ATE458022T1 - Koordinationskomplex von diaminocyclohexanplatin(ii) mit einem blockcopolymer mit einem poly(carbonsäure)segment und diesen enthaltendes antitumormittel - Google Patents

Koordinationskomplex von diaminocyclohexanplatin(ii) mit einem blockcopolymer mit einem poly(carbonsäure)segment und diesen enthaltendes antitumormittel

Info

Publication number
ATE458022T1
ATE458022T1 AT04807038T AT04807038T ATE458022T1 AT E458022 T1 ATE458022 T1 AT E458022T1 AT 04807038 T AT04807038 T AT 04807038T AT 04807038 T AT04807038 T AT 04807038T AT E458022 T1 ATE458022 T1 AT E458022T1
Authority
AT
Austria
Prior art keywords
poly
segment
block copolymer
carbonic acid
agent containing
Prior art date
Application number
AT04807038T
Other languages
English (en)
Inventor
Kazunori Kataoka
Nobuhiro Nishiyama
Horacio Cabral
Soichiro Okazaki
Original Assignee
Toudai Tlo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toudai Tlo Ltd filed Critical Toudai Tlo Ltd
Application granted granted Critical
Publication of ATE458022T1 publication Critical patent/ATE458022T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G85/00—General processes for preparing compounds provided for in this subclass
    • C08G85/002—Post-polymerisation treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/10—Metal compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04807038T 2003-12-10 2004-12-08 Koordinationskomplex von diaminocyclohexanplatin(ii) mit einem blockcopolymer mit einem poly(carbonsäure)segment und diesen enthaltendes antitumormittel ATE458022T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003412315 2003-12-10
PCT/JP2004/018679 WO2005056641A1 (ja) 2003-12-10 2004-12-08 ジアミノシクロヘキサン白金(ii)とポリ(カルボン酸)セグメント含有ブロック共重合体との配位錯体、その抗腫瘍剤

Publications (1)

Publication Number Publication Date
ATE458022T1 true ATE458022T1 (de) 2010-03-15

Family

ID=34675022

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04807038T ATE458022T1 (de) 2003-12-10 2004-12-08 Koordinationskomplex von diaminocyclohexanplatin(ii) mit einem blockcopolymer mit einem poly(carbonsäure)segment und diesen enthaltendes antitumormittel

Country Status (17)

Country Link
US (1) US8012463B2 (de)
EP (1) EP1695991B1 (de)
JP (1) JP3955992B2 (de)
KR (1) KR100982933B1 (de)
CN (1) CN100457185C (de)
AT (1) ATE458022T1 (de)
AU (1) AU2004297126B2 (de)
CA (1) CA2548457C (de)
CY (1) CY1110233T1 (de)
DE (1) DE602004025612D1 (de)
DK (1) DK1695991T3 (de)
ES (1) ES2337904T3 (de)
PL (1) PL1695991T3 (de)
PT (1) PT1695991E (de)
RU (1) RU2335512C2 (de)
SI (1) SI1695991T1 (de)
WO (1) WO2005056641A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005079861A2 (en) * 2004-02-13 2005-09-01 Safeway Investments Ltd. Polymeric water soluble prodrugs
EP1867673B1 (de) * 2005-03-18 2011-11-16 The University of Tokyo Koordinationsverbindung aus diaminocyclohexan-platin(ii) und blockcopolymer und diese enthaltendes antikrebsmittel
JP4992090B2 (ja) * 2005-05-02 2012-08-08 国立大学法人 東京大学 静電結合型高分子ベシクル
BRPI0609095A2 (pt) * 2005-05-11 2010-02-17 Nippon Kayaku Kk derivado polimérico de antagonista metabólico de citidina, agente antitumor e antiviral e método para produzir o referido derivado
AU2006255938B2 (en) * 2005-06-09 2011-05-12 Nanocarrier Co., Ltd. Process for production of polymerized coordination compound of platinum complex
BRPI0619436A2 (pt) 2005-12-05 2011-10-04 Nitto Denko Corp métodos e conjugados de aminoácido-poliglutamato
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
WO2008120690A1 (ja) * 2007-03-29 2008-10-09 Osaka University 光学活性有機酸架橋二核白金（ｉｉ）錯体
EP2144631A2 (de) * 2007-04-10 2010-01-20 Nitto Denko Corporation Multifunktionale polyglutamat-wirkstoffträger
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
KR20100017540A (ko) 2007-05-09 2010-02-16 닛토덴코 가부시키가이샤 소수성 화합물 및 폴리아미노산 콘쥬게이트를 포함하는 조성물
JPWO2009096245A1 (ja) * 2008-01-28 2011-05-26 ナノキャリア株式会社 医薬組成物又は組合せ剤
EP2262537A1 (de) * 2008-03-06 2010-12-22 Nitto Denko Corporation Polymer-paclitaxel-konjugate und verfahren zur behandlung von krebs
US20090232762A1 (en) * 2008-03-11 2009-09-17 May Pang Xiong Compositions for delivery of therapeutic agents
EP2308916B1 (de) * 2008-06-26 2016-11-09 Japan Science and Technology Agency Polymer/metallkomplex-verbundwerkstoff mit mrt-kontrastvermögen und mri-kontrastierungs- und/oder antitumorzusammensetzung unter verwendung davon
JP2011105792A (ja) * 2009-11-12 2011-06-02 Japan Science & Technology Agency ブロックコポリマー、ブロックコポリマー−金属錯体複合体、及びそれを用いた中空構造体キャリア
CN102091025B (zh) * 2009-12-14 2012-07-11 中国科学院化学研究所 抗肿瘤可注射水凝胶及其制备方法和用途
JP5594730B2 (ja) * 2010-11-02 2014-09-24 学校法人東京理科大学 金属高分子錯体からなるミセルの分散液
JP5086497B1 (ja) * 2011-03-31 2012-11-28 ナノキャリア株式会社 ボロン酸化合物を含有したブロック共重合体を含む医薬組成物
US8785569B2 (en) 2011-11-22 2014-07-22 Original Biomedicals Co., Ltd. Drug carrier with chelating complex micelles and the application thereof
TWI568453B (zh) * 2011-11-22 2017-02-01 原創生醫股份有限公司 具有螯合型複合微胞之藥物載體及其應用
CN105997878B (zh) * 2012-11-22 2019-03-22 原创生医股份有限公司 降低自由基伤害的复合微胞载体医药组成物
EP2740737B1 (de) * 2012-12-05 2015-09-16 Heraeus Deutschland GmbH & Co. KG 1,2-Cyclohexandiaminplatin(II) bis-(4-methylbenzolsulfonat) und dessen Hydrate
CN103394095B (zh) * 2013-08-19 2016-03-23 中国科学院长春应用化学研究所 二氯-1,2-环己二胺合铂配合物及其制备方法
EP3315487B1 (de) 2015-06-24 2020-10-28 Nippon Kayaku Kabushiki Kaisha Neuartiger platin-(iv)-komplex
EP3351580B1 (de) * 2015-09-14 2021-02-24 Nippon Kayaku Kabushiki Kaisha Polymerkonjugat aus hexa-koordiniertem platinkomplex
US10946028B2 (en) 2015-12-22 2021-03-16 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of sulfoxide derivative-coordinated platinum(II) complex
JP7281140B2 (ja) * 2019-04-15 2023-05-25 日油株式会社 生体関連物質とブロックポリマーとの結合体、および前記結合体を得るためのブロックポリマー誘導体
WO2022120147A1 (en) * 2020-12-04 2022-06-09 The Methodist Hospital System Amino acid polymer-platinum anticancer drug conjugates
CN113929898B (zh) * 2021-10-09 2023-03-24 苏州大学 一种金属基纳米聚合物及其制备方法与应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115418A (en) 1976-09-02 1978-09-19 Government Of The United States Of America 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
JPS5829957B2 (ja) 1977-09-12 1983-06-25 喜徳 喜谷 新規な白金錯体
GR75598B (de) * 1980-04-29 1984-08-01 Sanofi Sa
US4485093A (en) 1982-08-13 1984-11-27 Runge Richard G Immunotoxin conjugate which comprises arsanilic acid, useful for treating malignant tumors, particularly pancreatic cancer
IN165717B (de) 1986-08-07 1989-12-23 Battelle Memorial Institute
DK252688A (da) * 1987-05-08 1988-11-09 Sankyo Co Antitumorplatinkomplekser, fremgangsmaade til fremstilling deraf, samt deres terapeutiske anvendelse
RU2007413C1 (ru) * 1988-05-06 1994-02-15 Санкио Компани Лимитед Способ получения противоопухолевого комплекса платины
US4931553A (en) 1988-05-11 1990-06-05 Gill Devinder S Platinum-polymer complexes and their use as antitumor agents
JP2517760B2 (ja) 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
JPH05301884A (ja) * 1992-04-22 1993-11-16 Tanaka Kikinzoku Kogyo Kk 白金錯化合物の製造方法
JP3044512B2 (ja) * 1993-03-15 2000-05-22 デビオファーム エス．アー． 白金錯体の製造方法
JP3025602B2 (ja) * 1993-05-21 2000-03-27 デビオファーム エス．アー． 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法
CN1039588C (zh) * 1995-03-29 1998-08-26 邹娟 新的抗肿瘤铂络合物
US6153646A (en) 1996-03-11 2000-11-28 Yoshinori Kidani Binuclear platinum complexes, method for preparing same and pharmaceutical compositions containing said complexes
GB9804013D0 (en) * 1998-02-25 1998-04-22 Sanofi Sa Formulations
JP5096657B2 (ja) * 2000-08-11 2012-12-12 大日本住友製薬株式会社 シスプラチン耐性癌治療剤
KR100363394B1 (ko) * 2000-08-21 2002-12-05 한국과학기술연구원 온도감응성을 갖는 포스파젠삼량체-백금착물 복합체, 그의제조방법 및 그를 함유하는 항암제 조성물
ES2263659T3 (es) * 2000-09-26 2006-12-16 Toudai Tlo, Ltd. Micela polimerica que contiene cisplatino dentro de ella, y su uso.
US20030109432A1 (en) * 2001-12-10 2003-06-12 Zuo William W. Anticancer polypeptide-metal complexes and compositions, methods of making, and methods of using same

Also Published As

Publication number Publication date
CN1890295A (zh) 2007-01-03
CA2548457C (en) 2010-08-24
DK1695991T3 (da) 2010-04-19
JPWO2005056641A1 (ja) 2007-07-05
PT1695991E (pt) 2010-03-02
CY1110233T1 (el) 2015-01-14
RU2335512C2 (ru) 2008-10-10
WO2005056641A1 (ja) 2005-06-23
EP1695991A1 (de) 2006-08-30
PL1695991T3 (pl) 2010-05-31
US20070148125A1 (en) 2007-06-28
CA2548457A1 (en) 2005-06-23
US8012463B2 (en) 2011-09-06
CN100457185C (zh) 2009-02-04
DE602004025612D1 (de) 2010-04-01
KR20060123299A (ko) 2006-12-01
AU2004297126B2 (en) 2010-11-25
RU2006124552A (ru) 2008-01-20
SI1695991T1 (sl) 2010-04-30
ES2337904T3 (es) 2010-04-30
EP1695991A4 (de) 2009-06-24
EP1695991B1 (de) 2010-02-17
AU2004297126A1 (en) 2005-06-23
KR100982933B1 (ko) 2010-09-17
JP3955992B2 (ja) 2007-08-08

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