ATE465204T1 - Verfahren zur herstellung von carbonsäurefunktionalisierten polymeren - Google Patents

Verfahren zur herstellung von carbonsäurefunktionalisierten polymeren

Info

Publication number: ATE465204T1
Authority: AT; Austria
Prior art keywords: polymer; acid functionalized; carboxylic acid; carboxylate salt; producing
Prior art date: 2003-11-06

Application number

AT04810369T

Other languages

English (en)

Inventor

Milton Harris

Antoni Kozlowski

Lihong Guo

Original Assignee

Nektar Therapeutics

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-06

Filing date

2004-11-05

Publication date

2010-05-15

2004-11-05 Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE465204T1 publication Critical patent/ATE465204T1/de

Links

229920000642 polymer Polymers 0.000 title abstract 7
239000002253 acid Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
-1 poly(ethylene glycol) Polymers 0.000 abstract 5
150000001735 carboxylic acids Chemical class 0.000 abstract 3
125000000524 functional group Chemical group 0.000 abstract 3
239000007864 aqueous solution Substances 0.000 abstract 2
229920001223 polyethylene glycol Polymers 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000008027 tertiary esters Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
- C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
- C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
- C08F283/06—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polyethers, polyoxymethylenes or polyacetals
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F289/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
- C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
- C08G65/3346—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur having sulfur bound to carbon and oxygen

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Medicinal Preparation (AREA)
Polyethers (AREA)
Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Peptides Or Proteins (AREA)
Polyamides (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)

AT04810369T 2003-11-06 2004-11-05 Verfahren zur herstellung von carbonsäurefunktionalisierten polymeren ATE465204T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US51779403P	2003-11-06	2003-11-06
PCT/US2004/036850 WO2005047366A1 (en)	2003-11-06	2004-11-05	Method of preparing carboxylic acid functionalized polymers

Publications (1)

Publication Number	Publication Date
ATE465204T1 true ATE465204T1 (de)	2010-05-15

Family

ID=34590189

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04810369T ATE465204T1 (de)	2003-11-06	2004-11-05	Verfahren zur herstellung von carbonsäurefunktionalisierten polymeren

Country Status (17)

Country	Link
US (5)	US20050214250A1 (de)
EP (1)	EP1692206B1 (de)
JP (1)	JP5101884B2 (de)
KR (1)	KR101157007B1 (de)
CN (1)	CN100580005C (de)
AT (1)	ATE465204T1 (de)
AU (1)	AU2004289992B2 (de)
CA (1)	CA2544697C (de)
CY (1)	CY1110303T1 (de)
DE (1)	DE602004026770D1 (de)
DK (1)	DK1692206T3 (de)
ES (1)	ES2342294T3 (de)
IL (1)	IL175406A (de)
PL (1)	PL1692206T3 (de)
PT (1)	PT1692206E (de)
SI (1)	SI1692206T1 (de)
WO (1)	WO2005047366A1 (de)

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EP3187254B1 (de) *	2015-12-30	2020-09-02	Italmatch SC, LLC	Polymerischer emulgator und schmieradditive zum entfernen, formen, walzen von wässrigem metall oder andere anwendungen
WO2017214337A1 (en)	2016-06-07	2017-12-14	Massachusetts Institute Of Technology	Drug delivery polymers and uses thereof
WO2018039577A1 (en)	2016-08-26	2018-03-01	Massachusetts Institute Of Technology	Bottlebrush polymers and uses thereof
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JP6935059B2 (ja) *	2017-03-30	2021-09-15	日油株式会社	カルボキシル基を一つ有するポリエチレングリコールの精製方法
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WO2019006426A2 (en)	2017-06-30	2019-01-03	Massachusetts Institute Of Technology	RAMIFIED MULTIFUNCTIONAL MACROMONOMERS AND RELATED POLYMERS AND USES THEREOF
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WO2019200367A1 (en)	2018-04-13	2019-10-17	Massachusetts Institute Of Technology	Brush prodrugs and uses thereof
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WO2020037236A1 (en)	2018-08-17	2020-02-20	Massachusetts Institute Of Technology	Degradable polymers of a cyclic silyl ether and uses thereof
EP3950783B1 (de) *	2019-03-29	2023-11-08	NOF Corporation	Verfahren zur herstellung von polyethylenglykol, das eine endständige carboxylgruppe enthält, und verfahren zur herstellung von aktiviertem polyethylenglykol
WO2020208139A1 (en)	2019-04-10	2020-10-15	Cellestia Biotech Ag	Inhibitors of notch signalling pathway and use thereof in treatment of cancers
AU2020368453A1 (en)	2019-10-16	2022-04-21	Massachusetts Institute Of Technology	Brush prodrugs and uses thereof
WO2021141662A1 (en)	2020-01-10	2021-07-15	Massachusetts Institute Of Technology	Proteolysis targeting chimeric molecules (protacs) with functional handles and uses thereof
WO2021255487A2 (en)	2020-06-19	2021-12-23	Debreceni Egyetem	Zn-air rechargeable battery
WO2022122667A1 (en)	2020-12-07	2022-06-16	Cellestia Biotech Ag	Pharmaceutical combinations for treating cancer
EP4008324A1 (de)	2020-12-07	2022-06-08	Cellestia Biotech AG	Kombinationen, die einen inhibitor eines anti-apoptotischen proteins, wie bcl-2, bcl-xl, bclw oder mcl-1, und einen notch-signalweg-inhibitor zur behandlung von krebs umfassen
US20240269120A1 (en)	2021-06-02	2024-08-15	Cellestia Biotech Ag	Method for Treating an Autoimmune and Inflammatory Disease
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2004
- 2004-11-04 US US10/982,303 patent/US20050214250A1/en not_active Abandoned
- 2004-11-05 EP EP04810369A patent/EP1692206B1/de not_active Expired - Lifetime
- 2004-11-05 KR KR1020067008804A patent/KR101157007B1/ko not_active Expired - Lifetime
- 2004-11-05 DE DE602004026770T patent/DE602004026770D1/de not_active Expired - Lifetime
- 2004-11-05 DK DK04810369.1T patent/DK1692206T3/da active
- 2004-11-05 AU AU2004289992A patent/AU2004289992B2/en not_active Expired
- 2004-11-05 AT AT04810369T patent/ATE465204T1/de active
- 2004-11-05 CA CA2544697A patent/CA2544697C/en not_active Expired - Lifetime
- 2004-11-05 PT PT04810369T patent/PT1692206E/pt unknown
- 2004-11-05 CN CN200480039882A patent/CN100580005C/zh not_active Expired - Lifetime
- 2004-11-05 WO PCT/US2004/036850 patent/WO2005047366A1/en not_active Ceased
- 2004-11-05 PL PL04810369T patent/PL1692206T3/pl unknown
- 2004-11-05 SI SI200431461T patent/SI1692206T1/sl unknown
- 2004-11-05 JP JP2006539659A patent/JP5101884B2/ja not_active Expired - Lifetime
- 2004-11-05 ES ES04810369T patent/ES2342294T3/es not_active Expired - Lifetime
2006
- 2006-05-04 IL IL175406A patent/IL175406A/en active IP Right Grant
2010
- 2010-07-09 CY CY20101100646T patent/CY1110303T1/el unknown
2011
- 2011-02-09 US US13/023,960 patent/US8067505B2/en not_active Expired - Lifetime
- 2011-10-21 US US13/279,134 patent/US20120041155A1/en not_active Abandoned
2013
- 2013-06-19 US US13/922,020 patent/US10011682B2/en not_active Expired - Lifetime
2018
- 2018-06-05 US US16/000,561 patent/US11111335B2/en not_active Expired - Fee Related

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