ATE459353T1 - Gaboxadol zur behandlung von depressionen und anderen affektiven störungen - Google Patents
Gaboxadol zur behandlung von depressionen und anderen affektiven störungenInfo
- Publication number
- ATE459353T1 ATE459353T1 AT04738956T AT04738956T ATE459353T1 AT E459353 T1 ATE459353 T1 AT E459353T1 AT 04738956 T AT04738956 T AT 04738956T AT 04738956 T AT04738956 T AT 04738956T AT E459353 T1 ATE459353 T1 AT E459353T1
- Authority
- AT
- Austria
- Prior art keywords
- gaboxadol
- affective disorders
- treat depression
- pharmaceutical composition
- relates
- Prior art date
Links
- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 title abstract 3
- 229950004346 gaboxadol Drugs 0.000 title abstract 3
- 208000019022 Mood disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 abstract 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48301903P | 2003-06-25 | 2003-06-25 | |
| DKPA200300956 | 2003-06-25 | ||
| US53512304P | 2004-01-07 | 2004-01-07 | |
| DKPA200400016 | 2004-01-07 | ||
| PCT/DK2004/000459 WO2004112786A2 (en) | 2003-06-25 | 2004-06-25 | Gaboxadol for treating depression and other affective disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE459353T1 true ATE459353T1 (de) | 2010-03-15 |
Family
ID=33545397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04738956T ATE459353T1 (de) | 2003-06-25 | 2004-06-25 | Gaboxadol zur behandlung von depressionen und anderen affektiven störungen |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP1641456B1 (de) |
| JP (1) | JP2007508236A (de) |
| AT (1) | ATE459353T1 (de) |
| AU (1) | AU2004248890A1 (de) |
| BR (1) | BRPI0410857A (de) |
| CY (1) | CY1110046T1 (de) |
| DE (1) | DE602004025808D1 (de) |
| DK (1) | DK1641456T3 (de) |
| ES (1) | ES2341004T3 (de) |
| HR (1) | HRP20100276T1 (de) |
| IL (2) | IL172631A0 (de) |
| MX (1) | MXPA05013016A (de) |
| NZ (1) | NZ543586A (de) |
| PL (1) | PL1641456T3 (de) |
| PT (1) | PT1641456E (de) |
| SI (1) | SI1641456T1 (de) |
| WO (1) | WO2004112786A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1663218A1 (de) * | 2003-09-10 | 2006-06-07 | MERCK SHARP & DOHME LTD. | Verwendung von gabaa-rezeptor-agonisten zur behandlung von hör-, vestibular- und aufmerksamkeitsstörungen, intentionstremor und ruhelosen beinen |
| PL1691811T3 (pl) | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
| GB0402118D0 (en) * | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| JP2007523165A (ja) | 2004-02-18 | 2007-08-16 | セプレイコー インコーポレイテッド | 睡眠の質を改善するためのドーパミン作動薬併用療法 |
| GB0417558D0 (en) * | 2004-08-06 | 2004-09-08 | Merck Sharp & Dohme | Novel combination therapy |
| US8022084B2 (en) | 2005-01-28 | 2011-09-20 | H. Lundbeck A/S | Polymorphic forms of a GABAA agonist |
| EP1906953A4 (de) * | 2005-04-29 | 2009-05-20 | Lundbeck & Co As H | Säure- und basensalzformen von gaboxadol |
| TW200920358A (en) * | 2007-08-13 | 2009-05-16 | Lundbeck & Co As H | Method of treating stress-mediated depression |
| US20090143335A1 (en) * | 2007-10-29 | 2009-06-04 | H. Lundbeck A/S | Modified absorption formulation of gaboxadol |
| EP2334299A1 (de) * | 2008-09-01 | 2011-06-22 | H. Lundbeck A/S | Pharmazeutische zusammensetzung mit gaboxadol und einem patl- oder oat-hemmer |
| DK3274331T3 (da) | 2015-03-24 | 2020-03-23 | H Lundbeck As | Fremstilling af 4,5,6,7-tetrahydroisozaxolo[5,4-c]pyridin-3-ol |
| IL256912B2 (en) | 2015-07-17 | 2024-01-01 | Ovid Therapeutics Inc | Methods of treating developmental disorders with gaboxadol |
| AU2017363598A1 (en) * | 2016-11-22 | 2019-05-23 | Ovid Therapeutics Inc. | Methods of treating developmental disorders and/or seizure disorders with flupirtine |
| US20180338959A1 (en) * | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
| KR20210039324A (ko) * | 2018-04-06 | 2021-04-09 | 오비드 테라퓨틱스 인크. | 물질 사용 장애들의 치료에서 가복사돌의 사용 |
| WO2020061410A1 (en) | 2018-09-20 | 2020-03-26 | Ovid Therapeutics Inc. | Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering |
| GB2594616A (en) * | 2018-11-21 | 2021-11-03 | Certego Therapeutics Inc | Gaboxadol for reducing risk of suicide and rapid relief of depression |
| JP2022511755A (ja) * | 2018-11-21 | 2022-02-01 | セルテゴ セラピューティクス インコーポレイテッド | 精神障害の治療のためのガボキサドールとリチウムとの組み合わせ |
| CN113423399A (zh) | 2018-12-17 | 2021-09-21 | 奥维德医疗公司 | 加波沙朵用于治疗非24小时睡眠-觉醒障碍的用途 |
| CN114786669A (zh) | 2019-12-18 | 2022-07-22 | 奥维德医疗公司 | 用于1p36缺失综合征的治疗性治疗的加波沙朵 |
| IL298334A (en) | 2020-05-20 | 2023-01-01 | Certego Therapeutics Inc | Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK270378A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Isoxazolderivater |
| DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| AR031473A1 (es) * | 2000-11-20 | 2003-09-24 | Lundbeck & Co As H | Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide |
| US20020165217A1 (en) * | 2001-05-01 | 2002-11-07 | Pfizer Inc. | Combination treatment for anxiety and depression |
| WO2002094225A1 (en) | 2001-05-21 | 2002-11-28 | H. Lundbeck A/S | Granular preparations of gaboxadol |
-
2004
- 2004-06-25 EP EP04738956A patent/EP1641456B1/de not_active Expired - Lifetime
- 2004-06-25 PT PT04738956T patent/PT1641456E/pt unknown
- 2004-06-25 AT AT04738956T patent/ATE459353T1/de not_active IP Right Cessation
- 2004-06-25 SI SI200431414T patent/SI1641456T1/sl unknown
- 2004-06-25 EP EP09173892A patent/EP2145620A3/de not_active Withdrawn
- 2004-06-25 WO PCT/DK2004/000459 patent/WO2004112786A2/en not_active Ceased
- 2004-06-25 DK DK04738956.4T patent/DK1641456T3/da active
- 2004-06-25 NZ NZ543586A patent/NZ543586A/en unknown
- 2004-06-25 DE DE602004025808T patent/DE602004025808D1/de not_active Expired - Lifetime
- 2004-06-25 BR BRPI0410857-4A patent/BRPI0410857A/pt not_active IP Right Cessation
- 2004-06-25 PL PL04738956T patent/PL1641456T3/pl unknown
- 2004-06-25 AU AU2004248890A patent/AU2004248890A1/en not_active Abandoned
- 2004-06-25 ES ES04738956T patent/ES2341004T3/es not_active Expired - Lifetime
- 2004-06-25 JP JP2006515735A patent/JP2007508236A/ja active Pending
- 2004-06-25 MX MXPA05013016A patent/MXPA05013016A/es active IP Right Grant
- 2004-06-25 HR HR20100276T patent/HRP20100276T1/hr unknown
-
2005
- 2005-12-15 IL IL172631A patent/IL172631A0/en unknown
-
2009
- 2009-11-12 IL IL202106A patent/IL202106A0/en unknown
-
2010
- 2010-05-14 CY CY20101100433T patent/CY1110046T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL202106A0 (en) | 2010-06-16 |
| CY1110046T1 (el) | 2015-01-14 |
| AU2004248890A1 (en) | 2004-12-29 |
| EP2145620A2 (de) | 2010-01-20 |
| EP2145620A3 (de) | 2010-03-17 |
| PT1641456E (pt) | 2010-06-01 |
| WO2004112786A3 (en) | 2005-04-14 |
| NZ543586A (en) | 2009-07-31 |
| IL172631A0 (en) | 2006-04-10 |
| BRPI0410857A (pt) | 2006-07-04 |
| PL1641456T3 (pl) | 2010-08-31 |
| WO2004112786A2 (en) | 2004-12-29 |
| DK1641456T3 (da) | 2010-06-21 |
| HRP20100276T1 (hr) | 2010-06-30 |
| EP1641456B1 (de) | 2010-03-03 |
| ES2341004T3 (es) | 2010-06-14 |
| SI1641456T1 (sl) | 2010-06-30 |
| JP2007508236A (ja) | 2007-04-05 |
| EP1641456A2 (de) | 2006-04-05 |
| DE602004025808D1 (de) | 2010-04-15 |
| MXPA05013016A (es) | 2006-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE459353T1 (de) | Gaboxadol zur behandlung von depressionen und anderen affektiven störungen | |
| BRPI0607017B8 (pt) | composição farmacêutica compreendendo memantina e donezepil, e seu uso para o tratamento de condições relacionadas ao snc | |
| ATE492542T1 (de) | Herstellung und anwendung von biphenyl-4-yl- carbonylaminosäurederivaten zur behandlung von obesitas | |
| ATE376828T1 (de) | Verwendung von rotigotin zur behandlung und prävention des parkinson-plus-syndroms | |
| DE602004032522D1 (de) | Mit n-alkylhydroxamsäuren substituierte isoindolylverbindungen und deren pharmazeutische verwendung | |
| EA201000603A1 (ru) | ПРИМЕНЕНИЕ АНТИТЕЛ К TrkB ДЛЯ ЛЕЧЕНИЯ РЕСПИРАТОРНЫХ НАРУШЕНИЙ | |
| DE602004031134D1 (de) | Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa | |
| ATE534391T1 (de) | 3,11b-cis-dihydrotetrabenazin zur behandlung von psychosen | |
| EP1934025A4 (de) | Zusammensetzung zur behandlung von holz, verfahren zur behandlung von holz und holzprodukt | |
| ATE537819T1 (de) | Nutrazeutische zusammensetzungen zur behandlung von muskelschwund | |
| DE602006015387D1 (de) | Beta-2 Adrenoceptor Agonisten zur Behandlung von Bindegewebserkrankungen der Haut | |
| CL2008003231A1 (es) | Compuestos derivados de 1,3-dihidro-5-isobenzofurancarbonitrilo sustituido, inhibidores selectivos de la recaptacion de serotonina; composicion farmaceutica; procedimiento de preparacion; utiles en el tratamiento y/o prevencion de la eyaculacion prematura. | |
| BRPI0415781A (pt) | método para o tratamento de diabetes em um paciente e kit farmacêutico | |
| ATE376419T1 (de) | Carbostyril-derivate mit selektiven serotonin- aufnahme inhibitoren, zur behandlung von gemütskrankheiten | |
| TW200735868A (en) | Compositions and methods for treating CNS disorders | |
| BRPI0411175A (pt) | combinação do modafinil analéptico e um antidepressivo para o tratamento da depressão | |
| BRPI0607684A2 (pt) | composição farmacêutica, método para prevenir ou tratar distúrbios de depressão ou ansiedade, e, uso de (s)-n-[2-(1,6,7,8-tetraidro-2h-indeno[5,4-b]furan-8-il)-eti l]-propionamida | |
| CY1110156T1 (el) | Υποκατεστημενες ενωσεις 4,5,6,7-τετραϋδρο-βενζοθειαζολ-2-υλαμινης | |
| ATE460168T1 (de) | Nicht-radioaktives strontiummittel zur behandlung von krebs | |
| TW200509918A (en) | Treatment of depression and other affective disorders | |
| ATE482217T1 (de) | Dithiolopyrrolon-derivate zur behandlung von proliferativen störungen | |
| DE602004009068D1 (de) | Glycosaminoglykane zur behandlung emotionaler störungen | |
| CL2009001113A1 (es) | Compuestos derivados de 4,5-diarilpirrol-2-carboxamida; procedimiento de preparacion de estos; composicion farmaceutica que los comprende; uso en el tratamiento y/o prevencion de trastornos psiquiatricos, dependencia a sustancias, entre otras. | |
| EA200600183A1 (ru) | Сочетание ингибитора обратного захвата серотонина и агомелатина |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1641456 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |