ATE461931T1 - Herstellungsverfahren für 9-ä4-acetoxy-3- (acetoxymethyl)but-1-ylü-2-aminopurin unter verwendung einer verbindung von 2-amino-9-(2- substituierte ethyl)purine - Google Patents

Herstellungsverfahren für 9-ä4-acetoxy-3- (acetoxymethyl)but-1-ylü-2-aminopurin unter verwendung einer verbindung von 2-amino-9-(2- substituierte ethyl)purine

Info

Publication number: ATE461931T1
Authority: AT; Austria
Prior art keywords: amino; purine; substituted ethyl; compound; famciclovir
Prior art date: 2003-06-13

Application number

AT04773919T

Other languages

English (en)

Inventor

Byoung-Suk Lee

Sang-Hoon Shin

Jong-Sik Park

Original Assignee

Kyungdong Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-13

Filing date

2004-06-12

Publication date

2010-04-15

2004-06-12 Application filed by Kyungdong Pharm Co Ltd filed Critical Kyungdong Pharm Co Ltd

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE461931T1 publication Critical patent/ATE461931T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title abstract 2
150000003212 purines Chemical class 0.000 title abstract 2
-1 2-amino-9-(2-substituted ethyl)purine Chemical class 0.000 abstract 4
GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 abstract 4
229960004396 famciclovir Drugs 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 2
LTMRRSWNXVJMBA-UHFFFAOYSA-L 2,2-diethylpropanedioate Chemical compound CCC(CC)(C([O-])=O)C([O-])=O LTMRRSWNXVJMBA-UHFFFAOYSA-L 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
230000002140 halogenating effect Effects 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000005905 mesyloxy group Chemical group 0.000 abstract 1
125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT04773919T 2003-06-13 2004-06-12 Herstellungsverfahren für 9-ä4-acetoxy-3- (acetoxymethyl)but-1-ylü-2-aminopurin unter verwendung einer verbindung von 2-amino-9-(2- substituierte ethyl)purine ATE461931T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR1020030038417A KR100573860B1 (ko)	2003-06-13	2003-06-13	2-아미노-9-(2-치환에틸)푸린을 이용한 9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의 제조방법
PCT/KR2004/001405 WO2004110343A2 (en)	2003-06-13	2004-06-12	2-amino-9-(2-substituted ethyl)purines and preparing methods for 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]- 2- aminopurine using the same

Publications (1)

Publication Number	Publication Date
ATE461931T1 true ATE461931T1 (de)	2010-04-15

Family

ID=36788755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04773919T ATE461931T1 (de)	2003-06-13	2004-06-12	Herstellungsverfahren für 9-ä4-acetoxy-3- (acetoxymethyl)but-1-ylü-2-aminopurin unter verwendung einer verbindung von 2-amino-9-(2- substituierte ethyl)purine

Country Status (9)

Country	Link
US (1)	US7456282B2 (de)
EP (1)	EP1636231B1 (de)
JP (1)	JP2006523614A (de)
KR (1)	KR100573860B1 (de)
CN (1)	CN100455583C (de)
AT (1)	ATE461931T1 (de)
AU (1)	AU2004246958B2 (de)
DE (1)	DE602004026180D1 (de)
WO (1)	WO2004110343A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1532151A2 (de) *	2002-08-26	2005-05-25	Teva Pharmaceutical Industries Limited	Kristalline feste formen i, ii, iii des famciclovir and deren herstellung
EP1511750A1 (de) *	2003-04-30	2005-03-09	Teva Pharmaceutical Industries Ltd.	Verfahren zur herstellung von famciclovir
KR100573861B1 (ko) *	2003-07-18	2006-04-25	경동제약 주식회사	2-아미노-9-(2-할로게노에틸)푸린 및 그 중간체로서의 2-아미노-6,8-디클로로-9-(2-히드록시에틸)푸린의 제조방법
KR100618232B1 (ko) *	2004-09-22	2006-09-04	한미약품 주식회사	팜시클로버의 제조방법
GB2426247A (en)	2005-05-20	2006-11-22	Arrow Int Ltd	Methods of preparing purine derivatives such as famciclovir
WO2008072074A1 (en) *	2006-12-11	2008-06-19	Aurobindo Pharma Limited	An improved process for the preparation of purine derivative
WO2008155613A1 (en) *	2007-06-21	2008-12-24	Aurobindo Pharma Ltd	An improved process for preparing purine derivative
CN101555249B (zh) *	2008-04-08	2011-05-11	浙江海正药业股份有限公司	泛昔洛韦的合成方法
CN102924455A (zh) *	2011-08-11	2013-02-13	重庆圣华曦药业股份有限公司	一种泛昔洛韦中间体的合成方法
CN106749254B (zh) *	2017-01-10	2018-05-25	青岛科技大学	一种6-氨基嘌呤乙基萘乙酸酯类化合物及其作为植物生长调节剂的用途
CN108314685B (zh) *	2018-03-16	2020-08-25	上药康丽（常州）药业有限公司	一种2-氨基-6-氯-9-(4-乙酰氧基-3-乙酰氧甲基丁基)嘌呤的制备方法
CN109456329B (zh) *	2018-11-19	2021-03-09	迪嘉药业集团有限公司	一种泛昔洛韦的制备方法
WO2022090101A1 (en)	2020-10-26	2022-05-05	Boehringer Ingelheim International Gmbh	Process for synthesis of 2,4-dichloro-5-aminopyrimidine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5684153A (en) *	1984-08-16	1997-11-04	Beecham Group Plc	Process for the preparation of purine derivatives
GB8822236D0 (en) *	1988-09-21	1988-10-26	Beecham Group Plc	Chemical process
GB8922076D0 (en) *	1989-09-28	1989-11-15	Beecham Group Plc	Novel process
GB9220585D0 (en) *	1992-09-30	1992-11-11	Smithkline Beecham Plc	Pharmaceuticals
GB9402161D0 (en) *	1994-02-04	1994-03-30	Wellcome Found	Chloropyrimidine intermediates

2003
- 2003-06-13 KR KR1020030038417A patent/KR100573860B1/ko not_active Expired - Fee Related
2004
- 2004-06-12 DE DE602004026180T patent/DE602004026180D1/de not_active Expired - Fee Related
- 2004-06-12 JP JP2006500699A patent/JP2006523614A/ja active Pending
- 2004-06-12 AU AU2004246958A patent/AU2004246958B2/en not_active Ceased
- 2004-06-12 WO PCT/KR2004/001405 patent/WO2004110343A2/en not_active Ceased
- 2004-06-12 EP EP04773919A patent/EP1636231B1/de not_active Expired - Lifetime
- 2004-06-12 CN CNB2004800132912A patent/CN100455583C/zh not_active Expired - Lifetime
- 2004-06-12 AT AT04773919T patent/ATE461931T1/de not_active IP Right Cessation
- 2004-06-12 US US10/554,676 patent/US7456282B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2004110343A3 (en)	2005-09-01
US7456282B2 (en)	2008-11-25
AU2004246958B2 (en)	2010-09-16
DE602004026180D1 (de)	2010-05-06
AU2004246958A1 (en)	2004-12-23
WO2004110343A2 (en)	2004-12-23
KR100573860B1 (ko)	2006-04-25
JP2006523614A (ja)	2006-10-19
CN100455583C (zh)	2009-01-28
KR20040107812A (ko)	2004-12-23
EP1636231A2 (de)	2006-03-22
EP1636231B1 (de)	2010-03-24
US20060258862A1 (en)	2006-11-16
CN1791602A (zh)	2006-06-21

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Legal Events

Date	Code	Title	Description
2010-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties