ATE457994T1 - Verfahren zur aufreinigung von vancomycin - Google Patents

Verfahren zur aufreinigung von vancomycin

Info

Publication number: ATE457994T1
Authority: AT; Austria
Prior art keywords: macrolide antibiotics; purification; present; concerns; white powder
Prior art date: 2005-12-16

Application number

AT06841295T

Other languages

English (en)

Inventor

Tommaso Vincenzo De

Original Assignee

Axellia Pharmaceuticals Aps

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-16

Filing date

2006-12-07

Publication date

2010-03-15

2006-12-07 Application filed by Axellia Pharmaceuticals Aps filed Critical Axellia Pharmaceuticals Aps

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE457994T1 publication Critical patent/ATE457994T1/de

Links

238000000034 method Methods 0.000 title abstract 4
108010059993 Vancomycin Proteins 0.000 title abstract 2
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 title 1
229960003165 vancomycin Drugs 0.000 title 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 title 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 3
239000000843 powder Substances 0.000 abstract 3
238000000746 purification Methods 0.000 abstract 2
230000014759 maintenance of location Effects 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
238000000108 ultra-filtration Methods 0.000 abstract 1
229960001572 vancomycin hydrochloride Drugs 0.000 abstract 1
LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

AT06841295T 2005-12-16 2006-12-07 Verfahren zur aufreinigung von vancomycin ATE457994T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05112283A EP1798237A1 (de)	2005-12-16	2005-12-16	Prozess zur Reinigung von Makrolid-Antibiotika
PCT/EP2006/069414 WO2007068644A1 (en)	2005-12-16	2006-12-07	Process for the purification of macrolide antibiotics

Publications (1)

Publication Number	Publication Date
ATE457994T1 true ATE457994T1 (de)	2010-03-15

Family

ID=36177625

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06841295T ATE457994T1 (de)	2005-12-16	2006-12-07	Verfahren zur aufreinigung von vancomycin

Country Status (15)

Country	Link
US (1)	US8268963B2 (de)
EP (2)	EP1798237A1 (de)
JP (1)	JP5124475B2 (de)
CN (1)	CN101341167B (de)
AT (1)	ATE457994T1 (de)
AU (1)	AU2006326070B2 (de)
CA (1)	CA2628798C (de)
DE (1)	DE602006012360D1 (de)
DK (1)	DK1960418T3 (de)
ES (1)	ES2340804T3 (de)
NO (1)	NO20082935L (de)
PL (1)	PL1960418T3 (de)
PT (1)	PT1960418E (de)
RU (1)	RU2400489C2 (de)
WO (1)	WO2007068644A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101101663B1 (ko) *	2009-01-13	2011-12-30	(주) 제노텍	반코마이신 습체의 정제방법
ITLO20110001A1 (it)	2011-05-03	2012-11-04	Fisiopharma Srl	Flaconi di vancomicina cloroidrata con stabilità migliorata
EP2592090A1 (de) *	2011-11-11	2013-05-15	LEK Pharmaceuticals d.d.	Verfahren zur Reinigung von Teicoplanin

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2288473A1 (fr) *	1974-10-22	1976-05-21	Manche Union Coop Agr Laiti	Procede de traitement du lactoserum de fromagerie, notamment en vue de l'extraction de glycoproteides et d'acide sialique
US4667024A (en) *	1983-07-13	1987-05-19	Smithkline Beckman Corporation	Process for the preparation of purified vancomycin class antibiotics
IL73746A (en) *	1983-12-12	1988-07-31	Lilly Co Eli	Crystalline vancomycin diphosphate,its preparation,pharmaceutical compositions containing it and its conversion to vancomycin hydrochloride
JPH0260598A (ja) *	1988-08-22	1990-03-01	Glaxo Group Ltd	抗生物質の製造
JP2577133B2 (ja) *	1989-11-27	1997-01-29	スティフティングフォールドテフニスヘウェッテンスハッペン	船舶のプロペラ
US5258495A (en) *	1990-07-10	1993-11-02	Abbott Laboratories	Process for making vancomycin HC1
SI9500040B (sl) *	1995-02-07	2002-02-28	Lek,	Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC
SI9500039B (sl)	1995-02-07	2002-02-28	Lek,	Nov kombiniran postopek čiščenja Vankomicin hidroklorida
JPH10225299A (ja) *	1996-12-11	1998-08-25	Nippon Kayaku Co Ltd	バンコマイシンの製造方法
JP4142149B2 (ja)	1997-07-10	2008-08-27	明治製菓株式会社	バンコマイシンの凍結乾燥製剤
EP1025852A4 (de) *	1997-10-03	2001-11-07	Fujisawa Pharmaceutical Co	Hydrochloride von vancomycin-antibiotika sowie verfahren zu deren herstellung
CN1056377C (zh) *	1998-01-22	2000-09-13	清华大学	用环烷酸萃取体系提取和纯化抗生素
US6696412B1 (en) *	2000-01-20	2004-02-24	Cubist Pharmaceuticals, Inc.	High purity lipopeptides, Lipopeptide micelles and processes for preparing same
KR100870660B1 (ko) *	2001-12-31	2008-11-26	엘지디스플레이 주식회사	패널의 합착력이 향상된 액정표시소자 및 제조방법
KR100476818B1 (ko) *	2002-07-19	2005-03-17	종근당바이오 주식회사	테이코플라닌 에이 투 정제 방법
CN1301331C (zh) *	2003-12-26	2007-02-21	三达膜科技（厦门）有限公司	应用膜提取发酵类大环内酯型抗生素的方法
KR100474653B1 (ko) *	2004-04-16	2005-03-14	동국제약 주식회사	타이코플라닌의 고순도 생산방법
SI21924A (sl)	2004-12-07	2006-06-30	Lek Farmacevtska Druzba D.D.	Cist vankomicin hidroklorid

2005
- 2005-12-16 EP EP05112283A patent/EP1798237A1/de not_active Withdrawn
2006
- 2006-12-07 JP JP2008544968A patent/JP5124475B2/ja active Active
- 2006-12-07 ES ES06841295T patent/ES2340804T3/es active Active
- 2006-12-07 WO PCT/EP2006/069414 patent/WO2007068644A1/en not_active Ceased
- 2006-12-07 PL PL06841295T patent/PL1960418T3/pl unknown
- 2006-12-07 US US12/095,642 patent/US8268963B2/en active Active
- 2006-12-07 DE DE602006012360T patent/DE602006012360D1/de active Active
- 2006-12-07 DK DK06841295.6T patent/DK1960418T3/da active
- 2006-12-07 AU AU2006326070A patent/AU2006326070B2/en not_active Ceased
- 2006-12-07 CA CA2628798A patent/CA2628798C/en not_active Expired - Fee Related
- 2006-12-07 RU RU2008128465/04A patent/RU2400489C2/ru not_active IP Right Cessation
- 2006-12-07 EP EP06841295A patent/EP1960418B1/de active Active
- 2006-12-07 PT PT06841295T patent/PT1960418E/pt unknown
- 2006-12-07 CN CN200680045911XA patent/CN101341167B/zh not_active Expired - Fee Related
- 2006-12-07 AT AT06841295T patent/ATE457994T1/de active
2008
- 2008-06-30 NO NO20082935A patent/NO20082935L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE602006012360D1 (de)	2010-04-01
US20100228005A1 (en)	2010-09-09
AU2006326070A1 (en)	2007-06-21
PT1960418E (pt)	2010-05-05
WO2007068644A1 (en)	2007-06-21
RU2008128465A (ru)	2010-01-27
CA2628798C (en)	2014-08-05
ES2340804T3 (es)	2010-06-09
EP1960418A1 (de)	2008-08-27
NO20082935L (no)	2008-06-30
US8268963B2 (en)	2012-09-18
CA2628798A1 (en)	2007-06-21
RU2400489C2 (ru)	2010-09-27
CN101341167A (zh)	2009-01-07
PL1960418T3 (pl)	2010-07-30
EP1960418B1 (de)	2010-02-17
DK1960418T3 (da)	2010-05-31
CN101341167B (zh)	2012-08-15
JP2009519294A (ja)	2009-05-14
AU2006326070B2 (en)	2011-08-25
JP5124475B2 (ja)	2013-01-23
EP1798237A1 (de)	2007-06-20

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