ATE456600T1 - Biologisch abbaubare verzweigte polylactidderivate, die zur bildung von polymermicellen befähigt sind, herstellungsverfahren dafür und verwendung davon - Google Patents

Biologisch abbaubare verzweigte polylactidderivate, die zur bildung von polymermicellen befähigt sind, herstellungsverfahren dafür und verwendung davon

Info

Publication number
ATE456600T1
ATE456600T1 AT04808305T AT04808305T ATE456600T1 AT E456600 T1 ATE456600 T1 AT E456600T1 AT 04808305 T AT04808305 T AT 04808305T AT 04808305 T AT04808305 T AT 04808305T AT E456600 T1 ATE456600 T1 AT E456600T1
Authority
AT
Austria
Prior art keywords
capability
production process
forming polymer
polymer micelles
biodegradable branched
Prior art date
Application number
AT04808305T
Other languages
English (en)
Inventor
Min-Hyo Seo
Bong-Oh Kim
In-Ja Choi
Myung-Seob Shim
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Application granted granted Critical
Publication of ATE456600T1 publication Critical patent/ATE456600T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04808305T 2003-12-04 2004-12-03 Biologisch abbaubare verzweigte polylactidderivate, die zur bildung von polymermicellen befähigt sind, herstellungsverfahren dafür und verwendung davon ATE456600T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020030087459A KR20050054129A (ko) 2003-12-04 2003-12-04 고분자 미셀을 형성하는 생분해성 분지형 폴리락트산유도체, 및 그의 제조방법 및 용도
PCT/KR2004/003174 WO2005054333A1 (en) 2003-12-04 2004-12-03 Biodegradable branched polylactide derivativescapable of forming polymeric micelles, and their preparation method and use

Publications (1)

Publication Number Publication Date
ATE456600T1 true ATE456600T1 (de) 2010-02-15

Family

ID=36642449

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04808305T ATE456600T1 (de) 2003-12-04 2004-12-03 Biologisch abbaubare verzweigte polylactidderivate, die zur bildung von polymermicellen befähigt sind, herstellungsverfahren dafür und verwendung davon

Country Status (12)

Country Link
US (1) US8021652B2 (de)
EP (1) EP1633797B1 (de)
JP (2) JP2006526053A (de)
KR (2) KR20050054129A (de)
CN (1) CN100386358C (de)
AT (1) ATE456600T1 (de)
AU (1) AU2004295264B2 (de)
CA (1) CA2523989C (de)
DE (1) DE602004025344D1 (de)
MX (1) MXPA05011584A (de)
NZ (1) NZ543001A (de)
WO (1) WO2005054333A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2463517C (en) * 2001-10-18 2010-03-16 Samyang Corporation Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery
EP1367080A1 (de) 2002-05-29 2003-12-03 Hycail B.V. Hyperverzweigte Polyhydroxycarbonsäurepolymere
JP2012233208A (ja) * 2005-10-03 2012-11-29 Dai Ichi Kogyo Seiyaku Co Ltd 機能性フィラーおよびそれを含有する樹脂組成物
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
US8802126B2 (en) * 2008-06-30 2014-08-12 Abbott Cardiovascular Systems Inc. Polyester implantable medical device with controlled in vivo biodegradability
US8137818B2 (en) * 2008-07-28 2012-03-20 Tate & Lyle Ingredients Americas Llc Poly(lactic acid)-containing compositions for use in imparting oil, grease, or water resistance to paper
WO2010053242A1 (en) * 2008-11-07 2010-05-14 Samyang Corporation Highly purified polylactic acid or a derivative thereof, a salt of the same, and purification method thereof
EP2201935B1 (de) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymere Mizellenzusammensetzung, die ein schlecht lösliches Arzneimittel enthält, und zugehöriges Herstellungsverfahren
ATE539778T1 (de) * 2009-04-23 2012-01-15 Vivoxid Oy Biokompatibler verbund und seine verwendung
FR2967416B1 (fr) * 2010-11-15 2012-12-21 Ipsen Pharma Sas Procede de preparation de polymeres a architecture variee et amorcage amide
KR101467275B1 (ko) * 2011-12-19 2014-12-02 주식회사 삼양바이오팜 분산성이 향상된 생분해성 고분자 미립자의 조성물 및 그 제조방법
WO2013124867A1 (en) 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules
FR2995901B1 (fr) * 2012-09-21 2015-08-14 Inst Corps Gras Etudes Et Rech S Tech Iterg Nouveaux pre-polymeres biosources et leurs utilisations pour la preparation de polymeres utiles comme additifs dans une matrice poly(acide lactique)
JP6164860B2 (ja) * 2013-02-15 2017-07-19 三井化学株式会社 ポリマンデル酸
WO2014141289A1 (en) 2013-03-12 2014-09-18 Amrita Vishwa Vidyapeetham University Photo - chemo composition on the basis of microcapsules with a core -shell structure
CN104292444B (zh) * 2014-10-15 2016-06-29 四川大学 具有精确可控分子结构的类流星锤型聚乳酸的合成方法
KR20230005125A (ko) * 2020-02-21 2023-01-09 네이쳐웍스 엘엘씨 저 분자량 비정질 등급 폴리락트산 수지를 함유하는 화장료 조성물
KR102460624B1 (ko) 2020-09-22 2022-10-28 가톨릭대학교 산학협력단 제어 약물 방출 및 x-선 이미징이 가능한 약물 전달체 및 이의 용도
EP4317245A4 (de) * 2021-05-06 2024-10-23 Lg Chem, Ltd. Verzweigtes poly(milchsäure-3-hydroxypropionsäure)polymer und verfahren zur herstellung davon
CN117242114A (zh) * 2021-05-06 2023-12-15 株式会社Lg化学 支化聚(乳酸-3-羟基丙酸)共聚物及其制备方法
CN114437319B (zh) * 2022-01-12 2023-08-15 青岛科技大学 一种利用平推流反应器快速可控制备乙交酯-丙交酯共聚物的方法
CN114773581B (zh) * 2022-04-25 2024-06-25 万华化学集团股份有限公司 一种聚乳酸组合物及其制备方法
CN115260478B (zh) * 2022-07-19 2024-02-02 绍兴文理学院 一种高强高韧性聚乳酸共聚物的制备方法及其应用
CN120478586A (zh) * 2022-12-26 2025-08-15 上海湃肽生物科技有限公司 一种分子伴侣协同蓝铜肽及其用途
CN118994552A (zh) * 2024-08-19 2024-11-22 安徽丰原发酵技术工程研究有限公司 一种端羧基聚乳酸及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3065384B2 (ja) * 1991-06-05 2000-07-17 旭硝子株式会社 ラクチド系重合体の製造方法
JPH06322805A (ja) * 1993-05-13 1994-11-22 Matsushita Electric Ind Co Ltd 画像認識装置付き便所
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
WO1997006202A1 (en) * 1995-08-10 1997-02-20 Kazunori Kataoka Block polymer having functional groups at both ends
KR0180334B1 (ko) 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
JP3155013B2 (ja) * 1996-04-23 2001-04-09 キナートン・リミテッド 酸性ポリ乳酸ポリマー
JPH10110019A (ja) * 1996-10-08 1998-04-28 Kazunori Kataoka 安定化高分子ミセルおよび生理活性物質のキヤリヤーとしてのその使用
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
JP4565290B2 (ja) * 1999-12-01 2010-10-20 東洋紡績株式会社 高水酸基濃度を有するオキシ酸系脂肪族ポリエステルおよびオキシ酸系脂肪族ポリエステル組成物
EP1306013A1 (de) * 2001-03-28 2003-05-02 Hycail B.V. Biologisch abbaubare Kaugummigrundmasse
KR100492805B1 (ko) * 2001-10-18 2005-06-07 주식회사 삼양사 안정성이 향상된 고분자 미셀 조성물
CA2463517C (en) 2001-10-18 2010-03-16 Samyang Corporation Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery
KR100531269B1 (ko) * 2001-12-04 2005-11-28 주식회사 삼양사 수용액에서 안정한 미셀 또는 나노 파티클을 형성하는고분자 조성물
KR100703872B1 (ko) * 2003-10-10 2007-04-09 주식회사 삼양사 양친성 블록 공중합체 및 이를 포함하는 약물 전달용고분자 조성물

Also Published As

Publication number Publication date
JP5579406B2 (ja) 2014-08-27
AU2004295264A1 (en) 2005-06-16
KR20060009831A (ko) 2006-02-01
JP2009263680A (ja) 2009-11-12
CA2523989C (en) 2009-01-27
CN100386358C (zh) 2008-05-07
MXPA05011584A (es) 2005-12-14
US20070003625A1 (en) 2007-01-04
US8021652B2 (en) 2011-09-20
JP2006526053A (ja) 2006-11-16
KR100724719B1 (ko) 2007-06-04
DE602004025344D1 (de) 2010-03-18
EP1633797A1 (de) 2006-03-15
AU2004295264B2 (en) 2009-10-29
KR20050054129A (ko) 2005-06-10
EP1633797B1 (de) 2010-01-27
NZ543001A (en) 2009-09-25
HK1089459A1 (zh) 2006-12-01
CN1780868A (zh) 2006-05-31
WO2005054333A1 (en) 2005-06-16
CA2523989A1 (en) 2005-06-16
EP1633797A4 (de) 2009-05-13

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