ATE461205T1 - Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren - Google Patents

Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren

Info

Publication number: ATE461205T1
Authority: AT; Austria
Prior art keywords: bisphosphonic acids; certain solvents; acid; diluent; aromatic hydrocarbon
Prior art date: 2002-05-17

Application number

AT03729005T

Other languages

English (en)

Inventor

Rami Lidor-Hadas

Zvi Harel

Revital Lifshitz-Liron

Eti Kovalevski-Liron

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-17

Filing date

2003-05-19

Publication date

2010-04-15

2003-05-19 Application filed by Teva Pharma filed Critical Teva Pharma

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE461205T1 publication Critical patent/ATE461205T1/de

Links

239000002253 acid Substances 0.000 title abstract 2
150000007513 acids Chemical class 0.000 title abstract 2
239000002904 solvent Substances 0.000 title 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
125000002029 aromatic hydrocarbon group Chemical group 0.000 abstract 2
239000003085 diluting agent Substances 0.000 abstract 2
IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 abstract 1
150000001735 carboxylic acids Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000012530 fluid Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
235000011007 phosphoric acid Nutrition 0.000 abstract 1
229920001296 polysiloxane Polymers 0.000 abstract 1
-1 risedronic acid Chemical class 0.000 abstract 1
229960000759 risedronic acid Drugs 0.000 abstract 1
ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03729005T 2002-05-17 2003-05-19 Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren ATE461205T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US38128402P	2002-05-17	2002-05-17
US40131302P	2002-08-06	2002-08-06
US42333702P	2002-11-01	2002-11-01
US43183802P	2002-12-09	2002-12-09
US45019303P	2003-02-25	2003-02-25
PCT/US2003/015676 WO2003097655A1 (en)	2002-05-17	2003-05-19	Use of certain diluents for making bisphosphonic acids

Publications (1)

Publication Number	Publication Date
ATE461205T1 true ATE461205T1 (de)	2010-04-15

Family

ID=29554537

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03729005T ATE461205T1 (de)	2002-05-17	2003-05-19	Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren

Country Status (12)

Country	Link
US (3)	US7038083B2 (de)
EP (1)	EP1476451B1 (de)
JP (1)	JP3857706B2 (de)
KR (1)	KR100681282B1 (de)
CN (1)	CN1665825A (de)
AT (1)	ATE461205T1 (de)
AU (1)	AU2003233569A1 (de)
CA (2)	CA2485443C (de)
DE (1)	DE60331724D1 (de)
IL (1)	IL165227A0 (de)
PL (1)	PL373574A1 (de)
WO (1)	WO2003097655A1 (de)

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JP4642762B2 (ja)	2003-08-21	2011-03-02	サン・ファーマシューティカル・インダストリーズ・リミテッド	ビスホスホン酸化合物の製造方法
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US7358361B2 (en)	2004-10-08	2008-04-15	The Board Of Trustees Of The University Of Illinois	Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
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WO2006134603A1 (en)	2005-06-13	2006-12-21	Jubilant Organosys Limited	Process for producing bisphosphonic acids and forms thereof
US8003820B2 (en) *	2005-10-20	2011-08-23	Dr. Reddy's Laboratories Limited	Process for preparing bisphosphonic acids
EP1963345A2 (de) *	2005-12-16	2008-09-03	Wockhardt Limited	Verfahren zur herstellung reiner zoledronsäure
WO2007083240A2 (en)	2006-01-20	2007-07-26	Aurobindo Pharma Limited	An improved process for the preparation of bisphosphonic acids
CN101421284A (zh) *	2006-04-25	2009-04-29	特瓦制药工业有限公司	伊班膦酸的结晶形式和其制备方法
WO2007125521A2 (en) *	2006-05-02	2007-11-08	Ranbaxy Laboratories Limited	Polymorphic form of zoledronic acid and processes for their preparation
JP5354858B2 (ja) *	2006-05-09	2013-11-27	株式会社Ａｄｅｋａ	スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
WO2007132478A2 (en)	2006-05-11	2007-11-22	Ind-Swift Laboratories Limited	Process for the preparation of pure risedronic acid or salts
WO2008044245A2 (en) *	2006-10-10	2008-04-17	Matrix Laboratories Ltd	A process for the preparation of risedronate sodium hemipentahydrate
CA2570949A1 (en) *	2006-12-12	2008-06-12	Apotex Pharmachem Inc.	Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
BRPI0809548A8 (pt)	2007-04-11	2018-10-16	Hoffmann La Roche	processo para a preparação do sal ácido- (mono-hidratado)-3- (n-metil-n-pentil) amino-1-hidroxipropano-1, 1-difosfônico monossódico
US7605148B2 (en) *	2007-04-16	2009-10-20	Aurobindo Pharma Ltd.	Aqueous oral solution of bisphosphonic acid
US20100317859A1 (en) *	2007-05-16	2010-12-16	Actavis Group Ptc Ehf	Process for the Preparation of Risedronate Sodium
WO2009050731A2 (en) *	2007-06-20	2009-04-23	Alkem Laboratories Ltd	Novel process for preparing risedronic acid
KR100877667B1 (ko)	2007-06-28	2009-01-08	보령제약 주식회사	리세드로네이트의 제조 방법
WO2009034580A1 (en) *	2007-09-11	2009-03-19	Fleming Laboratories Limited	Improved process for the preparation of risedronate sodium hemipentahydrate
JP5258370B2 (ja) *	2008-05-08	2013-08-07	ダイト株式会社	リセドロン酸の工業的製造方法
US8026388B2 (en) *	2008-07-11	2011-09-27	Synthon Bv	Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
PL213599B1 (pl)	2008-10-31	2013-03-29	Politechnika Gdanska	Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego
EP2192126B1 (de)	2008-11-26	2013-03-27	Synthon B.V.	Verfahren zur Herstellung von Zoledronsäure
WO2010060619A1 (en) *	2008-11-26	2010-06-03	Synthon B.V.	Process for making zoledronic acid
US20100130746A1 (en) *	2008-11-26	2010-05-27	Martin Kas	Process for Making Zoledronic Acid
US9169279B2 (en)	2009-07-31	2015-10-27	Thar Pharmaceuticals, Inc.	Crystallization method and bioavailability
US20160016982A1 (en)	2009-07-31	2016-01-21	Thar Pharmaceuticals, Inc.	Crystallization method and bioavailability
CA2769633C (en) *	2009-07-31	2017-06-06	Thar Pharma, Llc	Crystallization method and bioavailability
WO2011016738A1 (en)	2009-08-05	2011-02-10	Zaklady Farmaceutyczne Polpharma Sa	A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate
EA201270328A1 (ru)	2009-08-28	2012-09-28	Синтон Б. В.	Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
US8882740B2 (en) *	2009-12-23	2014-11-11	Stryker Trauma Gmbh	Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
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2003
- 2003-05-19 KR KR1020047018564A patent/KR100681282B1/ko not_active Expired - Fee Related
- 2003-05-19 PL PL03373574A patent/PL373574A1/xx not_active Application Discontinuation
- 2003-05-19 AU AU2003233569A patent/AU2003233569A1/en not_active Abandoned
- 2003-05-19 US US10/442,001 patent/US7038083B2/en not_active Expired - Fee Related
- 2003-05-19 AT AT03729005T patent/ATE461205T1/de not_active IP Right Cessation
- 2003-05-19 CA CA2485443A patent/CA2485443C/en not_active Expired - Fee Related
- 2003-05-19 EP EP03729005A patent/EP1476451B1/de not_active Expired - Lifetime
- 2003-05-19 CA CA002657002A patent/CA2657002A1/en not_active Abandoned
- 2003-05-19 CN CN038160226A patent/CN1665825A/zh active Pending
- 2003-05-19 WO PCT/US2003/015676 patent/WO2003097655A1/en not_active Ceased
- 2003-05-19 JP JP2004505386A patent/JP3857706B2/ja not_active Expired - Lifetime
- 2003-05-19 IL IL16522703A patent/IL165227A0/xx unknown
- 2003-05-19 DE DE60331724T patent/DE60331724D1/de not_active Expired - Fee Related
2006
- 2006-02-08 US US11/350,462 patent/US20060128960A1/en not_active Abandoned
2009
- 2009-02-10 US US12/368,805 patent/US20090209763A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2003097655A1 (en)	2003-11-27
CA2485443A1 (en)	2003-11-27
AU2003233569A1 (en)	2003-12-02
US20090209763A1 (en)	2009-08-20
JP3857706B2 (ja)	2006-12-13
KR100681282B1 (ko)	2007-02-12
IL165227A0 (en)	2005-12-18
JP2005526140A (ja)	2005-09-02
US7038083B2 (en)	2006-05-02
CA2485443C (en)	2010-04-06
EP1476451B1 (de)	2010-03-17
PL373574A1 (en)	2005-09-05
US20060128960A1 (en)	2006-06-15
US20040043967A1 (en)	2004-03-04
CN1665825A (zh)	2005-09-07
CA2657002A1 (en)	2003-11-27
EP1476451A1 (de)	2004-11-17
DE60331724D1 (de)	2010-04-29
KR20040111633A (ko)	2004-12-31

Legal Events

Date	Code	Title	Description
2010-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE461205T1 (de)	2010-04-15	Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
ATE451380T1 (de)	2009-12-15	Verfahren zur herstellung von bisphosphonsäureverbindungen
ATE318926T1 (de)	2006-03-15	Verfahren zur herstellung von cadaverindicarboxylat und dessen verwendung zur herstellung von nylon
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