ATE461208T1 - Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern - Google Patents

Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern

Info

Publication number: ATE461208T1
Authority: AT; Austria
Prior art keywords: butyl; enzymatic hydrolysis; selective enzymatic; terminal; terminal tert
Prior art date: 2006-01-17

Application number

AT07703919T

Other languages

English (en)

Inventor

Ivo Eggen

Carmen Boeriu

Original Assignee

Organon Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-01-17

Filing date

2007-01-16

Publication date

2010-04-15

2007-01-16 Application filed by Organon Nv filed Critical Organon Nv

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE461208T1 publication Critical patent/ATE461208T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
230000007071 enzymatic hydrolysis Effects 0.000 title abstract 2
238000006047 enzymatic hydrolysis reaction Methods 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
DHHKPEUQJIEKOA-UHFFFAOYSA-N tert-butyl 2-[6-(nitromethyl)-6-bicyclo[3.2.0]hept-3-enyl]acetate Chemical group C1C=CC2C(CC(=O)OC(C)(C)C)(C[N+]([O-])=O)CC21 DHHKPEUQJIEKOA-UHFFFAOYSA-N 0.000 title 1
210000004899 c-terminal region Anatomy 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000787 Subtilisin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)

AT07703919T 2006-01-17 2007-01-16 Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern ATE461208T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06100420		2006-01-17
PCT/EP2007/050409 WO2007082890A1 (en)	2006-01-17	2007-01-16	SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL tert-BUTYL ESTERS OF PEPTIDES

Publications (1)

Publication Number	Publication Date
ATE461208T1 true ATE461208T1 (de)	2010-04-15

Family

ID=37025119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07703919T ATE461208T1 (de)	2006-01-17	2007-01-16	Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern

Country Status (8)

Country	Link
US (2)	US20090093016A1 (de)
EP (1)	EP1979370B1 (de)
AT (1)	ATE461208T1 (de)
BR (1)	BRPI0706400A2 (de)
DE (1)	DE602007005349D1 (de)
DK (1)	DK1979370T3 (de)
ES (1)	ES2340885T3 (de)
WO (1)	WO2007082890A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2155884A1 (de) *	2007-06-19	2010-02-24	DSM IP Assets B.V.	Verfahren zur selektiven enzymatischen hydrolyse von hängenden estern eines polymers
US8450084B2 (en)	2007-10-12	2013-05-28	Enzypep B.V.	Chemo-enzymatic peptide synthesis via C-terminal ester interconversion
JP2024510435A (ja)	2021-03-18	2024-03-07	シージェンインコーポレイテッド	生体活性化合物の内部移行複合体からの選択的薬物放出

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3733222A1 (de) *	1987-10-01	1989-04-13	Hoechst Ag	Verfahren zur herstellung von optisch reinem homophenylalanin
ZW6189A1 (en) *	1988-05-09	1990-05-09	Smithkline Beckman Corp	Anti-aggregatory peptides
US5665587A (en) *	1989-06-26	1997-09-09	Novo Nordisk A/S	Modified subtilisins and detergent compositions containing same
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
US5275950A (en) *	1990-05-11	1994-01-04	Abbott Laboratories	Process for the preparation of a renin inhibiting compound
US5256814A (en) *	1990-12-07	1993-10-26	Scios Nova Inc.	Excitatory amino acid antagonists
ES2051647B1 (es) *	1992-12-10	1995-01-16	Lipotec Sa	Procedimiento para la preparacion de calcitonina de salmon.
US6187579B1 (en) *	1993-10-28	2001-02-13	Carlsberg A/S	Customized proteases
US5981267A (en) *	1996-01-24	1999-11-09	The Scripps Research Institute	Enantioselection of amines using homocarbonates with hydrolase
TW505654B (en) *	1996-07-30	2002-10-11	Hoffmann La Roche	Synthesis of analogs of PTH and PTHrP
CA2331783C (en) *	1998-07-02	2009-12-29	Genencor International, Inc.	Chemically modified proteins with a carbohydrate moiety
FR2814744B1 (fr) *	2000-10-04	2002-11-29	Commissariat Energie Atomique	Cyclopeptides, leur procede de preparation et leur utilisation comme inhibiteur ou activateur de l'angiogenese
NL1017258C2 (nl) *	2001-02-01	2002-08-02	Univ Delft Tech	Werkwijze voor het maken van vernette enzymaggregaten.
AU2002310050A1 (en) *	2001-05-23	2002-12-03	Diversa Corporation	Peptide synthesis method
TWI247012B (en) *	2001-07-19	2006-01-11	Akzo Nobel Nv	Process for rapid solution synthesis of peptides
IL150600A (en) *	2001-07-19	2005-09-25	Akzo Nobel Nv	Process for the preparation of compounds containing one or more amide bonds using an excess of an activated carboxylic component and scavenging the residual activated carboxylic component
US7084247B2 (en) *	2004-03-11	2006-08-01	Peptimmune, Inc.	Identification of self and non-self antigens implicated in autoimmune diseases
US8124372B2 (en) *	2007-06-25	2012-02-28	N.V. Organon	Selective enzymatic amidation of C-terminal esters or acids of peptides

2007
- 2007-01-16 BR BRPI0706400-4A patent/BRPI0706400A2/pt active IP Right Grant
- 2007-01-16 US US12/087,849 patent/US20090093016A1/en not_active Abandoned
- 2007-01-16 WO PCT/EP2007/050409 patent/WO2007082890A1/en not_active Ceased
- 2007-01-16 ES ES07703919T patent/ES2340885T3/es active Active
- 2007-01-16 DK DK07703919.6T patent/DK1979370T3/da active
- 2007-01-16 DE DE602007005349T patent/DE602007005349D1/de active Active
- 2007-01-16 EP EP07703919A patent/EP1979370B1/de active Active
- 2007-01-16 AT AT07703919T patent/ATE461208T1/de not_active IP Right Cessation
2012
- 2012-05-17 US US13/474,125 patent/US20120231497A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090093016A1 (en)	2009-04-09
US20120231497A1 (en)	2012-09-13
BRPI0706400A2 (pt)	2011-03-29
ES2340885T3 (es)	2010-06-10
WO2007082890A1 (en)	2007-07-26
DK1979370T3 (da)	2010-06-28
DE602007005349D1 (de)	2010-04-29
EP1979370B1 (de)	2010-03-17
EP1979370A1 (de)	2008-10-15

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Legal Events

Date	Code	Title	Description
2010-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties