ATE458506T1 - Knochenmarkersatzmaterial-verbundwerkstoff, verfahren zu seiner herstelllung und kit - Google Patents

Knochenmarkersatzmaterial-verbundwerkstoff, verfahren zu seiner herstelllung und kit

Info

Publication number
ATE458506T1
ATE458506T1 AT02719067T AT02719067T ATE458506T1 AT E458506 T1 ATE458506 T1 AT E458506T1 AT 02719067 T AT02719067 T AT 02719067T AT 02719067 T AT02719067 T AT 02719067T AT E458506 T1 ATE458506 T1 AT E458506T1
Authority
AT
Austria
Prior art keywords
kit
production
graft material
composite material
bone marrow
Prior art date
Application number
AT02719067T
Other languages
English (en)
Inventor
George F Muschler
Original Assignee
Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cleveland Clinic Foundation filed Critical Cleveland Clinic Foundation
Application granted granted Critical
Publication of ATE458506T1 publication Critical patent/ATE458506T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/025—Pointed or sharp biopsy instruments for taking bone, bone marrow or cartilage samples
    • A61B2010/0258—Marrow samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4601—Special tools for implanting artificial joints for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT02719067T 2001-02-28 2002-02-26 Knochenmarkersatzmaterial-verbundwerkstoff, verfahren zu seiner herstelllung und kit ATE458506T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/795,254 US6723131B2 (en) 2001-02-28 2001-02-28 Composite bone marrow graft material with method and kit
PCT/US2002/005583 WO2002068010A1 (en) 2001-02-28 2002-02-26 Composite bone marrow graft material with method and kit

Publications (1)

Publication Number Publication Date
ATE458506T1 true ATE458506T1 (de) 2010-03-15

Family

ID=25165118

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02719067T ATE458506T1 (de) 2001-02-28 2002-02-26 Knochenmarkersatzmaterial-verbundwerkstoff, verfahren zu seiner herstelllung und kit

Country Status (14)

Country Link
US (1) US6723131B2 (de)
EP (1) EP1399199B1 (de)
JP (2) JP4481566B2 (de)
KR (1) KR100564716B1 (de)
CN (1) CN1503683A (de)
AT (1) ATE458506T1 (de)
AU (1) AU2002250173B2 (de)
BR (1) BR0207722A (de)
CA (1) CA2439747C (de)
DE (1) DE60235464D1 (de)
ES (1) ES2341169T3 (de)
MX (1) MXPA03007740A (de)
NZ (1) NZ528218A (de)
WO (1) WO2002068010A1 (de)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824084A (en) * 1996-07-03 1998-10-20 The Cleveland Clinic Foundation Method of preparing a composite bone graft
US6258124B1 (en) * 1999-05-10 2001-07-10 C. R. Bard, Inc. Prosthetic repair fabric
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US20030069545A1 (en) * 1999-12-06 2003-04-10 Arm Douglas M. Graft delivery syringe
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
MY133943A (en) 2000-08-22 2007-11-30 Synthes Gmbh Bone replacement material
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US6623959B2 (en) * 2001-06-13 2003-09-23 Ethicon, Inc. Devices and methods for cell harvesting
CA2433038A1 (en) 2001-10-12 2003-04-17 Osteotech, Inc. Bone graft compositions with improved growth factor stability
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
KR100811995B1 (ko) 2001-12-07 2008-03-10 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
AU2002226426A1 (en) * 2002-01-09 2003-07-24 Alberto Gorrochategui Barrueta Composition and method of creating, regenerating and repairing tissues using a cell-carrying biological implant which is enriched with a platelet concentrate and supplements
US20070141036A1 (en) * 2002-01-09 2007-06-21 Alberto Gorrochategui Barrueta Composition and procedure for tissue creation, regeneration and repair by a cell-bearing biological implant enriched with platelet concentrate and supplements
US8313742B2 (en) 2002-03-29 2012-11-20 Depuy Acromed, Inc. Cell-containing bone graft material
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US7374678B2 (en) 2002-05-24 2008-05-20 Biomet Biologics, Inc. Apparatus and method for separating and concentrating fluids containing multiple components
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7179391B2 (en) 2002-05-24 2007-02-20 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US20070276352A1 (en) * 2002-06-04 2007-11-29 Stemcor Systems, Inc. Removable device and method for tissue disruption
US7462181B2 (en) 2002-06-04 2008-12-09 Stanford Office Of Technology Licensing Device and method for rapid aspiration and collection of body tissue from within an enclosed body space
AU2003247492B2 (en) * 2002-06-06 2009-05-14 The Brigham And Women's Hospital, Inc. Non-polymeric hematopoietic cell clots for delivery of active agents
US7498040B2 (en) 2005-10-12 2009-03-03 Lifenet Health Compositions for repair of defects in osseous tissues, and methods of making the same
US7744597B2 (en) * 2002-06-26 2010-06-29 Lifenet Health Device and process for producing fiber products and fiber products produced thereby
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
US7776594B2 (en) * 2002-10-10 2010-08-17 Wright Medical Technology, Inc. Bone marrow infusion chamber and method
US7682392B2 (en) * 2002-10-30 2010-03-23 Depuy Spine, Inc. Regenerative implants for stabilizing the spine and devices for attachment of said implants
US7582309B2 (en) * 2002-11-15 2009-09-01 Etex Corporation Cohesive demineralized bone compositions
US6981948B2 (en) * 2002-11-18 2006-01-03 Depuy Spine, Inc. Bone marrow aspiration system
US20050124993A1 (en) * 2002-12-02 2005-06-09 Chappuis James L. Facet fusion system
AT500418B1 (de) * 2002-12-05 2009-12-15 Winkler Heinz Dr Gezüchtete knorpelzellen beinhaltendes implantat und verfahren zur herstellung desselben
US7794408B2 (en) * 2003-03-28 2010-09-14 Ethicon, Inc. Tissue collection device and methods
US7494811B2 (en) 2003-05-01 2009-02-24 Lifenet Health In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby
KR20060031808A (ko) 2003-06-11 2006-04-13 오스테오테크, 인코포레이티드 뼈 임플란트 및 그의 제조 방법
JP4607762B2 (ja) * 2003-08-08 2011-01-05 ジンテーズ ゲゼルシャフト ミト ベシュレンクテル ハフツング 多孔性骨代替材料を含浸する方法
US8034003B2 (en) 2003-09-11 2011-10-11 Depuy Mitek, Inc. Tissue extraction and collection device
US7611473B2 (en) 2003-09-11 2009-11-03 Ethicon, Inc. Tissue extraction and maceration device
US7189263B2 (en) 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
KR101161898B1 (ko) 2004-06-03 2012-07-09 신세스 게엠바하 다공성의 뼈 대체물질을 주입하는 장치
JP2006006125A (ja) * 2004-06-22 2006-01-12 Nipro Corp 骨髄単核細胞の調製方法及び細胞調製装置
US9220595B2 (en) 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
JP4937119B2 (ja) * 2004-07-01 2012-05-23 サイトリ セラピューティクス インコーポレイテッド 筋骨格疾患の治療に再生細胞を使用する方法
US20060083769A1 (en) * 2004-10-14 2006-04-20 Mukesh Kumar Method and apparatus for preparing bone
US7670384B2 (en) * 2004-10-14 2010-03-02 Biomet Manufacturing Corp. Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
US7993578B2 (en) * 2004-10-29 2011-08-09 Depuy Spine, Inc. Methods and kits for aseptic filling of products
CN103055350B (zh) * 2004-12-08 2014-12-10 夏尔再生医学公司 含细胞的可流动组合物的最小侵入性给药的材料和方法
WO2006062871A2 (en) * 2004-12-08 2006-06-15 Pervasis Therapeutics, Inc. Materials and methods for minimally-invasive administration of a cell-containing flowable composition
AU2005322113B2 (en) * 2004-12-23 2010-05-13 Harvest Technologies Corporation Hydrating anhydrous graft materials
MX2007008561A (es) * 2005-01-14 2008-02-21 Osteotech Inc Osteoimplante expandible.
US20090087414A1 (en) * 2005-04-21 2009-04-02 Pervasis Therapeutics, Inc. Materials and methods for altering an immune response to exogenous and endogenous immunogens, including syngeneic and non-syngeneic cells, tissues or organs
US7513901B2 (en) * 2005-05-19 2009-04-07 Warsaw Orthopedic, Inc. Graft syringe assembly
CN101257861B (zh) * 2005-06-21 2012-12-05 渗透治疗有限公司 用于增强血管通路的方法和组合物
US20100280493A1 (en) * 2005-06-23 2010-11-04 Asha Nayak Methods and Systems for Treating Injured Cardiac Tissue
US20070172472A1 (en) * 2005-06-23 2007-07-26 Asha Nayak Methods and Systems for Treating Injured Cardiac Tissue
US20070093748A1 (en) * 2005-06-23 2007-04-26 Medtronic Vascular, Inc. Methods and systems for treating injured cardiac tissue
US20070014784A1 (en) * 2005-06-23 2007-01-18 Medtronic Vascular, Inc. Methods and Systems for Treating Injured Cardiac Tissue
US20070036766A1 (en) * 2005-08-09 2007-02-15 Sherwin Kevy Tissue graft composition comprising autologous bone marrow and purified autologous thrombin
US8048297B2 (en) 2005-08-23 2011-11-01 Biomet Biologics, Llc Method and apparatus for collecting biological materials
US7771590B2 (en) * 2005-08-23 2010-08-10 Biomet Manufacturing Corp. Method and apparatus for collecting biological materials
WO2007048016A2 (en) 2005-10-20 2007-04-26 Synthes (U.S.A.) Perfusion device and method
WO2007056671A1 (en) 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
WO2007053918A1 (en) * 2005-11-11 2007-05-18 Gm Dos Reis Jr Indústria E Comércio De Equipamentos Médicos Device, kit to filter bone marrow aspirate
US20100204783A1 (en) * 2005-12-06 2010-08-12 Helen Marie Nugent Methods and compositions for enhancing vascular access
KR100833793B1 (ko) * 2006-05-16 2008-05-29 세원셀론텍(주) 골수 유래 골 생성용 유핵 세포 분리 방법
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
AU2007265379B9 (en) 2006-06-29 2014-05-29 Orthovita, Inc. Bioactive bone graft substitute
US20080033572A1 (en) * 2006-08-03 2008-02-07 Ebi L.P. Bone graft composites and methods of treating bone defects
US8858560B2 (en) * 2006-08-23 2014-10-14 Arthrex, Inc. Arthroscopic harvesting and therapeutic application of bone marrow aspirate
US8721646B2 (en) 2006-10-10 2014-05-13 William Casey Fox Methods and apparatus for a staple
AU2007325460B2 (en) * 2006-10-23 2013-09-05 Cook Biotech Incorporated Processed ECM materials with enhanced component profiles
JP5372764B2 (ja) * 2006-11-07 2013-12-18 シャイア リジェネラティブ メディシン， インコーポレイテッド 血管形成関連疾患の治療および管理のための材料および方法
GB2447019A (en) * 2007-02-27 2008-09-03 Apatech Ltd Bone-replacement material
US20080234825A1 (en) * 2007-03-16 2008-09-25 Chappuis James L Modular Lumbar Interbody Fixation Systems and Methods
US8992616B2 (en) * 2007-03-19 2015-03-31 James L. Chappuis Modular lumbar interbody fixation systems and methods with reconstruction endplates
US8696674B2 (en) 2007-03-30 2014-04-15 Smith & Nephew, Inc. Tissue harvesting
CA2682317C (en) * 2007-04-03 2017-01-17 The Cleveland Clinic Foundation Enrichment of tissue-derived adult stem cells based on retained extracellular matrix material
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
EP2146794B1 (de) 2007-04-12 2016-10-19 Biomet Biologics, LLC Fraktionierungssystem für suspensionen mit trennungsschwimmer
KR20100039284A (ko) * 2007-05-21 2010-04-15 웨이크 포리스트 유니버시티 헬스 사이언시즈 소변으로부터의 전구 세포 및 이를 사용하는 방법
US20100111914A1 (en) * 2007-05-21 2010-05-06 Yuanyuan Zhang Stem cells from urine and methods for using the same
EP2155294B1 (de) * 2007-06-13 2012-02-15 Pervasis Therapeutics, Inc. Verfahren und vorrichtungen zur minimal invasiven abgabe von zellhaltigen fliessfähigen zusammensetzungen
CA2690457C (en) * 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
US20090005868A1 (en) * 2007-06-27 2009-01-01 Depuy Products, Inc. Osteogenic prosthesis, associated instrument, and associated method
US9486317B2 (en) * 2007-08-27 2016-11-08 Arthrex Inc. Method of arthroscopic osteochondral resurfacing using PRP strengthened with fibrin glue
EP2620139B1 (de) 2008-02-27 2016-07-20 Biomet Biologics, LLC Interleukin-1-Rezeptorantagonisten-reiche Lösungen
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
ITMI20080643A1 (it) * 2008-04-11 2009-10-12 Fin Ceramica Faenza Spa Metodo per perfondere un innesto di materiale biocompatibile con un liquido e kit di perfusione
JP2011525229A (ja) * 2008-06-19 2011-09-15 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 骨ネジの足掛かり増強インプラント、システム、及び技術
FR2932687B1 (fr) * 2008-06-23 2010-09-17 Centre Nat Rech Scient Biomateriaux a base de phosphates de calcium.
FR2932686B1 (fr) * 2008-06-23 2010-08-27 Centre Nat Rech Scient Combinaison de sang et de particules de ceramique de phosphates de calcium biphases.
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US8808294B2 (en) * 2008-09-09 2014-08-19 William Casey Fox Method and apparatus for a multiple transition temperature implant
JP2012506733A (ja) 2008-10-24 2012-03-22 ウォーソー・オーソペディック・インコーポレーテッド 骨形成を促進するための組成物および方法
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
WO2010127310A1 (en) 2009-05-01 2010-11-04 Cytori Therapeutics, Inc. Systems, methods and compositions for optimizing tissue and cell enriched grafts
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
WO2011031783A1 (en) * 2009-09-08 2011-03-17 Baxter International Inc. Reconstitution and applicator system for wound sealant product
US20110082424A1 (en) * 2009-10-02 2011-04-07 Barnhouse Michael P Method and apparatus for bone graft insertion
US8979748B2 (en) * 2009-10-23 2015-03-17 James L. Chappuis Devices and methods for temporarily retaining spinal rootlets within dural sac
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8968323B2 (en) 2010-11-22 2015-03-03 Warsaw Orthopedic, Inc. Bone graft injection syringe
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
DE102011108010A1 (de) * 2011-07-20 2013-01-24 Heraeus Medical Gmbh Applikator-Kit
KR101398406B1 (ko) * 2011-09-29 2014-05-28 (주)시지바이오 골 재생용 조성물
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US9114190B2 (en) 2013-02-08 2015-08-25 Laser Spine Institute, Llc Regeneration of spinal discs
WO2014130953A1 (en) 2013-02-22 2014-08-28 Lifenet Health Packaging assembly for storing tissue and cellular material
US9604184B2 (en) 2013-03-06 2017-03-28 Orthovita, Inc. Mixing system and valve assembly
US9283013B2 (en) 2013-03-14 2016-03-15 Warsaw Orthopedic, Inc. Filling systems for bone delivery devices
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9301980B2 (en) * 2013-07-16 2016-04-05 The Board Of Trustees Of The Leland Stanford Junio Enhancement of osteogenic potential of bone grafts
US10188499B2 (en) * 2013-09-19 2019-01-29 Universitätsspital Basel Artificial vascular graft
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
EP3057600B1 (de) 2013-10-18 2019-03-13 Fortus Medical, Inc. Herstellungsmethode eines durch ein knochenmarkabsaugungsprodukt verbessertes knochenimplantat
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
CN103952296B (zh) * 2014-01-14 2018-11-30 卢建熙 多功能医学治疗物质体复合器
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
US9364583B2 (en) 2014-04-25 2016-06-14 Warsaw Orthopedic, Inc. Osteoinductive demineralized bone implant
US10183095B2 (en) * 2014-10-23 2019-01-22 Spinesmith Partners, L.P. Treatment of skeletal voids with implantable substrate hydrated with bone marrow concentrate
US10238507B2 (en) 2015-01-12 2019-03-26 Surgentec, Llc Bone graft delivery system and method for using same
US10006705B2 (en) 2015-02-09 2018-06-26 Warsaw Orthopedic, Inc. Methods for treating tissue materials
WO2016183017A1 (en) 2015-05-08 2016-11-17 Fortus Medical, Inc. Bone fragment and tissue harvesting system
EP3297694A1 (de) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modifizierte demineralisierte kortikale knochenfasern
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
EP3380019A1 (de) * 2015-11-25 2018-10-03 Smith & Nephew, Inc Gewebefalle für system zur übertragung chondraler autotransplantate
US10596069B2 (en) 2015-12-22 2020-03-24 Ethicon, Inc. Syringes with mixing chamber in a removable cap
US10433921B2 (en) * 2015-12-28 2019-10-08 Mako Surgical Corp. Apparatus and methods for robot assisted bone treatment
WO2017136273A1 (en) 2016-02-01 2017-08-10 RegenMed Systems, Inc. Cannula for tissue disruption
