ATE461202T1 - Hiv-integrasehemmer - Google Patents

Hiv-integrasehemmer

Info

Publication number
ATE461202T1
ATE461202T1 AT06837651T AT06837651T ATE461202T1 AT E461202 T1 ATE461202 T1 AT E461202T1 AT 06837651 T AT06837651 T AT 06837651T AT 06837651 T AT06837651 T AT 06837651T AT E461202 T1 ATE461202 T1 AT E461202T1
Authority
AT
Austria
Prior art keywords
hiv integrase
integrase inhibitors
inhibitors
hiv
integrase
Prior art date
Application number
AT06837651T
Other languages
English (en)
Inventor
Narasimhulu B Naidu
Yasutsugu Ueda
John D Matiskella
Michael A Walker
Jacques Banville
Francis Beaulieu
Carl Ouellet
Serge Plamondon
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE461202T1 publication Critical patent/ATE461202T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06837651T 2005-11-17 2006-11-15 Hiv-integrasehemmer ATE461202T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73778105P 2005-11-17 2005-11-17
US11/590,637 US8039458B2 (en) 2005-11-17 2006-10-31 HIV integrase inhibitors
PCT/US2006/044320 WO2007061714A1 (en) 2005-11-17 2006-11-15 Hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
ATE461202T1 true ATE461202T1 (de) 2010-04-15

Family

ID=38041727

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06837651T ATE461202T1 (de) 2005-11-17 2006-11-15 Hiv-integrasehemmer

Country Status (20)

Country Link
US (1) US8039458B2 (de)
EP (1) EP1948666B1 (de)
JP (1) JP2009515981A (de)
KR (1) KR20080069254A (de)
CN (1) CN101360752B (de)
AR (1) AR057896A1 (de)
AT (1) ATE461202T1 (de)
AU (1) AU2006316582B2 (de)
CY (1) CY1110665T1 (de)
DE (1) DE602006013025D1 (de)
DK (1) DK1948666T3 (de)
ES (1) ES2341132T3 (de)
HR (1) HRP20100247T1 (de)
NO (1) NO20081935L (de)
PE (1) PE20071080A1 (de)
PL (1) PL1948666T3 (de)
PT (1) PT1948666E (de)
SI (1) SI1948666T1 (de)
TW (1) TW200738728A (de)
WO (1) WO2007061714A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763630B2 (en) * 2007-06-06 2010-07-27 Bristol-Myers Squibb Company HIV integrase inhibitors
CN101939295B (zh) 2008-02-07 2013-04-24 拜尔农作物科学股份公司 杀虫的芳基吡咯啉
US8129398B2 (en) * 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
EP2349276B1 (de) * 2008-10-06 2019-11-27 Merck Sharp & Dohme Corp. Hiv-integrasehemmer
US8143244B2 (en) 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
ES2536278T3 (es) 2009-05-19 2015-05-22 Bayer Intellectual Property Gmbh Arilpirrolinas insecticidas
WO2011045330A1 (en) * 2009-10-13 2011-04-21 Tibotec Pharmaceuticals Macrocyclic integrase inhibitors
US8383639B2 (en) * 2009-10-15 2013-02-26 Bristol-Myers Squibb Company HIV integrase inhibitors
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
WO2012123449A1 (en) 2011-03-14 2012-09-20 Boehringer Ingelheim International Gmbh N- cyclopropyl - n- piperidinylbenzamides as gpr119 modulators
US8921398B2 (en) 2011-06-09 2014-12-30 Boehringer Ingelheim International Gmbh N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
JP2015523404A (ja) 2012-08-02 2015-08-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｎ−シクロプロピル−ｎ−ピペリジニル−アミド、これらを含有する医薬組成物およびその使用
EP2931730B1 (de) 2012-12-17 2019-08-07 Merck Sharp & Dohme Corp. 4-pyridinonetriazinderivate als hiv-integrase-hemmer
US9493479B2 (en) 2013-04-16 2016-11-15 Merck Sharp & Dohme Corp. Substituted pyrido[1,2-a]pyrazines as HIV integrase inhibitors
US10233179B2 (en) 2013-04-22 2019-03-19 Abbvie Inc. Thiazoles and uses thereof
SI2997033T1 (en) 2013-05-17 2018-04-30 Merck Sharp & Dohme Corp. FUZYCLE TRICYCLE HETEROCYCLIC COMPOUNDS AS HIV INTEGRATED INHIBITORS
US9951079B2 (en) 2013-06-13 2018-04-24 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
CA2924829C (en) 2013-09-27 2019-10-29 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors
WO2016113277A1 (en) * 2015-01-16 2016-07-21 Bayer Cropscience Aktiengesellschaft Method for preparing 4-cyanopiperidine hydrochloride
WO2016187788A1 (en) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds useful for treating hiv infection
US10548910B2 (en) 2015-11-17 2020-02-04 Merck Sharp & Dohme Corp. Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors
EP3389380B1 (de) 2015-12-15 2021-07-21 Merck Sharp & Dohme Corp. Spirocyclische chinolizinderivate zur verwendung als hiv-integrase-inhibitoren
WO2017113288A1 (en) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
EP3486235A4 (de) * 2016-07-15 2020-02-12 Oriental (Luzhou) Agrochemicals. Co., Ltd. Synthetisches verfahren für 1,2,4-triazol-3-thion-verbindung und zwischenprodukt davon
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
WO2018102634A1 (en) 2016-12-02 2018-06-07 Merck Sharp & Dohme Corp. Tricyclic heterocycle compounds useful as hiv integrase inhibitors
WO2018140368A1 (en) 2017-01-26 2018-08-02 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors
WO2020221294A1 (zh) * 2019-04-30 2020-11-05 上海拓界生物医药科技有限公司 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途
CN114426540B (zh) * 2020-10-29 2024-04-26 上海拓界生物医药科技有限公司 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用
CN113372335B (zh) * 2021-07-05 2023-02-24 山东大学 一种含有1,2,4-三唑硫醚的苯丙氨酸衍生物及其制备方法与应用
WO2026070814A1 (ja) * 2024-09-30 2026-04-02 大日本印刷株式会社 重合性液晶化合物及びその製造方法、重合性組成物、重合体、位相差フィルム及びその製造方法、転写用積層体、光学部材及びその製造方法、並びに表示装置
CN121873064A (zh) * 2024-10-17 2026-04-17 博远医药(苏州)有限公司 杂环类衍生物及其药物组合物和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058756A1 (en) * 2002-12-27 2004-07-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
AR046938A1 (es) 2003-12-12 2006-01-04 Merck & Co Inc Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
WO2006103399A1 (en) 2005-03-31 2006-10-05 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors
WO2006121831A2 (en) 2005-05-10 2006-11-16 Merck & Co., Inc. Hiv integrase inhibitors

Also Published As

Publication number Publication date
PE20071080A1 (es) 2007-11-19
US20070111984A1 (en) 2007-05-17
EP1948666A1 (de) 2008-07-30
SI1948666T1 (sl) 2010-06-30
PL1948666T3 (pl) 2010-08-31
DE602006013025D1 (de) 2010-04-29
AU2006316582B2 (en) 2012-01-19
JP2009515981A (ja) 2009-04-16
AU2006316582A1 (en) 2007-05-31
HRP20100247T1 (hr) 2010-06-30
CN101360752A (zh) 2009-02-04
NO20081935L (no) 2008-06-24
KR20080069254A (ko) 2008-07-25
US8039458B2 (en) 2011-10-18
CN101360752B (zh) 2012-09-05
EP1948666B1 (de) 2010-03-17
PT1948666E (pt) 2010-05-17
CY1110665T1 (el) 2015-06-10
TW200738728A (en) 2007-10-16
ES2341132T3 (es) 2010-06-15
AR057896A1 (es) 2007-12-26
WO2007061714A1 (en) 2007-05-31
DK1948666T3 (da) 2010-05-25

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