ATE457314T1 - Antibiotische spiroderivate - Google Patents

Antibiotische spiroderivate

Info

Publication number: ATE457314T1
Authority: AT; Austria
Prior art keywords: ch2ch2; compounds; halogen; spiroderivatives; antibiotic
Prior art date: 2006-08-30

Application number

AT07826189T

Other languages

English (en)

Inventor

Christian Hubschwerlen

Jean-Philippe Surivet

Acklin Cornelia Zumbrunn

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-30

Filing date

2007-08-29

Publication date

2010-02-15

2007-08-29 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2010-02-15 Application granted granted Critical

2010-02-15 Publication of ATE457314T1 publication Critical patent/ATE457314T1/de

Links

230000003115 biocidal effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
239000004599 antimicrobial Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT07826189T 2006-08-30 2007-08-29 Antibiotische spiroderivate ATE457314T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IB2006053012		2006-08-30
IB2006054045		2006-11-01
PCT/IB2007/053472 WO2008026172A1 (en)	2006-08-30	2007-08-29	Spiro antibiotic derivatives

Publications (1)

Publication Number	Publication Date
ATE457314T1 true ATE457314T1 (de)	2010-02-15

Family

ID=38973769

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07826189T ATE457314T1 (de)	2006-08-30	2007-08-29	Antibiotische spiroderivate

Country Status (10)

Country	Link
US (1)	US7999115B2 (de)
EP (1)	EP2066678B1 (de)
JP (1)	JP2010502589A (de)
CN (1)	CN101511845B (de)
AT (1)	ATE457314T1 (de)
CA (1)	CA2659493A1 (de)
DE (1)	DE602007004740D1 (de)
ES (1)	ES2339507T3 (de)
TW (1)	TW200819457A (de)
WO (1)	WO2008026172A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0907892A2 (pt)	2008-02-20	2015-07-28	Actelion Pharmaceuticals Ltd	Composto antibiótico azatricíclico, medicamento, composição farmacêutica que o contém e uso do mesmo
WO2010015985A1 (en) *	2008-08-04	2010-02-11	Actelion Pharmaceuticals Ltd	Tricyclic alkylaminomethyloxazolidinone derivatives
JP4833385B1 (ja)	2008-10-07	2011-12-07	アクテリオンファーマシューティカルズリミテッド	三環式オキサゾリジノン抗生物質化合物
ES2395491T3 (es) *	2008-10-10	2013-02-13	Actelion Pharmaceuticals Ltd.	2-Benzotiofenil y 2-naftil-oxazolidinonas y sus análogos azaisósteros como agentes antibacterianos
JP5490809B2 (ja)	2008-10-10	2014-05-14	アクテリオンファーマシューティカルズリミテッド	オキサゾリジニル抗生物質
JP5685589B2 (ja) *	2010-05-25	2015-03-18	大正製薬株式会社	新規な複素環化合物又はその塩
TW201309689A (zh)	2011-02-07	2013-03-01	Daiichi Sankyo Co Ltd	含胺基之吡咯啶酮衍生物
US8927585B2 (en)	2011-06-17	2015-01-06	Glaxosmithkline Intellectual Property (No.2) Limited	TRPV4 antagonists
JO3154B1 (ar) *	2011-06-17	2017-09-20	Glaxosmithkline Llc	عوامل مضادة لـ trpv4
US9487507B2 (en) *	2011-06-17	2016-11-08	Glaxosmithkline Intellectual Property (No. 2) Limited	TRPV4 antagonists
TW201326180A (zh)	2011-11-30	2013-07-01	Actelion Pharmaceuticals Ltd	３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素
WO2014024056A1 (en)	2012-08-06	2014-02-13	Daiichi Sankyo Company, Limited	Pyrrolidine derivatives with antibacterial properties

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4244961A (en)	1978-10-26	1981-01-13	Syntex (U.S.A.) Inc.	1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
US4353901A (en)	1981-10-19	1982-10-12	Syntex (U.S.A.) Inc.	9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones
TW209870B (de)	1990-01-18	1993-07-21	Pfizer
AU698867B2 (en)	1995-04-21	1998-11-12	Shinnippon Pharmaceutical Inc.	Fused imidazo 1,2-a pyridines
WO2000040554A1 (en)	1999-01-07	2000-07-13	American Home Products Corporation	Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
GB9914486D0 (en)	1999-06-21	1999-08-18	Smithkline Beecham Plc	Medicaments
CN1452619A (zh)	2000-07-26	2003-10-29	史密斯克莱·比奇曼公司	具有抗细菌活性的氨基哌啶喹啉和它们的氮杂等排的类似物
GB0112834D0 (en)	2001-05-25	2001-07-18	Smithkline Beecham Plc	Medicaments
JP4445753B2 (ja) *	2002-01-29	2010-04-07	グラクソグループリミテッド	アミノピペリジン誘導体
BR0309546A (pt)	2002-04-26	2005-02-15	Hoffmann La Roche	Composto, composição farmacêutica que compreende o mesmo, processo para a sua preparação e utilização e método para tratamento profilático ou terapêutico de diabetes do tipo ii
AR040336A1 (es)	2002-06-26	2005-03-30	Glaxo Group Ltd	Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
GB0217294D0 (en)	2002-07-25	2002-09-04	Glaxo Group Ltd	Medicaments
AU2003268512A1 (en) *	2002-09-09	2004-03-29	Janssen Pharmaceutica N.V.	Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
JP4602903B2 (ja)	2002-10-10	2010-12-22	モルフォケムアクチェンゲゼルシャフトフュアコンビナトリシェヘミー	抗菌活性を有する新規化合物
DE10316081A1 (de)	2003-04-08	2004-10-21	Morphochem AG Aktiengesellschaft für kombinatorische Chemie	Neue Verbindungen mit antibakterieller Aktivität
US20080194547A1 (en) *	2004-07-09	2008-08-14	Glaxo Group Limited	Antibacterial Agents
DE102004041163A1 (de)	2004-08-25	2006-03-02	Morphochem Aktiengesellschaft für kombinatorische Chemie	Neue Verbindungen mit antibakterieller Aktivität
JP4887297B2 (ja) *	2004-09-24	2012-02-29	アクテリオンファーマシューティカルズリミテッド	新規二環式抗生物質
CA2581057A1 (en) *	2004-10-05	2006-04-13	Actelion Pharmaceuticals Ltd	New piperidine antibiotics
JP5314244B2 (ja)	2004-10-27	2013-10-16	富山化学工業株式会社	新規な含窒素複素環化合物およびその塩
WO2006081182A2 (en) *	2005-01-25	2006-08-03	Glaxo Group Limited	Antibacterial agents

2007
- 2007-08-28 TW TW096131944A patent/TW200819457A/zh unknown
- 2007-08-29 DE DE602007004740T patent/DE602007004740D1/de active Active
- 2007-08-29 ES ES07826189T patent/ES2339507T3/es active Active
- 2007-08-29 CN CN2007800321903A patent/CN101511845B/zh not_active Expired - Fee Related
- 2007-08-29 JP JP2009526247A patent/JP2010502589A/ja active Pending
- 2007-08-29 CA CA002659493A patent/CA2659493A1/en not_active Abandoned
- 2007-08-29 WO PCT/IB2007/053472 patent/WO2008026172A1/en not_active Ceased
- 2007-08-29 AT AT07826189T patent/ATE457314T1/de not_active IP Right Cessation
- 2007-08-29 US US12/439,571 patent/US7999115B2/en not_active Expired - Fee Related
- 2007-08-29 EP EP07826189A patent/EP2066678B1/de not_active Not-in-force

Also Published As

Publication number	Publication date
WO2008026172A1 (en)	2008-03-06
US7999115B2 (en)	2011-08-16
EP2066678B1 (de)	2010-02-10
CN101511845A (zh)	2009-08-19
JP2010502589A (ja)	2010-01-28
EP2066678A1 (de)	2009-06-10
ES2339507T3 (es)	2010-05-20
TW200819457A (en)	2008-05-01
CA2659493A1 (en)	2008-03-06
US20090270375A1 (en)	2009-10-29
DE602007004740D1 (de)	2010-03-25
CN101511845B (zh)	2012-01-04

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Legal Events

Date	Code	Title	Description
2010-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties