ATE457314T1 - Antibiotische spiroderivate - Google Patents

Antibiotische spiroderivate

Info

Publication number: ATE457314T1
Authority: AT; Austria
Prior art keywords: ch2ch2; compounds; halogen; spiroderivatives; antibiotic
Prior art date: 2006-08-30

Application number

AT07826189T

Other languages

English (en)

Inventor

Christian Hubschwerlen

Jean-Philippe Surivet

Acklin Cornelia Zumbrunn

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-30

Filing date

2007-08-29

Publication date

2010-02-15

2007-08-29 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2010-02-15 Application granted granted Critical

2010-02-15 Publication of ATE457314T1 publication Critical patent/ATE457314T1/de

Links

230000003115 biocidal effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
239000004599 antimicrobial Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

AT07826189T 2006-08-30 2007-08-29 Antibiotische spiroderivate ATE457314T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IB2006053012		2006-08-30
IB2006054045		2006-11-01
PCT/IB2007/053472 WO2008026172A1 (en)	2006-08-30	2007-08-29	Spiro antibiotic derivatives

Publications (1)

Publication Number	Publication Date
ATE457314T1 true ATE457314T1 (de)	2010-02-15

Family

ID=38973769

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07826189T ATE457314T1 (de)	2006-08-30	2007-08-29	Antibiotische spiroderivate

Country Status (10)

Country	Link
US (1)	US7999115B2 (de)
EP (1)	EP2066678B1 (de)
JP (1)	JP2010502589A (de)
CN (1)	CN101511845B (de)
AT (1)	ATE457314T1 (de)
CA (1)	CA2659493A1 (de)
DE (1)	DE602007004740D1 (de)
ES (1)	ES2339507T3 (de)
TW (1)	TW200819457A (de)
WO (1)	WO2008026172A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8349828B2 (en)	2008-02-20	2013-01-08	Actelion Pharmaceuticals Ltd.	Azatricyclic antibiotic compounds
BRPI0916571A2 (pt) *	2008-08-04	2015-11-10	Actelion Pharmaceuticals Ltd	composto derivado de alquilaminometiloxazolidinona tricíclo, medicamento e composição farmacêutica que o contém e uso do composto
PT2344495E (pt)	2008-10-07	2015-04-01	Actelion Pharmaceuticals Ltd	Compostos antibióticos de oxazolidinona tricíclica
US8507478B2 (en)	2008-10-10	2013-08-13	Actelion Pharmaceuticals Ltd.	Oxazolidinyl antibiotics
EP2346862B1 (de) *	2008-10-10	2012-09-12	Actelion Pharmaceuticals Ltd.	2-benzothiophenyl- und 2-naphthyloxazolidinone und ihre azaisosteranaloga als antibakterielle mittel
TW201209056A (en) *	2010-05-25	2012-03-01	Taisho Pharmaceutical Co Ltd	Novel heterocyclic compound or salt thereof
JPWO2012108376A1 (ja)	2011-02-07	2014-07-03	第一三共株式会社	アミノ基含有ピロリジノン誘導体
US9487507B2 (en) *	2011-06-17	2016-11-08	Glaxosmithkline Intellectual Property (No. 2) Limited	TRPV4 antagonists
JP5969015B2 (ja) *	2011-06-17	2016-08-10	グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙ（Ｎｏ．２）Ｌｉｍｉｔｅｄ	Ｔｒｐｖ４拮抗薬
JO3154B1 (ar) *	2011-06-17	2017-09-20	Glaxosmithkline Llc	عوامل مضادة لـ trpv4
CN103958525A (zh) *	2011-11-30	2014-07-30	埃科特莱茵药品有限公司	3,7-二取代八氢-2H-吡啶并[4,3-e][1,3]噁嗪-2-酮抗生素
WO2014024056A1 (en)	2012-08-06	2014-02-13	Daiichi Sankyo Company, Limited	Pyrrolidine derivatives with antibacterial properties

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4244961A (en)	1978-10-26	1981-01-13	Syntex (U.S.A.) Inc.	1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
US4353901A (en)	1981-10-19	1982-10-12	Syntex (U.S.A.) Inc.	9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones
TW209870B (de)	1990-01-18	1993-07-21	Pfizer
EP0822194A4 (de)	1995-04-21	1998-04-29	Shinnippon Pharmaceutical Inc	ANNELLIIERTE IMIDAZO[1,2-a]PYRIDINE
EP1147083B1 (de)	1999-01-07	2004-06-16	Wyeth	Arylpiperazinyl-cyclohexyl indolderivate zur behandlung von depressionen
GB9914486D0 (en)	1999-06-21	1999-08-18	Smithkline Beecham Plc	Medicaments
IL154107A0 (en)	2000-07-26	2003-07-31	Smithkline Beecham Plc	Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0112834D0 (en)	2001-05-25	2001-07-18	Smithkline Beecham Plc	Medicaments
WO2003064421A1 (en) *	2002-01-29	2003-08-07	Glaxo Group Limited	Aminopiperidine derivatives
DK1501815T3 (da)	2002-04-26	2007-04-02	Hoffmann La Roche	Substituerede phenylacetamider og anvendelse deraf som glucokinaseaktivatorer
TW200409637A (en)	2002-06-26	2004-06-16	Glaxo Group Ltd	Compounds
GB0217294D0 (en)	2002-07-25	2002-09-04	Glaxo Group Ltd	Medicaments
US7081463B2 (en) *	2002-09-09	2006-07-25	Janssen Pharmaceutica N.V.	Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders
BR0315221A (pt)	2002-10-10	2005-08-23	Morphochem Ag Komb Chemie	Compostos com atividade antibacteriana
DE10316081A1 (de)	2003-04-08	2004-10-21	Morphochem AG Aktiengesellschaft für kombinatorische Chemie	Neue Verbindungen mit antibakterieller Aktivität
JP2008505926A (ja) *	2004-07-09	2008-02-28	グラクソ　グループ　リミテッド	抗細菌剤
DE102004041163A1 (de)	2004-08-25	2006-03-02	Morphochem Aktiengesellschaft für kombinatorische Chemie	Neue Verbindungen mit antibakterieller Aktivität
CA2580621A1 (en) *	2004-09-24	2006-03-30	Actelion Pharmaceuticals Ltd	New bicyclic antibiotics
CA2581057A1 (en) *	2004-10-05	2006-04-13	Actelion Pharmaceuticals Ltd	New piperidine antibiotics
JP5314244B2 (ja)	2004-10-27	2013-10-16	富山化学工業株式会社	新規な含窒素複素環化合物およびその塩
JP2008528588A (ja) *	2005-01-25	2008-07-31	グラクソグループリミテッド	抗菌剤

2007
- 2007-08-28 TW TW096131944A patent/TW200819457A/zh unknown
- 2007-08-29 EP EP07826189A patent/EP2066678B1/de not_active Not-in-force
- 2007-08-29 CA CA002659493A patent/CA2659493A1/en not_active Abandoned
- 2007-08-29 CN CN2007800321903A patent/CN101511845B/zh not_active Expired - Fee Related
- 2007-08-29 JP JP2009526247A patent/JP2010502589A/ja active Pending
- 2007-08-29 AT AT07826189T patent/ATE457314T1/de not_active IP Right Cessation
- 2007-08-29 US US12/439,571 patent/US7999115B2/en not_active Expired - Fee Related
- 2007-08-29 WO PCT/IB2007/053472 patent/WO2008026172A1/en not_active Ceased
- 2007-08-29 DE DE602007004740T patent/DE602007004740D1/de active Active
- 2007-08-29 ES ES07826189T patent/ES2339507T3/es active Active

Also Published As

Publication number	Publication date
TW200819457A (en)	2008-05-01
WO2008026172A1 (en)	2008-03-06
CN101511845B (zh)	2012-01-04
CA2659493A1 (en)	2008-03-06
US20090270375A1 (en)	2009-10-29
CN101511845A (zh)	2009-08-19
EP2066678B1 (de)	2010-02-10
ES2339507T3 (es)	2010-05-20
JP2010502589A (ja)	2010-01-28
DE602007004740D1 (de)	2010-03-25
EP2066678A1 (de)	2009-06-10
US7999115B2 (en)	2011-08-16

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Legal Events

Date	Code	Title	Description
2010-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties