ATE457314T1 - Antibiotische spiroderivate - Google Patents
Antibiotische spiroderivateInfo
- Publication number
- ATE457314T1 ATE457314T1 AT07826189T AT07826189T ATE457314T1 AT E457314 T1 ATE457314 T1 AT E457314T1 AT 07826189 T AT07826189 T AT 07826189T AT 07826189 T AT07826189 T AT 07826189T AT E457314 T1 ATE457314 T1 AT E457314T1
- Authority
- AT
- Austria
- Prior art keywords
- ch2ch2
- compounds
- halogen
- spiroderivatives
- antibiotic
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2006053012 | 2006-08-30 | ||
| IB2006054045 | 2006-11-01 | ||
| PCT/IB2007/053472 WO2008026172A1 (en) | 2006-08-30 | 2007-08-29 | Spiro antibiotic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE457314T1 true ATE457314T1 (de) | 2010-02-15 |
Family
ID=38973769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07826189T ATE457314T1 (de) | 2006-08-30 | 2007-08-29 | Antibiotische spiroderivate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7999115B2 (de) |
| EP (1) | EP2066678B1 (de) |
| JP (1) | JP2010502589A (de) |
| CN (1) | CN101511845B (de) |
| AT (1) | ATE457314T1 (de) |
| CA (1) | CA2659493A1 (de) |
| DE (1) | DE602007004740D1 (de) |
| ES (1) | ES2339507T3 (de) |
| TW (1) | TW200819457A (de) |
| WO (1) | WO2008026172A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2411930T3 (es) | 2008-02-20 | 2013-07-09 | Actelion Pharmaceuticals Ltd. | Compuestos antibióticos azatricíclicos |
| CN102105467A (zh) * | 2008-08-04 | 2011-06-22 | 埃科特莱茵药品有限公司 | 三环烷氨基甲基噁唑烷酮衍生物 |
| DK2344495T3 (en) | 2008-10-07 | 2015-02-02 | Actelion Pharmaceuticals Ltd | TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS |
| ES2395491T3 (es) * | 2008-10-10 | 2013-02-13 | Actelion Pharmaceuticals Ltd. | 2-Benzotiofenil y 2-naftil-oxazolidinonas y sus análogos azaisósteros como agentes antibacterianos |
| RU2516701C2 (ru) | 2008-10-10 | 2014-05-20 | Актелион Фармасьютиклз Лтд | Оксазолидиниловые антибиотики |
| TW201209056A (en) * | 2010-05-25 | 2012-03-01 | Taisho Pharmaceutical Co Ltd | Novel heterocyclic compound or salt thereof |
| EP2674430A4 (de) | 2011-02-07 | 2014-07-02 | Daiichi Sankyo Co Ltd | Aminogruppenhaltige pyrrolidinonderivate |
| EP2720546B1 (de) * | 2011-06-17 | 2016-04-06 | Glaxosmithkline Intellectual Property (No. 2) Limited | Spirocyclische trpv4-antagonisten |
| US8927585B2 (en) | 2011-06-17 | 2015-01-06 | Glaxosmithkline Intellectual Property (No.2) Limited | TRPV4 antagonists |
| JO3154B1 (ar) * | 2011-06-17 | 2017-09-20 | Glaxosmithkline Llc | عوامل مضادة لـ trpv4 |
| TW201326180A (zh) | 2011-11-30 | 2013-07-01 | Actelion Pharmaceuticals Ltd | ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素 |
| WO2014024056A1 (en) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Pyrrolidine derivatives with antibacterial properties |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4244961A (en) | 1978-10-26 | 1981-01-13 | Syntex (U.S.A.) Inc. | 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents |
| US4353901A (en) | 1981-10-19 | 1982-10-12 | Syntex (U.S.A.) Inc. | 9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones |
| TW209870B (de) | 1990-01-18 | 1993-07-21 | Pfizer | |
| CN1064360C (zh) | 1995-04-21 | 2001-04-11 | 新日本药品株式会社 | 稠合咪唑并[1,2－a]吡啶类 |
| ES2219302T3 (es) | 1999-01-07 | 2004-12-01 | Wyeth | Derivados de arilpiperazinil-ciclohexilindol para el tratamiento de la depresion. |
| GB9914486D0 (en) | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
| EP1305308B1 (de) | 2000-07-26 | 2006-12-20 | Smithkline Beecham Plc | Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| US7312212B2 (en) * | 2002-01-29 | 2007-12-25 | Glaxo Group Limited | Aminopiperidine derivatives |
| EP1501815B1 (de) | 2002-04-26 | 2006-11-22 | F. Hoffmann-La Roche Ag | Substituierte phenylacetamide und deren verwendung als glucokinaseaktivatoren |
| AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| GB0217294D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicaments |
| JP4712384B2 (ja) | 2002-09-09 | 2011-06-29 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体 |
| EP1551829B1 (de) | 2002-10-10 | 2010-04-07 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Neue verbindungen mit antibakterieller aktivität |
| DE10316081A1 (de) | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| US20080194547A1 (en) * | 2004-07-09 | 2008-08-14 | Glaxo Group Limited | Antibacterial Agents |
| DE102004041163A1 (de) | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| JP4887297B2 (ja) | 2004-09-24 | 2012-02-29 | アクテリオン ファーマシューティカルズ リミテッド | 新規二環式抗生物質 |
| DE602005021133D1 (de) * | 2004-10-05 | 2010-06-17 | Actelion Pharmaceuticals Ltd | Neue piperidin-antibiotika |
| JP5314244B2 (ja) | 2004-10-27 | 2013-10-16 | 富山化学工業株式会社 | 新規な含窒素複素環化合物およびその塩 |
| WO2006081182A2 (en) * | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
-
2007
- 2007-08-28 TW TW096131944A patent/TW200819457A/zh unknown
- 2007-08-29 ES ES07826189T patent/ES2339507T3/es active Active
- 2007-08-29 EP EP07826189A patent/EP2066678B1/de not_active Not-in-force
- 2007-08-29 DE DE602007004740T patent/DE602007004740D1/de active Active
- 2007-08-29 CN CN2007800321903A patent/CN101511845B/zh not_active Expired - Fee Related
- 2007-08-29 WO PCT/IB2007/053472 patent/WO2008026172A1/en not_active Ceased
- 2007-08-29 CA CA002659493A patent/CA2659493A1/en not_active Abandoned
- 2007-08-29 AT AT07826189T patent/ATE457314T1/de not_active IP Right Cessation
- 2007-08-29 JP JP2009526247A patent/JP2010502589A/ja active Pending
- 2007-08-29 US US12/439,571 patent/US7999115B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008026172A1 (en) | 2008-03-06 |
| US20090270375A1 (en) | 2009-10-29 |
| EP2066678B1 (de) | 2010-02-10 |
| CN101511845B (zh) | 2012-01-04 |
| EP2066678A1 (de) | 2009-06-10 |
| TW200819457A (en) | 2008-05-01 |
| CN101511845A (zh) | 2009-08-19 |
| US7999115B2 (en) | 2011-08-16 |
| CA2659493A1 (en) | 2008-03-06 |
| ES2339507T3 (es) | 2010-05-20 |
| JP2010502589A (ja) | 2010-01-28 |
| DE602007004740D1 (de) | 2010-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |