ATE461199T1 - Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie - Google Patents
Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographieInfo
- Publication number
- ATE461199T1 ATE461199T1 AT05820862T AT05820862T ATE461199T1 AT E461199 T1 ATE461199 T1 AT E461199T1 AT 05820862 T AT05820862 T AT 05820862T AT 05820862 T AT05820862 T AT 05820862T AT E461199 T1 ATE461199 T1 AT E461199T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrocodone
- purification
- preparative chromatography
- column
- separation
- Prior art date
Links
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 title abstract 3
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 title abstract 3
- 229960000240 hydrocodone Drugs 0.000 title abstract 3
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004237 preparative chromatography Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 230000005526 G1 to G0 transition Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000013110 organic ligand Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/287—Non-polar phases; Reversed phases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62243004P | 2004-10-27 | 2004-10-27 | |
| PCT/US2005/038603 WO2006052456A1 (en) | 2004-10-27 | 2005-10-26 | Method for separation and purification of hydrocodone by preparative chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE461199T1 true ATE461199T1 (de) | 2010-04-15 |
Family
ID=35833523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05820862T ATE461199T1 (de) | 2004-10-27 | 2005-10-26 | Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7692013B2 (de) |
| EP (1) | EP1807433B1 (de) |
| JP (1) | JP2008518237A (de) |
| CN (1) | CN101065384A (de) |
| AT (1) | ATE461199T1 (de) |
| AU (1) | AU2005305236A1 (de) |
| CA (1) | CA2585533A1 (de) |
| DE (1) | DE602005020049D1 (de) |
| ES (1) | ES2341121T3 (de) |
| MX (1) | MX2007004855A (de) |
| WO (1) | WO2006052456A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7625918B2 (en) | 2005-03-11 | 2009-12-01 | Noramco, Inc. | Hydrocodone polymorphs |
| CN101171253A (zh) * | 2005-03-11 | 2008-04-30 | 诺拉姆科有限公司 | 氢可酮多晶型物 |
| WO2011005452A1 (en) * | 2009-07-09 | 2011-01-13 | Mallinckrodt Inc. | Method for the enrichment of buprenorphine using chromatographic techniques |
| EP2812091B1 (de) * | 2012-09-17 | 2021-03-10 | W.R. Grace & CO. - CONN. | Chromatographiemedien und -vorrichtungen |
| ES2887110T3 (es) | 2014-01-16 | 2021-12-21 | Grace W R & Co | Medios para cromatografía de afinidad y dispositivos para cromatografía |
| PL3137209T3 (pl) | 2014-05-02 | 2023-01-02 | W.R. Grace & Co. - Conn. | Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego |
| KR102566292B1 (ko) | 2015-06-05 | 2023-08-10 | 더블유.알. 그레이스 앤드 캄파니-콘. | 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법 |
| CN107304213B (zh) * | 2016-04-20 | 2021-08-20 | 李显林 | 一种罂粟提取物处理方法及设备 |
| US10081636B2 (en) | 2016-07-08 | 2018-09-25 | Cody Laboratories, Inc. | Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates |
| US20220395767A1 (en) * | 2021-06-15 | 2022-12-15 | Perkinelmer Health Sciences, Inc. | Enhancing lcms analyte signals |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2715626A (en) | 1950-07-05 | 1955-08-16 | Merck & Co Inc | Process of preparing dihydrocodeinone |
| US4241065A (en) | 1979-07-02 | 1980-12-23 | E. I. Du Pont De Nemours And Company | Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both |
| CA2132342A1 (en) | 1992-04-06 | 1993-10-14 | Kenneth F. Buechler | Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels |
| GB9601724D0 (en) | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
| US5677279A (en) | 1996-12-16 | 1997-10-14 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treating pain with amylin or agonists thereof |
| GB9717629D0 (en) | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
| US6359111B1 (en) | 1998-05-28 | 2002-03-19 | Neorx Corporation | Opioid receptor targeting |
| GB9904786D0 (en) | 1999-03-02 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
| AU2001282875A1 (en) | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| WO2002030542A2 (en) | 2000-10-12 | 2002-04-18 | Robert Corcoran | Purification of substance by reaction affinity chromatography |
| WO2003074526A2 (en) | 2002-02-28 | 2003-09-12 | Mallinckrodt Inc. | Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography |
| US7226925B2 (en) | 2002-06-19 | 2007-06-05 | Biovitrum Ab | Compounds, their use and preparation |
| US7629355B2 (en) * | 2003-10-14 | 2009-12-08 | Lawson John A | Treatment of chemical dependency with substantially nonaddicting normorphine and norcodeine derivatives |
-
2005
- 2005-10-26 ES ES05820862T patent/ES2341121T3/es not_active Expired - Lifetime
- 2005-10-26 WO PCT/US2005/038603 patent/WO2006052456A1/en not_active Ceased
- 2005-10-26 CN CNA2005800408984A patent/CN101065384A/zh active Pending
- 2005-10-26 JP JP2007539074A patent/JP2008518237A/ja not_active Withdrawn
- 2005-10-26 CA CA002585533A patent/CA2585533A1/en not_active Abandoned
- 2005-10-26 US US11/576,059 patent/US7692013B2/en not_active Expired - Fee Related
- 2005-10-26 DE DE602005020049T patent/DE602005020049D1/de not_active Expired - Lifetime
- 2005-10-26 MX MX2007004855A patent/MX2007004855A/es not_active Application Discontinuation
- 2005-10-26 AT AT05820862T patent/ATE461199T1/de not_active IP Right Cessation
- 2005-10-26 EP EP05820862A patent/EP1807433B1/de not_active Expired - Lifetime
- 2005-10-26 AU AU2005305236A patent/AU2005305236A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006052456A1 (en) | 2006-05-18 |
| CN101065384A (zh) | 2007-10-31 |
| EP1807433B1 (de) | 2010-03-17 |
| MX2007004855A (es) | 2007-06-13 |
| US7692013B2 (en) | 2010-04-06 |
| EP1807433A1 (de) | 2007-07-18 |
| US20070293676A1 (en) | 2007-12-20 |
| DE602005020049D1 (de) | 2010-04-29 |
| JP2008518237A (ja) | 2008-05-29 |
| AU2005305236A1 (en) | 2006-05-18 |
| CA2585533A1 (en) | 2006-05-18 |
| ES2341121T3 (es) | 2010-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |