ATE458475T1 - Getrocknetes, gemahlenes granulat und verfahren - Google Patents

Getrocknetes, gemahlenes granulat und verfahren

Info

Publication number
ATE458475T1
ATE458475T1 AT06813925T AT06813925T ATE458475T1 AT E458475 T1 ATE458475 T1 AT E458475T1 AT 06813925 T AT06813925 T AT 06813925T AT 06813925 T AT06813925 T AT 06813925T AT E458475 T1 ATE458475 T1 AT E458475T1
Authority
AT
Austria
Prior art keywords
dried ground
ground granules
particle size
granulate
granules
Prior art date
Application number
AT06813925T
Other languages
English (en)
Inventor
Sara Chastain
Walid Habib
Derek Moe
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Application granted granted Critical
Publication of ATE458475T1 publication Critical patent/ATE458475T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Processing Of Solid Wastes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
AT06813925T 2005-08-30 2006-08-29 Getrocknetes, gemahlenes granulat und verfahren ATE458475T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71258005P 2005-08-30 2005-08-30
US11/507,240 US20070048373A1 (en) 2005-08-30 2006-08-21 Dried milled granulate and methods
PCT/US2006/033779 WO2007027720A2 (en) 2005-08-30 2006-08-29 Dried milled granulate and methods

Publications (1)

Publication Number Publication Date
ATE458475T1 true ATE458475T1 (de) 2010-03-15

Family

ID=37804492

Family Applications (2)

Application Number Title Priority Date Filing Date
AT10001313T ATE539739T1 (de) 2005-08-30 2006-08-29 Getrocknetes, gemahlenes granulat und verfahren
AT06813925T ATE458475T1 (de) 2005-08-30 2006-08-29 Getrocknetes, gemahlenes granulat und verfahren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT10001313T ATE539739T1 (de) 2005-08-30 2006-08-29 Getrocknetes, gemahlenes granulat und verfahren

Country Status (11)

Country Link
US (1) US20070048373A1 (de)
EP (3) EP2359811B1 (de)
JP (1) JP5144519B2 (de)
AT (2) ATE539739T1 (de)
CA (1) CA2621079C (de)
DE (1) DE602006012503D1 (de)
DK (1) DK2198855T3 (de)
ES (3) ES2398637T3 (de)
MX (1) MX2008002779A (de)
PT (1) PT2198855E (de)
WO (1) WO2007027720A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
CN103040773A (zh) * 2003-07-25 2013-04-17 沃纳奇尔科特有限责任公司 多西环素金属络合物固体剂型
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US7444197B2 (en) 2004-05-06 2008-10-28 Smp Logic Systems Llc Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US7883039B2 (en) * 2007-02-27 2011-02-08 Collette Nv Continuous granulating and drying apparatus including measurement units
US8173169B2 (en) * 2007-07-11 2012-05-08 Hikma Pharmaceuticals Formulation and process for the preparation of modafinil
CN102639118B (zh) 2009-07-22 2015-07-29 格吕伦塔尔有限公司 氧化稳定的抗干扰剂型
CN102958515A (zh) * 2009-12-02 2013-03-06 阿普塔利斯制药有限公司 非索非那定微胶囊及含有非索非那定微胶囊的组合物
TR201000688A2 (tr) * 2010-01-29 2011-08-22 B�Lg�� Mahmut Aktif madde olarak sefaklor ve klavulanik asit içeren efervesan formülasyonlar.
FR2959130A1 (fr) * 2010-04-21 2011-10-28 Sanofi Aventis Procede de preparation de compositions pharmaceutiques destinees a l'administration par voie orale comprenant un ou plusieurs principes actifs et les compositions les comprenant.
JP6133009B2 (ja) * 2010-08-11 2017-05-24 協和発酵キリン株式会社 トピラマート顆粒
BR112013005194A2 (pt) 2010-09-02 2016-05-03 Gruenenthal Gmbh forma de dosagem resistente à violação compreendendo sal inorgânico
TR201009396A2 (tr) * 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Desloratadin granüller
KR101380836B1 (ko) * 2011-01-18 2014-04-09 한국기계연구원 상온진공과립분사 공정을 위한 취성재료 과립 및 이를 이용한 코팅층의 형성방법
JP5830412B2 (ja) * 2011-03-02 2015-12-09 ライオン株式会社 水難溶性薬物と賦形剤との粉砕物の製造方法、造粒粒子の製造方法、錠剤の製造方法
BR112014001091A2 (pt) 2011-07-29 2017-02-14 Gruenenthal Gmbh comprimido resistente à adulteração que fornece liberação imediata do fármaco
EA201400172A1 (ru) 2011-07-29 2014-06-30 Грюненталь Гмбх Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
EP2838512B1 (de) 2012-04-18 2018-08-22 Grünenthal GmbH Fälschungssichere und dose dumping sichere pharmazeutische darreichungsform
WO2014207769A1 (en) 2013-06-27 2014-12-31 Mylan Laboratories Ltd Process for the preparation of nepafenac
BR112016000194A8 (pt) 2013-07-12 2019-12-31 Gruenenthal Gmbh forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila
EP3073994A1 (de) * 2013-11-26 2016-10-05 Grünenthal GmbH Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels kryogenen mahlens
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
MX377527B (es) * 2015-10-27 2025-03-10 Shinetsu Chemical Co Éter de celulosa porosa no iónico soluble en agua que tiene excelente solubilidad y método para producir el mismo.
US20220362191A1 (en) * 2021-05-12 2022-11-17 Spectrix Therapeutics, LLC Compositions and methods
WO2024167932A1 (en) * 2023-02-06 2024-08-15 Novatec, Inc. Systems and processes for determining drying times for granulate materials based on initial moisture content of the materials

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
IL92343A0 (en) * 1988-12-20 1990-07-26 Gist Brocades Nv Granulate for multiparticulate controlled release oral compositions,their preparation and oral pharmaceutical compositions containing them
US5178878A (en) * 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
WO1994007467A1 (en) * 1992-09-30 1994-04-14 Ascent Pharmaceuticals, Inc. Calcium polycarbophil sprinkle
US5503846A (en) * 1993-03-17 1996-04-02 Cima Labs, Inc. Base coated acid particles and effervescent formulation incorporating same
US6077533A (en) * 1994-05-25 2000-06-20 Purdue Pharma L.P. Powder-layered oral dosage forms
US6039275A (en) * 1996-07-04 2000-03-21 Holland Sweetener Company V.O.F. Aspartame powders for powder mixtures
PT1015352E (pt) * 1997-04-01 2007-09-24 Cima Labs Inc ''embalagem alveolar e comprimidos embalados''
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
JPH1121236A (ja) * 1997-07-01 1999-01-26 Ohara Yakuhin Kogyo Kk ロキソプロフェン・ナトリウム固形製剤
US6387410B1 (en) * 1998-09-10 2002-05-14 Norton Healthcare Ltd Anti-inflammatory pharmaceutical formulations
US6740341B1 (en) * 1998-11-25 2004-05-25 Cima Labs Inc. Taste masking rapid release coating system
DE19859636A1 (de) * 1998-12-23 2000-06-29 Hexal Ag Kontrolliert freisetzende pharmazeutische Zusammensetzung mit Tilidinmesylat als Wirkstoff
EP1207860B1 (de) * 1999-09-02 2007-10-24 Nostrum Pharmaceuticals, Inc. Pellet formulierung mit gesteuerter freisetzung
US7297346B2 (en) * 2001-05-25 2007-11-20 Cephalon Inc. Pharmaceutical formulations of modafinil
US7323192B2 (en) * 2001-09-28 2008-01-29 Mcneil-Ppc, Inc. Immediate release tablet
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
US6827946B2 (en) * 2001-12-05 2004-12-07 Collegium Pharmaceutical, Inc. Compositions containing both sedative and non-sedative antihistamines
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
US7207505B2 (en) * 2004-06-04 2007-04-24 Bender Martin P Method for producing small granules

Also Published As

Publication number Publication date
US20070048373A1 (en) 2007-03-01
CA2621079A1 (en) 2007-03-08
ATE539739T1 (de) 2012-01-15
HK1111622A1 (en) 2008-08-15
HK1145146A1 (en) 2011-04-08
MX2008002779A (es) 2008-04-07
EP1919454B1 (de) 2010-02-24
JP5144519B2 (ja) 2013-02-13
HK1160010A1 (en) 2012-08-10
EP2198855B1 (de) 2012-01-04
EP2198855A1 (de) 2010-06-23
CA2621079C (en) 2014-02-18
DE602006012503D1 (de) 2010-04-08
EP1919454A2 (de) 2008-05-14
WO2007027720A3 (en) 2007-08-02
EP2359811A1 (de) 2011-08-24
ES2379333T3 (es) 2012-04-25
ES2339979T3 (es) 2010-05-27
ES2398637T3 (es) 2013-03-20
JP2009505798A (ja) 2009-02-12
WO2007027720A2 (en) 2007-03-08
DK2198855T3 (da) 2012-04-02
EP2359811B1 (de) 2012-11-14
PT2198855E (pt) 2012-03-19

Similar Documents

Publication Publication Date Title
ATE539739T1 (de) Getrocknetes, gemahlenes granulat und verfahren
EP1608359A4 (de) Mit arzneimittel beladene teilchen mit tumor-target
DK1896006T3 (da) Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet
FI20070521A0 (fi) Rakeita, tabletteja ja rakeistusmenetelmä
AP2344A (en) N-Thio-anthranilamid compounds and their use as pesticides.
EP1599430A4 (de) Granulatförmiger dünger
EP1930713A4 (de) Feinpartikelzählgerät
IL188177A0 (en) Novel granulation process and granulate produced therefrom
DK1523329T3 (da) Viruspartikeladjuvant
DE602006012866D1 (de) Vorrichtung zum zuführen von pulver und granulat
EP1953177A4 (de) Methacrylharz und herstellungsverfahren dafür
ATE540910T1 (de) Düngergranulat und verfahren zu seiner herstellung
NL1031392A1 (nl) Granulair vast wasdeeltje.
DE602006006255D1 (de) Reifenlauffläche enthaltend Kern-Hülle-Teilchen
DE602005014972D1 (de) Teilchen
WO2007038407A3 (en) Compositions and methods for treating nervous system disorders
DE602006009327D1 (de) Verfahren zur Optimierung und Einstellung des Streuens, zugehörige Streuer und Computerprogramm
DE602006002898D1 (de) Verfahren zur Optimierung und Einstellung des Streuens, zugehörige Streuer und Computerprogramm
GB0322688D0 (en) Mouse trap
BRPI0613947A2 (pt) conjunto, e, pneumático
FI20050322A0 (fi) Lannoitepartikkelituote, sen valmistus ja käyttö
DE602004004979D1 (de) Pestizidpartikel
Vonnegut So it goes
NL1032717A1 (nl) Wegbermbekleding.
GB0513855D0 (en) Wet granulation process

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties