ATE465204T1 - Verfahren zur herstellung von carbonsäurefunktionalisierten polymeren - Google Patents

Verfahren zur herstellung von carbonsäurefunktionalisierten polymeren

Info

Publication number: ATE465204T1
Authority: AT; Austria
Prior art keywords: polymer; acid functionalized; carboxylic acid; carboxylate salt; producing
Prior art date: 2003-11-06

Application number

AT04810369T

Other languages

English (en)

Inventor

Milton Harris

Antoni Kozlowski

Lihong Guo

Original Assignee

Nektar Therapeutics

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-06

Filing date

2004-11-05

Publication date

2010-05-15

2004-11-05 Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE465204T1 publication Critical patent/ATE465204T1/de

Links

229920000642 polymer Polymers 0.000 title abstract 7
239000002253 acid Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
-1 poly(ethylene glycol) Polymers 0.000 abstract 5
150000001735 carboxylic acids Chemical class 0.000 abstract 3
125000000524 functional group Chemical group 0.000 abstract 3
239000007864 aqueous solution Substances 0.000 abstract 2
229920001223 polyethylene glycol Polymers 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000008027 tertiary esters Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
- C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
- C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
- C08F283/06—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polyethers, polyoxymethylenes or polyacetals
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F289/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
- C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
- C08G65/3346—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur having sulfur bound to carbon and oxygen

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Medicinal Preparation (AREA)
Polyethers (AREA)
Compositions Of Macromolecular Compounds (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyamides (AREA)
Peptides Or Proteins (AREA)

AT04810369T 2003-11-06 2004-11-05 Verfahren zur herstellung von carbonsäurefunktionalisierten polymeren ATE465204T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US51779403P	2003-11-06	2003-11-06
PCT/US2004/036850 WO2005047366A1 (en)	2003-11-06	2004-11-05	Method of preparing carboxylic acid functionalized polymers

Publications (1)

Publication Number	Publication Date
ATE465204T1 true ATE465204T1 (de)	2010-05-15

Family

ID=34590189

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04810369T ATE465204T1 (de)	2003-11-06	2004-11-05	Verfahren zur herstellung von carbonsäurefunktionalisierten polymeren

Country Status (17)

Country	Link
US (5)	US20050214250A1 (de)
EP (1)	EP1692206B1 (de)
JP (1)	JP5101884B2 (de)
KR (1)	KR101157007B1 (de)
CN (1)	CN100580005C (de)
AT (1)	ATE465204T1 (de)
AU (1)	AU2004289992B2 (de)
CA (1)	CA2544697C (de)
CY (1)	CY1110303T1 (de)
DE (1)	DE602004026770D1 (de)
DK (1)	DK1692206T3 (de)
ES (1)	ES2342294T3 (de)
IL (1)	IL175406A (de)
PL (1)	PL1692206T3 (de)
PT (1)	PT1692206E (de)
SI (1)	SI1692206T1 (de)
WO (1)	WO2005047366A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050214250A1 (en) *	2003-11-06	2005-09-29	Harris J M	Method of preparing carboxylic acid functionalized polymers
CA2553528C (en) *	2004-01-21	2012-12-04	Nektar Therapeutics Al, Corporation	Method of preparing propionic acid-terminated polymers
JP4920593B2 (ja) *	2004-10-25	2012-04-18	インテザインテクノロジーズ，インコーポレイテッド	ヘテロ二官能性ポリ（エチレングリコール）およびそれらの使用
US7989554B2 (en) *	2006-01-10	2011-08-02	Enzon Pharmaceuticals, Inc.	Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
US8133707B2 (en)	2006-01-17	2012-03-13	Enzon Pharmaceuticals, Inc.	Methods of preparing activated polymers having alpha nitrogen groups
US7462627B2 (en) *	2006-02-09	2008-12-09	Enzon Pharmaceuticals, Inc.	Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) *	2006-02-09	2010-03-02	Enzon Pharmaceuticals, Inc.	Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
EP2010477A4 (de) *	2006-04-27	2012-05-30	Intezyne Technologies Inc	Poly (ethylenglykol) mit chemisch ungleichen endgruppen
PL2054074T3 (pl)	2006-08-04	2015-03-31	Prolong Pharmaceuticals Llc	Zmodyfikowana erytropoetyna
RU2009133793A (ru) *	2007-02-09	2011-03-20	Энзон Фармасьютикалз, Инк. (Us)	Лечение резистентных или невосприимчивых форм рака конъюгатами 7-этил-10-гидроксикампотецина с множеством ответвлений цепи
CN101357986B (zh) *	2007-06-13	2013-06-05	康达医药科技有限公司	聚乙二醇功能性衍生物和制造方法
WO2010025337A1 (en) *	2008-08-29	2010-03-04	Enzon Pharmaceuticals, Inc.	Method of treating ras associated cancer
US8119742B2 (en)	2008-09-28	2012-02-21	Knc Ner Acquisition Sub, Inc.	Multi-armed catechol compound blends
BRPI0919842A8 (pt) *	2008-10-21	2015-09-22	Enzon Pharmaceuticals Inc	tratamento de neuroblastioma com conjugados poliméricos de múltiplos braços de 7-etil-10-hidroxicamptotecina
WO2010091302A1 (en) *	2009-02-06	2010-08-12	Nerites Corporation	Multi-linked star-shaped polymers and synthetic methods therfor
WO2011140409A2 (en) *	2010-05-06	2011-11-10	Cornell University	Tunable lcst polymers and methods of preparation
EP2606884A1 (de)	2011-12-21	2013-06-26	Ecole Polytechnique Fédérale de Lausanne (EPFL)	Inhibitoren des Notch-Signalwegs und deren Verwendung bei der Krebsbehandlung
US9381253B2 (en)	2013-04-09	2016-07-05	Massachusetts Institute Of Technology	Drug delivery polymer and uses thereof
WO2015120391A1 (en)	2014-02-07	2015-08-13	Massachusetts Institute Of Technology	Suprametallogels and uses thereof
WO2016167759A1 (en) *	2015-04-15	2016-10-20	Multisorb Technologies, Inc.	Surface modification of a resin
JP6777390B2 (ja) *	2015-10-30	2020-10-28	株式会社日本触媒	生体適合性医療用材料
EP3187254B1 (de) *	2015-12-30	2020-09-02	Italmatch SC, LLC	Polymerischer emulgator und schmieradditive zum entfernen, formen, walzen von wässrigem metall oder andere anwendungen
US10105449B2 (en)	2016-06-07	2018-10-23	Massachusetts Institute Of Technology	Drug delivery polymers and uses thereof
WO2018039577A1 (en)	2016-08-26	2018-03-01	Massachusetts Institute Of Technology	Bottlebrush polymers and uses thereof
WO2018067702A1 (en)	2016-10-04	2018-04-12	Massachusetts Institute Of Technology	Bottlebrush copolymers and uses thereof
JP6935059B2 (ja) *	2017-03-30	2021-09-15	日油株式会社	カルボキシル基を一つ有するポリエチレングリコールの精製方法
JP7158143B2 (ja) *	2017-04-13	2022-10-21	株式会社日本触媒	生体適合性医療用材料
US10973847B2 (en)	2017-06-30	2021-04-13	Massachusetts Institute Of Technology	Core-to-surface polymerization for the synthesis of star polymers and uses thereof
WO2019006425A1 (en)	2017-06-30	2019-01-03	Massachusetts Institute Of Technology	IMAGING AGENTS OF BRUSH ARRAY STAR POLYMERS AND USES THEREOF
CN111263758A (zh)	2017-06-30	2020-06-09	麻省理工学院	支链的多官能大分子单体和相关聚合物及其用途
CA3129412A1 (en)	2018-04-13	2019-10-17	Massachusetts Institute Of Technology	Brush prodrugs and uses thereof
US11472771B2 (en)	2018-06-21	2022-10-18	Cellestia Biotech Ag	Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts
EP3837266A1 (de)	2018-08-17	2021-06-23	Massachusetts Institute of Technology	Abbaubare polymere aus einem cyclischen silylether und deren verwendungen
WO2020203583A1 (ja) *	2019-03-29	2020-10-08	日油株式会社	末端カルボキシル基含有ポリエチレングリコールの製造方法および活性化ポリエチレングリコールの製造方法
CN113966324B (zh)	2019-04-10	2024-09-03	塞莱斯蒂亚生物技术股份公司	Notch信号传导途径抑制剂及其在癌症治疗的用途
US12478683B2 (en)	2019-10-16	2025-11-25	Massachusetts Institute Of Technology	Brush prodrugs and uses thereof
US12042513B2 (en)	2020-01-10	2024-07-23	Massachusetts Institute Of Technology	Proteolysis targeting chimeric molecules (PROTACs) with functional handles and uses thereof
EP4169113A2 (de)	2020-06-19	2023-04-26	Debreceni Egyetem	Zn-luft wiederaufladbare batterie
EP4255409A1 (de)	2020-12-07	2023-10-11	Cellestia Biotech AG	Pharmazeutische kombinationen zur behandlung von krebs
EP4008324A1 (de)	2020-12-07	2022-06-08	Cellestia Biotech AG	Kombinationen, die einen inhibitor eines anti-apoptotischen proteins, wie bcl-2, bcl-xl, bclw oder mcl-1, und einen notch-signalweg-inhibitor zur behandlung von krebs umfassen
CN117794536A (zh)	2021-06-02	2024-03-29	塞莱斯蒂亚生物技术股份公司	在治疗自身免疫性和炎症性疾病的方法中使用的化合物
US20250000870A1 (en)	2021-11-08	2025-01-02	Cellestia Biotech Ag	Pharmaceutical Combinations for Treating Cancer
WO2023121753A1 (en)	2021-12-20	2023-06-29	Massachusetts Institute Of Technology	Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent
EP4223292A1 (de)	2022-02-07	2023-08-09	Cellestia Biotech AG	Pharmazeutische kombinationen zur behandlung von krebs
CN115193363B (zh) *	2022-09-16	2023-02-24	世名(苏州)新材料研究院有限公司	高酸值低酯值氧化蜡、其制备工艺及由其制得的酯化蜡

