DK1896006T3 - Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet - Google Patents

Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet

Info

Publication number: DK1896006T3
Authority: DK; Denmark
Prior art keywords: entacapone; preparation; dosage form; oral dosage; containing granules
Prior art date: 2005-06-08

Application number

DK06755404T

Other languages

English (en)

Inventor

Kari Vahervuo

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-08

Filing date

2006-06-07

Publication date

2009-12-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37400847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1896006(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-07 Application filed by Orion Corp filed Critical Orion Corp

2009-12-07 Application granted granted Critical

2009-12-07 Publication of DK1896006T3 publication Critical patent/DK1896006T3/da

Links

JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 title abstract 2
229960003337 entacapone Drugs 0.000 title abstract 2
239000006186 oral dosage form Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000008187 granular material Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK06755404T 2005-06-08 2006-06-07 Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet DK1896006T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68833405P	2005-06-08	2005-06-08
PCT/FI2006/000182 WO2006131591A2 (en)	2005-06-08	2006-06-07	An entacapone-containing oral dosage form

Publications (1)

Publication Number	Publication Date
DK1896006T3 true DK1896006T3 (da)	2009-12-07

Family

ID=37400847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06755404T DK1896006T3 (da)	2005-06-08	2006-06-07	Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet

Country Status (19)

Country	Link
US (3)	US20080187590A1 (da)
EP (5)	EP1896006B1 (da)
JP (2)	JP5336181B2 (da)
KR (2)	KR101617990B1 (da)
CN (1)	CN101184483B (da)
AT (1)	ATE444746T1 (da)
AU (1)	AU2006256724B2 (da)
CA (1)	CA2611114C (da)
CY (1)	CY1109587T1 (da)
DE (1)	DE602006009652D1 (da)
DK (1)	DK1896006T3 (da)
EA (1)	EA013161B1 (da)
ES (1)	ES2311442T3 (da)
MX (1)	MX2007015377A (da)
NO (1)	NO345046B1 (da)
PL (1)	PL1896006T3 (da)
PT (2)	PT2050447T (da)
SI (1)	SI1896006T1 (da)
WO (1)	WO2006131591A2 (da)

Families Citing this family (32)

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GB2429645A (en) *	2006-03-10	2007-03-07	Sekhsaria Chemicals Ltd	Solid pharmaceutical composition comprising a COMT inhibitor, a starch and a wetting agent
EP2114374A4 (en) *	2006-12-27	2011-03-23	Wockhardt Research Center	PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE
EP1946756A1 (en) *	2007-01-17	2008-07-23	Revotar Biopharmaceuticals AG	Use of entacapone in cosmetic, dermatological and pharmaceutical compositions
AU2009211028B2 (en)	2008-02-06	2013-12-05	Wockhardt Research Centre	Pharmaceutical compositions of entacapone, levodopa and carbidopa with improved bioavailability
ATE534382T1 (de) *	2008-02-06	2011-12-15	Wockhardt Ltd	Pharmazeutische zusammensetzungen von mit zuckeralkoholen zusammen mikronisiertem entacapon
BRPI0916922A2 (pt) *	2008-08-22	2015-11-24	Wockhardt Research Center	composição farmacêutica de liberação prolongada de entacapona ou sais da mesma
TR200806646A2 (tr) *	2008-09-03	2009-06-22	Dr. F. Fri̇k İlaç San. Ve Ti̇c. A.Ş.	Entakapon, levodopa ve karbidoba içeren farmasötik kombinasyonlar
KR101868326B1 (ko)	2010-03-04	2018-06-19	오리온 코포레이션	파킨슨병의 치료를 위한 레보도파, 카르비도파 및 엔타카폰의 용도
DE102010023828A1 (de) *	2010-06-15	2011-12-15	IIP - Institut für industrielle Pharmazie, Forschungs- und Entwicklungsgesellschaft mbH	Pharmazeutisches Präparat, welches Entacapon, Levodopa und Carbidopa enthält
US8263119B2 (en) *	2010-12-01	2012-09-11	Shire Llc	Capsule formulations containing lanthanum compounds
EP2702991A4 (en) *	2011-04-26	2015-02-18	Innopharmax Inc	COMPOSITION OF ENTACOPONE
CN103845318A (zh) *	2012-12-07	2014-06-11	天津市汉康医药生物技术有限公司	恩他卡朋分散片
RU2677278C2 (ru) *	2013-03-13	2019-01-16	Неуродерм Лтд	Способ лечения болезни паркинсона
IL299897B2 (en) *	2013-08-19	2024-02-01	Taris Biomedical Llc	Devices and methods for administering multiple units of drug
US10258585B2 (en)	2014-03-13	2019-04-16	Neuroderm, Ltd.	DOPA decarboxylase inhibitor compositions
EP3116475B1 (en)	2014-03-13	2020-11-04	Neuroderm Ltd	Dopa decarboxylase inhibitor compositions
WO2016083863A1 (en)	2014-11-28	2016-06-02	Bial - Portela & Ca, S.A.	Medicaments for slowing parkinson's disease
JP6411265B2 (ja) *	2015-03-30	2018-10-24	共和薬品工業株式会社	エンタカポン含有医薬組成物
RU2017134106A (ru) *	2015-05-08	2019-04-05	Вокхардт Лимитед	Стабильные фармацевтические композиции, включающие антибактериальный реагент
CN107921042A (zh) *	2015-08-20	2018-04-17	东生华制药股份有限公司	包含氨氯地平和右美沙芬的药物组合物
EP3275433A1 (en) *	2016-07-29	2018-01-31	Som Innovation Biotech S.L.	Sustained release composition comprising micronized tolcapone
EP3500246B1 (en) *	2016-08-18	2021-08-04	Ilko Ilaç Sanayi Ve Ticaret Anonim Sirketi	Antiparkinson tablet formulation with improved dissolution profile
CN106236720A (zh) *	2016-08-29	2016-12-21	海南通用康力制药有限公司	一种恩他卡朋的药物组合物及其制备方法
TWI595871B (zh) *	2016-09-22	2017-08-21	生達化學製藥股份有限公司	含有兒茶酚－ｏ－甲基轉移酶抑制劑之口服醫藥組成物及其製造方法
JP6735007B2 (ja) *	2018-09-26	2020-08-05	共和薬品工業株式会社	エンタカポン含有医薬組成物
CN120478288A (zh) *	2020-03-13	2025-08-15	巴尔-波特拉及康邦亚股份有限公司	微粉化的奥匹卡朋
US11213502B1 (en)	2020-11-17	2022-01-04	Neuroderm, Ltd.	Method for treatment of parkinson's disease
US11331293B1 (en)	2020-11-17	2022-05-17	Neuroderm, Ltd.	Method for treatment of Parkinson's disease
US11844754B2 (en)	2020-11-17	2023-12-19	Neuroderm, Ltd.	Methods for treatment of Parkinson's disease
US20240300930A1 (en) *	2021-02-26	2024-09-12	Msn Laboratories Private Limited, R&D Center	Novel process for the preparation of 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine-1-oxide
CN113274362A (zh) *	2021-03-31	2021-08-20	海南通用康力制药有限公司	恩他卡朋片的生产方法
US12161612B2 (en)	2023-04-14	2024-12-10	Neuroderm, Ltd.	Methods and compositions for reducing symptoms of Parkinson's disease

