ATE496036T1 - Zwischenprodukte für die herstellung von pramipexol - Google Patents

Zwischenprodukte für die herstellung von pramipexol

Info

Publication number: ATE496036T1
Authority: AT; Austria
Prior art keywords: pramipexole; production; intermediate products; intermediates; synthesis
Prior art date: 2004-03-19

Application number

AT05728706T

Other languages

English (en)

Inventor

Graziano Castaldi

Alberto Bologna

Pietro Allegrini

Gabriele Razzetti

Vittorio Lucchini

Original Assignee

Dipharma Francis Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-19

Filing date

2005-03-11

Publication date

2011-02-15

2004-03-19 Priority claimed from ITMI20040531 external-priority patent/ITMI20040531A1/it

2005-01-28 Priority claimed from ITMI20050126 external-priority patent/ITMI20050126A1/it

2005-03-11 Application filed by Dipharma Francis Srl filed Critical Dipharma Francis Srl

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE496036T1 publication Critical patent/ATE496036T1/de

Links

FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 title abstract 2
229960003089 pramipexole Drugs 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT05728706T 2004-03-19 2005-03-11 Zwischenprodukte für die herstellung von pramipexol ATE496036T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI20040531 ITMI20040531A1 (it)	2004-03-19	2004-03-19	Intermedi per la preparazione di pramipexolo
ITMI20050126 ITMI20050126A1 (it)	2005-01-28	2005-01-28	Intermedi per la preparazione di pramipexolo
PCT/EP2005/002641 WO2005092871A2 (en)	2004-03-19	2005-03-11	Intermediates for the preparation of pramipexole

Publications (1)

Publication Number	Publication Date
ATE496036T1 true ATE496036T1 (de)	2011-02-15

Family

ID=34963371

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05728706T ATE496036T1 (de)	2004-03-19	2005-03-11	Zwischenprodukte für die herstellung von pramipexol

Country Status (8)

Country	Link
US (2)	US7741490B2 (de)
EP (2)	EP2289885A1 (de)
JP (1)	JP2007529446A (de)
AT (1)	ATE496036T1 (de)
CA (1)	CA2560128A1 (de)
DE (1)	DE602005025988D1 (de)
IL (1)	IL178156A0 (de)
WO (1)	WO2005092871A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL378587A1 (pl) *	2005-12-29	2007-07-09	Instytut Farmaceutyczny	Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) *	2006-01-13	2007-07-14	Dipharma Spa	Sintesi di intermedi pr la preparazione di pramipexolo
US8518926B2 (en) *	2006-04-10	2013-08-27	Knopp Neurosciences, Inc.	Compositions and methods of using (R)-pramipexole
KR20090021169A (ko)	2006-05-16	2009-02-27	크놉 뉴로사이언시스 인코포레이티드	Ｒ(+) 및 ｓ(-) 프라미펙솔을 포함하는 조성물 및 이의 사용 방법
ATE405554T1 (de) *	2006-06-26	2008-09-15	Helm Ag	Verfahren zur herstellung von pramipexole
US8524695B2 (en)	2006-12-14	2013-09-03	Knopp Neurosciences, Inc.	Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
CN101715443A (zh)	2007-03-14	2010-05-26	诺普神经科学股份有限公司	手性纯化的取代的苯并噻唑二胺的合成
GB0721333D0 (en) *	2007-10-31	2007-12-12	Motac Neuroscience Ltd	Medicaments
GB0721332D0 (en) *	2007-10-31	2007-12-12	Motac Neuroscience Ltd	Medicaments
US20110190356A1 (en) *	2008-08-19	2011-08-04	Knopp Neurosciences Inc.	Compositions and Methods of Using (R)- Pramipexole
CN101676272A (zh) *	2008-09-17	2010-03-24	北京德众万全药物技术开发有限公司	一种普拉克索的制备方法
WO2011021214A2 (en) *	2009-08-07	2011-02-24	Msn Laboratories Limited	Improved process for the preparation of (s)-2-amino-4,5,6,7-tetrahydro-6 - (propylamino) benzothiazole and its pharmaceutically acceptable salts
ITMI20101998A1 (it) *	2010-10-27	2012-04-28	Dipharma Francis Srl	Procedimento per la racemizzazione di acidi carbossilici
CN102442972B (zh) *	2011-10-18	2014-06-25	济南富创医药科技有限公司	一种普拉克索及其二盐酸盐一水合物的工业化制备方法
WO2013096816A1 (en)	2011-12-22	2013-06-27	Biogen Idec Ma Inc.	Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
CN103183650A (zh) *	2011-12-31	2013-07-03	天津药物研究院	(s)-(-)2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
CN103183649A (zh) *	2011-12-31	2013-07-03	天津药物研究院	2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
US9662313B2 (en)	2013-02-28	2017-05-30	Knopp Biosciences Llc	Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9468630B2 (en)	2013-07-12	2016-10-18	Knopp Biosciences Llc	Compositions and methods for treating conditions related to increased eosinophils
ES3043076T3 (en)	2013-07-12	2025-11-24	Areteia Therapeutics Inc	Treating elevated levels of eosinophils and/or basophils
ES2871556T3 (es)	2013-08-13	2021-10-29	Knopp Biosciences Llc	Composiciones y métodos para el tratamiento de la urticaria crónica
WO2015023786A1 (en)	2013-08-13	2015-02-19	Knopp Biosciences Llc	Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
CA3186844A1 (en) *	2020-08-05	2022-02-10	Calman Philip PRUSSIN	Use of dexpramipexole for the treatment of moderate to severe asthma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3572485D1 (en)	1984-12-22	1989-09-28	Thomae Gmbh Dr K	Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
DE3447075A1 (de) *	1984-12-22	1986-07-03	Dr. Karl Thomae Gmbh, 7950 Biberach	Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
ZA864626B (en)	1985-06-24	1988-02-24	Lilly Co Eli	Dialkylaminotetrahydrobenzothiazoles and oxazoles
US4988699A (en)	1989-03-14	1991-01-29	Warner-Lambert Company	Substituted tetrahydrobenzothiazoles as dopaminergic agents
SK285371B6 (sk) *	1997-12-22	2006-12-07	Bayer Corporation	Aryl- a heteroaryl-substituované heterocyklické močoviny, ich použitie a farmaceutické kompozície sich obsahom
JP2000119226A (ja) *	1998-10-13	2000-04-25	Banyu Pharmaceut Co Ltd	クルチウス転移反応を固相合成に利用した新規な芳香族アミン類又は芳香族複素環アミン類の製造方法
ES2187249B1 (es)	2000-09-18	2004-09-16	Synthon Bv	Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
JP2002173476A (ja) *	2000-12-07	2002-06-21	Sumitomo Pharmaceut Co Ltd	１，４−フェニレンジアミン誘導体及びその製造法
CL2004000553A1 (es) *	2003-03-20	2005-02-04	Actelion Pharmaceuticals Ltd	Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende.
US20070105908A1 (en) *	2003-06-27	2007-05-10	Dainippon Sumitomo Pharma Co., Ltd.	Thiazolimine compound and oxazolimine compound

2005
- 2005-03-11 US US10/593,269 patent/US7741490B2/en not_active Expired - Fee Related
- 2005-03-11 WO PCT/EP2005/002641 patent/WO2005092871A2/en not_active Ceased
- 2005-03-11 DE DE602005025988T patent/DE602005025988D1/de not_active Expired - Lifetime
- 2005-03-11 EP EP10180254A patent/EP2289885A1/de not_active Withdrawn
- 2005-03-11 CA CA002560128A patent/CA2560128A1/en not_active Abandoned
- 2005-03-11 EP EP05728706A patent/EP1730129B1/de not_active Expired - Lifetime
- 2005-03-11 JP JP2007503255A patent/JP2007529446A/ja active Pending
- 2005-03-11 AT AT05728706T patent/ATE496036T1/de not_active IP Right Cessation
2006
- 2006-09-18 IL IL178156A patent/IL178156A0/en unknown
2010
- 2010-05-10 US US12/776,588 patent/US8203002B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2007529446A (ja)	2007-10-25
US7741490B2 (en)	2010-06-22
WO2005092871A3 (en)	2005-12-01
DE602005025988D1 (de)	2011-03-03
EP1730129A2 (de)	2006-12-13
EP1730129B1 (de)	2011-01-19
CA2560128A1 (en)	2005-10-06
IL178156A0 (en)	2006-12-31
EP2289885A1 (de)	2011-03-02
US20070191439A1 (en)	2007-08-16
US20100222595A1 (en)	2010-09-02
WO2005092871A2 (en)	2005-10-06
US8203002B2 (en)	2012-06-19

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Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties