU2017313917B2 (en) 2016-08-18 2023-12-21 The Regents Of The University Of California CRISPR-Cas genome engineering via a modular AAV delivery system
WO2018044933A1 (en) 2016-08-30 2018-03-08 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
JP7794421B2 (ja) 2016-12-12 2026-01-06 ソーク インスティテュート フォー バイオロジカル スタディーズ 腫瘍を標的にする合成アデノウイルスおよびその使用
CN106754760A (zh) * 2017-01-20 2017-05-31 华南农业大学 一种嵌合ibdv中和表位的重组人3型腺病毒的制备方法和应用
CN111108198A (zh) 2017-05-05 2020-05-05 沃雅戈治疗公司 治疗亨廷顿病的组合物和方法
CA3061652A1 (en) 2017-05-05 2018-11-08 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
CN111132626B (zh) 2017-07-17 2024-01-30 沃雅戈治疗公司 轨迹阵列引导系统
AU2018338728B2 (en) 2017-09-29 2025-01-02 Centre National De La Recherche Scientifique (Cnrs) Rescue of central and peripheral neurological phenotype of Friedreich's Ataxia by intravenous delivery
CN111479924B (zh) 2017-10-16 2024-06-14 沃雅戈治疗公司 肌萎缩性侧索硬化症(als)的治疗
US20200237799A1 (en) 2017-10-16 2020-07-30 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (als)
EP3723771A4 (de) * 2017-12-11 2022-04-06 Beth Israel Deaconess Medical Center, Inc. Rekombinante adenoviren und verwendungen davon
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
AU2019268330A1 (en) 2018-05-15 2020-11-26 Voyager Therapeutics, Inc. Compositions and methods for the treatment of Parkinson's disease
EP3856762A1 (de) 2018-09-28 2021-08-04 Voyager Therapeutics, Inc. Frataxin-expressionskonstrukte mit gentechnisch veränderten promotoren und verfahren zu deren verwendung
EP3927833A4 (de) * 2019-02-21 2022-11-30 Unleash Immuno Oncolytics, Inc. Onkolytischer adenoviraler vektor und verfahren zur verwendung
EP3812465A1 (de) * 2019-10-21 2021-04-28 Universität Ulm Adenovirus, ein modifiziertes adenovirus-hexon-protein umfassend

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465253B1 (en) * 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US6211160B1 (en) * 1996-09-06 2001-04-03 The Trustees Of The University Of Pennsylvania Method for tolerizing a mammalian patient to administration of gene therapy virus vectors
AU4255397A (en) * 1996-09-06 1998-03-26 Trustees Of The University Of Pennsylvania, The Chimpanzee adenovirus vectors
JP2002523105A (ja) * 1998-08-27 2002-07-30 アバンテイス・フアルマ・エス・アー 異種遺伝子の運搬用の標的化アデノウイルスベクター
US6955808B2 (en) * 1999-09-24 2005-10-18 Uab Research Foundation Capsid-modified recombinant adenovirus and methods of use
HU230364B1 (hu) * 2001-11-21 2016-03-29 The Trustees Of The University Of Pennsylvania Simian adenovírus nukleinsav és aminosav-szekvencia, azt tartalmazó vektorok, és eljárások annak alkalmazására
EP1388541A1 (de) * 2002-08-09 2004-02-11 Centre National De La Recherche Scientifique (Cnrs) Pyrrolopyrazine als Kinasehemmer
US7291498B2 (en) * 2003-06-20 2007-11-06 The Trustees Of The University Of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
JP4754480B2 (ja) * 2003-06-20 2011-08-24 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア キメラアデノウイルスの作成法およびそのようなキメラアデノウイルスの使用
US7144712B2 (en) * 2003-07-30 2006-12-05 Vaccine Research Institute Of San Diego Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof
FR2860004A1 (fr) * 2003-09-18 2005-03-25 Roussy Inst Gustave Nouveau vecteur adenoviral pour l'infection de cellules deficientes ou depourvues en recepteurs car

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CY1110002T1 (el) 2015-01-14
WO2008010864A2 (en) 2008-01-24
US20090074810A1 (en) 2009-03-19
DE602007004470D1 (de) 2010-03-11
PT2012822E (pt) 2010-04-27
CN101437538A (zh) 2009-05-20
DK2012822T3 (da) 2010-05-25
WO2008010864A3 (en) 2008-05-02
PL2012822T3 (pl) 2010-06-30
ES2341501T3 (es) 2010-06-21
JP2009535032A (ja) 2009-10-01
HRP20100228T1 (hr) 2010-07-31
EP2012822B1 (de) 2010-01-20
US20170096646A1 (en) 2017-04-06
RS51250B (sr) 2010-12-31
SI2012822T1 (sl) 2010-06-30
EP2012822A2 (de) 2009-01-14
US20160102295A1 (en) 2016-04-14

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