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GB2238047B (en)	1989-11-03	1993-02-10	Orion Yhtymae Oy	Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
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US6599530B2 (en) *	1998-09-14	2003-07-29	Orion Corporation	Oral compacted composition comprising catechol derivatives
US20080118556A1 (en) *	1998-11-02	2008-05-22	Elan Corporation, Plc	Modified Release of Compositions Containing a Combination of Carbidopa, Levodopa and Entacapone
US7374779B2 (en) *	1999-02-26	2008-05-20	Lipocine, Inc.	Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
FI109453B (fi) *	1999-06-30	2002-08-15	Orion Yhtymae Oyj	Farmaseuttinen koostumus
BR0307331A (pt) *	2002-02-01	2004-12-07	Pfizer Prod Inc	Formulações granuladas a seco de azitromicina
US20040166159A1 (en) *	2002-05-29	2004-08-26	Chien-Hsuan Han	Pharmaceutical dosage forms having immediate and controlled release properties that contain an aromatic amino acid decarboxylase inhibitor and levodopa
EP1713768A2 (de)	2003-12-31	2006-10-25	Cilag AG	Neue kristalline formen von entacapone und deren herstellung
US20060222703A1 (en) *	2005-04-01	2006-10-05	Iprbox Oy	Pharmaceutical composition and preparation method thereof
EP1970055B1 (en) *	2005-12-29	2010-11-24	Osmotica Kereskedelmi És Szolgáltató Kft	Multi-layered tablet with triple release combination
US20090155369A1 (en) *	2007-12-13	2009-06-18	Laboratorios Lesvi, S.L.	Pharmaceutical composition containing levodopa, entacapone and carbidopa

2006
- 2006-06-07 AT AT06755404T patent/ATE444746T1/de active
- 2006-06-07 EA EA200702616A patent/EA013161B1/ru not_active IP Right Cessation
- 2006-06-07 ES ES06755404T patent/ES2311442T3/es active Active
- 2006-06-07 WO PCT/FI2006/000182 patent/WO2006131591A2/en not_active Ceased
- 2006-06-07 EP EP06755404A patent/EP1896006B1/en not_active Revoked
- 2006-06-07 EP EP10011644A patent/EP2335696A1/en not_active Withdrawn
- 2006-06-07 JP JP2008515235A patent/JP5336181B2/ja active Active
- 2006-06-07 EP EP10011645A patent/EP2316448A1/en not_active Withdrawn
- 2006-06-07 AU AU2006256724A patent/AU2006256724B2/en active Active
- 2006-06-07 CN CN2006800187628A patent/CN101184483B/zh not_active Ceased
- 2006-06-07 DE DE602006009652T patent/DE602006009652D1/de active Active
- 2006-06-07 DK DK06755404T patent/DK1896006T3/da active
- 2006-06-07 US US11/916,460 patent/US20080187590A1/en not_active Abandoned
- 2006-06-07 CA CA2611114A patent/CA2611114C/en active Active
- 2006-06-07 PT PT90004052T patent/PT2050447T/pt unknown
- 2006-06-07 PT PT06755404T patent/PT1896006E/pt unknown
- 2006-06-07 EP EP10011858A patent/EP2308487A1/en not_active Withdrawn
- 2006-06-07 SI SI200630519T patent/SI1896006T1/sl unknown
- 2006-06-07 KR KR1020147032488A patent/KR101617990B1/ko active Active
- 2006-06-07 MX MX2007015377A patent/MX2007015377A/es active IP Right Grant
- 2006-06-07 EP EP09000405.2A patent/EP2050447B1/en active Active
- 2006-06-07 PL PL06755404T patent/PL1896006T3/pl unknown
2007
- 2007-12-06 KR KR1020077028533A patent/KR101468738B1/ko active Active
- 2007-12-28 NO NO20076687A patent/NO345046B1/no unknown
2009
- 2009-12-11 CY CY20091101296T patent/CY1109587T1/el unknown
2011
- 2011-11-11 US US13/294,209 patent/US20120289594A1/en not_active Abandoned
2013
- 2013-04-10 JP JP2013082320A patent/JP2013173760A/ja active Pending
- 2013-06-06 US US13/911,185 patent/US20130274330A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP2335696A1 (en)	2011-06-22
PT2050447T (pt)	2018-01-17
EP2316448A1 (en)	2011-05-04
SI1896006T1 (sl)	2010-02-26
EP1896006B1 (en)	2009-10-07
EA200702616A1 (ru)	2008-04-28
PT1896006E (pt)	2009-10-19
KR20150001843A (ko)	2015-01-06
AU2006256724A1 (en)	2006-12-14
MX2007015377A (es)	2008-02-14
KR101468738B1 (ko)	2014-12-03
PL1896006T3 (pl)	2010-03-31
AU2006256724B2 (en)	2012-06-07
US20120289594A1 (en)	2012-11-15
KR101617990B1 (ko)	2016-05-03
NO345046B1 (no)	2020-09-07
DE602006009652D1 (de)	2009-11-19
CN101184483B (zh)	2011-08-10
JP2013173760A (ja)	2013-09-05
EP2050447B1 (en)	2017-10-11
NO20076687L (no)	2007-12-28
EP2050447A1 (en)	2009-04-22
ES2311442T1 (es)	2009-02-16
WO2006131591A3 (en)	2007-03-01
CN101184483A (zh)	2008-05-21
CY1109587T1 (el)	2014-08-13
JP5336181B2 (ja)	2013-11-06
ES2311442T3 (es)	2010-01-07
US20080187590A1 (en)	2008-08-07
EP1896006A2 (en)	2008-03-12
WO2006131591A2 (en)	2006-12-14
KR20080012945A (ko)	2008-02-12
US20130274330A1 (en)	2013-10-17
EA013161B1 (ru)	2010-02-26
JP2008542434A (ja)	2008-11-27
CA2611114A1 (en)	2006-12-14
EP2308487A1 (en)	2011-04-13
ATE444746T1 (de)	2009-10-15
CA2611114C (en)	2014-09-23

Publication	Publication Date	Title
NO20076687L (no)	2007-12-28	Oral doseringsform
CY2018013I2 (el)	2018-09-05	Ανθρωπινα anti-il-23 αντισωματα, συνθεσεις, μεθοδοι και χρησεις
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CY1109916T1 (el)	2014-09-10	Βενζιμιδαζολο-θειοφαινικες ενωσεις ως plk αναστολεις
FR2883179B1 (fr)	2009-04-17	Comprime enrobe
PH12015500550A1 (en)	2016-06-13	Anti-notch1 nrr antibodies and methods using same
NO20070753L (no)	2007-05-07	Fremgangsmåte for fremstilling av dihydropteridinoner
DE602006020327D1 (de)	2011-04-07	2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-aminder-hemmer zur behandlung thromboembolischer erkrankungen
ATE548374T1 (de)	2012-03-15	2'-fluor-2'-desoxytetrahydrouridine als cytidindeaminaseinhibitoren
DK1893586T3 (da)	2009-01-05	Fremgangsmåde til fremstilling af 1-alkyl-3-phenyluraciler
ATE542823T1 (de)	2012-02-15	4,5-dihydro-ä1,2,4ütriazoloä4,3-füpteridine als plk1-proteinkinasehemmer zur behandlung proliferativer erkrankungen
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