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4721579A (en) *	1980-08-15	1988-01-26	Basf Corporation	Sodium carboxymethyl derivatives of polyoxyalkylene glycols, their production, and use in functional fluids
DE3032061C1 (de) *	1980-08-26	1982-06-09	Chem-y, Fabriek van Chemische Produkten B.V., Bodegraven	Verfahren zur Herstellung eines verpumpbaren oberflaechenaktiven Produktes auf Basis von Polyaetheressigsaeuren
DE3120195C2 (de) *	1981-05-21	1986-09-04	Degussa Ag, 6000 Frankfurt	Polymere Ammoniumverbindungen mit kieselsäureartigem Grundgerüst, Verfahren zu ihrer Herstellung und Verwendung
JPH04199152A (ja) *	1990-11-29	1992-07-20	Toshiba Corp	感光性組成物
US5483008A (en) *	1992-02-07	1996-01-09	Research Development Corporation Of Japan	Polyether having heterofunctional groups at both ends, process for the preparation thereof and polymerization initiator therefor
US5278303A (en)	1992-06-12	1994-01-11	University Of Toronto Innovations Foundation	Polymer-supported solution synthesis of oligosaccharides
JP3236087B2 (ja) *	1992-10-26	2001-12-04	株式会社トクヤマ	重合性磁性流体製造用界面活性剤
US5919455A (en) *	1993-10-27	1999-07-06	Enzon, Inc.	Non-antigenic branched polymer conjugates
US5605976A (en)	1995-05-15	1997-02-25	Enzon, Inc.	Method of preparing polyalkylene oxide carboxylic acids
US5693609A (en)	1994-11-17	1997-12-02	Eli Lilly And Company	Acylated insulin analogs
US5932462A (en)	1995-01-10	1999-08-03	Shearwater Polymers, Inc.	Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en)	1995-07-07	1997-09-30	Shearwater Polymers, Inc.	Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
JPH1087815A (ja) *	1996-08-22	1998-04-07	Enzon Inc	ポリアルキレンオキシドカルボン酸の改良製造方法
JP3855344B2 (ja) *	1997-02-19	2006-12-06	日本油脂株式会社	ポリオキシアルキレンカルボン酸の製造方法
US6448369B1 (en) *	1997-11-06	2002-09-10	Shearwater Corporation	Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US6362254B2 (en)	1998-03-12	2002-03-26	Shearwater Corporation	Poly(ethylene glycol) derivatives with proximal reactive groups
DE19928128C1 (de) *	1999-06-19	2000-11-30	Clariant Gmbh	Verfahren zur Herstellung von Ethercarbonsäuren mit niedrigem Restalkohol
AU781336B2 (en) *	1999-10-08	2005-05-19	Nektar Therapeutics	Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
TWI246524B (en)	2001-01-19	2006-01-01	Shearwater Corp	Multi-arm block copolymers as drug delivery vehicles
RU2288212C2 (ru) *	2002-07-24	2006-11-27	Ф.Хоффманн-Ля Рош Аг	Производные альдегида полиэтиленгликоля
US20050214250A1 (en)	2003-11-06	2005-09-29	Harris J M	Method of preparing carboxylic acid functionalized polymers

2004
- 2004-11-04 US US10/982,303 patent/US20050214250A1/en not_active Abandoned
- 2004-11-05 ES ES04810369T patent/ES2342294T3/es not_active Expired - Lifetime
- 2004-11-05 WO PCT/US2004/036850 patent/WO2005047366A1/en not_active Ceased
- 2004-11-05 CN CN200480039882A patent/CN100580005C/zh not_active Expired - Lifetime
- 2004-11-05 KR KR1020067008804A patent/KR101157007B1/ko not_active Expired - Lifetime
- 2004-11-05 AT AT04810369T patent/ATE465204T1/de active
- 2004-11-05 PL PL04810369T patent/PL1692206T3/pl unknown
- 2004-11-05 CA CA2544697A patent/CA2544697C/en not_active Expired - Lifetime
- 2004-11-05 DE DE602004026770T patent/DE602004026770D1/de not_active Expired - Lifetime
- 2004-11-05 SI SI200431461T patent/SI1692206T1/sl unknown
- 2004-11-05 JP JP2006539659A patent/JP5101884B2/ja not_active Expired - Lifetime
- 2004-11-05 PT PT04810369T patent/PT1692206E/pt unknown
- 2004-11-05 AU AU2004289992A patent/AU2004289992B2/en not_active Expired
- 2004-11-05 DK DK04810369.1T patent/DK1692206T3/da active
- 2004-11-05 EP EP04810369A patent/EP1692206B1/de not_active Expired - Lifetime
2006
- 2006-05-04 IL IL175406A patent/IL175406A/en active IP Right Grant
2010
- 2010-07-09 CY CY20101100646T patent/CY1110303T1/el unknown
2011
- 2011-02-09 US US13/023,960 patent/US8067505B2/en not_active Expired - Lifetime
- 2011-10-21 US US13/279,134 patent/US20120041155A1/en not_active Abandoned
2013
- 2013-06-19 US US13/922,020 patent/US10011682B2/en not_active Expired - Lifetime
2018
- 2018-06-05 US US16/000,561 patent/US11111335B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1692206B1 (de)	2010-04-21
KR101157007B1 (ko)	2012-06-21
CN100580005C (zh)	2010-01-13
PL1692206T3 (pl)	2011-06-30
SI1692206T1 (sl)	2010-08-31
AU2004289992B2 (en)	2010-05-20
JP2007510800A (ja)	2007-04-26
US20110130539A1 (en)	2011-06-02
IL175406A (en)	2012-01-31
US20180282476A1 (en)	2018-10-04
US8067505B2 (en)	2011-11-29
KR20060117936A (ko)	2006-11-17
AU2004289992A1 (en)	2005-05-26
US20050214250A1 (en)	2005-09-29
IL175406A0 (en)	2006-09-05
ES2342294T3 (es)	2010-07-05
CA2544697A1 (en)	2005-05-26
US20130281634A1 (en)	2013-10-24
WO2005047366A1 (en)	2005-05-26
CY1110303T1 (el)	2015-01-14
EP1692206A1 (de)	2006-08-23
DE602004026770D1 (de)	2010-06-02
DK1692206T3 (da)	2011-05-23
PT1692206E (pt)	2010-07-19
US11111335B2 (en)	2021-09-07
CA2544697C (en)	2012-10-16
US10011682B2 (en)	2018-07-03
CN1902257A (zh)	2007-01-24
JP5101884B2 (ja)	2012-12-19
US20120041155A1 (en)	2012-02-16

Legal Events

Date

Code

Title

Description

2010-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1692206

Country of ref document: EP

Publication	Publication Date	Title
ATE465204T1 (de)	2010-05-15	Verfahren zur herstellung von carbonsäurefunktionalisierten polymeren
DE602005025177D1 (de)	2011-01-20	Verfahren zur Herstellung einer wässrigen Dispersion enthaltend einen Komplex von Poly(3,4-dialkoxythiophen) und einem Polyanion
Wang et al.	2013	Grafting of carboxybetaine brush onto cellulose membranes via surface-initiated ARGET-ATRP for improving blood compatibility
ATE428736T1 (de)	2009-05-15	Verfahren zur herstellung von emulsionspolymerisaten
DE602004019443D1 (de)	2009-03-26	Verfahren zur herstellung von aliphatischem polyester
DE60225445D1 (de)	2008-04-17	Polyhydroxycarbonsäure und verfahren zu dessen herstellung
ATE485344T1 (de)	2010-11-15	Verfahren zur herstellung modifizierter pigmente
ATE540070T1 (de)	2012-01-15	Verfahren zur herstellung von aliphatischem polyester mit verringertem restgehalt an cyclischem ester
DE502005006445D1 (de)	2009-02-26	Verfahren zur herstellung von polymeren
WO2009066879A3 (en)	2009-07-23	Organic-inorganic hybrid scaffolds with surface-immobilized nano-hydroxyapatite and preparation method thereof
ATE453676T1 (de)	2010-01-15	Polyorganosilylierte carboxylatmonomere oder polymere daraus und verfahren zu deren herstellung
ATE446321T1 (de)	2009-11-15	Verfahren zur herstellung von polymeren durch sprühpolymerisation
ATE384754T1 (de)	2008-02-15	Verfahren zur herstellung von hochverzweigten polyamiden
DE502005001316D1 (de)	2007-10-04	Verfahren zur herstellung von gut in wasser redispergierbaren polymerisatpulvern
ATE286869T1 (de)	2005-01-15	Verfahren zur herstellung eines diols
JP2019210404A (ja)	2019-12-12	自己修復性ゲル
ATE304529T1 (de)	2005-09-15	Verfahren zur herstellung von hydroxy- peroxyestern
ATE264877T1 (de)	2004-05-15	Verfahren zur herstellung von wasserlöslichen polymerisaten, die polyalkylenglykolether- seitenketten enthalten
DE502005004152D1 (de)	2008-06-26	Verfahren zur herstellung wasserabsorbierender polymere
ATE238324T1 (de)	2003-05-15	Verfahren zur herstellung von polyguluronsäuren
DE502006008732D1 (de)	2011-02-24	Verfahren zur herstellung von polyisobuten
DE69813765D1 (de)	2003-05-28	Verfahren zur herstellung von wasserlöslichen polymer dispersionen
DE602005005215D1 (de)	2008-04-17	Verfahren zur herstellung von aminterminierten caprolactonpolymeren und verwendung der hergestellten polymere
ATE432357T1 (de)	2009-06-15	Verfahren zur trocknung von biologisch abbaubaren polymeren
ATE348118T1 (de)	2007-01-15	Verfahren zur herstellung von partikelförmigen polymerisaten