ATE461273T1 - Herstellung von polyhydroxyalkanoaten mittlerer kettenlänge aus fettsäure-biosynthesewegen - Google Patents
Herstellung von polyhydroxyalkanoaten mittlerer kettenlänge aus fettsäure-biosynthesewegenInfo
- Publication number
- ATE461273T1 ATE461273T1 AT01985993T AT01985993T ATE461273T1 AT E461273 T1 ATE461273 T1 AT E461273T1 AT 01985993 T AT01985993 T AT 01985993T AT 01985993 T AT01985993 T AT 01985993T AT E461273 T1 ATE461273 T1 AT E461273T1
- Authority
- AT
- Austria
- Prior art keywords
- coa synthetase
- acyl coa
- fatty acid
- medium chain
- pha
- Prior art date
Links
- 235000014113 dietary fatty acids Nutrition 0.000 title abstract 4
- 229930195729 fatty acid Natural products 0.000 title abstract 4
- 239000000194 fatty acid Substances 0.000 title abstract 4
- 150000004665 fatty acids Chemical class 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
- 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 abstract 5
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 abstract 5
- 229920000903 polyhydroxyalkanoate Polymers 0.000 abstract 5
- 102000005870 Coenzyme A Ligases Human genes 0.000 abstract 4
- 108700021044 acyl-ACP thioesterase Proteins 0.000 abstract 2
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 2
- 210000000172 cytosol Anatomy 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 210000002824 peroxisome Anatomy 0.000 abstract 2
- 108010010718 poly(3-hydroxyalkanoic acid) synthase Proteins 0.000 abstract 2
- 239000002028 Biomass Substances 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 210000003763 chloroplast Anatomy 0.000 abstract 1
- 210000002706 plastid Anatomy 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polyesters Or Polycarbonates (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24953500P | 2000-11-17 | 2000-11-17 | |
| PCT/US2001/043686 WO2002040690A2 (en) | 2000-11-17 | 2001-11-16 | Production of medium chain length polyhydroxyalkanoates from fatty acid biosynthetic pathways |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE461273T1 true ATE461273T1 (de) | 2010-04-15 |
Family
ID=22943899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01985993T ATE461273T1 (de) | 2000-11-17 | 2001-11-16 | Herstellung von polyhydroxyalkanoaten mittlerer kettenlänge aus fettsäure-biosynthesewegen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7786355B2 (de) |
| EP (1) | EP1334181B1 (de) |
| JP (4) | JP4024676B2 (de) |
| AT (1) | ATE461273T1 (de) |
| AU (2) | AU3646402A (de) |
| CA (1) | CA2428713C (de) |
| DE (1) | DE60141594D1 (de) |
| ES (1) | ES2340915T3 (de) |
| WO (1) | WO2002040690A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000008198A1 (en) * | 1998-08-04 | 2000-02-17 | Metabolix, Inc. | Polyhydroxyalkanoate production from polyols |
| EP2431475B1 (de) * | 2002-05-10 | 2019-07-10 | Tepha, Inc. | Bioabsorbierbares polymer mit 2-hydroxysäure-monomeren |
| DE10240035A1 (de) | 2002-08-30 | 2004-03-11 | Rehm, Bernd H.A., PD Dr.rer.nat. | Biogene Polyester-Partikel definierter Größe mit funktionalisierten Oberflächen:Herstellungsverfahren und pharmazeutische Zubereitungen, in denen diese enthalten sind |
| CA2600882C (en) | 2005-03-16 | 2013-02-26 | Metabolix, Inc. | Chemically inducible expression of biosynthetic pathways |
| KR100979694B1 (ko) * | 2005-05-24 | 2010-09-02 | 한국과학기술원 | 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법 |
| EP1752532A1 (de) * | 2005-08-09 | 2007-02-14 | Helmholtz-Zentrum für Infektionsforschung GmbH | Extrazelluläre Polyhydroxyalkanoate hergestellt aus gentechnisch veränderten Mikroorganismen |
| EP1929010B1 (de) * | 2005-09-27 | 2013-12-18 | PolyBatics Limited | Verwendung von polymerteilchen |
| WO2008119082A2 (en) * | 2007-03-28 | 2008-10-02 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| WO2008008008A1 (en) * | 2006-07-13 | 2008-01-17 | St. Jude Medical Ab | Information management in devices worn by a use |
| CA3101888A1 (en) | 2008-05-16 | 2009-11-19 | REG Life Sciences, LLC | Methods and compositions for producing hydrocarbons |
| CN105154380B (zh) | 2008-10-28 | 2018-11-09 | Reg生命科学有限责任公司 | 用于产生脂肪醇的方法和组合物 |
| CN102317437B (zh) | 2008-12-12 | 2013-08-21 | 麦特波力克斯公司 | 用于制备聚(5-羟基戊酸)和5碳化合物的绿色工艺和组合物 |
| EP2403949A1 (de) | 2009-03-05 | 2012-01-11 | Metabolix, Inc. | Stabile, fruchtbare pflanzen mit hoher polyhydroxyalkansäureester-produktion und verfahren zu deren herstellung |
| US20100229256A1 (en) | 2009-03-05 | 2010-09-09 | Metabolix, Inc. | Propagation of transgenic plants |
| EP2425007A4 (de) | 2009-04-27 | 2013-01-02 | Ls9 Inc | Herstellung von fettsäureestern |
| CZ304183B6 (cs) | 2012-08-27 | 2013-12-11 | Vysoké ucení technické v Brne | Zpusob produkce polyhydroxyalkanoátu (PHA) na olejovém substrátu |
| US20140073022A1 (en) | 2012-09-10 | 2014-03-13 | Wisconsin Alumni Research Foundation | Production of polyhydroxyalkanoates with a defined composition from an unrelated carbon source |
| US9708630B1 (en) | 2013-10-08 | 2017-07-18 | Wisconsin Alumni Research Foundation | Cells and methods for producing fatty alcohols |
| JP6779652B2 (ja) | 2016-04-20 | 2020-11-04 | 花王株式会社 | 脂質の製造方法 |
| WO2020251932A1 (en) * | 2019-06-10 | 2020-12-17 | Yield10 Bioscience, Inc. | Transgenic land plants that express a polyhydroxyalkanoate synthase seed specifically with cytosolic localization |
| WO2021236919A1 (en) | 2020-05-20 | 2021-11-25 | Wisconsin Alumni Research Foundation | Cells and methods for producing methyl ketones |
| CN114717208B (zh) * | 2022-05-18 | 2024-07-09 | 上海交通大学 | 一种酰基CoA合成酶及其应用 |
| EP4594514A1 (de) * | 2022-09-30 | 2025-08-06 | Kimberly-Clark Worldwide, Inc. | In-vitro-bioproduktion von monomeren mit spezifischer kettenlänge von polyhydroxyalkanoaten |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5352605A (en) | 1983-01-17 | 1994-10-04 | Monsanto Company | Chimeric genes for transforming plant cells using viral promoters |
| US5034322A (en) | 1983-01-17 | 1991-07-23 | Monsanto Company | Chimeric genes suitable for expression in plant cells |
| US5668298A (en) | 1984-12-24 | 1997-09-16 | Eli Lilly And Company | Selectable marker for development of vectors and transformation systems in plants |
| US5420034A (en) | 1986-07-31 | 1995-05-30 | Calgene, Inc. | Seed-specific transcriptional regulation |
| US5276268A (en) | 1986-08-23 | 1994-01-04 | Hoechst Aktiengesellschaft | Phosphinothricin-resistance gene, and its use |
| US5268463A (en) | 1986-11-11 | 1993-12-07 | Jefferson Richard A | Plant promoter α-glucuronidase gene construct |
| US5250430A (en) | 1987-06-29 | 1993-10-05 | Massachusetts Institute Of Technology | Polyhydroxyalkanoate polymerase |
| US5245023A (en) | 1987-06-29 | 1993-09-14 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| US5614395A (en) | 1988-03-08 | 1997-03-25 | Ciba-Geigy Corporation | Chemically regulatable and anti-pathogenic DNA sequences and uses thereof |
| EP0388186A1 (de) | 1989-03-17 | 1990-09-19 | E.I. Du Pont De Nemours And Company | Externe Regulierung der Genexpression |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| ATE227340T1 (de) | 1989-07-10 | 2002-11-15 | Massachusetts Inst Technology | Eine zur herstellung von polyhydroxybutyrat oder einem anderen polyhydroxyalkanoat geeignete pflanze oder pflanzliche zelle |
