ATE459353T1 - Gaboxadol zur behandlung von depressionen und anderen affektiven störungen - Google Patents
Gaboxadol zur behandlung von depressionen und anderen affektiven störungenInfo
- Publication number
- ATE459353T1 ATE459353T1 AT04738956T AT04738956T ATE459353T1 AT E459353 T1 ATE459353 T1 AT E459353T1 AT 04738956 T AT04738956 T AT 04738956T AT 04738956 T AT04738956 T AT 04738956T AT E459353 T1 ATE459353 T1 AT E459353T1
- Authority
- AT
- Austria
- Prior art keywords
- gaboxadol
- affective disorders
- treat depression
- pharmaceutical composition
- relates
- Prior art date
Links
- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 title abstract 3
- 229950004346 gaboxadol Drugs 0.000 title abstract 3
- 208000019022 Mood disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 abstract 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48301903P | 2003-06-25 | 2003-06-25 | |
| DKPA200300956 | 2003-06-25 | ||
| US53512304P | 2004-01-07 | 2004-01-07 | |
| DKPA200400016 | 2004-01-07 | ||
| PCT/DK2004/000459 WO2004112786A2 (en) | 2003-06-25 | 2004-06-25 | Gaboxadol for treating depression and other affective disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE459353T1 true ATE459353T1 (de) | 2010-03-15 |
Family
ID=33545397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04738956T ATE459353T1 (de) | 2003-06-25 | 2004-06-25 | Gaboxadol zur behandlung von depressionen und anderen affektiven störungen |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP1641456B1 (de) |
| JP (1) | JP2007508236A (de) |
| AT (1) | ATE459353T1 (de) |
| AU (1) | AU2004248890A1 (de) |
| BR (1) | BRPI0410857A (de) |
| CY (1) | CY1110046T1 (de) |
| DE (1) | DE602004025808D1 (de) |
| DK (1) | DK1641456T3 (de) |
| ES (1) | ES2341004T3 (de) |
| HR (1) | HRP20100276T1 (de) |
| IL (2) | IL172631A0 (de) |
| MX (1) | MXPA05013016A (de) |
| NZ (1) | NZ543586A (de) |
| PL (1) | PL1641456T3 (de) |
| PT (1) | PT1641456E (de) |
| SI (1) | SI1641456T1 (de) |
| WO (1) | WO2004112786A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1663218A1 (de) * | 2003-09-10 | 2006-06-07 | MERCK SHARP & DOHME LTD. | Verwendung von gabaa-rezeptor-agonisten zur behandlung von hör-, vestibular- und aufmerksamkeitsstörungen, intentionstremor und ruhelosen beinen |
| WO2005060968A1 (en) | 2003-12-11 | 2005-07-07 | Sepracor Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| GB0402118D0 (en) * | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| CA2556870C (en) | 2004-02-18 | 2014-01-28 | Timothy J. Barberich | Dopamine-agonist combination therapy for improving sleep quality |
| GB0417558D0 (en) * | 2004-08-06 | 2004-09-08 | Merck Sharp & Dohme | Novel combination therapy |
| EP1848420A4 (de) * | 2005-01-28 | 2008-01-23 | Merck & Co Inc | Polymorphe formen eines gabaa-agonisten |
| EP1906953A4 (de) * | 2005-04-29 | 2009-05-20 | Lundbeck & Co As H | Säure- und basensalzformen von gaboxadol |
| TW200920358A (en) * | 2007-08-13 | 2009-05-16 | Lundbeck & Co As H | Method of treating stress-mediated depression |
| US20090143335A1 (en) * | 2007-10-29 | 2009-06-04 | H. Lundbeck A/S | Modified absorption formulation of gaboxadol |
| CA2732636A1 (en) * | 2008-09-01 | 2009-05-07 | H. Lundbeck A/S | Pharmaceutical composition comprising gaboxadol and an inhibitor of pat1 or oat |
| DK3274331T3 (da) | 2015-03-24 | 2020-03-23 | H Lundbeck As | Fremstilling af 4,5,6,7-tetrahydroisozaxolo[5,4-c]pyridin-3-ol |
| KR20240160666A (ko) | 2015-07-17 | 2024-11-11 | 오비드 테라퓨틱스 인크. | 가복사돌로 발달장애들을 치료하는 방법들 |
| JP2019535760A (ja) * | 2016-11-22 | 2019-12-12 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | フルピルチンを用いた発達障害および／または発作性障害の処置方法 |
| US20180338959A1 (en) * | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
| EP3761979A4 (de) * | 2018-04-06 | 2021-06-30 | Ovid Therapeutics Inc. | Verwendung von gaboxadol zur behandlung von substanzmissbrauch |
| AU2019345312A1 (en) | 2018-09-20 | 2021-03-25 | Ovid Therapeutics Inc. | Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering |
| AU2019384561A1 (en) * | 2018-11-21 | 2021-06-10 | Certego Therapeutics Inc. | Combination of gaboxadol and lithium for the treatment of psychiatric disorders |
| WO2020106927A1 (en) * | 2018-11-21 | 2020-05-28 | Certego Therapeutics | Gaboxadol for reducing risk of suicide and rapid relief of depression |
| CN113423399A (zh) | 2018-12-17 | 2021-09-21 | 奥维德医疗公司 | 加波沙朵用于治疗非24小时睡眠-觉醒障碍的用途 |
| WO2021127308A1 (en) | 2019-12-18 | 2021-06-24 | Ovid Therapeutics Inc. | GABOXADOL FOR THERAPEUTIC TREATMENT OF 1p36 DELETION SYNDROME |
| MX2022014599A (es) | 2020-05-20 | 2022-12-16 | Certego Therapeutics Inc | Gaboxadol deuterado en anillo y su uso para el tratamiento de trastornos psiquiatricos. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK270278A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Cycliske aminosyrer |
| DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| AR031473A1 (es) * | 2000-11-20 | 2003-09-24 | Lundbeck & Co As H | Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide |
| US20020165217A1 (en) * | 2001-05-01 | 2002-11-07 | Pfizer Inc. | Combination treatment for anxiety and depression |
| EP1389091A1 (de) | 2001-05-21 | 2004-02-18 | H. Lundbeck A/S | Granulatförmige gaboxadol-zubereitungen |
-
2004
- 2004-06-25 EP EP04738956A patent/EP1641456B1/de not_active Expired - Lifetime
- 2004-06-25 NZ NZ543586A patent/NZ543586A/en unknown
- 2004-06-25 BR BRPI0410857-4A patent/BRPI0410857A/pt not_active IP Right Cessation
- 2004-06-25 DE DE602004025808T patent/DE602004025808D1/de not_active Expired - Lifetime
- 2004-06-25 DK DK04738956.4T patent/DK1641456T3/da active
- 2004-06-25 JP JP2006515735A patent/JP2007508236A/ja active Pending
- 2004-06-25 ES ES04738956T patent/ES2341004T3/es not_active Expired - Lifetime
- 2004-06-25 SI SI200431414T patent/SI1641456T1/sl unknown
- 2004-06-25 PL PL04738956T patent/PL1641456T3/pl unknown
- 2004-06-25 PT PT04738956T patent/PT1641456E/pt unknown
- 2004-06-25 AT AT04738956T patent/ATE459353T1/de not_active IP Right Cessation
- 2004-06-25 HR HR20100276T patent/HRP20100276T1/hr unknown
- 2004-06-25 AU AU2004248890A patent/AU2004248890A1/en not_active Abandoned
- 2004-06-25 MX MXPA05013016A patent/MXPA05013016A/es active IP Right Grant
- 2004-06-25 EP EP09173892A patent/EP2145620A3/de not_active Withdrawn
- 2004-06-25 WO PCT/DK2004/000459 patent/WO2004112786A2/en not_active Ceased
-
2005
- 2005-12-15 IL IL172631A patent/IL172631A0/en unknown
-
2009
- 2009-11-12 IL IL202106A patent/IL202106A0/en unknown
-
2010
- 2010-05-14 CY CY20101100433T patent/CY1110046T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2145620A2 (de) | 2010-01-20 |
| BRPI0410857A (pt) | 2006-07-04 |
| NZ543586A (en) | 2009-07-31 |
| AU2004248890A1 (en) | 2004-12-29 |
| DK1641456T3 (da) | 2010-06-21 |
| IL202106A0 (en) | 2010-06-16 |
| PL1641456T3 (pl) | 2010-08-31 |
| HRP20100276T1 (hr) | 2010-06-30 |
| WO2004112786A3 (en) | 2005-04-14 |
| SI1641456T1 (sl) | 2010-06-30 |
| MXPA05013016A (es) | 2006-03-02 |
| JP2007508236A (ja) | 2007-04-05 |
| EP1641456B1 (de) | 2010-03-03 |
| EP1641456A2 (de) | 2006-04-05 |
| DE602004025808D1 (de) | 2010-04-15 |
| EP2145620A3 (de) | 2010-03-17 |
| WO2004112786A2 (en) | 2004-12-29 |
| CY1110046T1 (el) | 2015-01-14 |
| IL172631A0 (en) | 2006-04-10 |
| PT1641456E (pt) | 2010-06-01 |
| ES2341004T3 (es) | 2010-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1641456 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |