ATE460944T1 - Verfahren und zusammensetzungen zur herstellung und steuerung des effektorprofils von t-zellen durch gleichzeitiges beladen und aktivieren ausgewählter untergruppen von antigen- präsentierenden zellen - Google Patents
Verfahren und zusammensetzungen zur herstellung und steuerung des effektorprofils von t-zellen durch gleichzeitiges beladen und aktivieren ausgewählter untergruppen von antigen- präsentierenden zellenInfo
- Publication number
- ATE460944T1 ATE460944T1 AT03797931T AT03797931T ATE460944T1 AT E460944 T1 ATE460944 T1 AT E460944T1 AT 03797931 T AT03797931 T AT 03797931T AT 03797931 T AT03797931 T AT 03797931T AT E460944 T1 ATE460944 T1 AT E460944T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- antigen
- compositions
- producing
- controlling
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 230000003213 activating effect Effects 0.000 title 1
- 210000000612 antigen-presenting cell Anatomy 0.000 title 1
- 239000012636 effector Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 108091027963 non-coding RNA Proteins 0.000 abstract 1
- 102000042567 non-coding RNA Human genes 0.000 abstract 1
Classifications
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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- A61K2039/6031—Proteins
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- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41221902P | 2002-09-20 | 2002-09-20 | |
| PCT/US2003/007995 WO2003078595A2 (en) | 2002-03-15 | 2003-03-14 | Immunostimulatory double stranded rna and methods of inducing, enhancing or modulating the immune response |
| PCT/US2003/030188 WO2004027049A2 (en) | 2002-09-20 | 2003-09-18 | Methods and compositions to generate and control the effector profile of t cells by simultaneous loading and activation of selected subsets of antigen presenting cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE460944T1 true ATE460944T1 (de) | 2010-04-15 |
Family
ID=32030833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03797931T ATE460944T1 (de) | 2002-09-20 | 2003-09-18 | Verfahren und zusammensetzungen zur herstellung und steuerung des effektorprofils von t-zellen durch gleichzeitiges beladen und aktivieren ausgewählter untergruppen von antigen- präsentierenden zellen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20060193855A1 (de) |
| EP (2) | EP2258712A3 (de) |
| JP (1) | JP2006514920A (de) |
| CN (1) | CN1703427A (de) |
| AT (1) | ATE460944T1 (de) |
| AU (1) | AU2003276932A1 (de) |
| CA (1) | CA2499066A1 (de) |
| DE (1) | DE60331741D1 (de) |
| WO (1) | WO2004027049A2 (de) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258712A3 (de) | 2002-03-15 | 2011-05-04 | Multicell Immunotherapeutics, Inc. | Zusammensetzungen und Verfahren zur Einleitung bzw. Verstärkung von Antikörper- und Haupthistokompatibilität-Klasse-I- oder-Klasse-II-beschränkten T-Zell-Reaktionen unter Anwendung von Immunmodulierenden, nicht-codierenden RNA-Motiven |
| US20050276812A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
| CN107213469A (zh) | 2003-11-06 | 2017-09-29 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| WO2007022477A2 (en) * | 2005-08-17 | 2007-02-22 | Multicell Immunotherapeutics, Inc. | Methods and compositions to generate and control the effector profile of t cells |
| PL1949913T3 (pl) * | 2005-10-07 | 2010-10-29 | Proyecto De Biomedicina Cima S L | Immunostymulująca kombinacja do profilaktyki i leczenia wirusowego zapalenia wątroby typu c |
| RU2539765C2 (ru) * | 2008-07-16 | 2015-01-27 | Бейлор Рисёч Инститьют | ВИЧ ВАКЦИНА, ОСНОВАННАЯ НА НАПРАВЛЕННОСТИ МАКСИМИЗИРОВАННЫХ Gag И Nef НА ДЕНДРИТНЫЕ КЛЕТКИ |
| CA2809819A1 (en) | 2009-09-09 | 2011-03-17 | Centrose, Llc | Extracellular targeted drug conjugates |
| WO2011130598A1 (en) | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines and conjugates thereof |
| MX336540B (es) | 2010-06-08 | 2016-01-22 | Genentech Inc | Conjugados y anticuerpos manipulados geneticamente con cisteina. |
| WO2012029792A1 (ja) * | 2010-08-30 | 2012-03-08 | 独立行政法人理化学研究所 | TGF-β受容体の活性化を抑制する活性を有する化合物、そのスクリーニング方法、並びにC型肝炎ウィルスに起因する疾患の予防又は治療のための組成物 |
| ES2544608T3 (es) | 2010-11-17 | 2015-09-02 | Genentech, Inc. | Conjugados de anticuerpo y de alaninil-maitansinol |
| MX2013013054A (es) | 2011-05-12 | 2014-02-20 | Genentech Inc | Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura. |
| CN102336821B (zh) * | 2011-08-11 | 2014-10-15 | 北京永泰免疫应用科技有限公司 | Melan-A表位肽及其在预防和/或治疗肿瘤中的用途 |
| WO2013055987A1 (en) | 2011-10-14 | 2013-04-18 | Spirogen Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| KR101645905B1 (ko) | 2012-10-12 | 2016-08-04 | 스피로즌 살 | 피롤로벤조디아제핀 및 그의 컨주게이트 |
| WO2014057117A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| HRP20181646T2 (hr) | 2012-10-12 | 2019-08-09 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin - anti-psma protutijela |
| WO2014057120A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| MX364328B (es) | 2012-10-12 | 2019-04-23 | Medimmune Ltd | Conjugados del anticuerpo pirrolobenzodiazepina. |
| ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
| PL2906251T3 (pl) | 2012-10-12 | 2018-02-28 | Adc Therapeutics Sa | Koniugaty pirolobenzodiazepina-przeciwciało anty-CD22 |
| CN105246894A (zh) | 2012-12-21 | 2016-01-13 | 斯皮罗根有限公司 | 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物 |
| AU2013366493B2 (en) | 2012-12-21 | 2017-08-24 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| EP2968585B1 (de) | 2013-03-13 | 2018-07-18 | Medimmune Limited | Pyrrolobenzodiazepine und konjugate davon |
| JP6445519B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
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- 2003-09-18 US US10/527,931 patent/US20060193855A1/en not_active Abandoned
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| JP2006514920A (ja) | 2006-05-18 |
| EP2258712A3 (de) | 2011-05-04 |
| AU2003276932A1 (en) | 2004-04-08 |
| EP1539819B1 (de) | 2010-03-17 |
| WO2004027049A3 (en) | 2004-05-21 |
| CN1703427A (zh) | 2005-11-30 |
| CA2499066A1 (en) | 2004-04-01 |
| EP2258712A2 (de) | 2010-12-08 |
| EP1539819A2 (de) | 2005-06-15 |
| US20110274705A1 (en) | 2011-11-10 |
| DE60331741D1 (de) | 2010-04-29 |
| EP1539819A4 (de) | 2007-08-08 |
| US20060193855A1 (en) | 2006-08-31 |
| WO2004027049B1 (en) | 2004-07-22 |
| US8809290B2 (en) | 2014-08-19 |
| WO2004027049A2 (en) | 2004-04-01 |
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