ATE455T1 - PROCESS FOR THE PREPARATION OF CARBAZOLE AND AN INTERMEDIATE THEREOF. - Google Patents

PROCESS FOR THE PREPARATION OF CARBAZOLE AND AN INTERMEDIATE THEREOF.

Info

Publication number
ATE455T1
ATE455T1 AT79101880T AT79101880T ATE455T1 AT E455 T1 ATE455 T1 AT E455T1 AT 79101880 T AT79101880 T AT 79101880T AT 79101880 T AT79101880 T AT 79101880T AT E455 T1 ATE455 T1 AT E455T1
Authority
AT
Austria
Prior art keywords
carbazole
preparation
carbazoles
tetrahydro
chloro
Prior art date
Application number
AT79101880T
Other languages
German (de)
Inventor
Leo Berger
John William Scott
Original Assignee
F. Hoffmann-La Roche & Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche & Co. Aktiengesellschaft filed Critical F. Hoffmann-La Roche & Co. Aktiengesellschaft
Application granted granted Critical
Publication of ATE455T1 publication Critical patent/ATE455T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to a process for the preparation of carbazoles of the formula <CHEM> wherein X is hydroxymethyl or a grouping COOR<1>, R<1> is hydrogen or lower alkyl, and the dotted line denotes an optional C-C bond and, where X is carboxy, salts thereof with bases, starting from 6-chloro-1,2,3,4-tetrahydro- carbazole-2-one, as well as to the novel carbazoles of formula <CHEM> wherein X is as above, and to the intermediate, 6-chloro-1,2,3,4-tetrahydro- carbazole-2-one.
AT79101880T 1978-06-12 1979-06-11 PROCESS FOR THE PREPARATION OF CARBAZOLE AND AN INTERMEDIATE THEREOF. ATE455T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/914,465 US4146542A (en) 1978-06-12 1978-06-12 Dihydrocarbazole acetic acid and esters thereof
EP79101880A EP0006208B1 (en) 1978-06-12 1979-06-11 Process for the preparation of carbazoles and an intermediate therefor

Publications (1)

Publication Number Publication Date
ATE455T1 true ATE455T1 (en) 1981-12-15

Family

ID=25434411

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101880T ATE455T1 (en) 1978-06-12 1979-06-11 PROCESS FOR THE PREPARATION OF CARBAZOLE AND AN INTERMEDIATE THEREOF.

Country Status (13)

Country Link
US (1) US4146542A (en)
EP (1) EP0006208B1 (en)
JP (1) JPS54163569A (en)
AT (1) ATE455T1 (en)
CA (1) CA1107288A (en)
DK (1) DK220079A (en)
ES (1) ES481437A1 (en)
FI (1) FI791865A7 (en)
GR (1) GR74058B (en)
HU (1) HU180247B (en)
NO (1) NO152132C (en)
PT (1) PT69755A (en)
YU (1) YU135279A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK12785A (en) * 1984-02-07 1985-08-08 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF CARBAZOL DERIVATIVES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3671544A (en) * 1970-07-13 1972-06-20 Warner Lambert Co 3,4,4a,9a-tetrahydro-2-(1h)carbazolones
ZA715217B (en) * 1970-08-20 1972-04-26 Org Nv Anti-inflammatory preparations
US3868387A (en) * 1971-04-15 1975-02-25 Hoffmann La Roche 1,2,3,4-tetrahydrocarbazole-2-carboxylic acids and their derivatives
AR205331A1 (en) * 1972-07-24 1976-04-30 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF CARBAZOLES

Also Published As

Publication number Publication date
EP0006208B1 (en) 1981-12-02
DK220079A (en) 1979-12-13
PT69755A (en) 1979-07-01
NO791949L (en) 1979-12-13
US4146542A (en) 1979-03-27
EP0006208A1 (en) 1980-01-09
ES481437A1 (en) 1980-08-16
NO152132C (en) 1985-08-14
FI791865A7 (en) 1981-01-01
JPS54163569A (en) 1979-12-26
NO152132B (en) 1985-04-29
YU135279A (en) 1982-10-31
JPS6133023B2 (en) 1986-07-31
HU180247B (en) 1983-02-28
CA1107288A (en) 1981-08-18
GR74058B (en) 1984-06-06

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification