ATE496036T1 - Zwischenprodukte für die herstellung von pramipexol - Google Patents

Zwischenprodukte für die herstellung von pramipexol

Info

Publication number
ATE496036T1
ATE496036T1 AT05728706T AT05728706T ATE496036T1 AT E496036 T1 ATE496036 T1 AT E496036T1 AT 05728706 T AT05728706 T AT 05728706T AT 05728706 T AT05728706 T AT 05728706T AT E496036 T1 ATE496036 T1 AT E496036T1
Authority
AT
Austria
Prior art keywords
pramipexole
production
intermediate products
intermediates
synthesis
Prior art date
Application number
AT05728706T
Other languages
English (en)
Inventor
Graziano Castaldi
Alberto Bologna
Pietro Allegrini
Gabriele Razzetti
Vittorio Lucchini
Original Assignee
Dipharma Francis Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20040531 external-priority patent/ITMI20040531A1/it
Priority claimed from ITMI20050126 external-priority patent/ITMI20050126A1/it
Application filed by Dipharma Francis Srl filed Critical Dipharma Francis Srl
Application granted granted Critical
Publication of ATE496036T1 publication Critical patent/ATE496036T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05728706T 2004-03-19 2005-03-11 Zwischenprodukte für die herstellung von pramipexol ATE496036T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20040531 ITMI20040531A1 (it) 2004-03-19 2004-03-19 Intermedi per la preparazione di pramipexolo
ITMI20050126 ITMI20050126A1 (it) 2005-01-28 2005-01-28 Intermedi per la preparazione di pramipexolo
PCT/EP2005/002641 WO2005092871A2 (en) 2004-03-19 2005-03-11 Intermediates for the preparation of pramipexole

Publications (1)

Publication Number Publication Date
ATE496036T1 true ATE496036T1 (de) 2011-02-15

Family

ID=34963371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05728706T ATE496036T1 (de) 2004-03-19 2005-03-11 Zwischenprodukte für die herstellung von pramipexol

Country Status (8)

Country Link
US (2) US7741490B2 (de)
EP (2) EP1730129B1 (de)
JP (1) JP2007529446A (de)
AT (1) ATE496036T1 (de)
CA (1) CA2560128A1 (de)
DE (1) DE602005025988D1 (de)
IL (1) IL178156A0 (de)
WO (1) WO2005092871A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
ATE537826T1 (de) 2006-05-16 2012-01-15 Knopp Neurosciences Inc Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung
ATE405554T1 (de) * 2006-06-26 2008-09-15 Helm Ag Verfahren zur herstellung von pramipexole
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
JP2010521496A (ja) 2007-03-14 2010-06-24 ノップ ニューロサイエンシーズ、インク． キラル精製置換ベンゾチアゾールジアミンの合成
GB0721332D0 (en) 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
GB0721333D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
CN101676272A (zh) * 2008-09-17 2010-03-24 北京德众万全药物技术开发有限公司 一种普拉克索的制备方法
WO2011021214A2 (en) * 2009-08-07 2011-02-24 Msn Laboratories Limited Improved process for the preparation of (s)-2-amino-4,5,6,7-tetrahydro-6 - (propylamino) benzothiazole and its pharmaceutically acceptable salts
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
CN102442972B (zh) * 2011-10-18 2014-06-25 济南富创医药科技有限公司 一种普拉克索及其二盐酸盐一水合物的工业化制备方法
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
CN103183649A (zh) * 2011-12-31 2013-07-03 天津药物研究院 2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
CN103183650A (zh) * 2011-12-31 2013-07-03 天津药物研究院 (s)-(-)2-氨基-6-丙氨基-4,5,6,7-四氢苯并噻唑的制备方法
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
PL3019167T3 (pl) 2013-07-12 2021-06-14 Knopp Biosciences Llc Leczenie podwyższonych poziomów eozynofili i/lub bazofili
DK3033081T3 (da) 2013-08-13 2021-05-31 Knopp Biosciences Llc Sammensætninger og fremgangsmåder til behandling af kronisk urticaria
EP3038467B1 (de) 2013-08-13 2020-07-29 Knopp Biosciences LLC Zusammensetzungen und verfahren zur behandlung von plasmazellenerkrankungen und prolymphozytischen b-zellen-erkrankungen
WO2022031956A1 (en) * 2020-08-05 2022-02-10 Knopp Biosciences Llc Use of dexpramipexole for the treatment of moderate to severe asthma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3447075A1 (de) * 1984-12-22 1986-07-03 Dr. Karl Thomae Gmbh, 7950 Biberach Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
DE3572485D1 (en) 1984-12-22 1989-09-28 Thomae Gmbh Dr K Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
EP0207696A1 (de) 1985-06-24 1987-01-07 Eli Lilly And Company Dialkylaminotetrahydrobenzothiazole und -oxazole
US4988699A (en) * 1989-03-14 1991-01-29 Warner-Lambert Company Substituted tetrahydrobenzothiazoles as dopaminergic agents
PT1056725E (pt) * 1997-12-22 2006-09-29 Bayer Pharmaceuticals Corp Inibicao da raf-quinase usando ureias heterociclicas substituidas com arilo e heteroarilo
JP2000119226A (ja) * 1998-10-13 2000-04-25 Banyu Pharmaceut Co Ltd クルチウス転移反応を固相合成に利用した新規な芳香族アミン類又は芳香族複素環アミン類の製造方法
ES2187249B1 (es) 2000-09-18 2004-09-16 Synthon Bv Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
JP2002173476A (ja) * 2000-12-07 2002-06-21 Sumitomo Pharmaceut Co Ltd １，４−フェニレンジアミン誘導体及びその製造法
CL2004000553A1 (es) * 2003-03-20 2005-02-04 Actelion Pharmaceuticals Ltd Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende.
EP1640369A4 (de) * 2003-06-27 2007-10-31 Dainippon Sumitomo Pharma Co Thiazoliminverbindung und oxazoliminverbindung

Also Published As

Publication number Publication date
WO2005092871A3 (en) 2005-12-01
JP2007529446A (ja) 2007-10-25
EP1730129A2 (de) 2006-12-13
EP2289885A1 (de) 2011-03-02
US20100222595A1 (en) 2010-09-02
WO2005092871A2 (en) 2005-10-06
CA2560128A1 (en) 2005-10-06
EP1730129B1 (de) 2011-01-19
US7741490B2 (en) 2010-06-22
US20070191439A1 (en) 2007-08-16
DE602005025988D1 (de) 2011-03-03
IL178156A0 (en) 2006-12-31
US8203002B2 (en) 2012-06-19

Similar Documents

Publication Publication Date Title
ATE496036T1 (de) Zwischenprodukte für die herstellung von pramipexol
ATE447564T1 (de) Zwischenprodukte für die herstellung von trans-5- chlor-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzä , 3:6,7üoxepinoä4,5-cüpyrrol
ATE434598T1 (de) Zwischenprodukte für die herstellung von dioxan-2-alkylcarbamaten
ATE348100T1 (de) Zwischenprodukten für die herstellung von pyridazinon aldose reductase inhibitoren.
ATE490253T1 (de) Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen
DK1613304T3 (da) DPP-IV-inhibitorer
ATE417046T1 (de) 8- ä3-amino-piperidin-1-ylü-xanthine, deren herstellung und deren verwendung als arzneimittel
ATE427932T1 (de) 11beta-hsd1-inhibitoren
MXPA05012362A (es) Yodopirazolilcarboxanilidas.
ATE381596T1 (de) Azo verbindung
IL175390A0 (en) Parocess for the preparation of telmisartan
ATE553095T1 (de) Neue imidazolderivate, deren herstellung und deren verwendung als intermediate zur herstellung von arzneimitteln und pestiziden
DE60316152D1 (de) Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen
DE502005008057D1 (de) Substituierte cyclopenten-verbindungen
DE602006019732D1 (de) Indolylmaleimidderivate
ATE517900T1 (de) Heptarylen-und octarylentetracarbonsäurediimide und deren herstellung
ATE445617T1 (de) Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel
DE60323748D1 (de) 1,3-diaza-dibenzoazulene als inhibitoren der produfür deren herstellung
DE602004008092D1 (de) Pressblasmaschine für die herstellung von hohlen glaswaren
DE60238030D1 (de) Katalysatorzusammensetzung für die Herstellung von Polyolefinen
WO2007017510A3 (de) Isophthalsäurediamide zur behandlung der alzheimer erkrankung
ATE377588T1 (de) Zwischenprodukt für die herstellung von pioglitazon
ATE540961T1 (de) Furanosederivate fuer die herstellung von atorvastatin
DE60321724D1 (de) 1,2-diaza-dibenzoazulene als inhibitoren der produfür deren herstellung
DE602005022213D1 (de) Verfahren zur herstellung von phenyl-2-pyrimidinyl-ketonen und neuen zwischenprodukten daraus

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties