ATE465242T1 - Exogene angiogene wachstumsfaktoren exprimierende keratinozyten - Google Patents

Exogene angiogene wachstumsfaktoren exprimierende keratinozyten

Info

Publication number
ATE465242T1
ATE465242T1 AT03726524T AT03726524T ATE465242T1 AT E465242 T1 ATE465242 T1 AT E465242T1 AT 03726524 T AT03726524 T AT 03726524T AT 03726524 T AT03726524 T AT 03726524T AT E465242 T1 ATE465242 T1 AT E465242T1
Authority
AT
Austria
Prior art keywords
growth factors
angiogenic growth
keratinocytes
skin tissue
cultured skin
Prior art date
Application number
AT03726524T
Other languages
English (en)
Inventor
Allen Comer
Michael Hoffmann
Lynn-Allen Hoffmann
Original Assignee
Stratatech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stratatech Corp filed Critical Stratatech Corp
Application granted granted Critical
Publication of ATE465242T1 publication Critical patent/ATE465242T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/17—Angiopoietin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Cosmetics (AREA)
AT03726524T 2002-04-30 2003-04-29 Exogene angiogene wachstumsfaktoren exprimierende keratinozyten ATE465242T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37648802P 2002-04-30 2002-04-30
PCT/US2003/013327 WO2003093418A2 (en) 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors
US10/425,784 US7498167B2 (en) 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors

Publications (1)

Publication Number Publication Date
ATE465242T1 true ATE465242T1 (de) 2010-05-15

Family

ID=29406758

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03726524T ATE465242T1 (de) 2002-04-30 2003-04-29 Exogene angiogene wachstumsfaktoren exprimierende keratinozyten

Country Status (9)

Country Link
US (5) US7498167B2 (de)
EP (1) EP1549738B1 (de)
JP (1) JP4753577B2 (de)
AT (1) ATE465242T1 (de)
CA (1) CA2483547C (de)
DE (1) DE60332256D1 (de)
IL (3) IL164817A0 (de)
NZ (1) NZ536205A (de)
WO (1) WO2003093418A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1549738B1 (de) 2002-04-30 2010-04-21 Stratatech Corporation Exogene angiogene wachstumsfaktoren exprimierende keratinozyten
WO2006094070A2 (en) 2005-03-01 2006-09-08 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
NO2215212T3 (de) 2007-11-14 2018-01-27
US8580314B2 (en) 2008-11-04 2013-11-12 Stratatech Corporation Dried and irradiated skin equivalents for ready use
US20100330046A1 (en) 2009-05-21 2010-12-30 Stratatech Corporation Human skin substitutes expressing il-12
TWI488966B (zh) * 2010-07-09 2015-06-21 優普生物科技股份有限公司 Ｄｎａ疫苗
US8978234B2 (en) 2011-12-07 2015-03-17 MoMelan Technologies, Inc. Methods of manufacturing devices for generating skin grafts
US9597111B2 (en) 2010-08-06 2017-03-21 Kci Licensing, Inc. Methods for applying a skin graft
JP2012205516A (ja) * 2011-03-29 2012-10-25 Osaka Univ 人工皮膚モデルの製造方法、及び人工皮膚モデル
US9663564B2 (en) 2013-03-15 2017-05-30 The Regents Of The University Of California Vectors and methods to treat ischemia
US20140065110A1 (en) 2012-08-31 2014-03-06 The Regents Of The University Of California Genetically modified msc and therapeutic methods
CA2890824A1 (en) 2012-11-09 2014-05-15 Marco Archetti Diffusible factors and cancer cells
CA2905656C (en) 2013-03-13 2020-04-14 Stratatech Corporation Cryopreservation of viable human skin substitutes
AU2014239952B2 (en) 2013-03-14 2018-09-27 Solventum Intellectual Properties Company Absorbent substrates for harvesting skin grafts
WO2015103043A1 (en) 2013-12-31 2015-07-09 Kci Licensing, Inc. Sensor systems for skin graft harvesting
US10463392B2 (en) 2013-12-31 2019-11-05 Kci Licensing, Inc. Fluid-assisted skin graft harvesting
WO2016067306A1 (en) * 2014-10-30 2016-05-06 Indian Council Of Medical Research A method for processing of feeder cells suitable for adult stem cell proliferation
US10912861B2 (en) 2015-04-09 2021-02-09 Kci Licensing, Inc. Soft-tack, porous substrates for harvesting skin grafts
WO2017079439A1 (en) 2015-11-03 2017-05-11 Kci Licensing, Inc. Device for creating an epidermal graft sheet
WO2017143229A1 (en) * 2016-02-19 2017-08-24 Kci Licensing, Inc. Transfected epidermal grafts and methods of making the same
US20200131482A1 (en) * 2016-12-09 2020-04-30 The University Of Chicago Tissue organoids
JP2022549688A (ja) * 2019-09-27 2022-11-28 ストラタテック コーポレーション 急性創傷を治療し、転帰を改善するための方法
EP4150053A4 (de) * 2020-05-13 2024-06-19 Stratatech Corporation Lebensfähige biotechnologisch hergestellte hautkonstrukte
EP4351603A1 (de) * 2021-06-08 2024-04-17 Stratatech Corporation Lebensfähige biotechnologisch hergestellte allogene zelluläre hautkonstrukte, die lösliche faktoren im zusammenhang mit regenerativer wundheilung sekretieren
WO2023017494A1 (en) * 2021-08-13 2023-02-16 Triovance Holding Llc A skin substitute composition and methods of producing and using the same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US448096A (en) * 1891-03-10 Hydrant
US4485096A (en) 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5292655A (en) * 1990-01-29 1994-03-08 Wille Jr John J Method for the formation of a histologically-complete skin substitute
HUT63319A (en) 1990-04-24 1993-08-30 Mark Eisenberg Method for producing composition equivalent with living skin
US5292566A (en) * 1990-05-22 1994-03-08 National Label Company Battery label with non-shrinkable top layer
IT1248934B (it) 1990-06-01 1995-02-11 Fidia Spa Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle
US5693332C1 (en) 1995-08-11 2001-01-09 Univ California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure
US5968546A (en) 1997-05-16 1999-10-19 Baur; Marcus Keratinocyte culture from precursor cells
US20010048917A1 (en) * 1998-03-09 2001-12-06 Warren Hoeffler Skin equivalent and methods of forming and using same
US5989837A (en) 1998-07-13 1999-11-23 Wisconsin Alumni Research Foundation Immortalized human keratinocyte cell line
US20030152562A1 (en) * 2001-10-23 2003-08-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Vitro micro-organs, and uses related thereto
US6458382B1 (en) * 1999-11-12 2002-10-01 Mirus Corporation Nucleic acid transfer complexes
AU2002224471A1 (en) * 2000-11-01 2002-05-15 Aventis Pharma S.A. In vivo stimulation of angiogenic activity
DK1404809T3 (da) * 2001-03-02 2014-03-17 Stratatech Corp Forbedrede hudsubstitutter og anvendelser deraf
US6849718B2 (en) 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
AU2002313559A1 (en) * 2001-08-23 2003-03-10 Oxford Biomedica (Uk) Limited Genes
US6838430B2 (en) 2001-09-28 2005-01-04 The Regents Of The University Of California Use of HIF-1a variants to accelerate wound healing
US20040190793A1 (en) 2002-03-01 2004-09-30 Rorvig Mark E. Method for retrieving images by content measure metadata encoding
EP1549738B1 (de) 2002-04-30 2010-04-21 Stratatech Corporation Exogene angiogene wachstumsfaktoren exprimierende keratinozyten
US7462448B2 (en) 2002-08-02 2008-12-09 Stratatech Corporation Species specific DNA detection
CA2527822A1 (en) 2003-05-30 2004-12-23 Stratatech Corporation Room temperature storage of organs
PT3100611T (pt) 2003-08-01 2018-12-14 Stratatech Corp Equivalentes de pele humana que expressam polipéptidos exógenos

