ATE458739T1 - Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine - Google Patents

Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine

Info

Publication number: ATE458739T1
Authority: AT; Austria
Prior art keywords: pyrazolopyrimidines; substituted; pyrimidin; phenyl; salt
Prior art date: 2004-01-14

Application number

AT04812693T

Other languages

English (en)

Inventor

Gary Lee Cantrell

Frank William Moser

Robert Edward Halvachs

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-14

Filing date

2004-12-02

Publication date

2010-03-15

2004-12-02 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE458739T1 publication Critical patent/ATE458739T1/de

Links

238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 abstract 1
CBIAWPMZSFFRGN-UHFFFAOYSA-N Indiplon Chemical compound CC(=O)N(C)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C(=O)C=2SC=CC=2)=C1 CBIAWPMZSFFRGN-UHFFFAOYSA-N 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
-1 aminopyrazole compound Chemical class 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000012429 reaction media Substances 0.000 abstract 1
HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT04812693T 2004-01-14 2004-12-02 Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine ATE458739T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53630204P	2004-01-14	2004-01-14
PCT/US2004/040241 WO2005070931A1 (en)	2004-01-14	2004-12-02	Two-phase method for the synthesis of selected pyrazolopyrimidines

Publications (1)

Publication Number	Publication Date
ATE458739T1 true ATE458739T1 (de)	2010-03-15

Family

ID=34806998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04812693T ATE458739T1 (de)	2004-01-14	2004-12-02	Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine

Country Status (10)

Country	Link
US (1)	US7498434B2 (de)
EP (1)	EP1713808B1 (de)
JP (1)	JP2007517876A (de)
CN (1)	CN1906197A (de)
AT (1)	ATE458739T1 (de)
AU (1)	AU2004314335A1 (de)
CA (1)	CA2553465A1 (de)
DE (1)	DE602004025747D1 (de)
ES (1)	ES2338659T3 (de)
WO (1)	WO2005070931A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005099712A2 (en) *	2004-04-19	2005-10-27	Sanmar Speciality Chemicals Limited	Process for preparation of n-[3-(3-cyanopyrazolo [1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide
WO2006070244A2 (en) *	2004-11-22	2006-07-06	Bakulesh Mafatlal Khamar	A process for the preparation of zaleplon
CN102816163A (zh) *	2012-08-20	2012-12-12	四川禾邦阳光制药股份有限公司	扎来普隆的新晶型及制备方法
AU2021363703A1 (en)	2020-10-23	2023-06-22	S2Cbio Inc.	Cftr modulator compounds, compositions, and uses thereof
CN112939987B (zh) *	2021-02-18	2022-03-22	新乡医学院	一种茚地普隆中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4626538A (en) *	1983-06-23	1986-12-02	American Cyanamid Company	[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US5714607A (en) *	1995-12-01	1998-02-03	American Cyanamid Company	Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
US6472528B1 (en)	1999-08-10	2002-10-29	Neurocrine Biosciences, Inc.	Synthesis of substituted pyrazolopyrimidines
US6399621B1 (en) *	1999-08-10	2002-06-04	American Cyanamid Company	N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
AR029780A1 (es) *	2000-12-13	2003-07-16	Gador Sa	Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida
DE02778962T1 (de) *	2001-06-12	2005-02-10	Biogal Gyogyszergyar Rt.	VERFAHREN ZUR HERSTELLUNG VON N ç3 (3 CYANOPYRAZOLOç1,5 A!PYRIMIDIN 7 YL)PHENYL!-N-ETHYLACETAMID (ZALEPLON)
PL374176A1 (en) *	2001-08-01	2005-10-03	Biogal Gyogyszergyar Rt	Process for purifying n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide(zaleplon) and crystalline forms of zaleplon accessible with the process

2004
- 2004-12-02 US US10/585,006 patent/US7498434B2/en not_active Expired - Fee Related
- 2004-12-02 ES ES04812693T patent/ES2338659T3/es not_active Expired - Lifetime
- 2004-12-02 DE DE602004025747T patent/DE602004025747D1/de not_active Expired - Lifetime
- 2004-12-02 CN CNA2004800404724A patent/CN1906197A/zh active Pending
- 2004-12-02 EP EP04812693A patent/EP1713808B1/de not_active Expired - Lifetime
- 2004-12-02 AT AT04812693T patent/ATE458739T1/de not_active IP Right Cessation
- 2004-12-02 JP JP2006549260A patent/JP2007517876A/ja not_active Withdrawn
- 2004-12-02 WO PCT/US2004/040241 patent/WO2005070931A1/en not_active Ceased
- 2004-12-02 AU AU2004314335A patent/AU2004314335A1/en not_active Abandoned
- 2004-12-02 CA CA002553465A patent/CA2553465A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2005070931A1 (en)	2005-08-04
DE602004025747D1 (de)	2010-04-08
EP1713808B1 (de)	2010-02-24
AU2004314335A1 (en)	2005-08-04
CN1906197A (zh)	2007-01-31
JP2007517876A (ja)	2007-07-05
US7498434B2 (en)	2009-03-03
CA2553465A1 (en)	2005-08-04
US20070155995A1 (en)	2007-07-05
EP1713808A1 (de)	2006-10-25
ES2338659T3 (es)	2010-05-11

Similar Documents

Publication	Publication Date	Title
CA2191647A1 (en)	1997-06-02	Process improvement in the synthesis of n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide
CA2493359A1 (en)	2004-03-04	Novel polymorph of n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-.alpha.]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
HRP20070534T3 (en)	2007-12-31	Phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
SG170783A1 (en)	2011-05-30	Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis
IL190398A0 (en)	2008-11-03	Imidazo benzodiazepine derivatives
WO2001062760A3 (en)	2001-12-06	A NOVEL CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR
ATE458739T1 (de)	2010-03-15	Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine
WO2002100828A3 (en)	2003-05-01	Process for the production of zaleplon
DE60019350D1 (de)	2005-05-12	Synthese substituierter Pyrazolopyrimidine
PL374176A1 (en)	2005-10-03	Process for purifying n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide(zaleplon) and crystalline forms of zaleplon accessible with the process
ES8505958A1 (es)	1985-07-01	Procedimiento para preparar pirazol (1,5-a)pirimidin-metanonas
WO2005103052A8 (en)	2006-04-13	Pyrazolo [1,5-a] pyrimidin-7-one compounds and uses thereof
DE69930416D1 (de)	2006-05-11	Cgmp pde5 inhibitoren zur inhalationsbehandlung von sexueller dysfunktion
CA2417875A1 (en)	2002-02-14	Polymorphs of zaleplon and methods for the preparation thereof
Petek et al.	2022	2-Acyl-1-aryl-6, 7-dihydro-1H, 5H-pyrazolo [1, 2-a] pyrazole derivatives: Versatile fluorescent probes with remarkably large Stokes shift
Rahmati	2012	One-pot synthesis of 2-alkyl-7-amino-5-aryl-pyrazolo [1, 5-a] pyrimidine-6-carbonitriles via a domino three-component condensation-oxidation reaction
DE60309159D1 (de)	2006-11-30	Verfahren zur herstellung von zaleplon
PT2081935T (pt)	2017-08-29	Polimorfo b de n-{2-fluoro-5-3-(tiofeno-2-carbonil)- pirazolo[1,5-a] pirimidin-7-il]-fenil}-n-metil-acetamida
ATE368667T1 (de)	2007-08-15	Verfahren zur herstellung von n-ethyl-n-(3-(3- cyanopyrazolo-(1,5-a)-pyrimidin-7-yl)phenyl)- acetamid
WO2005099712A3 (en)	2006-12-21	Process for preparation of n-[3-(3-cyanopyrazolo [1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide
WO2006070244A3 (en)	2007-03-22	A process for the preparation of zaleplon
WO2006127574A3 (en)	2007-03-22	Method for the treatment of noise phobia in companion animals
EP1344768B1 (de)	2005-04-06	Synthese substituierter Pyrazolopyrimidine
WO2008068600A3 (en)	2008-08-07	An improved process for the preparation of zaleplo
CA2550874A1 (en)	2005-07-14	Process for the preparation of triazolopyrimidines

Legal Events

Date	Code	Title	Description
2010-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties