MX2017005268A - Tripeptidil peptidasas tolerantes a prolina y usos de las mismas. - Google Patents
Tripeptidil peptidasas tolerantes a prolina y usos de las mismas.Info
- Publication number
- MX2017005268A MX2017005268A MX2017005268A MX2017005268A MX2017005268A MX 2017005268 A MX2017005268 A MX 2017005268A MX 2017005268 A MX2017005268 A MX 2017005268A MX 2017005268 A MX2017005268 A MX 2017005268A MX 2017005268 A MX2017005268 A MX 2017005268A
- Authority
- MX
- Mexico
- Prior art keywords
- tolerant tripeptidyl
- proline tolerant
- proline
- tripeptidyl peptidase
- peptides
- Prior art date
Links
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 title abstract 10
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 title abstract 10
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 title abstract 8
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 title abstract 8
- 239000000413 hydrolysate Substances 0.000 abstract 3
- 102000018389 Exopeptidases Human genes 0.000 abstract 2
- 108010091443 Exopeptidases Proteins 0.000 abstract 2
- 101710118538 Protease Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004400 Aminopeptidases Human genes 0.000 abstract 1
- 108090000915 Aminopeptidases Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 239000002778 food additive Substances 0.000 abstract 1
- 235000019833 protease Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/14—Pretreatment of feeding-stuffs with enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/485—Exopeptidases (3.4.11-3.4.19)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
- C12Y304/14009—Tripeptidyl-peptidase I (3.4.14.9)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Fodder In General (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
Un método para producir un hidrolizado que comprende: (a) mezclar al menos una proteína o una porción de esta con: (A) al menos una endoproteasa; y (B) (a´) al menos una tripeptidil-peptidasa que tolera la prolina o fermentado que comprende una tripeptidil-peptidasa que tolera la prolina que tiene predominantemente actividad exopeptidasa, donde la tripeptidil-peptidasa que tolera la prolina es capaz de escindir tripéptidos del N-terminal de péptidos que tienen: prolina en P1, y aminoácidos sintéticos en P1; o (b´) al menos una tripeptidil-peptidasa que tolera la prolina que tiene actividad exopeptidasa donde la tripeptidil-peptidasa que tolera la prolina es capaz de escindir tripéptidos del N-terminal de péptidos que tienen: prolina en P1´; y aminoácidos sintéticos en P1´; y (b) recuperar el hidrolizado. La invención también se refiere amétodos para producir un hidrolizado que comprenden el uso de una endoproteasa, una exo-tripeptidil-peptidasa de la familia S53 y una aminopeptidasa, a usos de una tripeptidil-peptidasa que tolera la prolina, composiciones, composiciones de un aditivo alimentario y/o para piensos que la comprenden, así como también a hidrolizados y usus de tripeptidil-peptidasa que toleran la prolina.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462068264P | 2014-10-24 | 2014-10-24 | |
| US201462068282P | 2014-10-24 | 2014-10-24 | |
| US201462068243P | 2014-10-24 | 2014-10-24 | |
| US201462093301P | 2014-12-17 | 2014-12-17 | |
| PCT/EP2015/074600 WO2016062855A1 (en) | 2014-10-24 | 2015-10-23 | Proline tolerant tripeptidyl peptidases and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017005268A true MX2017005268A (es) | 2017-07-26 |
| MX384226B MX384226B (es) | 2025-03-14 |
Family
ID=54540018
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017005268A MX384226B (es) | 2014-10-24 | 2015-10-23 | Tripeptidil-peptidasas que toleran la prolina y sus usos. |
| MX2017005256A MX381014B (es) | 2014-10-24 | 2015-10-23 | Uso de tripeptidil-peptidasas que toleran la prolina en composiciones de un aditivo para piensos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017005256A MX381014B (es) | 2014-10-24 | 2015-10-23 | Uso de tripeptidil-peptidasas que toleran la prolina en composiciones de un aditivo para piensos. |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20170325479A1 (es) |
| EP (2) | EP3209774B1 (es) |
| JP (1) | JP6878275B2 (es) |
| CN (2) | CN107105707B (es) |
| AU (2) | AU2015334892A1 (es) |
| BR (2) | BR112017008406A2 (es) |
| CA (2) | CA2965423A1 (es) |
| DK (2) | DK3209773T3 (es) |
| ES (1) | ES2791891T3 (es) |
| MX (2) | MX384226B (es) |
| RU (1) | RU2741080C2 (es) |
| WO (2) | WO2016062857A1 (es) |
| ZA (1) | ZA201702889B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017220776A1 (en) * | 2016-06-23 | 2017-12-28 | Ew Nutrition Gmbh | Feed composition comprising an acid protease |
| WO2018005229A1 (en) | 2016-06-30 | 2018-01-04 | Dupont Nutrition Biosciences Aps | In feed assay of microbial proteases using peptide substrates |
| MX2019007604A (es) | 2016-12-23 | 2019-08-16 | Heidelberg Pharma Res Gmbh | Novedoso conjugado de amanitina. |
| WO2018224035A1 (en) * | 2017-06-09 | 2018-12-13 | Novozymes A/S | Polypeptide, use and method for hydrolysing protein |
| CN107467370A (zh) * | 2017-10-13 | 2017-12-15 | 无锡正大生物股份有限公司 | 一种饲料用功能性诱食剂及其制备方法 |
| US10980253B2 (en) * | 2017-12-28 | 2021-04-20 | Global Earth Solutions, Llc | Composition, system and method for pellet or flake production |
| US20210346332A1 (en) * | 2018-10-11 | 2021-11-11 | Imbria Pharmaceuticals, Inc. | Compositions and methods for treating and preventing leber's hereditary optic neuropathy |
| AU2020216682B2 (en) * | 2019-01-28 | 2022-08-04 | Nutreco Ip Assets B.V. | Feed for aquatic species with a stable soft and elastic texture |
| CN110551790B (zh) * | 2019-07-29 | 2021-09-14 | 浙江大学 | 一种乳源活性肽的制备方法及应用 |
| CN114630584A (zh) | 2019-11-07 | 2022-06-14 | 纽崔西亚公司 | 具有致耐受性肽的深度乳清蛋白水解产物 |
| WO2022104279A1 (en) * | 2020-11-16 | 2022-05-19 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Vibrio toxin binding proteins in shrimp and uses thereof |
| EP4437856A1 (en) * | 2023-03-31 | 2024-10-02 | DSM IP Assets B.V. | Novel enzyme composition and novel beer brewing process |
| EP4687490A1 (en) * | 2023-03-27 | 2026-02-11 | DSM IP Assets B.V. | Enzyme composition and beer brewing process |
| LU504450B1 (en) * | 2023-06-07 | 2024-12-09 | Traceless Mat Gmbh | Process for producing an animal feed |
| CN117491351B (zh) * | 2023-12-27 | 2024-04-05 | 中国农业科学院北京畜牧兽医研究所 | 一种肉鸡饲料有效磷的仿生消化测定试剂盒和测定方法 |
| CN118931885A (zh) * | 2024-06-17 | 2024-11-12 | 深极美泰(山东)生物科技有限公司 | 一种金属蛋白酶Aquinlysin及其制备鳀鱼粉活性肽的应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| DE3588239T3 (de) | 1985-03-30 | 2007-03-08 | Kauffman, Stuart A., Santa Fe | Verfahren zum Erhalten von DNS, RNS, Peptiden, Polypeptiden oder Proteinen durch DMS-Rekombinant-Verfahren |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| KR100225087B1 (ko) | 1990-03-23 | 1999-10-15 | 한스 발터라벤 | 피타아제의 식물내 발현 |
| AU639570B2 (en) | 1990-05-09 | 1993-07-29 | Novozymes A/S | A cellulase preparation comprising an endoglucanase enzyme |
| DE4112440C1 (es) | 1991-04-16 | 1992-10-22 | Diagen Institut Fuer Molekularbiologische Diagnostik Gmbh, 4000 Duesseldorf, De | |
| US5486461A (en) * | 1991-11-08 | 1996-01-23 | Novo Nordisk A/S | Casein hydrolyzate and method for production of such casein hydrolyzate |
| DK0673429T3 (da) | 1992-12-10 | 2002-10-07 | Dsm Nv | Fremstilling af heterologe proteiner i filamentøse svampe |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5741665A (en) | 1994-05-10 | 1998-04-21 | University Of Hawaii | Light-regulated promoters for production of heterologous proteins in filamentous fungi |
| CN1164868A (zh) * | 1994-11-08 | 1997-11-12 | 诺沃挪第克公司 | 三肽基氨肽酶 |
| AU2152897A (en) | 1996-03-27 | 1997-10-17 | Novo Nordisk A/S | Alkaline protease deficient filamentous fungi |
| CA2329122A1 (en) | 1999-03-26 | 2000-10-05 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
| EP1326957B1 (en) * | 2000-12-07 | 2004-05-06 | DSM IP Assets B.V. | Method for the prevention or reduction of haze in beverages |
| CN100582226C (zh) * | 2001-02-23 | 2010-01-20 | Dsmip资产有限公司 | 编码新蛋白水解酶的新基因 |
| AU2003236689A1 (en) * | 2002-06-04 | 2003-12-19 | Dsm Ip Assets B.V. | Protein hydrolysate rich in tripeptides |
| JP4719465B2 (ja) * | 2002-09-04 | 2011-07-06 | ディーエスエム アイピー アセッツ ビー.ブイ. | インスリン感受性増強剤およびペプチド画分を含む栄養補給用および治療用組成物 |
| NZ560601A (en) * | 2005-02-24 | 2009-09-25 | Dsm Ip Assets Bv | Process to produce IPP tripeptide from glycomacropeptide using proline specific proteolytic enzyme |
| DE602006007833D1 (de) * | 2005-04-28 | 2009-08-27 | Dsm Ip Assets Bv | Blutdrucksenkende proteinhydrolysate |
| DE202006021153U1 (de) | 2005-10-12 | 2013-02-22 | Danisco Us Inc. | Stabile, haltbare Granulate mit aktiven Mitteln |
| US8592194B2 (en) | 2007-10-09 | 2013-11-26 | Danisco Us Inc. | Glucoamylase variants with altered properties |
| EP2515932A2 (en) * | 2009-12-21 | 2012-10-31 | Centre Hospitalier Universitaire Vaudois (CHUV) | Synergic action of a prolyl protease and tripeptidyl proteases |
| EA028228B1 (ru) * | 2011-12-06 | 2017-10-31 | Фондацьоне Иституто Инсубрико Ди Ричерка Пер Ла Вита | Гидролизующая глютеновые олигопептиды эндопептидазная композиция, способ ее получения и применение |
| EP2800809B1 (en) * | 2012-01-05 | 2018-03-07 | Glykos Finland Oy | Protease deficient filamentous fungal cells and methods of use thereof |
| CN102771749B (zh) * | 2012-07-16 | 2013-10-16 | 中国农业科学院农产品加工研究所 | 一种利用小麦面筋蛋白制备热反应肉味香精的方法 |
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2015
- 2015-10-23 CN CN201580070603.1A patent/CN107105707B/zh not_active Expired - Fee Related
- 2015-10-23 EP EP15794483.6A patent/EP3209774B1/en active Active
- 2015-10-23 AU AU2015334892A patent/AU2015334892A1/en not_active Abandoned
- 2015-10-23 MX MX2017005268A patent/MX384226B/es unknown
- 2015-10-23 CA CA2965423A patent/CA2965423A1/en active Pending
- 2015-10-23 DK DK15793724.4T patent/DK3209773T3/da active
- 2015-10-23 AU AU2015334890A patent/AU2015334890B2/en not_active Ceased
- 2015-10-23 US US15/521,245 patent/US20170325479A1/en not_active Abandoned
- 2015-10-23 ES ES15794483T patent/ES2791891T3/es active Active
- 2015-10-23 CA CA2965438A patent/CA2965438A1/en not_active Abandoned
- 2015-10-23 DK DK15794483.6T patent/DK3209774T3/da active
- 2015-10-23 BR BR112017008406-6A patent/BR112017008406A2/pt not_active Application Discontinuation
- 2015-10-23 MX MX2017005256A patent/MX381014B/es unknown
- 2015-10-23 WO PCT/EP2015/074602 patent/WO2016062857A1/en not_active Ceased
- 2015-10-23 US US15/520,140 patent/US20180295858A1/en not_active Abandoned
- 2015-10-23 CN CN201580070214.9A patent/CN107105709B/zh not_active Expired - Fee Related
- 2015-10-23 BR BR112017008304-3A patent/BR112017008304A2/pt not_active Application Discontinuation
- 2015-10-23 JP JP2017522548A patent/JP6878275B2/ja not_active Expired - Fee Related
- 2015-10-23 WO PCT/EP2015/074600 patent/WO2016062855A1/en not_active Ceased
- 2015-10-23 EP EP15793724.4A patent/EP3209773B1/en active Active
- 2015-10-23 RU RU2017117858A patent/RU2741080C2/ru active
-
2017
- 2017-04-25 ZA ZA2017/02889A patent/ZA201702889B/en unknown
-
2020
- 2020-01-16 US US16/744,752 patent/US20200245642A1/en not_active Abandoned
-
2021
- 2021-11-24 US US17/534,663 patent/US20220174981A1/en not_active Abandoned
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