ATE464309T1 - Indolizinderivate und deren verwendung als crth2- antagonisten - Google Patents

Indolizinderivate und deren verwendung als crth2- antagonisten

Info

Publication number
ATE464309T1
ATE464309T1 AT06755627T AT06755627T ATE464309T1 AT E464309 T1 ATE464309 T1 AT E464309T1 AT 06755627 T AT06755627 T AT 06755627T AT 06755627 T AT06755627 T AT 06755627T AT E464309 T1 ATE464309 T1 AT E464309T1
Authority
AT
Austria
Prior art keywords
c1c6alkyl
hydrogen
fully
partially fluorinated
independently
Prior art date
Application number
AT06755627T
Other languages
English (en)
Inventor
George Hynd
Nicholas Ray
Harry Finch
David Middlemiss
Michael CRAMP
Paul Blaney
Karen Williams
Yan A Griffon
Trevor Keith Harrison
Peter Crackett
Original Assignee
Argenta Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Argenta Discovery Ltd filed Critical Argenta Discovery Ltd
Application granted granted Critical
Publication of ATE464309T1 publication Critical patent/ATE464309T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06755627T 2005-06-24 2006-06-26 Indolizinderivate und deren verwendung als crth2- antagonisten ATE464309T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0512944.0A GB0512944D0 (en) 2005-06-24 2005-06-24 Indolizine compounds
PCT/GB2006/002341 WO2006136859A2 (en) 2005-06-24 2006-06-26 Indoli zine derivatives and their use as crth2 antagonists

Publications (1)

Publication Number Publication Date
ATE464309T1 true ATE464309T1 (de) 2010-04-15

Family

ID=34856120

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06755627T ATE464309T1 (de) 2005-06-24 2006-06-26 Indolizinderivate und deren verwendung als crth2- antagonisten

Country Status (8)

Country Link
US (1) US20090163534A1 (de)
EP (1) EP1910357B1 (de)
JP (1) JP2008543921A (de)
CN (1) CN101243086A (de)
AT (1) ATE464309T1 (de)
DE (1) DE602006013643D1 (de)
GB (1) GB0512944D0 (de)
WO (1) WO2006136859A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2316824A1 (de) 2006-08-07 2011-05-04 Actelion Pharmaceuticals Ltd. (3-Amino-1,2,3,4-Tetrahydro-9H-Carbazol-9-yl)-Essigsäure Derivate
CN101605544A (zh) * 2006-12-21 2009-12-16 阿根塔发明有限公司 Crth2拮抗剂
GB0625842D0 (en) * 2006-12-22 2007-02-07 Argenta Discovery Ltd Indolizine derivatives
MX2009010068A (es) * 2007-03-21 2010-02-24 Argenta Oral Therapeutics Ltd Derivados de acido indolizin acetico como antagonistas de crth2.
JP2010522731A (ja) * 2007-03-29 2010-07-08 アージェンタ オーラル セラピューティクス リミテッド Ｃｒｔｈ２受容体リガンドとしてのキノリン誘導体
KR20100061746A (ko) * 2007-09-25 2010-06-08 액티미스 파마수티컬스 인코포레이티드 Ｃｒｔｈ２ 길항제로서의 ２－ｓ－벤질 치환된 피리미딘
GB0719521D0 (en) * 2007-10-05 2007-11-14 Argenta Discovery Ltd Compounds
JP5327762B2 (ja) 2007-12-14 2013-10-30 プルマジェン セラピューティクス（アズマ）リミテッド インドールおよびその治療的使用
WO2009102462A1 (en) * 2008-02-15 2009-08-20 Abbott Laboratories Thienopyrroles and pyrrolothiazoles as new therapeutic agents
JP5552121B2 (ja) 2008-09-04 2014-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のインドリジン阻害剤
RS52809B (sr) 2008-11-17 2013-10-31 F. Hoffmann-La Roche Ag. Naftilsirćetne kiseline
AR077428A1 (es) * 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
MX2012010820A (es) 2010-03-22 2012-10-10 Actelion Pharmaceuticals Ltd Derivados de 3-(heteroaril-amino)-1, 2, 3, 4-tetrahidro-9h-carbazo l y sus uso como moduladores del receptor de prostaglandina d2.
EP2457900A1 (de) 2010-11-25 2012-05-30 Almirall, S.A. Neue Pyrazolderivate mit CRTH2-antagonistischem Verhalten
WO2012140612A1 (en) 2011-04-14 2012-10-18 Actelion Pharmaceuticals Ltd 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators
CN104114169A (zh) 2011-12-16 2014-10-22 阿托佩斯治疗有限公司 用于治疗嗜酸细胞性食管炎的crth2拮抗剂和质子泵抑制剂的组合物
PH12016501764B1 (en) 2014-03-17 2024-05-17 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
WO2015140701A1 (en) 2014-03-18 2015-09-24 Actelion Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
WO2017046125A1 (en) 2015-09-15 2017-03-23 Actelion Pharmaceuticals Ltd Crystalline forms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174124A (en) * 1967-06-30 1969-12-10 Beecham Group Ltd Pharmacologically Active Indolizine Compounds
GB1268424A (en) * 1969-10-04 1972-03-29 Beecham Group Ltd Indolizine derivatives
ES421284A1 (es) * 1973-12-07 1976-04-16 Farmasimes S A Procedimiento para la preparacion de derivados de acidos pirrocolinaceticos.
WO2005040112A1 (en) * 2003-10-14 2005-05-06 Oxagen Limited Compounds with pgd2 antagonist activity
JP2007508363A (ja) * 2003-10-14 2007-04-05 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
GB2407318A (en) * 2003-10-23 2005-04-27 Oxagen Ltd Substituted Indol-3-yl acetic acid derivatives
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy

Also Published As

Publication number Publication date
WO2006136859A2 (en) 2006-12-28
JP2008543921A (ja) 2008-12-04
EP1910357A2 (de) 2008-04-16
US20090163534A1 (en) 2009-06-25
GB0512944D0 (en) 2005-08-03
DE602006013643D1 (de) 2010-05-27
EP1910357B1 (de) 2010-04-14
WO2006136859A3 (en) 2007-04-05
CN101243086A (zh) 2008-08-13

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