ATE455795T1 - Neue cyclodextrinderivate, herstellungsverfahren dafür und verwendung davon zur solubilisierung von pharmakologisch wirksamen substanzen - Google Patents

Neue cyclodextrinderivate, herstellungsverfahren dafür und verwendung davon zur solubilisierung von pharmakologisch wirksamen substanzen

Info

Publication number
ATE455795T1
ATE455795T1 AT04742303T AT04742303T ATE455795T1 AT E455795 T1 ATE455795 T1 AT E455795T1 AT 04742303 T AT04742303 T AT 04742303T AT 04742303 T AT04742303 T AT 04742303T AT E455795 T1 ATE455795 T1 AT E455795T1
Authority
AT
Austria
Prior art keywords
solubilizing
new
production process
active substances
pharmacologically active
Prior art date
Application number
AT04742303T
Other languages
English (en)
Inventor
Jacques Defaye
Carmen Ortiz-Mellet
Jose Manuel Garcia-Fernandez
Maria Gomez-Garcia
Kazimierz Chmurski
Jian-Xin Yu
Original Assignee
Centre Nat Rech Scient
Univ Grenoble 1
Consejo Superior Investigacion
Univ Sevilla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Univ Grenoble 1, Consejo Superior Investigacion, Univ Sevilla filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE455795T1 publication Critical patent/ATE455795T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT04742303T 2003-03-28 2004-03-22 Neue cyclodextrinderivate, herstellungsverfahren dafür und verwendung davon zur solubilisierung von pharmakologisch wirksamen substanzen ATE455795T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0303899A FR2852959B1 (fr) 2003-03-28 2003-03-28 Nouveaux derives de cyclodextrines, leur procede de preparation et leur utilisation notamment pour solubilisation de substances pharmacologiquement actives
PCT/FR2004/000691 WO2004087768A1 (fr) 2003-03-28 2004-03-22 Nouveaux derives de cyclodextrines, leur procede de preparation et leur utilisation notamment pour la solubilisation de substances pharmacologiquement actives

Publications (1)

Publication Number Publication Date
ATE455795T1 true ATE455795T1 (de) 2010-02-15

Family

ID=32947275

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04742303T ATE455795T1 (de) 2003-03-28 2004-03-22 Neue cyclodextrinderivate, herstellungsverfahren dafür und verwendung davon zur solubilisierung von pharmakologisch wirksamen substanzen

Country Status (9)

Country Link
US (2) US7632941B2 (de)
EP (1) EP1608687B1 (de)
JP (1) JP5054970B2 (de)
AT (1) ATE455795T1 (de)
CA (1) CA2520391C (de)
DE (1) DE602004025213D1 (de)
ES (1) ES2338558T3 (de)
FR (1) FR2852959B1 (de)
WO (1) WO2004087768A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080234182A1 (en) * 2007-03-22 2008-09-25 Innovative Biologics, Inc. Blockers of pore-forming virulence factors and their use as anti-infectives
JP2007538112A (ja) * 2004-01-29 2007-12-27 ピナクル ファーマシューティカルズ β−シクロデキストリン誘導体およびそれらの炭疽致死毒に対する使用
WO2005107730A2 (en) 2004-05-03 2005-11-17 Omega Bio-Pharma (I.P.3) Limited Cysteamines for treating complications of hypercholesterolemia and diabetes
CA2596026A1 (en) 2005-01-28 2006-08-10 Pinnacle Pharmaceuticals, Inc. .beta.-cyclodextrin derivatives as antibacterial agents
ES2294926B1 (es) * 2006-05-11 2009-02-16 Universidad De Sevilla Nuevos derivados de ciclodextrinas selectivamente funcionalizados en su cara secundaria, procedimiento de preparacion y utilizacion de los mismos.
FR2903987B1 (fr) * 2006-07-21 2012-12-21 Centre Nat Rech Scient Nouveaux derives de cyclodextrines amphiphiles, leur utilisation dans les domaines pharmaceutiques,cosmetiques, alimentaires et leur application a la production de nouveaux nanosystemes
EP2328579B1 (de) * 2008-07-17 2013-10-23 The Johns Hopkins University Trioxan-dimer-schwefelverbindungen
US20100056475A1 (en) * 2008-08-06 2010-03-04 Alexander Chucholowski Cyclodextrin conjugates
US10662260B2 (en) 2014-05-29 2020-05-26 Uti Limited Partnership Cyclodextrin-based polyanionic and non-ionic dendrimers
CN109762042B (zh) * 2018-09-21 2022-04-08 河北艾克美冀生物科技有限公司 一种治疗癌症的药物、其合成方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2648464B1 (fr) * 1989-06-14 1991-08-30 Commissariat Energie Atomique Derives de cyclomalto-oligosaccharides et leurs procedes de preparation
JPH06157330A (ja) * 1992-11-27 1994-06-03 Ensuiko Sugar Refining Co Ltd タキソールのサイクロデキストリン包接物，その製造法と用途
US5684169A (en) * 1992-11-27 1997-11-04 Ensuiko Sugar Refining Co., Ltd. Cyclodextrin inclusion complex of taxol, and method for its production and its use
US5959089A (en) * 1993-07-19 1999-09-28 Hannessian; Stephen Amino-cyclodextrin syntheses
FR2715307B1 (fr) * 1994-01-25 1996-04-05 Commissariat Energie Atomique Procédé de solubilisation dans un milieu aqueux d'agents antitumoraux de la famille du taxol, et cyclodextrines ramifiées utilisables pour cette solubilisation.
FR2716200B1 (fr) * 1994-02-11 1996-04-26 Commissariat Energie Atomique Procédé de préparation de cyclomaltooligosaccharides ramifiés, en particulier de cyclodextrines ramifiées.
FR2746103B1 (fr) * 1996-03-14 1998-07-24 Thioureido-cyclodextrines, utilisables en particulier pour solubiliser des agents antitumoraux et antiparasitaires et leurs procedes de preparation
US5770645A (en) * 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US6157642A (en) 1997-10-14 2000-12-05 Teledesic Llc Coding system and method for low-earth orbit satellite data communication
FI980489A7 (fi) * 1998-03-04 1999-09-05 Alexei Radievich Khomutov Syklodekstriinien uudet johdannaiset

Also Published As

Publication number Publication date
ES2338558T3 (es) 2010-05-10
FR2852959B1 (fr) 2008-02-15
FR2852959A1 (fr) 2004-10-01
EP1608687A1 (de) 2005-12-28
US7632941B2 (en) 2009-12-15
EP1608687B1 (de) 2010-01-20
US8440814B2 (en) 2013-05-14
DE602004025213D1 (de) 2010-03-11
US20070167401A1 (en) 2007-07-19
CA2520391C (fr) 2012-11-20
US20090264540A1 (en) 2009-10-22
JP5054970B2 (ja) 2012-10-24
CA2520391A1 (fr) 2004-10-14
WO2004087768A1 (fr) 2004-10-14
JP2006521440A (ja) 2006-09-21

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