ATE461915T1 - Substituierte (e)-styrylbenzylsulfone zur behandlung proliferativer erkrankungen - Google Patents

Substituierte (e)-styrylbenzylsulfone zur behandlung proliferativer erkrankungen

Info

Publication number: ATE461915T1
Authority: AT; Austria
Prior art keywords: sub; alkoxy; halogen; phosphonato; sulfamyl
Prior art date: 2000-10-05

Application number

AT01977567T

Other languages

English (en)

Inventor

E Reddy

M Reddy

Original Assignee

Univ Temple

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-05

Filing date

2001-10-05

Publication date

2010-04-15

2001-10-05 Application filed by Univ Temple filed Critical Univ Temple

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE461915T1 publication Critical patent/ATE461915T1/de

Links

201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000002062 proliferating effect Effects 0.000 title 1
-1 for example Substances 0.000 abstract 12
229910052736 halogen Inorganic materials 0.000 abstract 7
125000003545 alkoxy group Chemical group 0.000 abstract 5
150000002367 halogens Chemical class 0.000 abstract 5
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
MRTIWTGAGMZREP-VAWYXSNFSA-N [(e)-2-phenylethenyl]sulfonylmethylbenzene Chemical class C=1C=CC=CC=1/C=C/S(=O)(=O)CC1=CC=CC=C1 MRTIWTGAGMZREP-VAWYXSNFSA-N 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
- C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01977567T 2000-10-05 2001-10-05 Substituierte (e)-styrylbenzylsulfone zur behandlung proliferativer erkrankungen ATE461915T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23822200P	2000-10-05	2000-10-05
PCT/US2001/031337 WO2002028828A1 (en)	2000-10-05	2001-10-05	Substituted (e)-styryl benzylsulfones for treating proliferative disorders

Publications (1)

Publication Number	Publication Date
ATE461915T1 true ATE461915T1 (de)	2010-04-15

Family

ID=22896982

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01977567T ATE461915T1 (de)	2000-10-05	2001-10-05	Substituierte (e)-styrylbenzylsulfone zur behandlung proliferativer erkrankungen

Country Status (8)

Country	Link
US (1)	US7053123B2 (de)
EP (1)	EP1328511B1 (de)
JP (1)	JP2004510761A (de)
AT (1)	ATE461915T1 (de)
AU (1)	AU2001296677A1 (de)
CA (1)	CA2424884C (de)
DE (1)	DE60141641D1 (de)
WO (1)	WO2002028828A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6548553B2 (en) *	1997-10-03	2003-04-15	Temple University-Of The Commonwealth System Of Higher Education	Styryl sulfone anticancer agents
US6767926B1 (en) *	1999-10-12	2004-07-27	Temple University - Of The Commonwealth System Of Higher Education	Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
EP1534284B1 (de) *	2002-02-28	2011-07-27	Temple University - Of The Commonwealth System of Higher Education	Aminosubstituierte sulphonanilide und ihre derivate zur behandlung von proliferativen erkrankungen
NZ535232A (en) *	2002-02-28	2007-05-31	Univ Temple	Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
WO2005046599A2 (en) *	2003-11-14	2005-05-26	Temple University - Of The Commonwealth System Of Higher Education	Alpha, beta-unsaturated sulfoxides for treating proliferative disorders
NZ549962A (en)	2004-03-16	2010-04-30	Univ Temple	Substituted phenoxy-and phenylthio-derivatives for treating proliferative disorders
US8058313B2 (en)	2004-06-24	2011-11-15	Temple University—Of the Commonwealth System of Higher Education	Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof
JP5278968B2 (ja)	2006-08-30	2013-09-04	テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション	骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法
AU2013318206B2 (en)	2012-09-20	2018-07-26	Temple University - Of The Commonwealth System Of Higher Education	Substituted alkyl diaryl derivatives, methods of preparation and uses
WO2014089483A1 (en)	2012-12-07	2014-06-12	Onconova Therapeutics, Inc.	Methods and compositions for treatment of cancer
US10383831B2 (en)	2015-08-03	2019-08-20	Temple University—Of the Commonwealth System of Higher Education	2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2532612A (en)	1945-08-29	1950-12-05	Union Oil Co	Preparation of unsaturated thio-ethers
US3185743A (en)	1960-08-24	1965-05-25	Union Carbide Corp	Production of olefinic compounds from allyl sulfones
US3463774A (en)	1963-03-18	1969-08-26	Hoffmann La Roche	Novel 4,1-benzothiazepin-2-(1h)-ones and 4,1-benzothiazepines
US3418101A (en)	1965-12-15	1968-12-24	Pennsalt Chemicals Corp	Process for plant desiccation
US3514386A (en)	1967-12-11	1970-05-26	Exxon Research Engineering Co	Stereoselective addition of thiols to acetylenic compounds
US3917714A (en)	1972-09-06	1975-11-04	American Cyanamid Co	Bis(alkylsulfonyl)vinylbenzenes
US4161407A (en)	1977-10-06	1979-07-17	Eastman Kodak Company	Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin
US4386221A (en)	1981-10-28	1983-05-31	Eastman Kodak Company	Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones
US4937388A (en)	1985-08-09	1990-06-26	Imperial Chemical Industries Plc	Insecticidal ethers
US5659087A (en)	1995-06-07	1997-08-19	Eli Lilly And Company	Diarylvinyl sulfoxides
US5733909A (en)	1996-02-01	1998-03-31	Merck Frosst Canada, Inc.	Diphenyl stilbenes as prodrugs to COX-2 inhibitors
US6030961A (en) *	1997-03-11	2000-02-29	Bar-Ilan Research & Development Co., Ltd.	Oxyalkylene phosphate compounds and uses thereof
CN1163480C (zh)	1997-10-03	2004-08-25	坦普尔大学	苯乙烯砜抗癌剂
US6548553B2 (en)	1997-10-03	2003-04-15	Temple University-Of The Commonwealth System Of Higher Education	Styryl sulfone anticancer agents
US6201154B1 (en)	1999-03-31	2001-03-13	Temple University-Of The Commonwealth Of Higher Education	Z-styryl sulfone anticancer agents
US6762207B1 (en) *	1999-04-02	2004-07-13	Temple University - Of The Commonwealth System Of Higher Education	(E)-styryl sulfone anticancer agents
US6418101B1 (en) *	1999-09-03	2002-07-09	Zen Research (Ireland), Ltd.	Digital read channel for optical disk reader
US6767926B1 (en) *	1999-10-12	2004-07-27	Temple University - Of The Commonwealth System Of Higher Education	Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
WO2001026645A1 (en)	1999-10-12	2001-04-19	Temple University-Of The Commonwealth System Of Higher Education	Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
US6486210B2 (en)	2000-04-14	2002-11-26	Temple University—Of the Commonwealth System of Higher Education	Substituted styryl benzylsulfones for treating proliferative disorders
US6541475B2 (en) *	2000-04-14	2003-04-01	Temple University - Of The Commonwealth System Of Higher Education	α, β-unsaturated sulfones for treating proliferative disorders
WO2002069892A2 (en)	2001-02-28	2002-09-12	Temple University Of The Commonwealth System Of Higher Education	METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH α, β UNSATURATED ARYL SULFONES

2001
- 2001-10-05 AU AU2001296677A patent/AU2001296677A1/en not_active Abandoned
- 2001-10-05 WO PCT/US2001/031337 patent/WO2002028828A1/en not_active Ceased
- 2001-10-05 DE DE60141641T patent/DE60141641D1/de not_active Expired - Lifetime
- 2001-10-05 JP JP2002532414A patent/JP2004510761A/ja active Pending
- 2001-10-05 AT AT01977567T patent/ATE461915T1/de not_active IP Right Cessation
- 2001-10-05 US US10/398,545 patent/US7053123B2/en not_active Expired - Fee Related
- 2001-10-05 CA CA002424884A patent/CA2424884C/en not_active Expired - Fee Related
- 2001-10-05 EP EP01977567A patent/EP1328511B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2002028828A1 (en)	2002-04-11
EP1328511A1 (de)	2003-07-23
DE60141641D1 (de)	2010-05-06
US7053123B2 (en)	2006-05-30
EP1328511A4 (de)	2005-11-30
US20050101528A1 (en)	2005-05-12
JP2004510761A (ja)	2004-04-08
AU2001296677A1 (en)	2002-04-15
CA2424884C (en)	2009-12-15
EP1328511B1 (de)	2010-03-24
CA2424884A1 (en)	2002-04-11

Legal Events

Date	Code	Title	Description
2010-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
WO2001064639A3 (en)	2002-02-28	Pde iv inhibiting amides, compositions and pharmaceutical use
BR0211910A (pt)	2004-10-19	Derivados de tiazolila 2,4,5-trissubstituìdos e a atividade antiinflamatória dos mesmos
TW200420549A (en)	2004-10-16	Thiazole derivatives
EP1340755A4 (de)	2004-03-17	Mittel mit wirkung gegen helicobacter
AR012660A1 (es)	2000-11-08	Uso de compuestos de quinazolina para la manufactura de un medicamento util para el tratamiento de enfermedades poliquisticas del rinon.
AU2002246728A1 (en)	2002-08-28	Carboline derivatives
HRP20090162T1 (en)	2009-05-31	Quinolinone-carboxamide compounds as 5-ht4 receptor agonists
AU2002314914A1 (en)	2002-12-16	Hydroxy alkyl amine derivatives as beta-secretase inhibitors and their use for the treatment of alzheimer's disease and similar diseases
WO2005030120A3 (en)	2005-12-15	Antiangiogenic agents
WO2005030766A8 (en)	2006-03-02	Phenyl - carboxamide compounds useful for treating pain
ATE461915T1 (de)	2010-04-15	Substituierte (e)-styrylbenzylsulfone zur behandlung proliferativer erkrankungen
AU2002213421A1 (en)	2002-04-15	Condensed pyridoindole derivatives
AU2002249890A1 (en)	2002-08-28	Carboline derivatives
EE200000472A (et)	2001-12-17	Kasvajavastased toimeained
PT1272481E (pt)	2004-08-31	4-trifluorometil-2h-benzopiranos antiestrogenicos com accao estrogenica selectiva
AU1182702A (en)	2002-04-15	Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same
SE0301320D0 (sv)	2003-05-06	Positive modulators of nicotinic acetylcholine receptors
MXPA03010766A (es)	2005-03-07	Nuevos compuestos y composiciones como inhibicores de las catepsinas.
SE0003476D0 (sv)	2000-09-28	Compounds
ATE417856T1 (de)	2009-01-15	Motilidverbindungen
AU2002211493A1 (en)	2002-05-15	Indole derivatives as pde5-inhibitors
AU2001296699A1 (en)	2002-05-21	Condensed pyrazindione derivatives as pde inhibitors
BR0112957A (pt)	2003-07-08	Composto, método de tratamento, uso de um composto, e, composição farmacêutica
NO20032411D0 (no)	2003-05-27	Anvendelse av substituerte 6-dimetylaminometyl-1-fenyl- cykloheksan-forbindelser for behandling av urininkontinens
NO20032407L (no)	2003-05-27	Anvendelse av 6-dimetylaminometyl-1-fenyl- cykloheksanforbindelser for behandling av urininkontinens