US10383731B2 (en) 2016-02-24 2019-08-20 Warsaw Orthopedic, Inc. Spinal implant system and method
AU2017204355B2 (en) 2016-07-08 2021-09-09 Mako Surgical Corp. Scaffold for alloprosthetic composite implant
EP3509520B1 (de) 2016-09-07 2021-07-28 Fortus Medical, Inc. Zubereitungssystem für knochenhohlraumfüller
JP6380868B1 (ja) * 2017-06-05 2018-08-29 オーソセル・リミテッド 医療処置キットおよび関連の方法
EP3634245A4 (de) * 2017-06-07 2021-03-17 Fortus Medical, Inc. Bindegewebevorläuferzellenaspirations- und -verarbeitungssystem
US20190091372A1 (en) * 2017-09-27 2019-03-28 Globus Medical, Inc. Coagulum-based biomaterial compositions and methods thereof
WO2019094617A1 (en) * 2017-11-09 2019-05-16 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Stem cells and devices for bone regeneration
WO2019182788A1 (en) * 2018-03-22 2019-09-26 Fortus Medical, Inc. Osteomedullary tissue processing system
US11116647B2 (en) 2018-04-13 2021-09-14 Surgentec, Llc Bone graft delivery system and method for using same
US10687828B2 (en) 2018-04-13 2020-06-23 Surgentec, Llc Bone graft delivery system and method for using same
CN108379663B (zh) * 2018-04-24 2023-05-26 中国人民解放军第四军医大学 一种多孔规则体支架材料中截留及富集细胞的装置和方法
US10813676B2 (en) * 2018-08-29 2020-10-27 Warsaw Orthopedic, Inc. Bone material hydration devices and methods
KR20200070764A (ko) * 2018-12-10 2020-06-18 메디칸(주) 생체 적합성 히알루론산 필러 입도 조절 방법 및 장치
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same
AU2021261864A1 (en) 2020-11-03 2022-05-19 Mako Surgical Corp. Multi-component locking implant
CN112891630B (zh) * 2021-01-27 2022-05-13 苏州大学 一种用于骨修复的可植入血块凝胶组合物及其制备方法
US12048628B2 (en) * 2021-11-09 2024-07-30 Warsaw Orthopedic, Inc. Systems and methods of coating bone material
DE102022121044A1 (de) * 2022-08-19 2024-02-22 H & B Electronic Gmbh & Co. Kg Aufbereitungsanordnung
CN120265224A (zh) * 2022-09-16 2025-07-04 康乐保公司 用于制造含脂肪的皮肤移植治疗组合物的系统、含脂肪的皮肤移植治疗组合物及其制造方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609551A (en) 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4608199A (en) 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
US5226914A (en) 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5197985A (en) 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5733542A (en) 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US5425580A (en) * 1990-12-28 1995-06-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Dosage form for micro-bubble echo contrast agents
US5366507A (en) * 1992-03-06 1994-11-22 Sottosanti John S Method for use in bone tissue regeneration
BR9306855A (pt) * 1992-08-07 1998-12-08 West Co Dispositivo de batoque para uso com recipientes para proporcionar acesso isento de agulha ao recipiente com uma cânula e sistema para produtos farmacêuticos
CA2153661A1 (en) 1993-01-12 1994-07-21 Anthony George Gristina Methods and compositions for the direct concentrated delivery of passive immunity
US5626861A (en) 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
US5697932A (en) 1994-11-09 1997-12-16 Osteonics Corp. Bone graft delivery system and method
US5645729A (en) 1995-02-13 1997-07-08 Uop Separations by simulated moving bed chromatography operating at low k' values using weakly interacting adsorbents as the stationary phase
US5700289A (en) 1995-10-20 1997-12-23 North Shore University Hospital Research Corporation Tissue-engineered bone repair using cultured periosteal cells
CA2251983C (en) 1996-04-19 2003-12-16 Sudhakar Kadiyala Regeneration and augmentation of bone using mesenchymal stem cells
US5824084A (en) * 1996-07-03 1998-10-20 The Cleveland Clinic Foundation Method of preparing a composite bone graft
US6037519A (en) 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
US5914121A (en) 1997-02-12 1999-06-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts
US6234196B1 (en) * 1999-02-19 2001-05-22 Ultradent Products, Inc. Mixing adaptor and system

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US20020161449A1 (en) 2002-10-31
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DE60235464D1 (de) 2010-04-08
NZ528218A (en) 2006-11-30
MXPA03007740A (es) 2004-11-12
CN1503683A (zh) 2004-06-09
CA2439747C (en) 2008-10-28
JP4481566B2 (ja) 2010-06-16
WO2002068010A1 (en) 2002-09-06
US6723131B2 (en) 2004-04-20
KR100564716B1 (ko) 2006-03-28
AU2002250173B2 (en) 2006-02-02
JP2005506102A (ja) 2005-03-03
CA2439747A1 (en) 2002-09-06
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BR0207722A (pt) 2005-08-30
ES2341169T3 (es) 2010-06-16

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