ATE461916T1 - Syntheseverfahren und zwischenprodukte zur herstellung von rizatriptan - Google Patents
Syntheseverfahren und zwischenprodukte zur herstellung von rizatriptanInfo
- Publication number
- ATE461916T1 ATE461916T1 AT05707035T AT05707035T ATE461916T1 AT E461916 T1 ATE461916 T1 AT E461916T1 AT 05707035 T AT05707035 T AT 05707035T AT 05707035 T AT05707035 T AT 05707035T AT E461916 T1 ATE461916 T1 AT E461916T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- rizatriptan
- production
- synthesis process
- intermediate products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04100303 | 2004-01-28 | ||
| US54346304P | 2004-02-10 | 2004-02-10 | |
| PCT/EP2005/000793 WO2005075422A1 (en) | 2004-01-28 | 2005-01-27 | Synthesis methods and intermediates for the manufacture of rizatriptan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE461916T1 true ATE461916T1 (de) | 2010-04-15 |
Family
ID=34928868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05707035T ATE461916T1 (de) | 2004-01-28 | 2005-01-27 | Syntheseverfahren und zwischenprodukte zur herstellung von rizatriptan |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7786156B2 (de) |
| EP (1) | EP1751104B1 (de) |
| AT (1) | ATE461916T1 (de) |
| CA (1) | CA2553652A1 (de) |
| DK (1) | DK1751104T3 (de) |
| ES (1) | ES2340861T3 (de) |
| WO (1) | WO2005075422A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7645886B2 (en) | 2002-12-20 | 2010-01-12 | Ciba Specialty Corporation | Synthesis of amines and intermediates for the synthesis thereof |
| WO2007054979A1 (en) * | 2005-11-14 | 2007-05-18 | Matrix Laboratories Ltd | Process for the large scale production of rizatriptan benzoate |
| CN102659662A (zh) * | 2012-03-28 | 2012-09-12 | 华东师范大学 | 3-r-3-羟基-2-氧化吲哚类化合物的合成方法 |
| CN103664900B (zh) * | 2013-11-25 | 2016-02-24 | 四川大学 | 一种制备苯甲酸利扎曲坦的方法 |
| CN113968819B (zh) * | 2021-11-15 | 2023-05-05 | 成都普康唯新生物科技有限公司 | 一种多取代吡唑类化合物的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3362000D1 (en) * | 1982-06-18 | 1986-03-13 | Ciba Geigy Ag | Method for the production of 1-(2-(,4-dichlorphenyl)pentyl)-1h-1,2,4-triazole and hydrazone- or hydrazine-derivatives |
| CZ283018B6 (cs) | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
| GB9208463D0 (en) * | 1992-04-16 | 1992-06-03 | Merck Sharp & Dohme | Therapeutic agents |
| US5567824A (en) * | 1994-05-24 | 1996-10-22 | Merck & Co., Inc. | Palladium catalyzed ring closure of triazolyltryptamine |
| ES2204303B2 (es) * | 2002-08-07 | 2004-12-16 | Laboratorios Vita, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo. |
| US7645886B2 (en) | 2002-12-20 | 2010-01-12 | Ciba Specialty Corporation | Synthesis of amines and intermediates for the synthesis thereof |
-
2005
- 2005-01-27 US US10/586,958 patent/US7786156B2/en not_active Expired - Fee Related
- 2005-01-27 WO PCT/EP2005/000793 patent/WO2005075422A1/en not_active Ceased
- 2005-01-27 EP EP05707035A patent/EP1751104B1/de not_active Expired - Lifetime
- 2005-01-27 CA CA002553652A patent/CA2553652A1/en not_active Abandoned
- 2005-01-27 AT AT05707035T patent/ATE461916T1/de not_active IP Right Cessation
- 2005-01-27 DK DK05707035.1T patent/DK1751104T3/da active
- 2005-01-27 ES ES05707035T patent/ES2340861T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005075422A1 (en) | 2005-08-18 |
| EP1751104A1 (de) | 2007-02-14 |
| ES2340861T3 (es) | 2010-06-10 |
| EP1751104B1 (de) | 2010-03-24 |
| US20070123711A1 (en) | 2007-05-31 |
| US7786156B2 (en) | 2010-08-31 |
| CA2553652A1 (en) | 2005-08-18 |
| DK1751104T3 (da) | 2010-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |