ATE455852T1 - Neues hämopoietin rezeptorprotein nr10 - Google Patents
Neues hämopoietin rezeptorprotein nr10Info
- Publication number
- ATE455852T1 ATE455852T1 AT00931646T AT00931646T ATE455852T1 AT E455852 T1 ATE455852 T1 AT E455852T1 AT 00931646 T AT00931646 T AT 00931646T AT 00931646 T AT00931646 T AT 00931646T AT E455852 T1 ATE455852 T1 AT E455852T1
- Authority
- AT
- Austria
- Prior art keywords
- novel
- hemopoietin
- receptors
- hematopoietic
- immune system
- Prior art date
Links
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 title 1
- 108020003175 receptors Proteins 0.000 abstract 5
- 102000005962 receptors Human genes 0.000 abstract 4
- 210000000987 immune system Anatomy 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 210000000777 hematopoietic system Anatomy 0.000 abstract 1
- 230000011132 hemopoiesis Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15579799 | 1999-06-02 | ||
| JP21779799 | 1999-07-30 | ||
| PCT/JP2000/003556 WO2000075314A1 (en) | 1999-06-02 | 2000-06-01 | Novel hemopoietin receptor protein nr10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE455852T1 true ATE455852T1 (de) | 2010-02-15 |
Family
ID=26483716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00931646T ATE455852T1 (de) | 1999-06-02 | 2000-06-01 | Neues hämopoietin rezeptorprotein nr10 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US7482440B2 (de) |
| EP (3) | EP2135953B1 (de) |
| JP (7) | JP2007111051A (de) |
| AT (1) | ATE455852T1 (de) |
| AU (1) | AU4952400A (de) |
| CY (1) | CY1115582T1 (de) |
| DE (1) | DE60043728D1 (de) |
| DK (1) | DK1188830T3 (de) |
| ES (1) | ES2339843T3 (de) |
| PT (1) | PT1188830E (de) |
| WO (1) | WO2000075314A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1188830T3 (da) | 1999-06-02 | 2010-04-26 | Chugai Pharmaceutical Co Ltd | Nyt hæmopoietinreceptorprotein NR10 |
| EP1221482B1 (de) | 1999-09-27 | 2005-12-28 | Chugai Seiyaku Kabushiki Kaisha | HäMOPOIETINREZEPTOR-PROTEIN, NR12 |
| US20030096339A1 (en) | 2000-06-26 | 2003-05-22 | Sprecher Cindy A. | Cytokine receptor zcytor17 |
| EP1325115B1 (de) | 2000-06-26 | 2016-07-27 | ZymoGenetics, Inc. | Cytokinrezeptor zcytor17 |
| US7317075B2 (en) * | 2000-07-20 | 2008-01-08 | Genentech, Inc. | PRO21384 polypeptides |
| US20030059871A1 (en) * | 2000-10-06 | 2003-03-27 | Cosman David J. | Hematopoietin receptors HPR1 and HPR2 |
| WO2002077230A1 (fr) * | 2001-03-26 | 2002-10-03 | Chugai Seiyaku Kabushiki Kaisha | Variants d'epissage nr10 |
| US9738700B2 (en) | 2002-01-18 | 2017-08-22 | Zymogenetics Inc. | ZCYTOR17 heterodimeric cytokine receptor |
| WO2004003140A2 (en) | 2002-01-18 | 2004-01-08 | Zymogenetics, Inc. | Cytokine receptor zcytor17 multimers |
| RU2490276C2 (ru) | 2002-01-18 | 2013-08-20 | Займоджинетикс, Инк. | Новый лиганд рецептора цитокина zcytor17 |
| WO2003064469A2 (en) * | 2002-02-01 | 2003-08-07 | Bayer Healthcare Ag | Regulation of human hematopoietin receptor-like protein |
| US7303896B2 (en) * | 2002-02-25 | 2007-12-04 | Genentech, Inc. | Nucleic acid encoding novel type-1 cytokine receptor GLM-R |
| EP1858924A1 (de) | 2005-02-14 | 2007-11-28 | ZymoGenetics, Inc. | Verfahren zur behandlung von hauterkrankungen mit einem il-31ra-antagonisten |
| US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| CN101198624B (zh) | 2005-05-06 | 2012-10-10 | 津莫吉尼蒂克斯公司 | Il-31单克隆抗体及使用方法 |
| EP2001906A2 (de) | 2006-01-10 | 2008-12-17 | Zymogenetics, Inc. | Verfahren zur behandlung von schmerzen und entzündungen in einem nervengewebe mithilfe von il-31ra- und osmrb-antagonisten |
| EP4793360A2 (de) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur kontrolle der blut-pharmazeutizität von antikörpern |
| ES2544888T3 (es) * | 2006-06-08 | 2015-09-04 | Chugai Seiyaku Kabushiki Kaisha | Prevención o remedio para enfermedades inflamatorias |
| ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| EP3127921A1 (de) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstition in cdr |
| TWI548418B (zh) | 2007-12-05 | 2016-09-11 | 中外製藥股份有限公司 | Anti-NR10 / IL-31RA antibody and its use |
| CA2708065C (en) | 2007-12-05 | 2015-02-24 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for pruritus |
| SI2796466T1 (en) | 2007-12-07 | 2018-01-31 | Zymogenetics, Inc. | Molecules of Humanized Specifics Specifiable for IL-31 |
| TW201920257A (zh) | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| TW201029196A (en) * | 2008-10-23 | 2010-08-01 | Alta Devices Inc | Thin absorber layer of a photovoltaic device |
| KR20160062207A (ko) * | 2008-12-05 | 2016-06-01 | 추가이 세이야쿠 가부시키가이샤 | 항nr10 항체 및 그의 이용 |
| JP5139517B2 (ja) * | 2008-12-05 | 2013-02-06 | 中外製薬株式会社 | 抗nr10抗体、およびその利用 |
| JP2010210772A (ja) | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | 液晶表示装置の製造方法 |
| TWI544077B (zh) | 2009-03-19 | 2016-08-01 | 中外製藥股份有限公司 | Antibody constant region change body |
| JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
| TWI654203B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| FI3284480T3 (fi) | 2015-04-14 | 2025-09-11 | Chugai Pharmaceutical Co Ltd | IL-31-antagonistia vaikuttavana ainesosana sisältävä farmaseuttinen koostumus atooppisen ihottuman ehkäisemiseksi ja/tai hoitamiseksi |
| PL3749353T3 (pl) | 2018-02-09 | 2025-12-08 | Galderma Holding SA | Nemolizumab w leczeniu atopowego zapalenia skóry z przeczosami o nasileniu od umiarkowanego do ciężkiego |
| US11236157B2 (en) | 2019-01-28 | 2022-02-01 | Galderma Holding SA | Treatment of skin lesions and pruritus in prurigo nodularis patients |
| WO2021100794A1 (ja) | 2019-11-20 | 2021-05-27 | 中外製薬株式会社 | 抗体含有製剤 |
| CA3189847A1 (en) | 2020-09-01 | 2022-03-10 | Naoki Fukazawa | Pharmaceutical composition for prevention and/or treatment of dialysis pruritus containing il-31 antagonist as active ingredient |
| TW202304510A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商葛德瑪控股公司 | 結節性癢疹之治療 |
| EP4395657A1 (de) | 2021-08-30 | 2024-07-10 | Galderma Holding SA | Behandlungen von atopischer dermatitis |
| AU2023332656A1 (en) | 2022-09-02 | 2025-04-03 | Chugai Seiyaku Kabushiki Kaisha | Treatments for prurigo nodularis |
| WO2025226834A1 (en) | 2024-04-23 | 2025-10-30 | Attovia Therapeutics, Inc. | Il31-binding polypeptides and uses thereof |
| WO2026055142A1 (en) | 2024-09-03 | 2026-03-12 | Attovia Therapeutics, Inc. | Il13 and il31 bispecific polypeptides and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0239102A3 (de) | 1986-03-28 | 1989-07-12 | Tsuji, Kimiyoshi | Verfahren zur Herstellung eines Human-Human-Hybridoms |
| JP2898064B2 (ja) * | 1989-08-03 | 1999-05-31 | 忠三 岸本 | ヒトgp130蛋白質 |
| GB9016440D0 (en) | 1990-07-26 | 1990-09-12 | Elopak Systems | A laminate |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| WO1993002227A1 (en) | 1991-07-15 | 1993-02-04 | Eco-Tec Limited | Process and apparatus for treating fluoride containing acid solutions |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5783672A (en) * | 1994-05-26 | 1998-07-21 | Immunex Corporation | Receptor for oncostatin M |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| AUPN481295A0 (en) | 1995-08-16 | 1995-09-07 | Medvet Science Pty. Ltd. | Agonists of haemopoietic growth factors |
| AUPN564195A0 (en) * | 1995-09-26 | 1995-10-19 | Walter And Eliza Hall Institute Of Medical Research, The | A novel haemopoietin receptor and genetic sequences encoding same |
| ES2334408T3 (es) * | 1995-10-23 | 2010-03-09 | Zenyth Operations Pty Ltd | Receptor de hematopoyetina y secuencias geneticas que lo codifican. |
| US6642360B2 (en) * | 1997-12-03 | 2003-11-04 | Genentech, Inc. | Secreted polypeptides that stimulate release of proteoglycans from cartilage |
| US6747137B1 (en) * | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| WO1999067290A1 (fr) | 1998-06-24 | 1999-12-29 | Chugai Research Institute For Molecular Medicine, Inc. | Nouvelles proteines receptrices d'hemopoïetine |
| US20030082734A1 (en) | 1999-06-01 | 2003-05-01 | Dowling Lynette M. | Mammalian receptor proteins; related reagents and methods |
| EP1181366B2 (de) | 1999-06-01 | 2013-08-21 | Merck Sharp & Dohme Corp. | Säugetier-rezeptorproteine; ähnliche reagentien und methoden |
| DK1188830T3 (da) * | 1999-06-02 | 2010-04-26 | Chugai Pharmaceutical Co Ltd | Nyt hæmopoietinreceptorprotein NR10 |
| EP1221482B1 (de) * | 1999-09-27 | 2005-12-28 | Chugai Seiyaku Kabushiki Kaisha | HäMOPOIETINREZEPTOR-PROTEIN, NR12 |
| US6756481B2 (en) * | 2000-05-10 | 2004-06-29 | Schering Corporation | IL-23 receptor binding compositions |
| EP1325115B1 (de) | 2000-06-26 | 2016-07-27 | ZymoGenetics, Inc. | Cytokinrezeptor zcytor17 |
| US20030059871A1 (en) | 2000-10-06 | 2003-03-27 | Cosman David J. | Hematopoietin receptors HPR1 and HPR2 |
| WO2002077230A1 (fr) | 2001-03-26 | 2002-10-03 | Chugai Seiyaku Kabushiki Kaisha | Variants d'epissage nr10 |
| WO2004003140A2 (en) | 2002-01-18 | 2004-01-08 | Zymogenetics, Inc. | Cytokine receptor zcytor17 multimers |
| RU2490276C2 (ru) | 2002-01-18 | 2013-08-20 | Займоджинетикс, Инк. | Новый лиганд рецептора цитокина zcytor17 |
| US7303896B2 (en) | 2002-02-25 | 2007-12-04 | Genentech, Inc. | Nucleic acid encoding novel type-1 cytokine receptor GLM-R |
| US7579000B2 (en) | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| CN100412090C (zh) | 2002-05-01 | 2008-08-20 | 舍林股份公司 | 作为抗凝剂的新的靶向组织因子的血栓调节蛋白融合蛋白 |
| EP1671642A1 (de) | 2004-12-15 | 2006-06-21 | Universite D'angers | Zusammensetzungen mit (Ant)agonisten von Oncostatin M (OSM), IL-31 und IFN-gamma zur Modulierung der Migration und Funktion von Keratinozyten via einen Rezeptor welcher OSMRbeta als Untereinheit enthält, und entprechende Anwendungen |
| ES2579758T3 (es) | 2005-01-28 | 2016-08-16 | Zymogenetics, Inc. | Preparaciones homogéneas de IL-31 |
| EP1858924A1 (de) | 2005-02-14 | 2007-11-28 | ZymoGenetics, Inc. | Verfahren zur behandlung von hauterkrankungen mit einem il-31ra-antagonisten |
| JP4927762B2 (ja) | 2005-02-14 | 2012-05-09 | ザイモジェネティクス, インコーポレイテッド | Il−31アンタゴニストに対するアトピー性皮膚炎の治療応答を予測する方法 |
| CN101198624B (zh) | 2005-05-06 | 2012-10-10 | 津莫吉尼蒂克斯公司 | Il-31单克隆抗体及使用方法 |
| EP2001906A2 (de) | 2006-01-10 | 2008-12-17 | Zymogenetics, Inc. | Verfahren zur behandlung von schmerzen und entzündungen in einem nervengewebe mithilfe von il-31ra- und osmrb-antagonisten |
| ES2544888T3 (es) * | 2006-06-08 | 2015-09-04 | Chugai Seiyaku Kabushiki Kaisha | Prevención o remedio para enfermedades inflamatorias |
-
2000
- 2000-06-01 DK DK00931646.4T patent/DK1188830T3/da active
- 2000-06-01 EP EP09012659.0A patent/EP2135953B1/de not_active Expired - Lifetime
- 2000-06-01 WO PCT/JP2000/003556 patent/WO2000075314A1/ja not_active Ceased
- 2000-06-01 AT AT00931646T patent/ATE455852T1/de active
- 2000-06-01 AU AU49524/00A patent/AU4952400A/en not_active Abandoned
- 2000-06-01 DE DE60043728T patent/DE60043728D1/de not_active Expired - Lifetime
- 2000-06-01 EP EP00931646A patent/EP1188830B1/de not_active Expired - Lifetime
- 2000-06-01 PT PT00931646T patent/PT1188830E/pt unknown
- 2000-06-01 EP EP10180785.7A patent/EP2325316B8/de not_active Expired - Lifetime
- 2000-06-01 ES ES00931646T patent/ES2339843T3/es not_active Expired - Lifetime
-
2001
- 2001-12-03 US US10/006,265 patent/US7482440B2/en not_active Expired - Lifetime
-
2006
- 2006-10-25 JP JP2006289770A patent/JP2007111051A/ja not_active Withdrawn
-
2007
- 2007-10-30 US US11/980,135 patent/US8017738B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/980,117 patent/US8017731B2/en not_active Expired - Fee Related
-
2008
- 2008-10-17 US US12/253,506 patent/US8362223B2/en not_active Expired - Fee Related
- 2008-12-25 JP JP2008330001A patent/JP5634674B2/ja not_active Expired - Lifetime
-
2012
- 2012-02-02 JP JP2012020720A patent/JP2012147784A/ja not_active Withdrawn
- 2012-12-19 US US13/719,926 patent/US20130115620A1/en not_active Abandoned
-
2014
- 2014-02-28 JP JP2014038789A patent/JP2014168462A/ja not_active Withdrawn
- 2014-07-01 CY CY20141100484T patent/CY1115582T1/el unknown
-
2015
- 2015-07-21 JP JP2015143712A patent/JP2016000042A/ja not_active Withdrawn
-
2017
- 2017-09-15 US US15/705,720 patent/US20180002396A1/en not_active Abandoned
- 2017-10-03 JP JP2017193306A patent/JP2018033461A/ja not_active Withdrawn
-
2019
- 2019-10-30 JP JP2019197183A patent/JP2020036596A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1188830A1 (de) | 2002-03-20 |
| EP1188830B1 (de) | 2010-01-20 |
| JP2012147784A (ja) | 2012-08-09 |
| ES2339843T3 (es) | 2010-05-26 |
| JP2020036596A (ja) | 2020-03-12 |
| JP2007111051A (ja) | 2007-05-10 |
| WO2000075314A1 (en) | 2000-12-14 |
| EP2135953B1 (de) | 2014-04-23 |
| JP2018033461A (ja) | 2018-03-08 |
| EP2325316B8 (de) | 2017-04-19 |
| US20030125520A1 (en) | 2003-07-03 |
| EP2325316A1 (de) | 2011-05-25 |
| EP2325316B1 (de) | 2016-09-07 |
| US8362223B2 (en) | 2013-01-29 |
| JP5634674B2 (ja) | 2014-12-03 |
| JP2014168462A (ja) | 2014-09-18 |
| US20100240145A1 (en) | 2010-09-23 |
| DE60043728D1 (de) | 2010-03-11 |
| CY1115582T1 (el) | 2017-01-04 |
| JP2016000042A (ja) | 2016-01-07 |
| US20180002396A1 (en) | 2018-01-04 |
| AU4952400A (en) | 2000-12-28 |
| US20100240096A1 (en) | 2010-09-23 |
| US20100016552A1 (en) | 2010-01-21 |
| DK1188830T3 (da) | 2010-04-26 |
| US20130115620A1 (en) | 2013-05-09 |
| EP2135953A1 (de) | 2009-12-23 |
| PT1188830E (pt) | 2010-04-09 |
| US8017738B2 (en) | 2011-09-13 |
| US8017731B2 (en) | 2011-09-13 |
| EP1188830A4 (de) | 2005-02-09 |
| US7482440B2 (en) | 2009-01-27 |
| JP2009137978A (ja) | 2009-06-25 |
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