Also Published As

Publication number Publication date
US20090169528A1 (en) 2009-07-02
WO2003093418A3 (en) 2005-04-21
EP1549738A4 (de) 2006-11-02
IL164817A0 (en) 2005-12-18
US20040009591A1 (en) 2004-01-15
US7988959B2 (en) 2011-08-02
DE60332256D1 (de) 2010-06-02
AU2003228755A1 (en) 2003-11-17
JP4753577B2 (ja) 2011-08-24
US8808685B2 (en) 2014-08-19
CA2483547C (en) 2012-03-20
US20110059057A1 (en) 2011-03-10
EP1549738A2 (de) 2005-07-06
IL195518A (en) 2012-08-30
JP2006509529A (ja) 2006-03-23
US7498167B2 (en) 2009-03-03
US7915042B2 (en) 2011-03-29
WO2003093418A2 (en) 2003-11-13
IL164817A (en) 2010-12-30
US7807148B2 (en) 2010-10-05
EP1549738B1 (de) 2010-04-21
CA2483547A1 (en) 2003-11-13
US20110286985A1 (en) 2011-11-24
US20050013807A1 (en) 2005-01-20
NZ536205A (en) 2008-04-30

Similar Documents

Publication Publication Date Title
ATE465242T1 (de) Exogene angiogene wachstumsfaktoren exprimierende keratinozyten
Lu et al. Towards the development of a simplified long‐term organ culture method for human scalp skin and its appendages under serum‐free conditions
Iohara et al. A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp
Kang et al. Effect of mechanical stimulation on the differentiation of cord stem cells
WO2020186207A8 (en) Non-viral dna vectors and uses thereof for expressing fviii therapeutics
ECSP105739A (es) Anticuerpos de neutralización contra gdf-8
BR0306665A (pt) Uso de zeìna nativa para aperfeiçoamento do estado do cabelo e agentes
EP1585756A4 (de) Verabreichung von sirnas
ATE485366T1 (de) Verwendung von lysyloxydase inhibitoren zur zellkultur und gewebeaufbau
DE69922933D1 (de) Anwendungen für humane nicht autologe, mesenchymale stammzellen
Agabalyan et al. Hair follicle dermal stem cells and skin‐derived precursor cells: Exciting tools for endogenous and exogenous therapies
WO2005012492A8 (en) Human skin equivalents expressing exogenous polypeptides
DK1506301T3 (da) Rekombinant poxvirus, der udtrykker homologe gener, der er indsat i poxvirusgenomet
IL250575A0 (en) Stable serum-free cell-to-cell gene transfer and production of recombinant human proteins in human cell lines
DE60130464D1 (de) Pre-adipose zelllinien
PT749317E (pt) Aplicacoes terapeuticas de produtos dimericos de proteinas bactericidas indutoras da permeabilidade
MXPA03001673A (es) Bacteria de acido lactico capaz de reducir una tendencia individual a desarrollar reacciones alergicas.
ATE514771T1 (de) Haartransplantation
ATE493966T1 (de) Mittel zur förderung der hautkollagenproduktion
TW200738752A (en) Modulation of MDL-1 activity for treatment of inflammatory disease
TW200621293A (en) Cosmetic compositions containing fluorescent colorants for natural skin appearance
WO2004001024A3 (en) Genetically engineered keratinocytes expressing at least one growth factor and/or activated egf receptor, skin equivalent comprising said keratinocytes and toxicity assay using said keratinocytes
DE602004027483D1 (de) Herstellung von rekombinanten igm in den per.c6 zellen
CY1106955T1 (el) Μεθοδος για συνθεση για δερματικα μοσχευματα
Dieckmann et al. Human melanocytes can be isolated, propagated and expanded from plucked anagen hair follicles

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties