ATE461182T1 - Kristallines mycophenolat-natrium - Google Patents

Kristallines mycophenolat-natrium

Info

Publication number: ATE461182T1
Authority: AT; Austria
Prior art keywords: mycophenolate sodium; crystalline mycophenolate; crystalline; sodium; processes
Prior art date: 2004-07-20

Application number

AT05773805T

Other languages

English (en)

Inventor

Sandor Molnar

Csaba Szabo

Tivadar Tamas

Janos Hajko

Adrienne Kovacsne-Mezei

Judith Aronhime

Original Assignee

Teva Gyogyszergyar Zartkoeruen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-20

Filing date

2005-07-20

Publication date

2010-04-15

2005-07-20 Application filed by Teva Gyogyszergyar Zartkoeruen filed Critical Teva Gyogyszergyar Zartkoeruen

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE461182T1 publication Critical patent/ATE461182T1/de

Links

HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title abstract 2
229960000951 mycophenolic acid Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Transplantation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Furan Compounds (AREA)

AT05773805T 2004-07-20 2005-07-20 Kristallines mycophenolat-natrium ATE461182T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US58990904P	2004-07-20	2004-07-20
US63184904P	2004-11-29	2004-11-29
PCT/US2005/025816 WO2006012385A2 (en)	2004-07-20	2005-07-20	Crystalline mycophenolate sodium

Publications (1)

Publication Number	Publication Date
ATE461182T1 true ATE461182T1 (de)	2010-04-15

Family

ID=35385154

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05773805T ATE461182T1 (de)	2004-07-20	2005-07-20	Kristallines mycophenolat-natrium

Country Status (10)

Country	Link
US (4)	US7439373B2 (de)
EP (2)	EP1908756A1 (de)
JP (2)	JP2008506784A (de)
CN (2)	CN101052631A (de)
AT (1)	ATE461182T1 (de)
CA (2)	CA2573781A1 (de)
DE (1)	DE602005020014D1 (de)
ES (1)	ES2340184T3 (de)
TW (2)	TW200611692A (de)
WO (2)	WO2006012385A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2032712B1 (de) *	2006-06-29	2010-02-10	Ivax Pharmaceuticals S.R.O.	Regulation der säuremetabolitproduktion
US20080176937A1 (en) *	2007-01-23	2008-07-24	Apotex Fermentation Inc.	Novel crystalline mycophenolate sodium polymorph and processes to manufacture same
US20080182998A1 (en) *	2007-01-25	2008-07-31	Apotex Fermentation Inc.	Novel crystalline mycophenolate sodium polymorph and processes to manufacture same
WO2008127663A1 (en) *	2007-04-11	2008-10-23	Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság	Method for reducing impurity level in mycophenolic acid fermentation
WO2010004435A2 (en) *	2008-07-09	2010-01-14	Aspreva International Ltd.	Formulations for treating eye disorders
WO2010041269A1 (en) *	2008-09-10	2010-04-15	Ipca Laboratories Limited	Process for preparation of mycophenolic acid, its salt and ester derivatives
CN103880799A (zh) *	2010-11-16	2014-06-25	北京京卫信康医药科技发展有限公司	麦考酚酸钠的新晶型及其制备方法
CN102464639A (zh) *	2010-11-16	2012-05-23	北京京卫信康医药科技发展有限公司	麦考酚酸钠的新晶型及其制备方法
CN103880800A (zh) *	2010-11-16	2014-06-25	北京京卫信康医药科技发展有限公司	麦考酚酸钠的新晶型及其制备方法
CN103923044A (zh) *	2010-11-16	2014-07-16	北京京卫信康医药科技发展有限公司	麦考酚酸钠的新晶型及其制备方法
EP3578546A1 (de)	2013-11-15	2019-12-11	Akebia Therapeutics Inc.	Feste formen von {[5-(3-chlorophenyl)-3-hydroxypyridin-2-carbonyl]amino}essigsäure, zusammensetzungen und verwendungen davon
CN106350550B (zh) *	2016-11-28	2019-05-07	无锡福祈制药有限公司	一种自麦考酚酸菌株制备麦考酚钠的方法
CN106866594A (zh) *	2017-02-17	2017-06-20	上海华源医药科技发展有限公司	适用于麦考酚钠工业化生产的优化工艺
RU2723255C2 (ru) *	2018-11-14	2020-06-09	Общество с ограниченной ответственностью "Изварино Фарма"	Экструдат с микофенолятом натрия для получения пероральной твердой лекарственной формы
CN110922371B (zh) *	2019-12-27	2020-08-11	广东蓝宝制药有限公司	一种m2晶型麦考酚钠的制备方法
CN112645912B (zh) *	2020-12-27	2022-05-13	广东蓝宝制药有限公司	一种高纯度m2晶型麦考酚钠的制备方法
CN114478452B (zh) *	2022-02-22	2024-02-06	广东蓝宝制药有限公司	一种麦考酚钠的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1157099A (en)	1966-09-27	1969-07-02	Ici Ltd	Fermentation Process
GB1158387A (en)	1967-06-13	1969-07-16	Ici Ltd	Procedure for Isolation of Mycophenolic Acid
ZA684959B (en) *	1967-11-22	1969-05-22	Lilly Co Eli	Agents and methods for inhibiting the growth of malignant tumor cells in warm-blooded mammals
US4452891A (en) *	1980-09-08	1984-06-05	Ajinomoto Company Incorporated	Method for production of mycophenolic acid by fermentation
US4748173A (en) *	1987-01-30	1988-05-31	Syntex (U.S.A.) Inc.	Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
US4753935A (en) *	1987-01-30	1988-06-28	Syntex (U.S.A.) Inc.	Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US4861776A (en) *	1987-01-30	1989-08-29	Syntex (U.S.A) Inc.	Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
US5247083A (en) *	1992-07-10	1993-09-21	Syntex (U.S.A.) Inc.	Direct esterification of mycophenolic acid
US5455045A (en) *	1993-05-13	1995-10-03	Syntex (U.S.A.) Inc.	High dose formulations
BR9407469A (pt) *	1993-09-15	1996-11-12	Syntex Inc	Micofenolato mofetil anidro cristalino e formulação intravenosa do mesmo
PL177323B1 (pl) *	1993-10-01	1999-10-29	Syntex Inc	Kompozycja farmaceutyczna zawierająca mykofenolan mofetylu lub kwas mykofenolowy i sposób wytwarzania kompozycji farmaceutycznej zawierającej mykofenolan mofetylu lub kwas mykofenolowy
ID18663A (id) *	1996-04-12	1998-04-30	Novartis Ag	Komposisi farmasi berlapis enterik
GB9812413D0 (en) *	1998-06-10	1998-08-05	Glaxo Group Ltd	Compound and its use
IN188985B (de)	1998-12-09	2002-11-30	Biocon Ltd
HUP9903226A2 (en)	1999-09-23	2002-08-28	Gyogyszerki	Process for producing mycophenolic acid and derivatives thereof
US6927047B1 (en)	2000-02-29	2005-08-09	Biocon Limited	Manufacture and purification of mycophenolic acid
CZ292123B6 (cs)	2001-06-08	2003-08-13	Ivax Pharmaceuticals S.R.O.	Způsob přípravy mykofenolátu mofetilu
GB0124953D0 (en) *	2001-10-17	2001-12-05	Novartis Ag	Organic Compounds
WO2004020426A1 (en)	2002-08-29	2004-03-11	Biocon Limited	Process for the production of an immunosuppressant
GB0301259D0 (en)	2003-01-20	2003-02-19	Novartis Ag	Organic compounds
TWI221414B (en) *	2003-02-21	2004-10-01	Chunghwa Chemical Synthesis &	Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) *	2003-04-01	2003-05-07	Novartis Ag	Organic compounds

2005
- 2005-07-20 US US11/186,560 patent/US7439373B2/en not_active Expired - Fee Related
- 2005-07-20 CN CNA2005800239539A patent/CN101052631A/zh active Pending
- 2005-07-20 ES ES05773805T patent/ES2340184T3/es not_active Expired - Lifetime
- 2005-07-20 JP JP2007522726A patent/JP2008506784A/ja active Pending
- 2005-07-20 CA CA002573781A patent/CA2573781A1/en not_active Abandoned
- 2005-07-20 EP EP07023241A patent/EP1908756A1/de not_active Withdrawn
- 2005-07-20 AT AT05773805T patent/ATE461182T1/de not_active IP Right Cessation
- 2005-07-20 TW TW094124541A patent/TW200611692A/zh unknown
- 2005-07-20 WO PCT/US2005/025816 patent/WO2006012385A2/en not_active Ceased
- 2005-07-20 TW TW094124619A patent/TWI322147B/zh not_active IP Right Cessation
- 2005-07-20 CA CA002573784A patent/CA2573784A1/en not_active Abandoned
- 2005-07-20 US US11/186,164 patent/US20060069150A1/en not_active Abandoned
- 2005-07-20 EP EP05775059A patent/EP1699773A2/de not_active Ceased
- 2005-07-20 JP JP2007522720A patent/JP2008506783A/ja active Pending
- 2005-07-20 CN CNA2005800240659A patent/CN101014584A/zh active Pending
- 2005-07-20 WO PCT/US2005/025808 patent/WO2006012379A2/en not_active Ceased
- 2005-07-20 DE DE602005020014T patent/DE602005020014D1/de not_active Expired - Lifetime
2007
- 2007-12-14 US US12/002,069 patent/US20080097096A1/en not_active Abandoned
- 2007-12-14 US US12/002,049 patent/US20080103317A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2006012379A3 (en)	2006-06-22
US20060069152A1 (en)	2006-03-30
EP1908756A1 (de)	2008-04-09
TW200615272A (en)	2006-05-16
ES2340184T3 (es)	2010-05-31
US20080103317A1 (en)	2008-05-01
DE602005020014D1 (de)	2010-04-29
US20060069150A1 (en)	2006-03-30
JP2008506783A (ja)	2008-03-06
JP2008506784A (ja)	2008-03-06
WO2006012385A3 (en)	2006-06-22
US20080097096A1 (en)	2008-04-24
US7439373B2 (en)	2008-10-21
TW200611692A (en)	2006-04-16
TWI322147B (en)	2010-03-21
CA2573784A1 (en)	2006-02-02
WO2006012379A2 (en)	2006-02-02
WO2006012385A2 (en)	2006-02-02
CN101014584A (zh)	2007-08-08
EP1699773A2 (de)	2006-09-13
CN101052631A (zh)	2007-10-10
WO2006012379A8 (en)	2006-04-20
CA2573781A1 (en)	2006-02-02

Legal Events

Date	Code	Title	Description
2010-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
EP1786968A4 (de)	2011-03-16	Mit wasser aufgequollenes spunmelt-vlies
DE602004000470D1 (de)	2006-05-11	Fotomaske
EP1761430A4 (de)	2011-09-21	Drehflügler
DE602005020014D1 (de)	2010-04-29	Kristallines mycophenolat-natrium
DE602005004477D1 (de)	2008-03-13	Softrouter
DE602005027567D1 (de)	2011-06-01	1-aza-bicycloä3.3.1ünonane
DE602005016150D1 (de)	2009-10-01	Flügelzellen-nockenwellenversteller
FR2893200B1 (fr)	2008-01-18	Alternateur.
DE102004052020B8 (de)	2013-07-04	Druckformmanipulator
DE602004007387D1 (de)	2007-08-16	5-substituierte chinazolinonderivate
DE602004021069D1 (de)	2009-06-25	Nockenwellenverstellereinrichtung
DE60331395D1 (de)	2010-04-08	CO2 Inkubator
DE502005000334D1 (de)	2007-03-15	Spannvorrichtung
DE502005006071D1 (de)	2009-01-08	Flügelzellen-nockenwellenversteller
DE602006017660D1 (de)	2010-12-02	Maskenrohlinge
DE602004004284D1 (de)	2007-02-22	Datum-korrigierer
DE60327250D1 (de)	2009-05-28	Modifizierte bace
DE502005011057D1 (de)	2011-04-14	Laseranordnung
ITMI20051313A1 (it)	2007-01-13	Tutore per ginocchio
ITRM20040053A1 (it)	2004-04-29	Cuscino per gastroscopia.
DE502005000315D1 (de)	2007-03-08	Spannvorrichtung
ES1057865Y (es)	2005-01-16	Desatascador de desagues.
ES1056623Y (es)	2004-08-01	Flexometro perfeccionado.
ES1057444Y (es)	2004-11-16	Flexometro.
NO20035165D0 (no)	2003-11-20	Fremgangsmåte for effektiv meldingsutveksling