ATE458483T1 - Selektive pyrimidin-a2b-antagonistenverbindungen, ihre synthese und verwendung - Google Patents

Selektive pyrimidin-a2b-antagonistenverbindungen, ihre synthese und verwendung

Info

Publication number: ATE458483T1
Authority: AT; Austria
Prior art keywords: alkyl; substituted; heterocyclic; monocyclic; heteroaryl
Prior art date: 2001-12-20

Application number

AT02805676T

Other languages

English (en)

Inventor

Arlindo Castelhano

Bryan Mckibben

Arno Steinig

Eric William Collington

Original Assignee

Osi Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-20

Filing date

2002-12-20

Publication date

2010-03-15

2002-12-20 Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE458483T1 publication Critical patent/ATE458483T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
125000001072 heteroaryl group Chemical group 0.000 abstract 5
125000000623 heterocyclic group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 4
125000002950 monocyclic group Chemical group 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000005842 heteroatom Chemical group 0.000 abstract 2
125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
101150078577 Adora2b gene Proteins 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Obesity (AREA)
Dermatology (AREA)
Immunology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT02805676T 2001-12-20 2002-12-20 Selektive pyrimidin-a2b-antagonistenverbindungen, ihre synthese und verwendung ATE458483T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US34259501P	2001-12-20	2001-12-20
PCT/US2002/041273 WO2003053366A2 (en)	2001-12-20	2002-12-20	Pyrimidine a2b selective antagonist compounds, their synthesis and use

Publications (1)

Publication Number	Publication Date
ATE458483T1 true ATE458483T1 (de)	2010-03-15

Family

ID=23342484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02805676T ATE458483T1 (de)	2001-12-20	2002-12-20	Selektive pyrimidin-a2b-antagonistenverbindungen, ihre synthese und verwendung

Country Status (13)

Country	Link
US (2)	US6916804B2 (de)
EP (1)	EP1465631B1 (de)
JP (1)	JP4440642B2 (de)
KR (1)	KR20040068317A (de)
CN (1)	CN1620294A (de)
AT (1)	ATE458483T1 (de)
AU (1)	AU2002366811B2 (de)
BR (1)	BR0215202A (de)
CA (1)	CA2471059C (de)
DE (1)	DE60235500D1 (de)
EA (2)	EA007468B1 (de)
MX (1)	MXPA04005862A (de)
WO (1)	WO2003053366A2 (de)

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- 2002-12-20 KR KR10-2004-7009798A patent/KR20040068317A/ko not_active Abandoned
- 2002-12-20 WO PCT/US2002/041273 patent/WO2003053366A2/en not_active Ceased
- 2002-12-20 JP JP2003554126A patent/JP4440642B2/ja not_active Expired - Fee Related
- 2002-12-20 CA CA2471059A patent/CA2471059C/en not_active Expired - Fee Related
- 2002-12-20 BR BR0215202-9A patent/BR0215202A/pt not_active Application Discontinuation
- 2002-12-20 AU AU2002366811A patent/AU2002366811B2/en not_active Ceased
- 2002-12-20 AT AT02805676T patent/ATE458483T1/de not_active IP Right Cessation
- 2002-12-20 EA EA200400830A patent/EA007468B1/ru not_active IP Right Cessation
- 2002-12-20 EP EP02805676A patent/EP1465631B1/de not_active Expired - Lifetime
- 2002-12-20 DE DE60235500T patent/DE60235500D1/de not_active Expired - Lifetime
- 2002-12-20 US US10/326,204 patent/US6916804B2/en not_active Expired - Fee Related
- 2002-12-20 CN CNA028282701A patent/CN1620294A/zh active Pending
- 2002-12-20 EA EA200600315A patent/EA011809B1/ru not_active IP Right Cessation
2004
- 2004-06-16 MX MXPA04005862A patent/MXPA04005862A/es active IP Right Grant
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Publication number	Publication date
EA011809B1 (ru)	2009-06-30
EP1465631B1 (de)	2010-02-24
KR20040068317A (ko)	2004-07-30
WO2003053366A3 (en)	2004-01-29
EA007468B1 (ru)	2006-10-27
JP2005517659A (ja)	2005-06-16
AU2002366811A1 (en)	2003-07-09
US7501407B2 (en)	2009-03-10
EA200400830A1 (ru)	2004-12-30
EA200600315A1 (ru)	2006-06-30
BR0215202A (pt)	2004-10-13
WO2003053366A2 (en)	2003-07-03
CA2471059C (en)	2011-04-26
EP1465631A2 (de)	2004-10-13
MXPA04005862A (es)	2004-11-01
US20050119271A1 (en)	2005-06-02
US20030162764A1 (en)	2003-08-28
JP4440642B2 (ja)	2010-03-24
CA2471059A1 (en)	2003-07-03
AU2002366811B2 (en)	2009-01-15
US6916804B2 (en)	2005-07-12
CN1620294A (zh)	2005-05-25
DE60235500D1 (de)	2010-04-08
EP1465631A4 (de)	2005-03-30

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