| US5650554A (en) | 1991-02-22 | 1997-07-22 | Sembiosys Genetics Inc. | Oil-body proteins as carriers of high-value peptides in plants |
| WO1993020216A1 (en) | 1991-02-22 | 1993-10-14 | University Technologies International, Inc. | Oil-body protein cis-elements as regulatory signals |
| DK152291D0 (da) | 1991-08-28 | 1991-08-28 | Danisco | Fremgangsmaade og kemiske forbindelser |
| GB9304200D0 (en) | 1993-03-02 | 1993-04-21 | Sandoz Ltd | Improvements in or relating to organic compounds |
| DE69334225D1 (de) | 1992-07-07 | 2008-07-31 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| GB9326271D0 (en) | 1993-12-23 | 1994-02-23 | Zeneca Ltd | Expression of self-processing polyprotein in transgenic plants |
| DE4433134A1 (de) | 1994-09-16 | 1996-03-21 | Buck Chem Tech Werke | Verfahren zur Herstellung von Polyhydroxyfettsäuren sowie rekombinanter Bakterienstämme zur Durchführung des Verfahrens |
| US5750848A (en) * | 1996-08-13 | 1998-05-12 | Monsanto Company | DNA sequence useful for the production of polyhydroxyalkanoates |
| US5932440A (en) * | 1996-08-16 | 1999-08-03 | Life Technologies, Inc. | Mammalian ribonuclease inhibitors and use thereof |
| FI972293A7 (fi) | 1997-05-30 | 1998-12-01 | Timo Korpela | Useamman kuin yhden geenin yhteisekspressiomenetelmät |
| US6143952A (en) | 1998-03-31 | 2000-11-07 | Regents Of The University Of Minnesota | Modified pseudomonas oleovorans phaC1 nucleic acids encoding bispecific polyhydroxyalkanoate polymerase |
| WO2000008198A1 (en) | 1998-08-04 | 2000-02-17 | Metabolix, Inc. | Polyhydroxyalkanoate production from polyols |
| CA2365276C (en) | 1999-03-15 | 2009-08-25 | Universite Laval | Method for producing polyhydroxyalkanoates in recombinant organisms |
| EP2431475B1 (de) | 2002-05-10 | 2019-07-10 | Tepha, Inc. | Bioabsorbierbares polymer mit 2-hydroxysäure-monomeren |
-
2001
- 2001-11-16 ES ES01985993T patent/ES2340915T3/es not_active Expired - Lifetime
- 2001-11-16 AU AU3646402A patent/AU3646402A/xx active Pending
- 2001-11-16 US US09/991,152 patent/US7786355B2/en not_active Expired - Fee Related
- 2001-11-16 DE DE60141594T patent/DE60141594D1/de not_active Expired - Lifetime
- 2001-11-16 JP JP2002543002A patent/JP4024676B2/ja not_active Expired - Fee Related
- 2001-11-16 AT AT01985993T patent/ATE461273T1/de not_active IP Right Cessation
- 2001-11-16 CA CA2428713A patent/CA2428713C/en not_active Expired - Fee Related
- 2001-11-16 AU AU2002236464A patent/AU2002236464B2/en not_active Ceased
- 2001-11-16 WO PCT/US2001/043686 patent/WO2002040690A2/en not_active Ceased
- 2001-11-16 EP EP01985993A patent/EP1334181B1/de not_active Expired - Lifetime
-
2007
- 2007-02-15 JP JP2007035383A patent/JP2007125043A/ja not_active Withdrawn
- 2007-06-08 JP JP2007153418A patent/JP4121541B2/ja not_active Expired - Fee Related
-
2008
- 2008-03-11 JP JP2008061883A patent/JP2008194049A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE60141594D1 (de) | 2010-04-29 |
| US20030017576A1 (en) | 2003-01-23 |
| US7786355B2 (en) | 2010-08-31 |
| JP2008194049A (ja) | 2008-08-28 |
| JP2004534507A (ja) | 2004-11-18 |
| EP1334181B1 (de) | 2010-03-17 |
| AU3646402A (en) | 2002-05-27 |
| JP4024676B2 (ja) | 2007-12-19 |
| JP4121541B2 (ja) | 2008-07-23 |
| ES2340915T3 (es) | 2010-06-11 |
| AU2002236464B2 (en) | 2005-09-15 |
| JP2007125043A (ja) | 2007-05-24 |
| JP2007222185A (ja) | 2007-09-06 |
| CA2428713A1 (en) | 2002-05-23 |
| CA2428713C (en) | 2012-04-17 |
| WO2002040690A2 (en) | 2002-05-23 |
| WO2002040690A3 (en) | 2003-05-22 |
| EP1334181A2 (de) | 2003-08-13 |
| WO2002040690A9 (en) | 2003-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |