ATE459377T1 - Festphase fluorierung von uracil - Google Patents

Festphase fluorierung von uracil

Info

Publication number
ATE459377T1
ATE459377T1 AT03782657T AT03782657T ATE459377T1 AT E459377 T1 ATE459377 T1 AT E459377T1 AT 03782657 T AT03782657 T AT 03782657T AT 03782657 T AT03782657 T AT 03782657T AT E459377 T1 ATE459377 T1 AT E459377T1
Authority
AT
Austria
Prior art keywords
formula
tracer
fluoration
uracil
solid phase
Prior art date
Application number
AT03782657T
Other languages
English (en)
Inventor
Frank Brady
Sajinder Kaur Luthra
Edward George Robins
Original Assignee
Hammersmith Imanet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hammersmith Imanet Ltd filed Critical Hammersmith Imanet Ltd
Application granted granted Critical
Publication of ATE459377T1 publication Critical patent/ATE459377T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT03782657T 2002-12-20 2003-12-19 Festphase fluorierung von uracil ATE459377T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0229683.8A GB0229683D0 (en) 2002-12-20 2002-12-20 Preparation of radiopharmaceuticals
PCT/GB2003/005577 WO2004056400A1 (en) 2002-12-20 2003-12-19 Solid-phase fluorination of uracil and cytosine

Publications (1)

Publication Number Publication Date
ATE459377T1 true ATE459377T1 (de) 2010-03-15

Family

ID=9950058

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03782657T ATE459377T1 (de) 2002-12-20 2003-12-19 Festphase fluorierung von uracil

Country Status (9)

Country Link
US (1) US7504208B2 (de)
EP (1) EP1572249B1 (de)
JP (1) JP2006510707A (de)
AT (1) ATE459377T1 (de)
AU (1) AU2003290297A1 (de)
DE (1) DE60331586D1 (de)
ES (1) ES2341102T3 (de)
GB (1) GB0229683D0 (de)
WO (1) WO2004056400A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
EP2192928A4 (de) * 2007-10-03 2011-04-06 Ge Healthcare Ltd Perfluor-aryliodonium-salze in einer nukleophilen aromatischen 18f-fluorierung
ES2767973T3 (es) 2008-02-29 2020-06-19 Lantheus Medical Imaging Inc Agentes de contraste para aplicaciones que comprenden formación de imágenes de perfusión
AU2015264872B2 (en) * 2008-10-21 2018-02-22 Board Of Regents Of The University Of Nebraska Fluorination of aromatic ring systems
US9302990B2 (en) 2008-10-21 2016-04-05 Nutech Ventures Fluorination of aromatic ring systems
AU2009307715B2 (en) 2008-10-21 2015-08-27 Board Of Regents Of The University Of Nebraska Fluorination of aromatic ring systems
LT2419096T (lt) 2009-04-15 2020-04-10 Lantheus Medical Imaging, Inc. Radiofarmacinės kompozicijos stabilizavimas naudojant askorbo rūgštį
US8377704B2 (en) * 2009-10-20 2013-02-19 Nutech Ventures Detection and quantification of anions
US8546578B2 (en) * 2010-02-04 2013-10-01 Nutech Ventures Iodonium Cyclophanes for SECURE arene functionalization
KR101709372B1 (ko) 2010-02-08 2017-02-22 랜티우스 메디컬 이메징, 인크. 조영제 및 이의 중간체를 합성하는 방법 및 장치
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN105237483B (zh) * 2015-11-10 2018-04-20 东华大学 一种对称型嘧啶基碘鎓盐及其制备方法
USD813317S1 (en) 2017-03-30 2018-03-20 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3808097A (en) * 1972-11-28 1974-04-30 Energy Commission Production of fluorine-18 labeled 5-fluorouracil
US5312592A (en) * 1990-06-13 1994-05-17 Scanditronix Ab Disposable kit for preparation
BE1010280A3 (fr) * 1996-05-02 1998-05-05 Coincidence S A Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose.
DE19951715C1 (de) 1999-10-27 2001-03-22 Rossendorf Forschzent 18F-Radiotracer und deren Verwendung zum Monitoring der Expression der Cytosin-Deaminase nach Gentransfer sowie Verfahren zur Herstellung der 18F-Radiotracer
GB0115927D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination

Also Published As

Publication number Publication date
DE60331586D1 (de) 2010-04-15
GB0229683D0 (en) 2003-01-29
US20060120958A1 (en) 2006-06-08
WO2004056400A1 (en) 2004-07-08
US7504208B2 (en) 2009-03-17
EP1572249B1 (de) 2010-03-03
JP2006510707A (ja) 2006-03-30
AU2003290297A1 (en) 2004-07-14
EP1572249A1 (de) 2005-09-14
ES2341102T3 (es) 2010-06-15

Similar Documents

Publication Publication Date Title
DE60331586D1 (de) Festphase fluorierung von uracil
MXPA04002067A (es) Nuevas dihidropteridinonas, procedimientos para su preparacion y su uso como medicamento.
TR200001876T2 (tr) HIV proteaz inhibitörünün bisülfat tuzu.
BRPI0406926A (pt) Inibidores de polimerase viral
ATE292634T1 (de) Inhibitoren der alpha-l beta-2 vermittelten zelladhäsion
ATE338461T1 (de) Pyrazolpyrimidinfungizide
NO20060847L (no) Substituert 2-aminotetralin til behandling av depresjon
MXPA03009548A (es) Arilsulfonamidas como agentes antivirales.
SE0000933D0 (sv) Method of producing 6-substituted (S)-nicotine derivatives and intermediate compounds
BRPI0415203A (pt) pentanóis reestruturados, um processo para sua produção e seu uso como agentes antiinflamatórios
EA200300804A1 (ru) Усовершенствованный способ получения карбапенема
ATE409180T1 (de) Synthese von zyklopentadien derivaten
BRPI0506927A (pt) compostos orgánicos
BRPI0510335A (pt) composto heterocìclico
BR0113259A (pt) Processo para a preparação de um composto, composto e processo para a preparação de compostos
BRPI0409095A (pt) processos de sìntese do ácido (2s)-indolina-2-carboxìlico, e aplicação para a sìntese do perindopril
BR0211903A (pt) Isoxazolopiridinonas
ATE373636T1 (de) Amidderivate als inhibitoren der enzymatischen aktivität von renin
HUP0402224A2 (hu) Helyettesített tetraciklusos tetrahidrofurán-származékok új mandelátsói
CO5611175A2 (es) 1,2-dihidropirazol-3-onas como mediadores de citosina
SE0003186D0 (sv) New process
TW200719889A (en) Amino acid derivatives
EP1571144A4 (de) Hydroxyalkylierte cyclischediaminverbindung
BR0317719A (pt) Derivados de fosforamida
BRPI0417423A (pt) processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties