ATE456651T1 - Metalloprotease mit aggrecanase-aktivität - Google Patents

Metalloprotease mit aggrecanase-aktivität

Info

Publication number
ATE456651T1
ATE456651T1 AT00974894T AT00974894T ATE456651T1 AT E456651 T1 ATE456651 T1 AT E456651T1 AT 00974894 T AT00974894 T AT 00974894T AT 00974894 T AT00974894 T AT 00974894T AT E456651 T1 ATE456651 T1 AT E456651T1
Authority
AT
Austria
Prior art keywords
metalloprotease
aggrecanase activity
inhibiting
aggrecanase
activity
Prior art date
Application number
AT00974894T
Other languages
English (en)
Inventor
Noboru Yamaji
Kouichi Nishimura
Kunitake Abe
Osamu Ohara
Takahiro Nagase
Nobuo Nomura
Original Assignee
Astellas Pharma Inc
Kazusa Dna Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc, Kazusa Dna Res Inst filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of ATE456651T1 publication Critical patent/ATE456651T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT00974894T 1999-11-11 2000-11-10 Metalloprotease mit aggrecanase-aktivität ATE456651T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP32174099 1999-11-11
JP2000144020 2000-05-16
PCT/JP2000/007917 WO2001034785A1 (en) 1999-11-11 2000-11-10 Novel metalloprotease having aggrecanase activity

Publications (1)

Publication Number Publication Date
ATE456651T1 true ATE456651T1 (de) 2010-02-15

Family

ID=26570581

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00974894T ATE456651T1 (de) 1999-11-11 2000-11-10 Metalloprotease mit aggrecanase-aktivität

Country Status (8)

Country Link
US (2) US6716613B1 (de)
EP (1) EP1234875B1 (de)
JP (1) JP3356771B2 (de)
AT (1) ATE456651T1 (de)
AU (1) AU1305501A (de)
DE (1) DE60043783D1 (de)
ES (1) ES2338210T3 (de)
WO (1) WO2001034785A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002215312A1 (en) * 2000-09-29 2002-04-08 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
ES2212695B1 (es) * 2001-09-14 2005-10-16 Universidad De Oviedo Procedimiento de identificacion de la proteina humana adamts-13.
ES2201874B1 (es) * 2001-09-24 2005-05-16 Univesidad De Oviedo Procedimiento de identificacion de la proteina humana adamts-17.
ES2204250B1 (es) * 2001-09-24 2005-08-16 Universidad De Oviedo Procedimiento de identificacion de la proteina humana adamts-16.
ES2205989B1 (es) * 2001-09-24 2005-08-16 Universidad De Oviedo Procedimiento de identificacion de la proteina humana adamts-15.
JP2003180384A (ja) * 2001-09-24 2003-07-02 Daiichi Fine Chemical Co Ltd Ａｄａｍｔｓ−１５，−１６，−１７，−１８及び−１９
ES2213428B1 (es) * 2001-09-25 2005-11-16 Universidad De Oviedo. Procedimiento de identificacion de la proteina humana adamts-19.
ES2211256B1 (es) * 2001-09-28 2005-10-16 Universidad De Oviedo. Procedimiento de identificacion de la proteina humana adamts-19.
EP1737973A1 (de) * 2004-04-16 2007-01-03 Wyeth Verkürzte adamts moleküle
EP2124062A1 (de) 2005-08-12 2009-11-25 Astellas Pharma Inc. Verfahren zur Identifizierung des Zielproteins eines Wirkstoffs und Verfahren zum Screening eines therapeutischen Wirkstoffs gegen Diabetes mittels des Zielproteins
CA2598893C (en) 2006-10-11 2012-04-10 Astellas Pharma Inc. Eml4-alk fusion gene
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0998572A2 (de) * 1997-07-25 2000-05-10 Du Pont Pharmaceuticals Company Aggrecan abbauende metalloproteasen
WO2001098468A2 (en) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases
AU2002215312A1 (en) * 2000-09-29 2002-04-08 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same

Also Published As

Publication number Publication date
EP1234875A4 (de) 2004-03-24
ES2338210T3 (es) 2010-05-05
US6716613B1 (en) 2004-04-06
EP1234875B1 (de) 2010-01-27
AU1305501A (en) 2001-06-06
EP1234875A1 (de) 2002-08-28
DE60043783D1 (de) 2010-03-18
JP3356771B2 (ja) 2002-12-16
WO2001034785A1 (en) 2001-05-17
US20040142445A1 (en) 2004-07-22

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