ATE139233T1 - Annelierte thiophen-derivate, ihre herstellung und verwendung - Google Patents

Annelierte thiophen-derivate, ihre herstellung und verwendung

Info

Publication number: ATE139233T1
Authority: AT; Austria
Prior art keywords: hydrogen; chem; halogen; optionally substituted; residue
Prior art date: 1990-02-22

Application number

AT91102513T

Other languages

English (en)

Inventor

Akira Morimoto

Kohei Nishikawa

Takehiko Naka

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-22

Filing date

1991-02-21

Publication date

1996-06-15

1991-02-21 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE139233T1 publication Critical patent/ATE139233T1/de

Links

YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical class C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
150000001450 anions Chemical class 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
229940123413 Angiotensin II antagonist Drugs 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
208000019622 heart disease Diseases 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
150000003577 thiophenes Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT91102513T 1990-02-22 1991-02-21 Annelierte thiophen-derivate, ihre herstellung und verwendung ATE139233T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP4212590		1990-02-22
JP395891		1991-01-17

Publications (1)

Publication Number	Publication Date
ATE139233T1 true ATE139233T1 (de)	1996-06-15

Family

ID=26337635

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91102513T ATE139233T1 (de)	1990-02-22	1991-02-21	Annelierte thiophen-derivate, ihre herstellung und verwendung

Country Status (4)

Country	Link
EP (1)	EP0443568B1 (de)
AT (1)	ATE139233T1 (de)
CA (1)	CA2036618C (de)
DE (1)	DE69120100T2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5223501A (en) *	1991-05-10	1993-06-29	Merck & Co., Inc.	Substituted pyrimidinones bearing acidic functional groups as angiotensin ii antagonists
WO1993003040A1 (fr) *	1991-08-05	1993-02-18	Taisho Pharmaceutical Co., Ltd.	Derive de thienopyrimidin-4-one
US5187168A (en) *	1991-10-24	1993-02-16	American Home Products Corporation	Substituted quinazolines as angiotensin II antagonists
US5674883A (en) *	1992-02-07	1997-10-07	Roussel Uclaf	Derivatives of pyridone, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
FR2687674B1 (fr) *	1992-02-07	1995-05-19	Roussel Uclaf	Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5610301A (en) *	1993-07-01	1997-03-11	American Cyanamid Company	Process for the regioselective n-alkylation of quinazolinones
US6140325A (en) *	1993-08-19	2000-10-31	Takeda Chemical Industries, Ltd.	Thienopyrimidine derivatives, their production and use
TW276256B (de) *	1993-08-26	1996-05-21	Takeda Pharm Industry Co Ltd
TW449600B (en) *	1994-04-19	2001-08-11	Takeda Chemical Industries Ltd	Condensed-ring thiophene derivatives, their production and use
UY23948A1 (es) *	1995-02-08	2001-10-25	Takeda Chemical Industries Ltd	Derivados de anillos condensados de tiofeno su producción y uso.
RU2158739C2 (ru) *	1995-02-08	2000-11-10	Такеда Кемикал Индастриз, Лтд.	Соединения тиенопиримидина, способ их получения, фармацевтическая композиция
CN1063446C (zh) *	1995-10-19	2001-03-21	武田药品工业株式会社	作为促性腺激素释放激素拮抗剂的噻吩并吡啶衍生物
EP0781774B1 (de) *	1995-12-08	2002-07-31	Takeda Chemical Industries, Ltd.	Hemmer der Prolaktinsynthese
ID17260A (id) *	1996-04-26	1997-12-11	Takeda Chemical Industries Ltd	Turunan tieno piridina dan produksi serta gunanya
AU2745199A (en)	1998-03-04	1999-09-20	Takeda Chemical Industries Ltd.	Sustained-release preparation for aii antagonist, production and use thereof
KR20010102543A (ko)	1999-03-09	2001-11-15	로렌스 티. 마이젠헬더	항바이러스제로서의4-옥소-4,7-디히드로-티에노[2,3-ｂ]피리딘-5-카르복스아미드
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
WO2003020728A1 (en)	2001-08-30	2003-03-13	Pharmacia & Upjohn Company	4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
EP1421089A1 (de)	2001-08-30	2004-05-26	Pharmacia & Upjohn Company	4-THIOXO-4,7-DIHYDROTHIENOç2,3-B!PYRIDIN-5-CARBONSÄUREAMIDE ALS ANTIVIRALE MITTEL
AR038294A1 (es)	2002-01-14	2005-01-12	Upjohn Co	Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
AR038117A1 (es)	2002-01-14	2004-12-29	Upjohn Co	Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
AR038118A1 (es)	2002-01-14	2004-12-29	Upjohn Co	Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
US6831081B2 (en)	2002-09-04	2004-12-14	Pharmacia & Upjohn	4-Oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
ES2522968T3 (es)	2008-06-04	2014-11-19	Synergy Pharmaceuticals Inc.	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
AU2014235215A1 (en)	2013-03-15	2015-10-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
BR112015030326A2 (pt)	2013-06-05	2017-08-29	Synergy Pharmaceuticals Inc	Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4670560A (en) *	1986-04-28	1987-06-02	Ortho Pharmaceutical Corporation	Thienopyrimidine-2,4-dione derivatives and intermediates thereof
US5015651A (en) *	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
US4835157A (en) *	1988-03-15	1989-05-30	Ortho Pharmaceutical Corporation	Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents
EP0400835A1 (de) *	1989-05-15	1990-12-05	Merck & Co. Inc.	Substituierte Benzimidazole als Angiotensin II-Hemmer

1991
- 1991-02-19 CA CA002036618A patent/CA2036618C/en not_active Expired - Fee Related
- 1991-02-21 EP EP91102513A patent/EP0443568B1/de not_active Expired - Lifetime
- 1991-02-21 AT AT91102513T patent/ATE139233T1/de not_active IP Right Cessation
- 1991-02-21 DE DE69120100T patent/DE69120100T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69120100D1 (de)	1996-07-18
EP0443568B1 (de)	1996-06-12
CA2036618A1 (en)	1991-08-23
DE69120100T2 (de)	1996-11-14
CA2036618C (en)	2002-10-29
EP0443568A1 (de)	1991-08-28

Legal Events

Date	Code	Title	Description
1996-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE139233T1 (de)	1996-06-15	Annelierte thiophen-derivate, ihre herstellung und verwendung
ATE123771T1 (de)	1995-06-15	Stickstoff enthaltende heterozyklische verbindungen, ihre herstellung und verwendung.
ATE169915T1 (de)	1998-09-15	Pyrimidindionderivate, deren herstellung und verwendung
NO913750D0 (no)	1991-09-24	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske derivater.
ATE235476T1 (de)	2003-04-15	Thiazolidindione derivate, ihre herstellung und verwendung
DK0870768T3 (da)	2002-07-01	Azaindol-ethylaminderivater som nikotinacetylcholinreceptor-bindingsmidler
ES8802517A1 (es)	1988-07-01	Un procedimiento para preparar fenoxialquil (substituido con heterocido)-isoxazoles y furanos.
NO178192C (no)	1996-02-07	Analogifremgangsmåte ved fremstilling av terapeutisk aktive 3-arylindol- og 3-arylindazolderivater
ATE134633T1 (de)	1996-03-15	Thienoimidazolderivate, ihre herstellung und verwendung
DE69202120D1 (de)	1995-05-24	Harnstoffderivate, ihre Herstellung und ihre Verwendung bei der Therapie.
NZ221699A (en)	1990-03-27	Pyridazinone derivatives; pharmaceutical compositions and intermediates
NO992676L (no)	1999-07-29	1,4-diazabicyklo[2,2,2]okt-2-ylmetylderivater, deres fremstilling og terapeutiske anvendelse
ATE140229T1 (de)	1996-07-15	Benzoxazepinon-verfahren
ES2111086T3 (es)	1998-03-01	Compuestos triciclicos anfoteros como agentes antihistaminicos y antialergicos.
EP0461264A4 (en)	1992-02-19	Ethynylphenyl derivative, production thereof, and remedy for diseases of circulatory organs containing the same as active ingredient
NO20021162D0 (no)	2002-03-08	5-aminoalkyl og 5-aminokarbonyl-substituerte indoler
ATE91487T1 (de)	1993-07-15	Dibenzodioxazecin- und dibenzodioxaazacycloundecin-derivate.