ATE465242T1 - Exogene angiogene wachstumsfaktoren exprimierende keratinozyten - Google Patents

Exogene angiogene wachstumsfaktoren exprimierende keratinozyten

Info

Publication number
ATE465242T1
ATE465242T1 AT03726524T AT03726524T ATE465242T1 AT E465242 T1 ATE465242 T1 AT E465242T1 AT 03726524 T AT03726524 T AT 03726524T AT 03726524 T AT03726524 T AT 03726524T AT E465242 T1 ATE465242 T1 AT E465242T1
Authority
AT
Austria
Prior art keywords
growth factors
angiogenic growth
keratinocytes
skin tissue
cultured skin
Prior art date
Application number
AT03726524T
Other languages
English (en)
Inventor
Allen Comer
Michael Hoffmann
Lynn-Allen Hoffmann
Original Assignee
Stratatech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stratatech Corp filed Critical Stratatech Corp
Application granted granted Critical
Publication of ATE465242T1 publication Critical patent/ATE465242T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/17—Angiopoietin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Prostheses (AREA)
AT03726524T 2002-04-30 2003-04-29 Exogene angiogene wachstumsfaktoren exprimierende keratinozyten ATE465242T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37648802P 2002-04-30 2002-04-30
PCT/US2003/013327 WO2003093418A2 (en) 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors
US10/425,784 US7498167B2 (en) 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors

Publications (1)

Publication Number Publication Date
ATE465242T1 true ATE465242T1 (de) 2010-05-15

Family

ID=29406758

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03726524T ATE465242T1 (de) 2002-04-30 2003-04-29 Exogene angiogene wachstumsfaktoren exprimierende keratinozyten

Country Status (9)

Country Link
US (5) US7498167B2 (de)
EP (1) EP1549738B1 (de)
JP (1) JP4753577B2 (de)
AT (1) ATE465242T1 (de)
CA (1) CA2483547C (de)
DE (1) DE60332256D1 (de)
IL (3) IL164817A0 (de)
NZ (1) NZ536205A (de)
WO (1) WO2003093418A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1549738B1 (de) * 2002-04-30 2010-04-21 Stratatech Corporation Exogene angiogene wachstumsfaktoren exprimierende keratinozyten
JP4993752B2 (ja) * 2005-03-01 2012-08-08 ストラタテック コーポレーション 外因性ポリペプチドを発現するヒト皮膚同等物
WO2009065005A1 (en) 2007-11-14 2009-05-22 Stratatech Corporation Cold storage of organotypically cultured skin equivalents for clinical applications
PT2352472T (pt) 2008-11-04 2017-04-11 Stratatech Corp Equivalentes de pele secos e irradiados prontos a utilizar
WO2010135655A2 (en) 2009-05-21 2010-11-25 Stratatech Corporation Human skin substitutes expressing il-12
TWI488966B (zh) * 2010-07-09 2015-06-21 優普生物科技股份有限公司 Ｄｎａ疫苗
US9597111B2 (en) 2010-08-06 2017-03-21 Kci Licensing, Inc. Methods for applying a skin graft
US8978234B2 (en) 2011-12-07 2015-03-17 MoMelan Technologies, Inc. Methods of manufacturing devices for generating skin grafts
JP2012205516A (ja) * 2011-03-29 2012-10-25 Osaka Univ 人工皮膚モデルの製造方法、及び人工皮膚モデル
US9663564B2 (en) 2013-03-15 2017-05-30 The Regents Of The University Of California Vectors and methods to treat ischemia
US20140065110A1 (en) 2012-08-31 2014-03-06 The Regents Of The University Of California Genetically modified msc and therapeutic methods
JP6410237B2 (ja) 2012-11-09 2018-10-24 マルコ アーケッティ 拡散性因子および癌細胞
CA3071928A1 (en) 2013-03-13 2014-10-02 Stratatech Corporation Cryopreservation of viable human skin substitutes
CN105636532B (zh) 2013-03-14 2019-06-21 凯希特许有限公司 用于采集皮肤移植片的吸收性基底
US10463392B2 (en) 2013-12-31 2019-11-05 Kci Licensing, Inc. Fluid-assisted skin graft harvesting
EP3243453B1 (de) 2013-12-31 2019-10-09 KCI Licensing, Inc. Hautimplantatentnahmevorrichtung
JP6766039B2 (ja) * 2014-10-30 2020-10-07 インディアン カウンシル オブ メディカル リサーチ 成体幹細胞増殖に適したフィーダー細胞の処置の方法
EP3804774A1 (de) 2015-04-09 2021-04-14 3M Innovative Properties Co. System zur entnahme von hauttransplantaten
EP3370630B1 (de) 2015-11-03 2021-06-16 3M Innovative Properties Company Vorrichtung zur herstellung einer epidermalen transplantatfolie
US20180344448A1 (en) * 2016-02-19 2018-12-06 Kci Licensing, Inc. Transfected epidermal grafts and methods of making the same
EP4074818A3 (de) * 2016-12-09 2023-01-18 The University of Chicago Gewebeorganoide
EP4034038A4 (de) * 2019-09-27 2023-11-01 Stratatech Corporation Verfahren zur behandlung von akuten wunden und verbesserung der ergebnisse
WO2021231775A1 (en) * 2020-05-13 2021-11-18 Stratatech Copporation Viable bioengineered skin constructs
JP2024521819A (ja) * 2021-06-08 2024-06-04 ストラタテック コーポレーション 再生創傷治癒に関連する可溶性因子を分泌する、生きた、生物工学によって作られた同種異系の細胞化された皮膚構築物
US20240366681A1 (en) * 2021-08-13 2024-11-07 Triovance Holding Llc A skin substitute composition and methods of producing and using the same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US448096A (en) * 1891-03-10 Hydrant
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5292655A (en) * 1990-01-29 1994-03-08 Wille Jr John J Method for the formation of a histologically-complete skin substitute
RU2135191C1 (ru) * 1990-04-24 1999-08-27 Ортек Интернэшнл, Инк. Композиционный эквивалент живой кожи, способ его получения, тест-набор
US5292566A (en) * 1990-05-22 1994-03-08 National Label Company Battery label with non-shrinkable top layer
IT1248934B (it) * 1990-06-01 1995-02-11 Fidia Spa Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle
US5693332C1 (en) * 1995-08-11 2001-01-09 Univ California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure
US5968546A (en) * 1997-05-16 1999-10-19 Baur; Marcus Keratinocyte culture from precursor cells
US20010048917A1 (en) * 1998-03-09 2001-12-06 Warren Hoeffler Skin equivalent and methods of forming and using same
US5989837A (en) * 1998-07-13 1999-11-23 Wisconsin Alumni Research Foundation Immortalized human keratinocyte cell line
US20030152562A1 (en) * 2001-10-23 2003-08-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Vitro micro-organs, and uses related thereto
US6458382B1 (en) * 1999-11-12 2002-10-01 Mirus Corporation Nucleic acid transfer complexes
EP1330252A4 (de) * 2000-11-01 2007-12-26 Ludwig Inst Cancer Res In-vivo-stimulierung der angiogenen aktivität
EP1404809B1 (de) * 2001-03-02 2013-12-11 Stratatech Corporation Verbesserte hautersatzstoffe und verwendungen davon
US6849718B2 (en) * 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
WO2003018621A2 (en) * 2001-08-23 2003-03-06 Oxford Biomedica (Uk) Limited Genes
US6838430B2 (en) * 2001-09-28 2005-01-04 The Regents Of The University Of California Use of HIF-1a variants to accelerate wound healing
US20040190793A1 (en) * 2002-03-01 2004-09-30 Rorvig Mark E. Method for retrieving images by content measure metadata encoding
EP1549738B1 (de) * 2002-04-30 2010-04-21 Stratatech Corporation Exogene angiogene wachstumsfaktoren exprimierende keratinozyten
EP1546392A4 (de) * 2002-08-02 2006-05-24 Stratatech Corp Spezies-spezifischer dna-nachweis
EP1633858A4 (de) * 2003-05-30 2006-11-02 Stratatech Corp Lagerung von organen bei raumtemperatur
CA2534349C (en) * 2003-08-01 2012-04-10 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides

Also Published As

Publication number Publication date
DE60332256D1 (de) 2010-06-02
EP1549738A4 (de) 2006-11-02
US7807148B2 (en) 2010-10-05
EP1549738A2 (de) 2005-07-06
CA2483547A1 (en) 2003-11-13
IL164817A0 (en) 2005-12-18
US20090169528A1 (en) 2009-07-02
AU2003228755A1 (en) 2003-11-17
US20110286985A1 (en) 2011-11-24
US20110059057A1 (en) 2011-03-10
US7988959B2 (en) 2011-08-02
WO2003093418A3 (en) 2005-04-21
US20040009591A1 (en) 2004-01-15
EP1549738B1 (de) 2010-04-21
IL164817A (en) 2010-12-30
NZ536205A (en) 2008-04-30
US8808685B2 (en) 2014-08-19
JP2006509529A (ja) 2006-03-23
US7498167B2 (en) 2009-03-03
JP4753577B2 (ja) 2011-08-24
IL195518A (en) 2012-08-30
CA2483547C (en) 2012-03-20
US20050013807A1 (en) 2005-01-20
US7915042B2 (en) 2011-03-29
WO2003093418A2 (en) 2003-11-13

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