ATE463478T1 - Diaryletherderivat, dessen additionssalz und immunosuppressivum - Google Patents
Diaryletherderivat, dessen additionssalz und immunosuppressivumInfo
- Publication number
- ATE463478T1 ATE463478T1 AT02768056T AT02768056T ATE463478T1 AT E463478 T1 ATE463478 T1 AT E463478T1 AT 02768056 T AT02768056 T AT 02768056T AT 02768056 T AT02768056 T AT 02768056T AT E463478 T1 ATE463478 T1 AT E463478T1
- Authority
- AT
- Austria
- Prior art keywords
- immunosuppressant
- addition salt
- diaryl ether
- ether derivative
- diaryl
- Prior art date
Links
- 150000001987 diarylethers Chemical class 0.000 title abstract 2
- 229960003444 immunosuppressant agent Drugs 0.000 title 1
- 230000001861 immunosuppressant effect Effects 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical group C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 abstract 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001297400 | 2001-09-27 | ||
| JP2002216191 | 2002-07-25 | ||
| PCT/JP2002/009864 WO2003029184A1 (en) | 2001-09-27 | 2002-09-25 | Diaryl ether derivative, addition salt thereof, and immunosuppressant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE463478T1 true ATE463478T1 (de) | 2010-04-15 |
Family
ID=26623110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02768056T ATE463478T1 (de) | 2001-09-27 | 2002-09-25 | Diaryletherderivat, dessen additionssalz und immunosuppressivum |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6963012B2 (de) |
| EP (1) | EP1431275B1 (de) |
| JP (1) | JP4152884B2 (de) |
| AT (1) | ATE463478T1 (de) |
| CA (1) | CA2460640C (de) |
| DE (1) | DE60235900D1 (de) |
| WO (1) | WO2003029184A1 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002332289B2 (en) * | 2001-09-27 | 2007-05-10 | Kyorin Pharmaceutical Co., Ltd. | Diaryl sulfide derivative, addition salt thereof, and immunosuppressant |
| RU2330839C2 (ru) | 2002-01-11 | 2008-08-10 | Санкио Компани, Лимитед | Производные аминоспиртов или производные фосфорных кислот и фармацевтические композиции, содержащие указанные производные |
| CA2483594C (en) | 2002-05-16 | 2011-02-15 | Novartis Ag | Use of edg receptor binding agents in cancer |
| AU2003264430B2 (en) * | 2002-09-19 | 2009-03-19 | Kyorin Pharmaceutical Co., Ltd. | Amino alcohol derivative, addition salt thereof, and immunosuppressant |
| MXPA05003254A (es) | 2002-09-24 | 2005-06-08 | Novartis Ag | Agonistas del receptor de esfingosina-1-fosfato en el tratamiento de trastornos de desmielinacion. |
| DE202004021680U1 (de) * | 2003-04-08 | 2010-04-22 | Novartis Ag | Feste pharmazeutische Zusammensetzung |
| ATE547395T1 (de) * | 2003-04-30 | 2012-03-15 | Novartis Pharma Gmbh | Aminopropanol-derivate als modulatoren des sphingosin-1-phosphat-rezeptors |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| GB0324210D0 (en) | 2003-10-15 | 2003-11-19 | Novartis Ag | Organic compounds |
| GB0329498D0 (en) | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| TW200526548A (en) * | 2003-12-25 | 2005-08-16 | Sankyo Co | Ether derivatives |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| TWI355934B (en) | 2004-02-24 | 2012-01-11 | Sankyo Co | Pharmaceutical composition for treatment or prophy |
| MXPA06012663A (es) | 2004-05-03 | 2007-01-16 | Novartis Ag | Combinaciones que comprenden un agonista del receptor s1p y un inhibidor de quinasa jak3. |
| ATE502630T1 (de) * | 2004-07-16 | 2011-04-15 | Kyorin Seiyaku Kk | Verfahren zur effektiven anwendung eines medikaments und verfahren zur prävention von nebenwirkungen |
| TW200611687A (en) * | 2004-07-29 | 2006-04-16 | Sankyo Co | Pharmaceutical compositions used for immunosuppressant |
| PT1773307E (pt) | 2004-07-30 | 2015-01-14 | Novartis Ag | Formulações de compostos à base de 2-amino-1,3- propanodiol |
| AU2005292984B2 (en) | 2004-10-12 | 2011-01-20 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride or hydrate thereof and intermediate for the same |
| SG187468A1 (en) | 2004-11-29 | 2013-02-28 | Novartis Ag | Dosage regimen of an s1p receptor agonist |
| GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| TWI418350B (zh) * | 2005-06-24 | 2013-12-11 | Sankyo Co | 含有ｐｐａｒ調節劑之醫藥組成物的用途 |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
| NZ588372A (en) * | 2005-09-09 | 2012-03-30 | Novartis Ag | Diphenyl ether or thioether derivatives for treatment of autoimmune diseases |
| RU2421214C2 (ru) * | 2005-10-07 | 2011-06-20 | Киорин Фармасьютикал Ко., Лтд. | Терапевтическое средство для лечения гепатита и способ лечения гепатита |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| CA2643680A1 (en) | 2006-04-11 | 2007-11-22 | Novartis Ag | Hcv/hiv inhibitors and their uses |
| JP5100641B2 (ja) | 2006-04-28 | 2012-12-19 | 田辺三菱製薬株式会社 | ２−アミノブタノール化合物及びその医薬用途 |
| TW200815600A (en) | 2006-08-04 | 2008-04-01 | Daiichi Sankyo Co Ltd | An enzyme for phosphorizing a medicine |
| US8232319B2 (en) | 2006-08-08 | 2012-07-31 | Kyorin Pharmaceutical Co., Ltd. | Amino phosphate derivative and S1P receptor modulator having same as an active ingredient |
| JP5140593B2 (ja) * | 2006-08-08 | 2013-02-06 | 杏林製薬株式会社 | アミノアルコール誘導体及びそれらを有効成分とする免疫抑制剤 |
| WO2008153159A1 (ja) | 2007-06-14 | 2008-12-18 | Mitsubishi Tanabe Pharma Corporation | アミン化合物及びその医薬用途 |
| PT2465492E (pt) | 2007-10-12 | 2015-10-15 | Novartis Ag | Composições que compreendem moduladores de receptores de esfingosina-1-fosfato (s1p) |
| US7816435B2 (en) * | 2007-10-31 | 2010-10-19 | Momentive Performance Materials Inc. | Halo-functional silane, process for its preparation, rubber composition containing same and articles manufactured therefrom |
| TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
| WO2009115954A1 (en) | 2008-03-17 | 2009-09-24 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective s1p1 receptor agonist |
| CA2724450A1 (en) * | 2008-05-19 | 2009-11-26 | Takeshi Tsubuki | Method for producing optically active aminoalcohol derivative |
| EP2305305A4 (de) * | 2008-05-20 | 2013-02-13 | Kyorin Seiyaku Kk | Mittel zur einleitung/erhaltung der remission |
| GB0901835D0 (en) | 2009-02-04 | 2009-03-11 | Syngenta Ltd | Novel herbicides |
| GB0901834D0 (en) | 2009-02-04 | 2009-03-11 | Syngenta Ltd | Novel herbicides |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| PT2452944E (pt) | 2009-07-09 | 2014-10-13 | Kyorin Seiyaku Kk | Derivados de sulfureto de difenilo e medicamentos que os contêm como ingredientes activos |
| KR101148098B1 (ko) | 2010-04-30 | 2012-05-22 | 한국화학연구원 | 1-［4-（4-니트로-페녹시）-페닐］-프로판-1-온을 유효성분으로 함유하는 톡소포자충 및 콕시디움에 기인한 질환의 예방 및 치료용 조성물 |
| AU2011249789B2 (en) | 2010-05-06 | 2015-03-19 | Novartis Ag | Dosage regimen of diaryl sulfide derivatives |
| NZ603999A (en) * | 2010-05-06 | 2014-06-27 | Novartis Ag | Treatment of autoimmune diseases |
| EP2624826B1 (de) | 2010-10-08 | 2018-07-18 | Novartis AG | Zusammensetzungen enthaltend vitamin e und sulfamide mit ns3 hemmender wirkung |
| TWI519539B (zh) | 2010-12-21 | 2016-02-01 | Kyorin Seiyaku Kk | Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof |
| CN102863345A (zh) * | 2011-07-06 | 2013-01-09 | 中国医学科学院药物研究所 | 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途 |
| ES2570187T3 (es) | 2011-07-13 | 2016-05-17 | Basf Agro Bv | Compuestos fungicidas de 2-[2-halogenoalquil-4-(fenoxi)-fenil]-1-[1,2,4]triazol-1-il-etanol sustituido |
| US9137996B2 (en) | 2011-07-15 | 2015-09-22 | Basf Se | Fungicidal alkyl- and aryl-substituted 2[-2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds |
| US9173402B2 (en) | 2011-07-15 | 2015-11-03 | Basf Se | Fungicidal alkyl-substituted 2[2-chloro-4-(4-chioro-phenoxy)-phenyl]-1[1,2,4]triazol-1-yl-ethanol compounds |
| BR112014003412A2 (pt) | 2011-08-15 | 2017-03-14 | Basf Se | compostos de fórmula i, processo, compostos de fórmula xii, viii e xi, composições agroquímicas, utilização e semente revestida |
| AU2012296887A1 (en) | 2011-08-15 | 2014-01-30 | Basf Se | Fungicidal substituted 1-{2-[2-halo-4-(4-halogen-phenoxy)-phenyl]-2-alkoxy-3-methyl-butyl}-1H-[1,2,4]triazole compounds |
| MX2014001669A (es) | 2011-08-15 | 2014-05-27 | Basf Se | Compuestos de fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-feni l]-2-alcoxi-2-alquinil/alquenil-etil}-1h-[1,2,4]triazol sustituidos. |
| US9657043B2 (en) | 2012-04-23 | 2017-05-23 | Mitsubishi Tanabe Pharma Corporation | Amine compound and use thereof for medical purposes |
| BR112015014753B8 (pt) | 2012-12-20 | 2020-03-03 | Basf Agro Bv | composições, uso de uma composição, método para o combate de fungos fitopatogênicos e uso dos componentes |
| BR112015016446B1 (pt) | 2013-01-09 | 2019-10-29 | Basf Agro Bv | processo para preparar compostos de fórmula ii, solução aquosa e uso da solução aquosa |
| BR112016000299B8 (pt) | 2013-07-08 | 2021-04-20 | Basf Agro Bv | composições, uso de uma composição, método para o combate dos fungos fitopatogênicos e uso dos componentes |
| CN104844486B (zh) * | 2014-02-17 | 2018-10-30 | 中国医学科学院药物研究所 | 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途 |
| AU2015281187B2 (en) | 2014-06-25 | 2018-10-04 | BASF Agro B.V. | Pesticidal compositions |
| UA120628C2 (uk) | 2014-11-07 | 2020-01-10 | Басф Се | Пестицидні суміші |
| US11241012B2 (en) | 2016-03-16 | 2022-02-08 | Basf Se | Use of tetrazolinones for combating resistant phytopathogenic fungi on soybean |
| WO2017157920A1 (en) | 2016-03-16 | 2017-09-21 | Basf Se | Use of tetrazolinones for combating resistant phytopathogenic fungi on fruits |
| EP3429357B1 (de) | 2016-03-16 | 2025-09-17 | Basf Se | Verwendung eines spezifischen tetrazolinons zur bekämpfung phytopathogener pilze in getreide |
| CN112512516A (zh) | 2018-07-27 | 2021-03-16 | 普瑞奥治疗有限公司 | 用于在已经经历造血干细胞移植的患者中抑制血液恶性肿瘤复发的活性剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627406B1 (de) * | 1992-10-21 | 1998-10-28 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1, 3- propandiolverbindung und immunosuppressium |
| JP3870419B2 (ja) * | 1994-08-22 | 2007-01-17 | 三菱ウェルファーマ株式会社 | ベンゼン化合物およびその医薬としての用途 |
| CA2286315C (en) | 1997-04-04 | 2007-03-06 | Yoshitomi Pharmaceutical Industries Ltd. | 2-aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor |
-
2002
- 2002-09-25 AT AT02768056T patent/ATE463478T1/de not_active IP Right Cessation
- 2002-09-25 EP EP02768056A patent/EP1431275B1/de not_active Expired - Lifetime
- 2002-09-25 DE DE60235900T patent/DE60235900D1/de not_active Expired - Lifetime
- 2002-09-25 CA CA2460640A patent/CA2460640C/en not_active Expired - Fee Related
- 2002-09-25 US US10/490,345 patent/US6963012B2/en not_active Expired - Fee Related
- 2002-09-25 JP JP2003532439A patent/JP4152884B2/ja not_active Expired - Fee Related
- 2002-09-25 WO PCT/JP2002/009864 patent/WO2003029184A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1431275A1 (de) | 2004-06-23 |
| CA2460640A1 (en) | 2003-04-10 |
| US20040242654A1 (en) | 2004-12-02 |
| JPWO2003029184A1 (ja) | 2005-01-13 |
| EP1431275B1 (de) | 2010-04-07 |
| CA2460640C (en) | 2011-03-29 |
| JP4152884B2 (ja) | 2008-09-17 |
| DE60235900D1 (de) | 2010-05-20 |
| EP1431275A4 (de) | 2006-05-31 |
| US6963012B2 (en) | 2005-11-08 |
| WO2003029184A1 (en) | 2003-04-10 |
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