ATE456651T1 - Metalloprotease mit aggrecanase-aktivität - Google Patents

Metalloprotease mit aggrecanase-aktivität

Info

Publication number
ATE456651T1
ATE456651T1 AT00974894T AT00974894T ATE456651T1 AT E456651 T1 ATE456651 T1 AT E456651T1 AT 00974894 T AT00974894 T AT 00974894T AT 00974894 T AT00974894 T AT 00974894T AT E456651 T1 ATE456651 T1 AT E456651T1
Authority
AT
Austria
Prior art keywords
metalloprotease
aggrecanase activity
inhibiting
aggrecanase
activity
Prior art date
Application number
AT00974894T
Other languages
English (en)
Inventor
Noboru Yamaji
Kouichi Nishimura
Kunitake Abe
Osamu Ohara
Takahiro Nagase
Nobuo Nomura
Original Assignee
Astellas Pharma Inc
Kazusa Dna Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc, Kazusa Dna Res Inst filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of ATE456651T1 publication Critical patent/ATE456651T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
AT00974894T 1999-11-11 2000-11-10 Metalloprotease mit aggrecanase-aktivität ATE456651T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP32174099 1999-11-11
JP2000144020 2000-05-16
PCT/JP2000/007917 WO2001034785A1 (en) 1999-11-11 2000-11-10 Novel metalloprotease having aggrecanase activity

Publications (1)

Publication Number Publication Date
ATE456651T1 true ATE456651T1 (de) 2010-02-15

Family

ID=26570581

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00974894T ATE456651T1 (de) 1999-11-11 2000-11-10 Metalloprotease mit aggrecanase-aktivität

Country Status (8)

Country Link
US (2) US6716613B1 (de)
EP (1) EP1234875B1 (de)
JP (1) JP3356771B2 (de)
AT (1) ATE456651T1 (de)
AU (1) AU1305501A (de)
DE (1) DE60043783D1 (de)
ES (1) ES2338210T3 (de)
WO (1) WO2001034785A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115842A1 (en) * 2000-09-29 2002-08-22 Friddle Carl Johan Novel human proteases and polynucleotides encoding the same
ES2212695B1 (es) * 2001-09-14 2005-10-16 Universidad De Oviedo Procedimiento de identificacion de la proteina humana adamts-13.
ES2201874B1 (es) * 2001-09-24 2005-05-16 Univesidad De Oviedo Procedimiento de identificacion de la proteina humana adamts-17.
ES2204250B1 (es) * 2001-09-24 2005-08-16 Universidad De Oviedo Procedimiento de identificacion de la proteina humana adamts-16.
ES2211256B1 (es) * 2001-09-28 2005-10-16 Universidad De Oviedo. Procedimiento de identificacion de la proteina humana adamts-19.
ES2205989B1 (es) * 2001-09-24 2005-08-16 Universidad De Oviedo Procedimiento de identificacion de la proteina humana adamts-15.
WO2003027282A1 (en) * 2001-09-24 2003-04-03 Daiichi Fine Chemical Co., Ltd. Adamts-15, -16, -17, -18 and -19
ES2213428B1 (es) * 2001-09-25 2005-11-16 Universidad De Oviedo. Procedimiento de identificacion de la proteina humana adamts-19.
WO2005103287A1 (en) * 2004-04-16 2005-11-03 Wyeth Truncated adamts molecules
JP4992716B2 (ja) 2005-08-12 2012-08-08 アステラス製薬株式会社 薬剤の標的蛋白質を同定する方法及び標的蛋白質を用いた糖尿病治療薬のスクリーニング方法
CA2598893C (en) 2006-10-11 2012-04-10 Astellas Pharma Inc. Eml4-alk fusion gene
US20200087390A1 (en) 2016-12-21 2020-03-19 Amgen Inc. Anti-tnf alpha antibody formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001511351A (ja) * 1997-07-25 2001-08-14 デュポン ファーマシューティカルズ カンパニー アグリカン分解性メタロプロテアーゼ
US20020115842A1 (en) * 2000-09-29 2002-08-22 Friddle Carl Johan Novel human proteases and polynucleotides encoding the same
EP1292684A2 (de) * 2000-06-16 2003-03-19 Incyte Genomics, Inc. Protease

Also Published As

Publication number Publication date
EP1234875A4 (de) 2004-03-24
US6716613B1 (en) 2004-04-06
EP1234875B1 (de) 2010-01-27
DE60043783D1 (de) 2010-03-18
US20040142445A1 (en) 2004-07-22
EP1234875A1 (de) 2002-08-28
ES2338210T3 (es) 2010-05-05
WO2001034785A1 (en) 2001-05-17
AU1305501A (en) 2001-06-06
JP3356771B2 (ja) 2002-12-16

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