ATE457314T1 - Antibiotische spiroderivate - Google Patents

Antibiotische spiroderivate

Info

Publication number: ATE457314T1
Authority: AT; Austria
Prior art keywords: ch2ch2; compounds; halogen; spiroderivatives; antibiotic
Prior art date: 2006-08-30

Application number

AT07826189T

Other languages

English (en)

Inventor

Christian Hubschwerlen

Jean-Philippe Surivet

Acklin Cornelia Zumbrunn

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-30

Filing date

2007-08-29

Publication date

2010-02-15

2007-08-29 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2010-02-15 Application granted granted Critical

2010-02-15 Publication of ATE457314T1 publication Critical patent/ATE457314T1/de

Links

230000003115 biocidal effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
239000004599 antimicrobial Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

AT07826189T 2006-08-30 2007-08-29 Antibiotische spiroderivate ATE457314T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IB2006053012		2006-08-30
IB2006054045		2006-11-01
PCT/IB2007/053472 WO2008026172A1 (en)	2006-08-30	2007-08-29	Spiro antibiotic derivatives

Publications (1)

Publication Number	Publication Date
ATE457314T1 true ATE457314T1 (de)	2010-02-15

Family

ID=38973769

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07826189T ATE457314T1 (de)	2006-08-30	2007-08-29	Antibiotische spiroderivate

Country Status (10)

Country	Link
US (1)	US7999115B2 (de)
EP (1)	EP2066678B1 (de)
JP (1)	JP2010502589A (de)
CN (1)	CN101511845B (de)
AT (1)	ATE457314T1 (de)
CA (1)	CA2659493A1 (de)
DE (1)	DE602007004740D1 (de)
ES (1)	ES2339507T3 (de)
TW (1)	TW200819457A (de)
WO (1)	WO2008026172A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2411930T3 (es)	2008-02-20	2013-07-09	Actelion Pharmaceuticals Ltd.	Compuestos antibióticos azatricíclicos
EP2321307B1 (de) *	2008-08-04	2012-12-19	Actelion Pharmaceuticals Ltd.	Tricyclische alkylaminomethyloxazolidinonderivate
KR101294962B1 (ko)	2008-10-07	2013-08-12	액테리온 파마슈티칼 리미티드	트리사이클 옥사졸리디논 항생제 화합물
CA2738775A1 (en) *	2008-10-10	2010-04-15	Actelion Pharmaceuticals Ltd	2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents
MX2011003188A (es)	2008-10-10	2011-04-27	Actelion Pharmaceuticals Ltd	Antibioticos de oxazolidinilo.
TW201209056A (en) *	2010-05-25	2012-03-01	Taisho Pharmaceutical Co Ltd	Novel heterocyclic compound or salt thereof
US8952010B2 (en)	2011-02-07	2015-02-10	Daiichi Sankyo Company, Limited	Amino group-containing pyrrolidinone derivative
JO3154B1 (ar) *	2011-06-17	2017-09-20	Glaxosmithkline Llc	عوامل مضادة لـ trpv4
EP2720546B1 (de) *	2011-06-17	2016-04-06	Glaxosmithkline Intellectual Property (No. 2) Limited	Spirocyclische trpv4-antagonisten
WO2012174340A1 (en) *	2011-06-17	2012-12-20	Glaxosmithkline Llc	Trpv4 antagonists
EP2785721A1 (de) *	2011-11-30	2014-10-08	Actelion Pharmaceuticals Ltd.	3,7-disubstituierte octahydro-2h-pyrido [4,3-e] [1,3] oxazin-2-on-antibiotika
WO2014024056A1 (en)	2012-08-06	2014-02-13	Daiichi Sankyo Company, Limited	Pyrrolidine derivatives with antibacterial properties

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4244961A (en)	1978-10-26	1981-01-13	Syntex (U.S.A.) Inc.	1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
US4353901A (en)	1981-10-19	1982-10-12	Syntex (U.S.A.) Inc.	9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones
TW209870B (de)	1990-01-18	1993-07-21	Pfizer
WO1996033195A1 (en)	1995-04-21	1996-10-24	Shinnippon Pharmaceutical Inc.	FUSED IMIDAZO[1,2-a]PYRIDINES
DE60011570T2 (de)	1999-01-07	2004-11-25	Wyeth	Arylpiperazinyl-cyclohexyl indolderivate zur behandlung von depressionen
GB9914486D0 (en)	1999-06-21	1999-08-18	Smithkline Beecham Plc	Medicaments
NZ523749A (en)	2000-07-26	2005-03-24	Smithkline Beecham P	Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0112834D0 (en)	2001-05-25	2001-07-18	Smithkline Beecham Plc	Medicaments
US7312212B2 (en) *	2002-01-29	2007-12-25	Glaxo Group Limited	Aminopiperidine derivatives
DE60309856T2 (de)	2002-04-26	2007-06-14	F. Hoffmann-La Roche Ag	Substituierte phenylacetamide und deren verwendung als glucokinaseaktivatoren
TW200409637A (en)	2002-06-26	2004-06-16	Glaxo Group Ltd	Compounds
GB0217294D0 (en)	2002-07-25	2002-09-04	Glaxo Group Ltd	Medicaments
AU2003268512A1 (en) *	2002-09-09	2004-03-29	Janssen Pharmaceutica N.V.	Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
EP1551829B1 (de)	2002-10-10	2010-04-07	Morphochem Aktiengesellschaft Für Kombinatorische Chemie	Neue verbindungen mit antibakterieller aktivität
DE10316081A1 (de)	2003-04-08	2004-10-21	Morphochem AG Aktiengesellschaft für kombinatorische Chemie	Neue Verbindungen mit antibakterieller Aktivität
EP1773847A2 (de) *	2004-07-09	2007-04-18	Glaxo Group Limited	Antibakterielle mittel
DE102004041163A1 (de)	2004-08-25	2006-03-02	Morphochem Aktiengesellschaft für kombinatorische Chemie	Neue Verbindungen mit antibakterieller Aktivität
JP4887297B2 (ja) *	2004-09-24	2012-02-29	アクテリオンファーマシューティカルズリミテッド	新規二環式抗生物質
DE602005021133D1 (de) *	2004-10-05	2010-06-17	Actelion Pharmaceuticals Ltd	Neue piperidin-antibiotika
WO2006046552A1 (ja)	2004-10-27	2006-05-04	Toyama Chemical Co., Ltd.	新規な含窒素複素環化合物およびその塩
JP2008528588A (ja) *	2005-01-25	2008-07-31	グラクソグループリミテッド	抗菌剤

2007
- 2007-08-28 TW TW096131944A patent/TW200819457A/zh unknown
- 2007-08-29 CA CA002659493A patent/CA2659493A1/en not_active Abandoned
- 2007-08-29 JP JP2009526247A patent/JP2010502589A/ja active Pending
- 2007-08-29 CN CN2007800321903A patent/CN101511845B/zh not_active Expired - Fee Related
- 2007-08-29 EP EP07826189A patent/EP2066678B1/de not_active Not-in-force
- 2007-08-29 US US12/439,571 patent/US7999115B2/en not_active Expired - Fee Related
- 2007-08-29 ES ES07826189T patent/ES2339507T3/es active Active
- 2007-08-29 WO PCT/IB2007/053472 patent/WO2008026172A1/en not_active Ceased
- 2007-08-29 AT AT07826189T patent/ATE457314T1/de not_active IP Right Cessation
- 2007-08-29 DE DE602007004740T patent/DE602007004740D1/de active Active

Also Published As

Publication number	Publication date
DE602007004740D1 (de)	2010-03-25
CN101511845A (zh)	2009-08-19
US20090270375A1 (en)	2009-10-29
EP2066678B1 (de)	2010-02-10
JP2010502589A (ja)	2010-01-28
WO2008026172A1 (en)	2008-03-06
TW200819457A (en)	2008-05-01
US7999115B2 (en)	2011-08-16
EP2066678A1 (de)	2009-06-10
CN101511845B (zh)	2012-01-04
ES2339507T3 (es)	2010-05-20
CA2659493A1 (en)	2008-03-06

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Legal Events

Date	Code	Title	Description
2010-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties