BRPI0412636A - imidazopirimidinas substituìdas para a prevenção e tratamento de cáncer - Google Patents

imidazopirimidinas substituìdas para a prevenção e tratamento de cáncer

Info

Publication number
BRPI0412636A
BRPI0412636A BRPI0412636-0A BRPI0412636A BRPI0412636A BR PI0412636 A BRPI0412636 A BR PI0412636A BR PI0412636 A BRPI0412636 A BR PI0412636A BR PI0412636 A BRPI0412636 A BR PI0412636A
Authority
BR
Brazil
Prior art keywords
sub
treatment
cancer prevention
substituted imidazopyrimidines
imidazopyrimidines
Prior art date
Application number
BRPI0412636-0A
Other languages
English (en)
Inventor
Juan Lorenzo Catena Ruiz
Carles Farrerons Gallemi
Anna Fernandez Serrat
Carmen Serra Comas
Dolors Balsa Lopez
Carmen Lagunas Arnal
Carolina Salcedo Roca
Andres Fernandez Garcia
Original Assignee
S A L V A T Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S A L V A T Lab Sa filed Critical S A L V A T Lab Sa
Publication of BRPI0412636A publication Critical patent/BRPI0412636A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"IMIDAZOPIRIMIDINAS SUBSTITUIDAS PARA A PREVENçãO E TRATAMENTO DE CáNCER". O presente invento se refere a compostos de fórmula geral (I): em que de A~ 1~, a A~ 5~, e de B~ 1~, a B~ 5~ são H, alquila, alcoxila, halogênio, derivados carboxílicos ou derivados sulfúricos, dentre outros; e de P¬ 1¬, a P¬ 3¬ são H, halogênio, alquila ou alcoxila, dentre outros. Ditos compostos podem ser usados para a quimio-prevenção e tratamento de lesões pré-cancerosas e de câncer.
BRPI0412636-0A 2003-07-30 2004-07-29 imidazopirimidinas substituìdas para a prevenção e tratamento de cáncer BRPI0412636A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200301906 2003-07-30
PCT/EP2004/008476 WO2005014598A1 (en) 2003-07-30 2004-07-29 Substituted imidazopyrimidines for the prevention and treatment of cancer

Publications (1)

Publication Number Publication Date
BRPI0412636A true BRPI0412636A (pt) 2006-09-26

Family

ID=34130555

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412636-0A BRPI0412636A (pt) 2003-07-30 2004-07-29 imidazopirimidinas substituìdas para a prevenção e tratamento de cáncer

Country Status (14)

Country Link
US (1) US20060189631A1 (pt)
EP (1) EP1660500B1 (pt)
JP (1) JP2007500160A (pt)
KR (1) KR20060034303A (pt)
CN (1) CN1860121A (pt)
AT (1) ATE380816T1 (pt)
AU (1) AU2004263297A1 (pt)
BR (1) BRPI0412636A (pt)
CA (1) CA2534292A1 (pt)
DE (1) DE602004010680T2 (pt)
EA (1) EA009038B1 (pt)
ES (1) ES2298798T3 (pt)
WO (1) WO2005014598A1 (pt)
ZA (1) ZA200601706B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007096764A2 (en) * 2006-02-27 2007-08-30 Glenmark Pharmaceuticals S.A. Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
JP2010500365A (ja) 2006-08-07 2010-01-07 インサイト・コーポレイション キナーゼ阻害剤としてのトリアゾロトリアジン
ES2560435T3 (es) 2006-11-22 2016-02-19 Incyte Holdings Corporation Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa
EP2062893A1 (en) * 2007-10-18 2009-05-27 Bayer Schering Pharma AG Fused imidazoles for cancer treatment
DE602008005894D1 (de) * 2007-08-14 2011-05-12 Bayer Schering Pharma Ag Kondensierte imidazole zur krebsbehandlung
MX393622B (es) 2008-05-21 2025-03-24 Incyte Corp Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida y procesos relacionados con la preparacion de las mismas.
BR112012008759A2 (pt) 2009-10-16 2020-08-25 Rib-X Pharmaceuticals, Inc. compostos antimicrobianos e métodos de fabricação e uso dos mesmos
JP5714030B2 (ja) 2010-02-03 2015-05-07 インサイト コーポレーションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｃ−Ｍｅｔ阻害剤としてのイミダゾ［１，２−ｂ］［１，２，４］トリアジン
US8410117B2 (en) * 2010-03-26 2013-04-02 Hoffmann-La Roche Inc. Imidazopyrimidine derivatives
EA024890B1 (ru) 2011-04-07 2016-10-31 Байер Интеллектчуал Проперти Гмбх Имидазопиридазины в качестве ингибиторов akt киназы
CN102796103A (zh) * 2011-05-23 2012-11-28 南京英派药业有限公司 6-（芳基甲酰）咪唑并[1,2-a]嘧啶和6-（芳基甲酰）[1,2,4]三唑并[4,3-a]嘧啶作为Hedgehog抑制剂及其应用
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
UY35400A (es) * 2013-03-15 2014-10-31 Novartis Ag Compuestos y composiciones para el tratamiento de enfermedades parasitarias
US9233961B2 (en) 2013-03-15 2016-01-12 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014151729A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
MY175865A (en) 2013-12-19 2020-07-14 Novartis Ag [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis
CN107922418A (zh) 2015-03-11 2018-04-17 梅琳塔治疗公司 抗微生物化合物及制备和使用所述化合物的方法
JP2019515041A (ja) 2016-05-06 2019-06-06 メリンタ セラピューティクス、 インコーポレイテッドＭｅｌｉｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 抗菌剤ならびにそれを作製および使用する方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455924A (en) * 1967-02-08 1969-07-15 Upjohn Co Dianisylimidazoles
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
ES2140354B1 (es) * 1998-08-03 2000-11-01 S A L V A T Lab Sa Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2.

Also Published As

Publication number Publication date
ES2298798T3 (es) 2008-05-16
EA009038B1 (ru) 2007-10-26
CA2534292A1 (en) 2005-02-17
EP1660500B1 (en) 2007-12-12
EA200600330A1 (ru) 2006-08-25
WO2005014598A1 (en) 2005-02-17
CN1860121A (zh) 2006-11-08
ZA200601706B (en) 2007-09-26
ATE380816T1 (de) 2007-12-15
EP1660500A1 (en) 2006-05-31
AU2004263297A1 (en) 2005-02-17
DE602004010680D1 (de) 2008-01-24
DE602004010680T2 (de) 2009-01-02
KR20060034303A (ko) 2006-04-21
JP2007500160A (ja) 2007-01-11
US20060189631A1 (en) 2006-08-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.