ATE460412T1 - Trisubstituierte thiophene als progesteronreceptor-modulatoren - Google Patents

Trisubstituierte thiophene als progesteronreceptor-modulatoren

Info

Publication number: ATE460412T1
Authority: AT; Austria
Prior art keywords: progesterone receptor; tris; receptor modulators; prevention; treatment
Prior art date: 2004-10-27

Application number

AT05816130T

Other languages

English (en)

Inventor

W Jiang

J J Fiordeliso

Z Sui

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-27

Filing date

2005-10-21

Publication date

2010-03-15

2005-10-21 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE460412T1 publication Critical patent/ATE460412T1/de

Links

150000003577 thiophenes Chemical class 0.000 title abstract 2
239000002379 progesterone receptor modulator Substances 0.000 title 1
229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title 1
229930192474 thiophene Natural products 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
201000000736 Amenorrhea Diseases 0.000 abstract 1
206010001928 Amenorrhoea Diseases 0.000 abstract 1
201000009030 Carcinoma Diseases 0.000 abstract 1
206010013908 Dysfunctional uterine bleeding Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
206010027514 Metrorrhagia Diseases 0.000 abstract 1
208000009956 adenocarcinoma Diseases 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
231100000540 amenorrhea Toxicity 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
210000000481 breast Anatomy 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
210000004696 endometrium Anatomy 0.000 abstract 1
230000037406 food intake Effects 0.000 abstract 1
235000012631 food intake Nutrition 0.000 abstract 1
230000003054 hormonal effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
210000001672 ovary Anatomy 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000010065 polycystic ovary syndrome Diseases 0.000 abstract 1
102000003998 progesterone receptors Human genes 0.000 abstract 1
108090000468 progesterone receptors Proteins 0.000 abstract 1
210000002307 prostate Anatomy 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Amplifiers (AREA)
Optical Communication System (AREA)

AT05816130T 2004-10-27 2005-10-21 Trisubstituierte thiophene als progesteronreceptor-modulatoren ATE460412T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US62258104P	2004-10-27	2004-10-27
PCT/US2005/037827 WO2006049891A1 (en)	2004-10-27	2005-10-21	Trisubstituted thiophenes as progesterone receptor modulators

Publications (1)

Publication Number	Publication Date
ATE460412T1 true ATE460412T1 (de)	2010-03-15

Family

ID=35840022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05816130T ATE460412T1 (de)	2004-10-27	2005-10-21	Trisubstituierte thiophene als progesteronreceptor-modulatoren

Country Status (10)

Country	Link
US (2)	US7638525B2 (de)
EP (1)	EP1807420B1 (de)
JP (1)	JP5137578B2 (de)
CN (1)	CN101087783B (de)
AT (1)	ATE460412T1 (de)
AU (1)	AU2005302708A1 (de)
CA (1)	CA2585337C (de)
DE (1)	DE602005019905D1 (de)
ES (1)	ES2341268T3 (de)
WO (1)	WO2006049891A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20081803A1 (es) *	2007-03-09	2008-12-11	Wyeth Corp	Sintesis y caracterizacion de la forma ii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo
EP3656403B1 (de)	2007-08-17	2022-05-11	Purdue Research Foundation	Verfahren zur herstellung von psma-bindende liganden-linker-konjugaten
US9951324B2 (en)	2010-02-25	2018-04-24	Purdue Research Foundation	PSMA binding ligand-linker conjugates and methods for using
EP2664325A1 (de) *	2012-05-16	2013-11-20	PregLem S.A.	Verfahren zur Prävention oder Behandlung von androgenvermittelten Erkrankungen
MX2015006109A (es)	2012-11-15	2016-02-05	Endocyte Inc	Conjugados para el tratamiento de enfermedades causadas por celulas que expresan psma.
GEP20237497B (en)	2013-10-18	2023-04-10	Deutsches Krebsforsch	Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
EP3777898B1 (de)	2013-11-14	2025-01-01	Endocyte, Inc.	Verbindungen für positronenemissionstomografie
US10188759B2 (en)	2015-01-07	2019-01-29	Endocyte, Inc.	Conjugates for imaging
WO2019204335A1 (en)	2018-04-17	2019-10-24	Endocyte, Inc.	Methods of treating cancer
EP3972627A4 (de)	2019-05-20	2023-06-21	Endocyte, Inc.	Verfahren zur herstellung von psma-konjugaten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD201306A1 (de) *	1981-12-10	1983-07-13	Juergen Liebscher	Verfahren zur herstellung von 5-acyl-3-aryl-2-dialkylaminothiophenen
US5696127A (en)	1994-12-22	1997-12-09	Ligand Pharmaceuticals Incorporated	Steroid receptor modulator compounds and methods
CN1349538A (zh) *	1999-05-04	2002-05-15	美国家庭用品有限公司	环氨基甲酸酯和环酰胺衍生物
US6306851B1 (en) *	1999-05-04	2001-10-23	American Home Products Corporation	Cyclocarbamate and cyclic amide derivatives
AUPR738301A0 (en)	2001-08-30	2001-09-20	Starpharma Limited	Chemotherapeutic agents

2005
- 2005-10-21 JP JP2007538998A patent/JP5137578B2/ja not_active Expired - Fee Related
- 2005-10-21 WO PCT/US2005/037827 patent/WO2006049891A1/en not_active Ceased
- 2005-10-21 AT AT05816130T patent/ATE460412T1/de not_active IP Right Cessation
- 2005-10-21 AU AU2005302708A patent/AU2005302708A1/en not_active Abandoned
- 2005-10-21 DE DE602005019905T patent/DE602005019905D1/de not_active Expired - Lifetime
- 2005-10-21 CN CN2005800446628A patent/CN101087783B/zh not_active Expired - Fee Related
- 2005-10-21 US US11/255,445 patent/US7638525B2/en not_active Expired - Fee Related
- 2005-10-21 CA CA2585337A patent/CA2585337C/en not_active Expired - Fee Related
- 2005-10-21 ES ES05816130T patent/ES2341268T3/es not_active Expired - Lifetime
- 2005-10-21 EP EP05816130A patent/EP1807420B1/de not_active Expired - Lifetime
2009
- 2009-08-17 US US12/542,135 patent/US20090306118A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090306118A1 (en)	2009-12-10
EP1807420B1 (de)	2010-03-10
US20060106047A1 (en)	2006-05-18
AU2005302708A1 (en)	2006-05-11
EP1807420A1 (de)	2007-07-18
WO2006049891A1 (en)	2006-05-11
US7638525B2 (en)	2009-12-29
DE602005019905D1 (de)	2010-04-22
ES2341268T3 (es)	2010-06-17
JP5137578B2 (ja)	2013-02-06
CN101087783A (zh)	2007-12-12
CN101087783B (zh)	2010-12-08
JP2008518011A (ja)	2008-05-29
CA2585337C (en)	2013-12-24
CA2585337A1 (en)	2006-05-11

Legal Events

Date	Code	Title	Description
2010-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
EA201200860A1 (ru)	2013-01-30	Нейтрализующие пролактиновый рецептор антитела и их терапевтическое применение
CY1121926T1 (el)	2020-10-14	(11.βητα., 17.βητα.)-17-υδροξυ-11-[4(μεθυλοσουλφονυλο)φαινυλο]-17-(πενταφθορομεθυλο)οιστρα-4,9-διεν-3-ονη για την αγωγη παθησεων
ATE460412T1 (de)	2010-03-15	Trisubstituierte thiophene als progesteronreceptor-modulatoren
CY1110017T1 (el)	2015-01-14	Μικρονισμενη ταναπρογετη και συνθεσεις που περιεχουν αυτην
WO2011098437A3 (de)	2011-10-27	Progesteronrezeptorantagonisten
NO20070248L (no)	2007-01-15	Fremgangsmater for fremstilling av gonadotropinfrigjorende hormon reseptor antagonister
EA201491344A1 (ru)	2015-04-30	Производные спироиндолина в качестве антагонистов рецептора гонадотропин-рилизинг гормона
TR200103285T2 (tr)	2002-02-21	Projesteron reseptörü modülatörleri olarak siklokarbamat türevleri.
CY1109919T1 (el)	2014-09-10	Παραγωγα της ινδολης που ειναι χρησιμα σα ρυθμιστες του υποδοχεα της προγεστερονης
ECSP078043A (es)	2008-01-23	Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona
EA201792524A1 (ru)	2018-04-30	Режим приема селективного модулятора рецептора прогестерона (sprm)
ATE275973T1 (de)	2004-10-15	Empfängnisverhütende zusammensetzungen die progestagen und progesteronantagonisten enthalten
DK1874278T3 (da)	2009-09-28	Sammensætninger indeholdende mikroniseret tanaproget
MA32477B1 (fr)	2011-07-03	Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique
NO20080440L (no)	2008-03-25	Ikke-steroide progesteronreseptormodulatorer
WO2008109055A8 (en)	2009-01-08	Cyanopyrrole sulfonamides useful for modulation of the progesterone receptor
UY30805A1 (es)	2008-07-31	Moduladores no esteroides de receptores de progesterona
AR023854A1 (es)	2002-09-04	Uso de derivados de indolina y equipo farmaceutico para regimenes ciclicos